LOCUS       NM_001017381            3179 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Fli-1 proto-oncogene, ETS transcription factor
            (Fli1), mRNA.
ACCESSION   NM_001017381 XM_235979
VERSION     NM_001017381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Saultier,P., Vidal,L., Canault,M., Bernot,D., Falaise,C.,
            Pouymayou,C., Bordet,J.C., Saut,N., Rostan,A., Baccini,V.,
            Peiretti,F., Favier,M., Lucca,P., Deleuze,J.F., Olaso,R.,
            Boland,A., Morange,P.E., Gachet,C., Malergue,F., Faure,S.,
            Eckly,A., Tregouet,D.A., Poggi,M. and Alessi,M.C.
  TITLE     Macrothrombocytopenia and dense granule deficiency associated with
            FLI1 variants: ultrastructural and pathogenic features
  JOURNAL   Haematologica 102 (6), 1006-1016 (2017)
   PUBMED   28255014
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Stevenson,W.S., Rabbolini,D.J., Beutler,L., Chen,Q., Gabrielli,S.,
            Mackay,J.P., Brighton,T.A., Ward,C.M. and Morel-Kopp,M.C.
  TITLE     Paris-Trousseau thrombocytopenia is phenocopied by the autosomal
            recessive inheritance of a DNA-binding domain mutation in FLI1
  JOURNAL   Blood 126 (17), 2027-2030 (2015)
   PUBMED   26316623
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Wei,G., Abraham,B.J., Yagi,R., Jothi,R., Cui,K., Sharma,S.,
            Narlikar,L., Northrup,D.L., Tang,Q., Paul,W.E., Zhu,J. and Zhao,K.
  TITLE     Genome-wide analyses of transcription factor GATA3-mediated gene
            regulation in distinct T cell types
  JOURNAL   Immunity 35 (2), 299-311 (2011)
   PUBMED   21867929
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Nowling,T.K., Fulton,J.D., Chike-Harris,K. and Gilkeson,G.S.
  TITLE     Ets factors and a newly identified polymorphism regulate Fli1
            promoter activity in lymphocytes
  JOURNAL   Mol Immunol 45 (1), 1-12 (2008)
   PUBMED   17606295
REFERENCE   5  (bases 1 to 3179)
  AUTHORS   Pimanda,J.E., Ottersbach,K., Knezevic,K., Kinston,S., Chan,W.Y.,
            Wilson,N.K., Landry,J.R., Wood,A.D., Kolb-Kokocinski,A.,
            Green,A.R., Tannahill,D., Lacaud,G., Kouskoff,V. and Gottgens,B.
  TITLE     Gata2, Fli1, and Scl form a recursively wired gene-regulatory
            circuit during early hematopoietic development
  JOURNAL   Proc Natl Acad Sci U S A 104 (45), 17692-17697 (2007)
   PUBMED   17962413
REFERENCE   6  (bases 1 to 3179)
  AUTHORS   Pang,L., Xue,H.H., Szalai,G., Wang,X., Wang,Y., Watson,D.K.,
            Leonard,W.J., Blobel,G.A. and Poncz,M.
  TITLE     Maturation stage-specific regulation of megakaryopoiesis by
            pointed-domain Ets proteins
  JOURNAL   Blood 108 (7), 2198-2206 (2006)
   PUBMED   16757682
REFERENCE   7  (bases 1 to 3179)
  AUTHORS   Raslova,H., Komura,E., Le Couedic,J.P., Larbret,F., Debili,N.,
            Feunteun,J., Danos,O., Albagli,O., Vainchenker,W. and Favier,R.
  TITLE     FLI1 monoallelic expression combined with its hemizygous loss
            underlies Paris-Trousseau/Jacobsen thrombopenia
  JOURNAL   J Clin Invest 114 (1), 77-84 (2004)
   PUBMED   15232614
REFERENCE   8  (bases 1 to 3179)
  AUTHORS   Waga,K., Nakamura,Y., Maki,K., Arai,H., Yamagata,T., Sasaki,K.,
            Kurokawa,M., Hirai,H. and Mitani,K.
  TITLE     Leukemia-related transcription factor TEL accelerates
            differentiation of Friend erythroleukemia cells
  JOURNAL   Oncogene 22 (1), 59-68 (2003)
   PUBMED   12527908
REFERENCE   9  (bases 1 to 3179)
  AUTHORS   Hart,A., Melet,F., Grossfeld,P., Chien,K., Jones,C.,
            Tunnacliffe,A., Favier,R. and Bernstein,A.
  TITLE     Fli-1 is required for murine vascular and megakaryocytic
            development and is hemizygously deleted in patients with
            thrombocytopenia
  JOURNAL   Immunity 13 (2), 167-177 (2000)
   PUBMED   10981960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Dec 3, 2020 this sequence version replaced NM_001017381.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY972521.1, SRR26360176.116051.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840115,
                                           SAMN16676785 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               JAXUCZ010000008.1  39208241-39208557   c
            318-529             JAXUCZ010000008.1  39144715-39144926   c
            530-684             JAXUCZ010000008.1  39133831-39133985   c
            685-888             JAXUCZ010000008.1  39129142-39129345   c
            889-954             JAXUCZ010000008.1  39120455-39120520   c
            955-1020            JAXUCZ010000008.1  39097505-39097570   c
            1021-1080           JAXUCZ010000008.1  39095608-39095667   c
            1081-1128           JAXUCZ010000008.1  39093308-39093355   c
            1129-3179           JAXUCZ010000008.1  39089533-39091583   c
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q21"
     gene            1..3179
                     /gene="Fli1"
                     /note="Fli-1 proto-oncogene, ETS transcription factor"
                     /db_xref="GeneID:315532"
                     /db_xref="RGD:1309837"
     exon            1..317
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..1658
                     /gene="Fli1"
                     /note="Friend leukemia virus integration 1; Friend
                     leukemia integration 1 transcription factor-like"
                     /codon_start=1
                     /product="Friend leukemia integration 1 transcription
                     factor"
                     /protein_id="NP_001017381.1"
                     /db_xref="GeneID:315532"
                     /db_xref="RGD:1309837"
                     /translation="MDGTIKEALSVVSDDQSLFDSAYGAAAHLPKADMTASGSPDYGQ
                     PHKINPLPPQQEWINQPVRVNVKREYDHMNGSRESPVDCSVSKCNKLVGGGEANPMNY
                     NSYMDEKNGPPPPNMTTNERRVIVPADPTLWTQEHVRQWLEWAIKEYGLMEIDTSFFQ
                     NMDGKELCKMSKEDFLRATSLYNTEVLLSHLSYLRESSLLAYNTPSHTDQSSRLNVKE
                     DPSYDSVRRGGWSNNMNSGINKSPPLGGAQSMGKNTEQRPQPDPYQILGPTSSRLANP
                     GSGQIQLWQFLLELLSDSANASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDK
                     LSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTETSMYKYPSDISYMPSYH
                     AHQQKVNFVQPHPSSMPVTSSSFFGAASQYWTSPTAGIYPNPSVPRHPNTHVPSHLGS
                     YY"
     exon            318..529
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..684
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..888
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            889..954
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1020
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1080
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1128
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..3179
                     /gene="Fli1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagagagaga gagagagaga gagagagaga gagataggac ttcctccccg atcgcaaagt
       61 gaagtcactt cccaaaatta gctgaaaaaa agtttcatcc ggttaactgt ctctttttcg
      121 atccgctaca acaacaaacg tgcacagggg agcgagggca gggtgctcac agggggcact
      181 cagagagggc ccagggcgcc aaagaggccg cgccgggcta atctgaaggg gctacggggt
      241 caggctgtaa ccgggtcaat gtgtggaata ttggggggct cggctgcaga attggccaaa
      301 tggacgggac tattaaggag gctctgtcag tggtgagtga cgaccagtcc ctttttgatt
      361 cagcatacgg agcggccgcc catctcccca aggcagatat gactgcttcg gggagtcctg
      421 actacgggca gccccacaaa atcaaccccc tgccaccaca gcaggagtgg atcaaccagc
      481 cagtgagggt caatgtcaag cgggaatatg atcacatgaa tggatccagg gagtctccgg
      541 tggactgcag tgtcagcaaa tgcaacaagc tggtgggtgg aggcgaagcc aaccccatga
      601 actacaatag ctacatggat gagaagaatg gcccccctcc tcccaacatg accaccaacg
      661 agcggagagt cattgtgcct gcagacccca cactgtggac acaggagcac gttcgacagt
      721 ggctggagtg ggccataaag gaatatggct tgatggagat tgacacttcc ttcttccaga
      781 acatggatgg caaggaactg tgtaaaatga gcaaggagga cttcctccga gccacctccc
      841 tctacaacac agaagtgctg ttgtcgcacc tcagttacct cagggaaagt tcactgctgg
      901 cctataatac accctcccac acagaccagt cctcacgact gaatgtcaag gaagaccctt
      961 cttatgactc tgtcaggaga gggggatgga gcaacaatat gaactctggc atcaacaaaa
     1021 gtcctcccct tggaggagca cagagcatgg gcaagaacac tgagcaacgg ccccagccag
     1081 atccttatca gatcctgggg cccaccagca gccgcctagc aaaccctgga agtgggcaga
     1141 tccaactgtg gcagtttctc ctggaactac tgtctgacag cgccaacgcc agttgcatta
     1201 cttgggaggg gaccaacggg gaattcaaaa tgacggaccc tgatgaggtg gccaggcgct
     1261 ggggagagcg gaagagcaag cccaacatga attacgataa gctgagccgg gccctccgat
     1321 actactacga taaaaacatt atgaccaaag tgcatggcaa aaggtatgcc tacaagtttg
     1381 acttccatgg cattgcccaa gccctgcagc cacacccaac agagacatca atgtacaagt
     1441 atccttctga catctcctac atgccttcct accatgccca tcaacaaaag gtgaactttg
     1501 tccagcccca cccatcctcc atgcctgtca cctcctccag cttctttgga gcagcgtcac
     1561 aatactggac ctcccccact gcggggatct acccgaaccc cagtgtaccc cgccatccta
     1621 acacccacgt gccttcacac ttaggcagct actactagaa cttaacacca gttggccttc
     1681 tggctgaagt tccagccctc acttctactg gatactctgg actctaaaag atgctgtagc
     1741 tttgaagaga taagaaaact ggatgttctt tcctttggat agaacctttg tacttgttct
     1801 tctaaaaatg attatttgta tgtttaaaaa aaaagaactt ttgcttcctc tacctaaaaa
     1861 agaaaaaaga aagaaaaaga aagaaagaaa gaaaaaagat ccttccatgg gccagtccac
     1921 caatttggat tctcaacctc ctatcattga atgagttaaa tatttaggtt actggaaccg
     1981 gttataccat gattccgaga atggagtatg cattttctgt attcttcttt tatgaccaaa
     2041 gcagtttctt atcagcacac gggtctcatc cttttaggat aatgaatcat gcatggactt
     2101 gaccagggtt ggtctggttt gaggctttag taaaaatcaa ggtaggatgt ttataatctt
     2161 ttcttaggag gacttaattc agcggatggc aactggaaca ccggctggga ggctggtgaa
     2221 gtccctgccc aactggaatt taaaagatgt gtgtgtatgt gtatatttaa gaagacatga
     2281 ctattacaaa attcctccca atgggccata tgcgcttggc tgactgttct ctccagaaat
     2341 agtcagaata tgaaccaaga aagtttaaca caaacacaga cactcctgaa ggacagtgga
     2401 ctaagtaact ttttgttttt gtttttgtgt tttagtgaca gtgagtccca ggactttgaa
     2461 aagtcagggg gatttctaaa ctcagacaga ttcgcaagcg ctgtgcgctt gtcagaccac
     2521 cagaccaagg tcaaccaatc agaaggcaac ttaactgtat aaattatgca gagttatttt
     2581 tcctatatct cacagtatta aaaaaaataa ataattaaaa agttaaagag tgaataaacg
     2641 agttgacctc ggtcacaaat gcagttttac tatcaaatca atcattgtta tttttttaaa
     2701 gtataatttg tacatctttt gtcaatctgt acatttgggc aatttgtacg tttttatagc
     2761 tggtctctct ctctctctct ttttttttaa ataagcataa tgtgactatt gatgaaaaga
     2821 aaacggagtg aaaagtcact aagttcttag gaagaaaagc cgtgatacag ttattttaac
     2881 gcgcatgccc aaacaagaga aaagatccct ttagatctac aatgcgtcag aaatgtttgt
     2941 aaataacaga gctgcaataa cctgagaagg acagacagac gtctcctcgt gcgcgcgagg
     3001 agctctcctg ctctatatag caatatattt ttagacgtga gaatatatat aattttgcag
     3061 gtaatcgtga ctttttaaat gatattaagg gttaagctga caactgtcca atgcagactg
     3121 agttgtaaaa taatttgacc tgaataaatt gtgccttctt ccttttcttc ttctttcag
//
