LOCUS       NM_001393766           23687 bp    mRNA    linear   ROD 19-MAR-2023
DEFINITION  Rattus norvegicus filaggrin (Flg), mRNA.
ACCESSION   NM_001393766
VERSION     NM_001393766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 23687)
  AUTHORS   Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C,
            Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A,
            Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA,
            Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM,
            Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN,
            Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A and
            Fallon PG.
  TITLE     Tmem79/Matt is the matted mouse gene and is a predisposing gene for
            atopic dermatitis in human subjects
  JOURNAL   J Allergy Clin Immunol 132 (5), 1121-1129 (2013)
   PUBMED   24084074
  REMARK    Erratum:[J Allergy Clin Immunol. 2015 Dec;136(6):1710. PMID:
            28843836]
REFERENCE   2  (bases 1 to 23687)
  AUTHORS   Pellerin L, Henry J, Hsu CY, Balica S, Jean-Decoster C, Mechin MC,
            Hansmann B, Rodriguez E, Weindinger S, Schmitt AM, Serre G, Paul C
            and Simon M.
  TITLE     Defects of filaggrin-like proteins in both lesional and nonlesional
            atopic skin
  JOURNAL   J Allergy Clin Immunol 131 (4), 1094-1102 (2013)
   PUBMED   23403047
REFERENCE   3  (bases 1 to 23687)
  AUTHORS   Okano J, Lichti U, Mamiya S, Aronova M, Zhang G, Yuspa SH, Hamada
            H, Sakai Y and Morasso MI.
  TITLE     Increased retinoic acid levels through ablation of Cyp26b1
            determine the processes of embryonic skin barrier formation and
            peridermal development
  JOURNAL   J Cell Sci 125 (Pt 7), 1827-1836 (2012)
   PUBMED   22366455
REFERENCE   4  (bases 1 to 23687)
  AUTHORS   de Mateo S, Castillo J, Estanyol JM, Ballesca JL and Oliva R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 23687)
  AUTHORS   Niderla-Bielinska J and Moskalewski S.
  TITLE     Involucrin, but not filaggrin and Kdap mRNA, expression is
            downregulated in 3-D cultures of intact rat hair bulbs after
            calcium stimulation
  JOURNAL   Folia Histochem Cytobiol 49 (2), 335-343 (2011)
   PUBMED   21744336
  REMARK    GeneRIF: The level of mRNA for differentiation markers: involucrin,
            filaggrin, keratinocyte differentiation associated protein and
            trichohyalin, was studied by RealTime PCR.
REFERENCE   6  (bases 1 to 23687)
  AUTHORS   Presland RB, Haydock PV, Fleckman P, Nirunsuksiri W and Dale BA.
  TITLE     Characterization of the human epidermal profilaggrin gene. Genomic
            organization and identification of an S-100-like calcium binding
            domain at the amino terminus
  JOURNAL   J Biol Chem 267 (33), 23772-23781 (1992)
   PUBMED   1429717
REFERENCE   7  (bases 1 to 23687)
  AUTHORS   Haydock PV and Dale BA.
  TITLE     Filaggrin, an intermediate filament-associated protein: structural
            and functional implications from the sequence of a cDNA from rat
  JOURNAL   DNA Cell Biol 9 (4), 251-261 (1990)
   PUBMED   1693512
REFERENCE   8  (bases 1 to 23687)
  AUTHORS   Holbrook,K.A., Dale,B.A. and Brown,K.S.
  TITLE     Abnormal epidermal keratinization in the repeated epilation mutant
            mouse
  JOURNAL   J Cell Biol 92 (2), 387-397 (1982)
   PUBMED   6174530
REFERENCE   9  (bases 1 to 23687)
  AUTHORS   Steinert,P.M., Cantieri,J.S., Teller,D.C., Lonsdale-Eccles,J.D. and
            Dale,B.A.
  TITLE     Characterization of a class of cationic proteins that specifically
            interact with intermediate filaments
  JOURNAL   Proc Natl Acad Sci U S A 78 (7), 4097-4101 (1981)
   PUBMED   6170061
REFERENCE   10 (bases 1 to 23687)
  AUTHORS   Lane,P.W.
  TITLE     Two new mutations in linkage group XVI of the house mouse. Flaky
            tail and varitint-waddler-J
  JOURNAL   J Hered 63 (3), 135-140 (1972)
   PUBMED   4557539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000069.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JACYVU010000069.1  45357213-45357261
            50-208              JACYVU010000069.1  45361087-45361245
            209-23687           JACYVU010000069.1  45361928-45385406
FEATURES             Location/Qualifiers
     source          1..23687
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..23687
                     /gene="Flg"
                     /gene_synonym="Pflg"
                     /note="filaggrin"
                     /db_xref="GeneID:24641"
                     /db_xref="RGD:2620"
     exon            1..49
                     /gene="Flg"
                     /gene_synonym="Pflg"
                     /inference="alignment:Splign:2.1.0"
     exon            50..208
                     /gene="Flg"
                     /gene_synonym="Pflg"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..23191
                     /gene="Flg"
                     /gene_synonym="Pflg"
                     /note="Filaggrin (profilaggrin)"
                     /codon_start=1
                     /product="filaggrin"
                     /protein_id="NP_001380695.1"
                     /db_xref="GeneID:24641"
                     /db_xref="RGD:2620"
                     /translation="MSTLLESITSMIDIFQQYSNNDKEEETLSKEELKELLEGELQAV
                     LKNPNDQDIAEVFMQMLDVDHDDKIDFTEYLLMVLKLAQAYYETSKKRRSQTKESGKR
                     NEHDYKGYEERREKVQRRHRRRNSGTDGKQENERSKSPRGRGNKRRGSSTISEESDTN
                     RNSDTENKRHHHGSNRRQRRGSNSSDRKETRSKKHREVKERNAGIYNDGKDGQDWEVN
                     YENCYYKTEESNREQREGRNHKTKESHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQRASAGGQAADTSSRSGASQGQAS
                     GQGRAGSRSREAQGIARHGQSTDSHRHSGAGQAQAHTATSIDSRRPRGSSESQASDSE
                     GHSDYSEAHTQGAHGGIQTSQRHEQRPSRGQQGSGHPQVYYYGVEETEDESDAQQGHH
                     QQQQQQRQQQRQRHQHEQEREHEHQQPESSHRQQGSSGRTHRAARHEQESDSTRQRGS
                     HQAHSSARTQEEIARGRSGASASEGPGPQREAARDSSEHAQSRRSETISRGRSGHSTG
                     RAHEDRHEQATDRSARSGSRGGQAGSHSESEASGGQAGRRGTAATRHTSRPEQSPDTA
                     GRTGSSRGQQSAQRHADSTPGSTRTGSRGRGESPAGQQSPDRARHIESRRGRTREASA
                     SQSSDSEGHSGAHAGIGQGQTSTTHRRAGSSSGSQQASVEGSDGYDSIVKSKYLSFSQ
                     SHCYYY"
     exon            209..23687
                     /gene="Flg"
                     /gene_synonym="Pflg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccagcaat ctccttcagc tgctttgatt caatcttctt ccaaacaagg tgcacacata
       61 caactaaaag atgtccactc tcctggaaag catcactagc atgattgaca tattccaaca
      121 atactcaaac aatgataagg aggaggaaac actgagcaaa gaagagctga aggaacttct
      181 ggaaggagaa ttacaagcag tcttgaagaa tccaaatgac caagacatag cagaggtctt
      241 catgcaaatg ctagatgtgg accacgatga caaaatagat ttcactgagt atttactaat
      301 ggtattaaag ctggcacaag catattatga aacatcaaaa aagagaagat cccaaacaaa
      361 agaatcagga aagagaaatg aacatgatta taaaggatat gaagaaagga gagaaaaagt
      421 acaaagaaga cacaggcgga ggaacagtgg aactgatgga aagcaagaaa atgaacgatc
      481 aaaaagccca agaggaagag ggaacaaaag acgaggatcc agcactataa gtgaggaaag
      541 tgacacaaac agaaatagtg atacagaaaa caaaaggcac catcatggtt caaacagaag
      601 gcaaagaaga ggttccaatt catctgacag gaaagagaca agaagtaaga aacacagaga
      661 ggtaaaagaa agaaatgctg ggatctataa cgatggaaaa gacggacaag attgggaagt
      721 aaactatgaa aactgttatt acaaaactga agaaagtaac agggaacaaa gagaaggacg
      781 gaatcataaa acaaaagaat cgcacagtga gagcgaggcc tccggtggtc aggccggccg
      841 cagaggcact gcagccacca ggcacacatc tcgccccgaa cagtctccag acactgctgg
      901 ccggaccgga tccagccgtg gacagcagtc cgcccaacga catgctgact caaccccggg
      961 cagcacaaga accggctcca gaggaagagg agagtcccca gctggccagc agtcccccga
     1021 cagagccagg cacatcgaat ccaggagggg tagaacccgg gaggccagcg ccagccagtc
     1081 cagtgacagc gaaggccatt ctggagccca tgccgggatc gggcaagggc agacctcaac
     1141 cactcacagg agggcaggct ccagctcagg gagccagcgg gcctctgctg gtggccaagc
     1201 agctgacacc tccagtcgct caggggccag tcaaggccag gcatcaggcc agggtcgtgc
     1261 agggtcccga agcagggaag ctcagggcat cgctcgtcat gggcagtcga cagacagcca
     1321 caggcactct ggggccgggc aagcacaagc ccacacagcc acaagcattg acagcaggag
     1381 gcctcgcggg tccagcgaga gtcaggccag cgacagcgag ggccactccg actactcaga
     1441 agcacacaca cagggagccc acggtgggat ccaaacaagc cagaggcacg agcagcgacc
     1501 ctcccgaggc cagcagggct ccggacaccc ccaggtgtac tactatggtg tagaagaaac
     1561 cgaggacgag tccgatgccc agcaggggca ccaccagcag cagcaacagc agcggcagca
     1621 gcagcggcag cggcaccagc atgaacagga acgagaacat gaacaccaac agccagagtc
     1681 cagccacagg cagcaggggt ccagtgggag aacgcaccgg gcagctcgcc atgaacagga
     1741 aagcgacagc accaggcaaa ggggctctca ccaggcgcac agctccgctc gcacccagga
     1801 ggagatcgca cgcggaaggt ctggagccag tgccagtgag ggtccggggc cccagaggga
     1861 ggctgccagg gacagctctg agcacgccca gtccagaagg agcgagacca tcagccgtgg
     1921 acgctcagga cactccactg ggagagccca cgaagaccgc cacgagcagg caacagaccg
     1981 ctctgcccgc tccgggtcca ggggaggcca ggccggctcc cacagtgaga gcgaggcctc
     2041 cggtggtcag gccggccgca gaggcactgc agccaccagg cacacatctc gccccgaaca
     2101 gtctccagac actgctggcc ggaccggatc cagccgtgga cagcagtccg cccaacgaca
     2161 tgctgactca accccgggca gcacaagaac cggctccaga ggaagaggag agtccccagc
     2221 tggccagcag tcccccgaca gagccaggca catcgaatcc aggaggggta gaacccggga
     2281 ggccagcgcc agccagtcca gtgacagcga aggccattct ggagcccatg ccgggatcgg
     2341 gcaagggcag acctcaacca ctcacaggag ggcaggctcc agctcaggga gccagcgggc
     2401 ctctgctggt ggccaagcag ctgacacctc cagtcgctca ggggccagtc aaggccaggc
     2461 atcaggccag ggtcgtgcag ggtcccgaag cagggaagct cagggcatcg ctcgtcatgg
     2521 gcagtcgaca gacagccaca ggcactctgg ggccgggcaa gcacaagccc acacagccac
     2581 aagcattgac agcaggaggc ctcgcgggtc cagcgagagt caggccagcg acagcgaggg
     2641 ccactccgac tactcagaag cacacacaca gggagcccac ggtgggatcc aaacaagcca
     2701 gaggcacgag cagcgaccct cccgaggcca gcagggctcc ggacaccccc aggtgtacta
     2761 ctatggtgta gaagaaaccg aggacgagtc cgatgcccag caggggcacc accagcagca
     2821 gcaacagcag cggcagcagc agcggcagcg gcaccagcat gaacaggaac gagaacatga
     2881 acaccaacag ccagagtcca gccacaggca gcaggggtcc agtgggagaa cgcaccgggc
     2941 agctcgccat gaacaggaaa gcgacagcac caggcaaagg ggctctcacc aggcgcacag
     3001 ctccgctcgc acccaggagg agatcgcacg cggaaggtct ggagccagtg ccagtgaggg
     3061 tccggggccc cagagggagg ctgccaggga cagctctgag cacgcccagt ccagaaggag
     3121 cgagaccatc agccgtggac gctcaggaca ctccactggg agagcccacg aagaccgcca
     3181 cgagcaggca acagaccgct ctgcccgctc cgggtccagg ggaggccagg ccggctccca
     3241 cagtgagagc gaggcctccg gtggtcaggc cggccgcaga ggcactgcag ccaccaggca
     3301 cacatctcgc cccgaacagt ctccagacac tgctggccgg accggatcca gccgtggaca
     3361 gcagtccgcc caacgacatg ctgactcaac cccgggcagc acaagaaccg gctccagagg
     3421 aagaggagag tccccagctg gccagcagtc ccccgacaga gccaggcaca tcgaatccag
     3481 gaggggtaga acccgggagg ccagcgccag ccagtccagt gacagcgaag gccattctgg
     3541 agcccatgcc gggatcgggc aagggcagac ctcaaccact cacaggaggg caggctccag
     3601 ctcagggagc cagcgggcct ctgctggtgg ccaagcagct gacacctcca gtcgctcagg
     3661 ggccagtcaa ggccaggcat caggccaggg tcgtgcaggg tcccgaagca gggaagctca
     3721 gggcatcgct cgtcatgggc agtcgacaga cagccacagg cactctgggg ccgggcaagc
     3781 acaagcccac acagccacaa gcattgacag caggaggcct cgcgggtcca gcgagagtca
     3841 ggccagcgac agcgagggcc actccgacta ctcagaagca cacacacagg gagcccacgg
     3901 tgggatccaa acaagccaga ggcacgagca gcgaccctcc cgaggccagc agggctccgg
     3961 acacccccag gtgtactact atggtgtaga agaaaccgag gacgagtccg atgcccagca
     4021 ggggcaccac cagcagcagc aacagcagcg gcagcagcag cggcagcggc accagcatga
     4081 acaggaacga gaacatgaac accaacagcc agagtccagc cacaggcagc aggggtccag
     4141 tgggagaacg caccgggcag ctcgccatga acaggaaagc gacagcacca ggcaaagggg
     4201 ctctcaccag gcgcacagct ccgctcgcac ccaggaggag atcgcacgcg gaaggtctgg
     4261 agccagtgcc agtgagggtc cggggcccca gagggaggct gccagggaca gctctgagca
     4321 cgcccagtcc agaaggagcg agaccatcag ccgtggacgc tcaggacact ccactgggag
     4381 agcccacgaa gaccgccacg agcaggcaac agaccgctct gcccgctccg ggtccagggg
     4441 aggccaggcc ggctcccaca gtgagagcga ggcctccggt ggtcaggccg gccgcagagg
     4501 cactgcagcc accaggcaca catctcgccc cgaacagtct ccagacactg ctggccggac
     4561 cggatccagc cgtggacagc agtccgccca acgacatgct gactcaaccc cgggcagcac
     4621 aagaaccggc tccagaggaa gaggagagtc cccagctggc cagcagtccc ccgacagagc
     4681 caggcacatc gaatccagga ggggtagaac ccgggaggcc agcgccagcc agtccagtga
     4741 cagcgaaggc cattctggag cccatgccgg gatcgggcaa gggcagacct caaccactca
     4801 caggagggca ggctccagct cagggagcca gcgggcctct gctggtggcc aagcagctga
     4861 cacctccagt cgctcagggg ccagtcaagg ccaggcatca ggccagggtc gtgcagggtc
     4921 ccgaagcagg gaagctcagg gcatcgctcg tcatgggcag tcgacagaca gccacaggca
     4981 ctctggggcc gggcaagcac aagcccacac agccacaagc attgacagca ggaggcctcg
     5041 cgggtccagc gagagtcagg ccagcgacag cgagggccac tccgactact cagaagcaca
     5101 cacacaggga gcccacggtg ggatccaaac aagccagagg cacgagcagc gaccctcccg
     5161 aggccagcag ggctccggac acccccaggt gtactactat ggtgtagaag aaaccgagga
     5221 cgagtccgat gcccagcagg ggcaccacca gcagcagcaa cagcagcggc agcagcagcg
     5281 gcagcggcac cagcatgaac aggaacgaga acatgaacac caacagccag agtccagcca
     5341 caggcagcag gggtccagtg ggagaacgca ccgggcagct cgccatgaac aggaaagcga
     5401 cagcaccagg caaaggggct ctcaccaggc gcacagctcc gctcgcaccc aggaggagat
     5461 cgcacgcgga aggtctggag ccagtgccag tgagggtccg gggccccaga gggaggctgc
     5521 cagggacagc tctgagcacg cccagtccag aaggagcgag accatcagcc gtggacgctc
     5581 aggacactcc actgggagag cccacgaaga ccgccacgag caggcaacag accgctctgc
     5641 ccgctccggg tccaggggag gccaggccgg ctcccacagt gagagcgagg cctccggtgg
     5701 tcaggccggc cgcagaggca ctgcagccac caggcacaca tctcgccccg aacagtctcc
     5761 agacactgct ggccggaccg gatccagccg tggacagcag tccgcccaac gacatgctga
     5821 ctcaaccccg ggcagcacaa gaaccggctc cagaggaaga ggagagtccc cagctggcca
     5881 gcagtccccc gacagagcca ggcacatcga atccaggagg ggtagaaccc gggaggccag
     5941 cgccagccag tccagtgaca gcgaaggcca ttctggagcc catgccggga tcgggcaagg
     6001 gcagacctca accactcaca ggagggcagg ctccagctca gggagccagc gggcctctgc
     6061 tggtggccaa gcagctgaca cctccagtcg ctcaggggcc agtcaaggcc aggcatcagg
     6121 ccagggtcgt gcagggtccc gaagcaggga agctcagggc atcgctcgtc atgggcagtc
     6181 gacagacagc cacaggcact ctggggccgg gcaagcacaa gcccacacag ccacaagcat
     6241 tgacagcagg aggcctcgcg ggtccagcga gagtcaggcc agcgacagcg agggccactc
     6301 cgactactca gaagcacaca cacagggagc ccacggtggg atccaaacaa gccagaggca
     6361 cgagcagcga ccctcccgag gccagcaggg ctccggacac ccccaggtgt actactatgg
     6421 tgtagaagaa accgaggacg agtccgatgc ccagcagggg caccaccagc agcagcaaca
     6481 gcagcggcag cagcagcggc agcggcacca gcatgaacag gaacgagaac atgaacacca
     6541 acagccagag tccagccaca ggcagcaggg gtccagtggg agaacgcacc gggcagctcg
     6601 ccatgaacag gaaagcgaca gcaccaggca aaggggctct caccaggcgc acagctccgc
     6661 tcgcacccag gaggagatcg cacgcggaag gtctggagcc agtgccagtg agggtccggg
     6721 gccccagagg gaggctgcca gggacagctc tgagcacgcc cagtccagaa ggagcgagac
     6781 catcagccgt ggacgctcag gacactccac tgggagagcc cacgaagacc gccacgagca
     6841 ggcaacagac cgctctgccc gctccgggtc caggggaggc caggccggct cccacagtga
     6901 gagcgaggcc tccggtggtc aggccggccg cagaggcact gcagccacca ggcacacatc
     6961 tcgccccgaa cagtctccag acactgctgg ccggaccgga tccagccgtg gacagcagtc
     7021 cgcccaacga catgctgact caaccccggg cagcacaaga accggctcca gaggaagagg
     7081 agagtcccca gctggccagc agtcccccga cagagccagg cacatcgaat ccaggagggg
     7141 tagaacccgg gaggccagcg ccagccagtc cagtgacagc gaaggccatt ctggagccca
     7201 tgccgggatc gggcaagggc agacctcaac cactcacagg agggcaggct ccagctcagg
     7261 gagccagcgg gcctctgctg gtggccaagc agctgacacc tccagtcgct caggggccag
     7321 tcaaggccag gcatcaggcc agggtcgtgc agggtcccga agcagggaag ctcagggcat
     7381 cgctcgtcat gggcagtcga cagacagcca caggcactct ggggccgggc aagcacaagc
     7441 ccacacagcc acaagcattg acagcaggag gcctcgcggg tccagcgaga gtcaggccag
     7501 cgacagcgag ggccactccg actactcaga agcacacaca cagggagccc acggtgggat
     7561 ccaaacaagc cagaggcacg agcagcgacc ctcccgaggc cagcagggct ccggacaccc
     7621 ccaggtgtac tactatggtg tagaagaaac cgaggacgag tccgatgccc agcaggggca
     7681 ccaccagcag cagcaacagc agcggcagca gcagcggcag cggcaccagc atgaacagga
     7741 acgagaacat gaacaccaac agccagagtc cagccacagg cagcaggggt ccagtgggag
     7801 aacgcaccgg gcagctcgcc atgaacagga aagcgacagc accaggcaaa ggggctctca
     7861 ccaggcgcac agctccgctc gcacccagga ggagatcgca cgcggaaggt ctggagccag
     7921 tgccagtgag ggtccggggc cccagaggga ggctgccagg gacagctctg agcacgccca
     7981 gtccagaagg agcgagacca tcagccgtgg acgctcagga cactccactg ggagagccca
     8041 cgaagaccgc cacgagcagg caacagaccg ctctgcccgc tccgggtcca ggggaggcca
     8101 ggccggctcc cacagtgaga gcgaggcctc cggtggtcag gccggccgca gaggcactgc
     8161 agccaccagg cacacatctc gccccgaaca gtctccagac actgctggcc ggaccggatc
     8221 cagccgtgga cagcagtccg cccaacgaca tgctgactca accccgggca gcacaagaac
     8281 cggctccaga ggaagaggag agtccccagc tggccagcag tcccccgaca gagccaggca
     8341 catcgaatcc aggaggggta gaacccggga ggccagcgcc agccagtcca gtgacagcga
     8401 aggccattct ggagcccatg ccgggatcgg gcaagggcag acctcaacca ctcacaggag
     8461 ggcaggctcc agctcaggga gccagcgggc ctctgctggt ggccaagcag ctgacacctc
     8521 cagtcgctca ggggccagtc aaggccaggc atcaggccag ggtcgtgcag ggtcccgaag
     8581 cagggaagct cagggcatcg ctcgtcatgg gcagtcgaca gacagccaca ggcactctgg
     8641 ggccgggcaa gcacaagccc acacagccac aagcattgac agcaggaggc ctcgcgggtc
     8701 cagcgagagt caggccagcg acagcgaggg ccactccgac tactcagaag cacacacaca
     8761 gggagcccac ggtgggatcc aaacaagcca gaggcacgag cagcgaccct cccgaggcca
     8821 gcagggctcc ggacaccccc aggtgtacta ctatggtgta gaagaaaccg aggacgagtc
     8881 cgatgcccag caggggcacc accagcagca gcaacagcag cggcagcagc agcggcagcg
     8941 gcaccagcat gaacaggaac gagaacatga acaccaacag ccagagtcca gccacaggca
     9001 gcaggggtcc agtgggagaa cgcaccgggc agctcgccat gaacaggaaa gcgacagcac
     9061 caggcaaagg ggctctcacc aggcgcacag ctccgctcgc acccaggagg agatcgcacg
     9121 cggaaggtct ggagccagtg ccagtgaggg tccggggccc cagagggagg ctgccaggga
     9181 cagctctgag cacgcccagt ccagaaggag cgagaccatc agccgtggac gctcaggaca
     9241 ctccactggg agagcccacg aagaccgcca cgagcaggca acagaccgct ctgcccgctc
     9301 cgggtccagg ggaggccagg ccggctccca cagtgagagc gaggcctccg gtggtcaggc
     9361 cggccgcaga ggcactgcag ccaccaggca cacatctcgc cccgaacagt ctccagacac
     9421 tgctggccgg accggatcca gccgtggaca gcagtccgcc caacgacatg ctgactcaac
     9481 cccgggcagc acaagaaccg gctccagagg aagaggagag tccccagctg gccagcagtc
     9541 ccccgacaga gccaggcaca tcgaatccag gaggggtaga acccgggagg ccagcgccag
     9601 ccagtccagt gacagcgaag gccattctgg agcccatgcc gggatcgggc aagggcagac
     9661 ctcaaccact cacaggaggg caggctccag ctcagggagc cagcgggcct ctgctggtgg
     9721 ccaagcagct gacacctcca gtcgctcagg ggccagtcaa ggccaggcat caggccaggg
     9781 tcgtgcaggg tcccgaagca gggaagctca gggcatcgct cgtcatgggc agtcgacaga
     9841 cagccacagg cactctgggg ccgggcaagc acaagcccac acagccacaa gcattgacag
     9901 caggaggcct cgcgggtcca gcgagagtca ggccagcgac agcgagggcc actccgacta
     9961 ctcagaagca cacacacagg gagcccacgg tgggatccaa acaagccaga ggcacgagca
    10021 gcgaccctcc cgaggccagc agggctccgg acacccccag gtgtactact atggtgtaga
    10081 agaaaccgag gacgagtccg atgcccagca ggggcaccac cagcagcagc aacagcagcg
    10141 gcagcagcag cggcagcggc accagcatga acaggaacga gaacatgaac accaacagcc
    10201 agagtccagc cacaggcagc aggggtccag tgggagaacg caccgggcag ctcgccatga
    10261 acaggaaagc gacagcacca ggcaaagggg ctctcaccag gcgcacagct ccgctcgcac
    10321 ccaggaggag atcgcacgcg gaaggtctgg agccagtgcc agtgagggtc cggggcccca
    10381 gagggaggct gccagggaca gctctgagca cgcccagtcc agaaggagcg agaccatcag
    10441 ccgtggacgc tcaggacact ccactgggag agcccacgaa gaccgccacg agcaggcaac
    10501 agaccgctct gcccgctccg ggtccagggg aggccaggcc ggctcccaca gtgagagcga
    10561 ggcctccggt ggtcaggccg gccgcagagg cactgcagcc accaggcaca catctcgccc
    10621 cgaacagtct ccagacactg ctggccggac cggatccagc cgtggacagc agtccgccca
    10681 acgacatgct gactcaaccc cgggcagcac aagaaccggc tccagaggaa gaggagagtc
    10741 cccagctggc cagcagtccc ccgacagagc caggcacatc gaatccagga ggggtagaac
    10801 ccgggaggcc agcgccagcc agtccagtga cagcgaaggc cattctggag cccatgccgg
    10861 gatcgggcaa gggcagacct caaccactca caggagggca ggctccagct cagggagcca
    10921 gcgggcctct gctggtggcc aagcagctga cacctccagt cgctcagggg ccagtcaagg
    10981 ccaggcatca ggccagggtc gtgcagggtc ccgaagcagg gaagctcagg gcatcgctcg
    11041 tcatgggcag tcgacagaca gccacaggca ctctggggcc gggcaagcac aagcccacac
    11101 agccacaagc attgacagca ggaggcctcg cgggtccagc gagagtcagg ccagcgacag
    11161 cgagggccac tccgactact cagaagcaca cacacaggga gcccacggtg ggatccaaac
    11221 aagccagagg cacgagcagc gaccctcccg aggccagcag ggctccggac acccccaggt
    11281 gtactactat ggtgtagaag aaaccgagga cgagtccgat gcccagcagg ggcaccacca
    11341 gcagcagcaa cagcagcggc agcagcagcg gcagcggcac cagcatgaac aggaacgaga
    11401 acatgaacac caacagccag agtccagcca caggcagcag gggtccagtg ggagaacgca
    11461 ccgggcagct cgccatgaac aggaaagcga cagcaccagg caaaggggct ctcaccaggc
    11521 gcacagctcc gctcgcaccc aggaggagat cgcacgcgga aggtctggag ccagtgccag
    11581 tgagggtccg gggccccaga gggaggctgc cagggacagc tctgagcacg cccagtccag
    11641 aaggagcgag accatcagcc gtggacgctc aggacactcc actgggagag cccacgaaga
    11701 ccgccacgag caggcaacag accgctctgc ccgctccggg tccaggggag gccaggccgg
    11761 ctcccacagt gagagcgagg cctccggtgg tcaggccggc cgcagaggca ctgcagccac
    11821 caggcacaca tctcgccccg aacagtctcc agacactgct ggccggaccg gatccagccg
    11881 tggacagcag tccgcccaac gacatgctga ctcaaccccg ggcagcacaa gaaccggctc
    11941 cagaggaaga ggagagtccc cagctggcca gcagtccccc gacagagcca ggcacatcga
    12001 atccaggagg ggtagaaccc gggaggccag cgccagccag tccagtgaca gcgaaggcca
    12061 ttctggagcc catgccggga tcgggcaagg gcagacctca accactcaca ggagggcagg
    12121 ctccagctca gggagccagc gggcctctgc tggtggccaa gcagctgaca cctccagtcg
    12181 ctcaggggcc agtcaaggcc aggcatcagg ccagggtcgt gcagggtccc gaagcaggga
    12241 agctcagggc atcgctcgtc atgggcagtc gacagacagc cacaggcact ctggggccgg
    12301 gcaagcacaa gcccacacag ccacaagcat tgacagcagg aggcctcgcg ggtccagcga
    12361 gagtcaggcc agcgacagcg agggccactc cgactactca gaagcacaca cacagggagc
    12421 ccacggtggg atccaaacaa gccagaggca cgagcagcga ccctcccgag gccagcaggg
    12481 ctccggacac ccccaggtgt actactatgg tgtagaagaa accgaggacg agtccgatgc
    12541 ccagcagggg caccaccagc agcagcaaca gcagcggcag cagcagcggc agcggcacca
    12601 gcatgaacag gaacgagaac atgaacacca acagccagag tccagccaca ggcagcaggg
    12661 gtccagtggg agaacgcacc gggcagctcg ccatgaacag gaaagcgaca gcaccaggca
    12721 aaggggctct caccaggcgc acagctccgc tcgcacccag gaggagatcg cacgcggaag
    12781 gtctggagcc agtgccagtg agggtccggg gccccagagg gaggctgcca gggacagctc
    12841 tgagcacgcc cagtccagaa ggagcgagac catcagccgt ggacgctcag gacactccac
    12901 tgggagagcc cacgaagacc gccacgagca ggcaacagac cgctctgccc gctccgggtc
    12961 caggggaggc caggccggct cccacagtga gagcgaggcc tccggtggtc aggccggccg
    13021 cagaggcact gcagccacca ggcacacatc tcgccccgaa cagtctccag acactgctgg
    13081 ccggaccgga tccagccgtg gacagcagtc cgcccaacga catgctgact caaccccggg
    13141 cagcacaaga accggctcca gaggaagagg agagtcccca gctggccagc agtcccccga
    13201 cagagccagg cacatcgaat ccaggagggg tagaacccgg gaggccagcg ccagccagtc
    13261 cagtgacagc gaaggccatt ctggagccca tgccgggatc gggcaagggc agacctcaac
    13321 cactcacagg agggcaggct ccagctcagg gagccagcgg gcctctgctg gtggccaagc
    13381 agctgacacc tccagtcgct caggggccag tcaaggccag gcatcaggcc agggtcgtgc
    13441 agggtcccga agcagggaag ctcagggcat cgctcgtcat gggcagtcga cagacagcca
    13501 caggcactct ggggccgggc aagcacaagc ccacacagcc acaagcattg acagcaggag
    13561 gcctcgcggg tccagcgaga gtcaggccag cgacagcgag ggccactccg actactcaga
    13621 agcacacaca cagggagccc acggtgggat ccaaacaagc cagaggcacg agcagcgacc
    13681 ctcccgaggc cagcagggct ccggacaccc ccaggtgtac tactatggtg tagaagaaac
    13741 cgaggacgag tccgatgccc agcaggggca ccaccagcag cagcaacagc agcggcagca
    13801 gcagcggcag cggcaccagc atgaacagga acgagaacat gaacaccaac agccagagtc
    13861 cagccacagg cagcaggggt ccagtgggag aacgcaccgg gcagctcgcc atgaacagga
    13921 aagcgacagc accaggcaaa ggggctctca ccaggcgcac agctccgctc gcacccagga
    13981 ggagatcgca cgcggaaggt ctggagccag tgccagtgag ggtccggggc cccagaggga
    14041 ggctgccagg gacagctctg agcacgccca gtccagaagg agcgagacca tcagccgtgg
    14101 acgctcagga cactccactg ggagagccca cgaagaccgc cacgagcagg caacagaccg
    14161 ctctgcccgc tccgggtcca ggggaggcca ggccggctcc cacagtgaga gcgaggcctc
    14221 cggtggtcag gccggccgca gaggcactgc agccaccagg cacacatctc gccccgaaca
    14281 gtctccagac actgctggcc ggaccggatc cagccgtgga cagcagtccg cccaacgaca
    14341 tgctgactca accccgggca gcacaagaac cggctccaga ggaagaggag agtccccagc
    14401 tggccagcag tcccccgaca gagccaggca catcgaatcc aggaggggta gaacccggga
    14461 ggccagcgcc agccagtcca gtgacagcga aggccattct ggagcccatg ccgggatcgg
    14521 gcaagggcag acctcaacca ctcacaggag ggcaggctcc agctcaggga gccagcgggc
    14581 ctctgctggt ggccaagcag ctgacacctc cagtcgctca ggggccagtc aaggccaggc
    14641 atcaggccag ggtcgtgcag ggtcccgaag cagggaagct cagggcatcg ctcgtcatgg
    14701 gcagtcgaca gacagccaca ggcactctgg ggccgggcaa gcacaagccc acacagccac
    14761 aagcattgac agcaggaggc ctcgcgggtc cagcgagagt caggccagcg acagcgaggg
    14821 ccactccgac tactcagaag cacacacaca gggagcccac ggtgggatcc aaacaagcca
    14881 gaggcacgag cagcgaccct cccgaggcca gcagggctcc ggacaccccc aggtgtacta
    14941 ctatggtgta gaagaaaccg aggacgagtc cgatgcccag caggggcacc accagcagca
    15001 gcaacagcag cggcagcagc agcggcagcg gcaccagcat gaacaggaac gagaacatga
    15061 acaccaacag ccagagtcca gccacaggca gcaggggtcc agtgggagaa cgcaccgggc
    15121 agctcgccat gaacaggaaa gcgacagcac caggcaaagg ggctctcacc aggcgcacag
    15181 ctccgctcgc acccaggagg agatcgcacg cggaaggtct ggagccagtg ccagtgaggg
    15241 tccggggccc cagagggagg ctgccaggga cagctctgag cacgcccagt ccagaaggag
    15301 cgagaccatc agccgtggac gctcaggaca ctccactggg agagcccacg aagaccgcca
    15361 cgagcaggca acagaccgct ctgcccgctc cgggtccagg ggaggccagg ccggctccca
    15421 cagtgagagc gaggcctccg gtggtcaggc cggccgcaga ggcactgcag ccaccaggca
    15481 cacatctcgc cccgaacagt ctccagacac tgctggccgg accggatcca gccgtggaca
    15541 gcagtccgcc caacgacatg ctgactcaac cccgggcagc acaagaaccg gctccagagg
    15601 aagaggagag tccccagctg gccagcagtc ccccgacaga gccaggcaca tcgaatccag
    15661 gaggggtaga acccgggagg ccagcgccag ccagtccagt gacagcgaag gccattctgg
    15721 agcccatgcc gggatcgggc aagggcagac ctcaaccact cacaggaggg caggctccag
    15781 ctcagggagc cagcgggcct ctgctggtgg ccaagcagct gacacctcca gtcgctcagg
    15841 ggccagtcaa ggccaggcat caggccaggg tcgtgcaggg tcccgaagca gggaagctca
    15901 gggcatcgct cgtcatgggc agtcgacaga cagccacagg cactctgggg ccgggcaagc
    15961 acaagcccac acagccacaa gcattgacag caggaggcct cgcgggtcca gcgagagtca
    16021 ggccagcgac agcgagggcc actccgacta ctcagaagca cacacacagg gagcccacgg
    16081 tgggatccaa acaagccaga ggcacgagca gcgaccctcc cgaggccagc agggctccgg
    16141 acacccccag gtgtactact atggtgtaga agaaaccgag gacgagtccg atgcccagca
    16201 ggggcaccac cagcagcagc aacagcagcg gcagcagcag cggcagcggc accagcatga
    16261 acaggaacga gaacatgaac accaacagcc agagtccagc cacaggcagc aggggtccag
    16321 tgggagaacg caccgggcag ctcgccatga acaggaaagc gacagcacca ggcaaagggg
    16381 ctctcaccag gcgcacagct ccgctcgcac ccaggaggag atcgcacgcg gaaggtctgg
    16441 agccagtgcc agtgagggtc cggggcccca gagggaggct gccagggaca gctctgagca
    16501 cgcccagtcc agaaggagcg agaccatcag ccgtggacgc tcaggacact ccactgggag
    16561 agcccacgaa gaccgccacg agcaggcaac agaccgctct gcccgctccg ggtccagggg
    16621 aggccaggcc ggctcccaca gtgagagcga ggcctccggt ggtcaggccg gccgcagagg
    16681 cactgcagcc accaggcaca catctcgccc cgaacagtct ccagacactg ctggccggac
    16741 cggatccagc cgtggacagc agtccgccca acgacatgct gactcaaccc cgggcagcac
    16801 aagaaccggc tccagaggaa gaggagagtc cccagctggc cagcagtccc ccgacagagc
    16861 caggcacatc gaatccagga ggggtagaac ccgggaggcc agcgccagcc agtccagtga
    16921 cagcgaaggc cattctggag cccatgccgg gatcgggcaa gggcagacct caaccactca
    16981 caggagggca ggctccagct cagggagcca gcgggcctct gctggtggcc aagcagctga
    17041 cacctccagt cgctcagggg ccagtcaagg ccaggcatca ggccagggtc gtgcagggtc
    17101 ccgaagcagg gaagctcagg gcatcgctcg tcatgggcag tcgacagaca gccacaggca
    17161 ctctggggcc gggcaagcac aagcccacac agccacaagc attgacagca ggaggcctcg
    17221 cgggtccagc gagagtcagg ccagcgacag cgagggccac tccgactact cagaagcaca
    17281 cacacaggga gcccacggtg ggatccaaac aagccagagg cacgagcagc gaccctcccg
    17341 aggccagcag ggctccggac acccccaggt gtactactat ggtgtagaag aaaccgagga
    17401 cgagtccgat gcccagcagg ggcaccacca gcagcagcaa cagcagcggc agcagcagcg
    17461 gcagcggcac cagcatgaac aggaacgaga acatgaacac caacagccag agtccagcca
    17521 caggcagcag gggtccagtg ggagaacgca ccgggcagct cgccatgaac aggaaagcga
    17581 cagcaccagg caaaggggct ctcaccaggc gcacagctcc gctcgcaccc aggaggagat
    17641 cgcacgcgga aggtctggag ccagtgccag tgagggtccg gggccccaga gggaggctgc
    17701 cagggacagc tctgagcacg cccagtccag aaggagcgag accatcagcc gtggacgctc
    17761 aggacactcc actgggagag cccacgaaga ccgccacgag caggcaacag accgctctgc
    17821 ccgctccggg tccaggggag gccaggccgg ctcccacagt gagagcgagg cctccggtgg
    17881 tcaggccggc cgcagaggca ctgcagccac caggcacaca tctcgccccg aacagtctcc
    17941 agacactgct ggccggaccg gatccagccg tggacagcag tccgcccaac gacatgctga
    18001 ctcaaccccg ggcagcacaa gaaccggctc cagaggaaga ggagagtccc cagctggcca
    18061 gcagtccccc gacagagcca ggcacatcga atccaggagg ggtagaaccc gggaggccag
    18121 cgccagccag tccagtgaca gcgaaggcca ttctggagcc catgccggga tcgggcaagg
    18181 gcagacctca accactcaca ggagggcagg ctccagctca gggagccagc gggcctctgc
    18241 tggtggccaa gcagctgaca cctccagtcg ctcaggggcc agtcaaggcc aggcatcagg
    18301 ccagggtcgt gcagggtccc gaagcaggga agctcagggc atcgctcgtc atgggcagtc
    18361 gacagacagc cacaggcact ctggggccgg gcaagcacaa gcccacacag ccacaagcat
    18421 tgacagcagg aggcctcgcg ggtccagcga gagtcaggcc agcgacagcg agggccactc
    18481 cgactactca gaagcacaca cacagggagc ccacggtggg atccaaacaa gccagaggca
    18541 cgagcagcga ccctcccgag gccagcaggg ctccggacac ccccaggtgt actactatgg
    18601 tgtagaagaa accgaggacg agtccgatgc ccagcagggg caccaccagc agcagcaaca
    18661 gcagcggcag cagcagcggc agcggcacca gcatgaacag gaacgagaac atgaacacca
    18721 acagccagag tccagccaca ggcagcaggg gtccagtggg agaacgcacc gggcagctcg
    18781 ccatgaacag gaaagcgaca gcaccaggca aaggggctct caccaggcgc acagctccgc
    18841 tcgcacccag gaggagatcg cacgcggaag gtctggagcc agtgccagtg agggtccggg
    18901 gccccagagg gaggctgcca gggacagctc tgagcacgcc cagtccagaa ggagcgagac
    18961 catcagccgt ggacgctcag gacactccac tgggagagcc cacgaagacc gccacgagca
    19021 ggcaacagac cgctctgccc gctccgggtc caggggaggc caggccggct cccacagtga
    19081 gagcgaggcc tccggtggtc aggccggccg cagaggcact gcagccacca ggcacacatc
    19141 tcgccccgaa cagtctccag acactgctgg ccggaccgga tccagccgtg gacagcagtc
    19201 cgcccaacga catgctgact caaccccggg cagcacaaga accggctcca gaggaagagg
    19261 agagtcccca gctggccagc agtcccccga cagagccagg cacatcgaat ccaggagggg
    19321 tagaacccgg gaggccagcg ccagccagtc cagtgacagc gaaggccatt ctggagccca
    19381 tgccgggatc gggcaagggc agacctcaac cactcacagg agggcaggct ccagctcagg
    19441 gagccagcgg gcctctgctg gtggccaagc agctgacacc tccagtcgct caggggccag
    19501 tcaaggccag gcatcaggcc agggtcgtgc agggtcccga agcagggaag ctcagggcat
    19561 cgctcgtcat gggcagtcga cagacagcca caggcactct ggggccgggc aagcacaagc
    19621 ccacacagcc acaagcattg acagcaggag gcctcgcggg tccagcgaga gtcaggccag
    19681 cgacagcgag ggccactccg actactcaga agcacacaca cagggagccc acggtgggat
    19741 ccaaacaagc cagaggcacg agcagcgacc ctcccgaggc cagcagggct ccggacaccc
    19801 ccaggtgtac tactatggtg tagaagaaac cgaggacgag tccgatgccc agcaggggca
    19861 ccaccagcag cagcaacagc agcggcagca gcagcggcag cggcaccagc atgaacagga
    19921 acgagaacat gaacaccaac agccagagtc cagccacagg cagcaggggt ccagtgggag
    19981 aacgcaccgg gcagctcgcc atgaacagga aagcgacagc accaggcaaa ggggctctca
    20041 ccaggcgcac agctccgctc gcacccagga ggagatcgca cgcggaaggt ctggagccag
    20101 tgccagtgag ggtccggggc cccagaggga ggctgccagg gacagctctg agcacgccca
    20161 gtccagaagg agcgagacca tcagccgtgg acgctcagga cactccactg ggagagccca
    20221 cgaagaccgc cacgagcagg caacagaccg ctctgcccgc tccgggtcca ggggaggcca
    20281 ggccggctcc cacagtgaga gcgaggcctc cggtggtcag gccggccgca gaggcactgc
    20341 agccaccagg cacacatctc gccccgaaca gtctccagac actgctggcc ggaccggatc
    20401 cagccgtgga cagcagtccg cccaacgaca tgctgactca accccgggca gcacaagaac
    20461 cggctccaga ggaagaggag agtccccagc tggccagcag tcccccgaca gagccaggca
    20521 catcgaatcc aggaggggta gaacccggga ggccagcgcc agccagtcca gtgacagcga
    20581 aggccattct ggagcccatg ccgggatcgg gcaagggcag acctcaacca ctcacaggag
    20641 ggcaggctcc agctcaggga gccagcgggc ctctgctggt ggccaagcag ctgacacctc
    20701 cagtcgctca ggggccagtc aaggccaggc atcaggccag ggtcgtgcag ggtcccgaag
    20761 cagggaagct cagggcatcg ctcgtcatgg gcagtcgaca gacagccaca ggcactctgg
    20821 ggccgggcaa gcacaagccc acacagccac aagcattgac agcaggaggc ctcgcgggtc
    20881 cagcgagagt caggccagcg acagcgaggg ccactccgac tactcagaag cacacacaca
    20941 gggagcccac ggtgggatcc aaacaagcca gaggcacgag cagcgaccct cccgaggcca
    21001 gcagggctcc ggacaccccc aggtgtacta ctatggtgta gaagaaaccg aggacgagtc
    21061 cgatgcccag caggggcacc accagcagca gcaacagcag cggcagcagc agcggcagcg
    21121 gcaccagcat gaacaggaac gagaacatga acaccaacag ccagagtcca gccacaggca
    21181 gcaggggtcc agtgggagaa cgcaccgggc agctcgccat gaacaggaaa gcgacagcac
    21241 caggcaaagg ggctctcacc aggcgcacag ctccgctcgc acccaggagg agatcgcacg
    21301 cggaaggtct ggagccagtg ccagtgaggg tccggggccc cagagggagg ctgccaggga
    21361 cagctctgag cacgcccagt ccagaaggag cgagaccatc agccgtggac gctcaggaca
    21421 ctccactggg agagcccacg aagaccgcca cgagcaggca acagaccgct ctgcccgctc
    21481 cgggtccagg ggaggccagg ccggctccca cagtgagagc gaggcctccg gtggtcaggc
    21541 cggccgcaga ggcactgcag ccaccaggca cacatctcgc cccgaacagt ctccagacac
    21601 tgctggccgg accggatcca gccgtggaca gcagtccgcc caacgacatg ctgactcaac
    21661 cccgggcagc acaagaaccg gctccagagg aagaggagag tccccagctg gccagcagtc
    21721 ccccgacaga gccaggcaca tcgaatccag gaggggtaga acccgggagg ccagcgccag
    21781 ccagtccagt gacagcgaag gccattctgg agcccatgcc gggatcgggc aagggcagac
    21841 ctcaaccact cacaggaggg caggctccag ctcagggagc cagcgggcct ctgctggtgg
    21901 ccaagcagct gacacctcca gtcgctcagg ggccagtcaa ggccaggcat caggccaggg
    21961 tcgtgcaggg tcccgaagca gggaagctca gggcatcgct cgtcatgggc agtcgacaga
    22021 cagccacagg cactctgggg ccgggcaagc acaagcccac acagccacaa gcattgacag
    22081 caggaggcct cgcgggtcca gcgagagtca ggccagcgac agcgagggcc actccgacta
    22141 ctcagaagca cacacacagg gagcccacgg tgggatccaa acaagccaga ggcacgagca
    22201 gcgaccctcc cgaggccagc agggctccgg acacccccag gtgtactact atggtgtaga
    22261 agaaaccgag gacgagtccg atgcccagca ggggcaccac cagcagcagc aacagcagcg
    22321 gcagcagcag cggcagcggc accagcatga acaggaacga gaacatgaac accaacagcc
    22381 agagtccagc cacaggcagc aggggtccag tgggagaacg caccgggcag ctcgccatga
    22441 acaggaaagc gacagcacca ggcaaagggg ctctcaccag gcgcacagct ccgctcgcac
    22501 ccaggaggag atcgcacgcg gaaggtctgg agccagtgcc agtgagggtc cggggcccca
    22561 gagggaggct gccagggaca gctctgagca cgcccagtcc agaaggagcg agaccatcag
    22621 ccgtggacgc tcaggacact ccactgggag agcccacgaa gaccgccacg agcaggcaac
    22681 agaccgctct gcccgctccg ggtccagggg aggccaggcc ggctcccaca gtgagagcga
    22741 ggcctccggt ggtcaggccg gccgcagagg cactgcagcc accaggcaca catctcgccc
    22801 cgaacagtct ccagacactg ctggccggac cggatccagc cgtggacagc agtccgccca
    22861 acgacatgct gactcaaccc cgggcagcac aagaaccggc tccagaggaa gaggagagtc
    22921 cccagctggc cagcagtccc ccgacagagc caggcacatc gaatccagga ggggtagaac
    22981 ccgggaggcc agcgccagcc agtccagtga cagcgaaggc cattctggag cccatgccgg
    23041 gatcgggcaa gggcagacct caaccactca caggagggca ggctccagct cagggagcca
    23101 gcaggcctct gttgaaggtt ctgatggcta tgattctatt gttaaatcta aatatcttag
    23161 ttttagtcaa tcacattgct attattatta acaatgagca gcaatttgca acagattaaa
    23221 tgctgaaata taacctcaaa catagggatt gttcatttta gtatttgggt ttttggttcc
    23281 ttattatcct taattcatat caggtatttc cttttccttt atagttccct ttactctatc
    23341 aatattttga gcctaaatcc tgagttttcg taatagatat ttcttaggat caagaattta
    23401 atttttaacc tcatgttgtt tcctatcata gttctttctt tcgtctttaa aatgtttaat
    23461 ttggttcatt gaagactaga cacaatttta cccaaaagtt ttaaaatact caaaatttat
    23521 aatgagtctt ttgtatgcat aatgccctgc ctgcactagg agtttatcat gtctatcctt
    23581 tgtactccta aaatctgtac tttcttcttc aatcatttaa atcccattgg acatttctaa
    23641 ttcaccacag taaaattgta taataattga aaataaacaa ttggcta
//
