LOCUS       NM_199390               2987 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus folliculin (Flcn), mRNA.
ACCESSION   NM_199390 XM_220518 XM_340808
VERSION     NM_199390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2987)
  AUTHORS   Shen,K., Rogala,K.B., Chou,H.T., Huang,R.K., Yu,Z. and
            Sabatini,D.M.
  TITLE     Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
  JOURNAL   Cell 179 (6), 1319-1329 (2019)
   PUBMED   31704029
REFERENCE   2  (bases 1 to 2987)
  AUTHORS   Lawrence,R.E., Fromm,S.A., Fu,Y., Yokom,A.L., Kim,D.J.,
            Thelen,A.M., Young,L.N., Lim,C.Y., Samelson,A.J., Hurley,J.H. and
            Zoncu,R.
  TITLE     Structural mechanism of a Rag GTPase activation checkpoint by the
            lysosomal folliculin complex
  JOURNAL   Science 366 (6468), 971-977 (2019)
   PUBMED   31672913
REFERENCE   3  (bases 1 to 2987)
  AUTHORS   Meng,J. and Ferguson,S.M.
  TITLE     GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates
            Rag GTPase heterodimer nucleotide status in response to amino acids
  JOURNAL   J Cell Biol 217 (8), 2765-2776 (2018)
   PUBMED   29848618
REFERENCE   4  (bases 1 to 2987)
  AUTHORS   Wada,S., Neinast,M., Jang,C., Ibrahim,Y.H., Lee,G., Babu,A., Li,J.,
            Hoshino,A., Rowe,G.C., Rhee,J., Martina,J.A., Puertollano,R.,
            Blenis,J., Morley,M., Baur,J.A., Seale,P. and Arany,Z.
  TITLE     The tumor suppressor FLCN mediates an alternate mTOR pathway to
            regulate browning of adipose tissue
  JOURNAL   Genes Dev 30 (22), 2551-2564 (2016)
   PUBMED   27913603
REFERENCE   5  (bases 1 to 2987)
  AUTHORS   Yan,M., Audet-Walsh,E., Manteghi,S., Dufour,C.R., Walker,B.,
            Baba,M., St-Pierre,J., Giguere,V. and Pause,A.
  TITLE     Chronic AMPK activation via loss of FLCN induces functional beige
            adipose tissue through PGC-1alpha/ERRalpha
  JOURNAL   Genes Dev 30 (9), 1034-1046 (2016)
   PUBMED   27151976
REFERENCE   6  (bases 1 to 2987)
  AUTHORS   Baba,M., Hong,S.B., Sharma,N., Warren,M.B., Nickerson,M.L.,
            Iwamatsu,A., Esposito,D., Gillette,W.K., Hopkins,R.F. 3rd,
            Hartley,J.L., Furihata,M., Oishi,S., Zhen,W., Burke,T.R. Jr.,
            Linehan,W.M., Schmidt,L.S. and Zbar,B.
  TITLE     Folliculin encoded by the BHD gene interacts with a binding
            protein, FNIP1, and AMPK, and is involved in AMPK and mTOR
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 103 (42), 15552-15557 (2006)
   PUBMED   17028174
REFERENCE   7  (bases 1 to 2987)
  AUTHORS   Togashi,Y., Kobayashi,T., Momose,S., Ueda,M., Okimoto,K. and
            Hino,O.
  TITLE     Transgenic rescue from embryonic lethality and renal carcinogenesis
            in the Nihon rat model by introduction of a wild-type Bhd gene
  JOURNAL   Oncogene 25 (20), 2885-2889 (2006)
   PUBMED   16369488
REFERENCE   8  (bases 1 to 2987)
  AUTHORS   Kouchi,M., Okimoto,K., Matsumoto,I., Tanaka,K., Yasuba,M. and
            Hino,O.
  TITLE     Natural history of the Nihon (Bhd gene mutant) rat, a novel model
            for human Birt-Hogg-Dube syndrome
  JOURNAL   Virchows Arch 448 (4), 463-471 (2006)
   PUBMED   16447066
  REMARK    GeneRIF: The Nihon rat is a useful tool for analyzing the events
            leading to renal tumorigenesis and for studying BHD gene functions.
REFERENCE   9  (bases 1 to 2987)
  AUTHORS   Okimoto,K., Sakurai,J., Kobayashi,T., Mitani,H., Hirayama,Y.,
            Nickerson,M.L., Warren,M.B., Zbar,B., Schmidt,L.S. and Hino,O.
  TITLE     A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise
            to the Nihon rat model of inherited renal cancer
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 2023-2027 (2004)
   PUBMED   14769940
  REMARK    GeneRIF: a germ-line mutation in the BHD gene caused by the
            insertion of a single nucleotide in the Nihon rat, results in a
            frameshift and produces a stop codon 26 aa downstream; the
            homozygous mutant condition was lethal at an early stage of fetal
            life
REFERENCE   10 (bases 1 to 2987)
  AUTHORS   Nickerson,M.L., Warren,M.B., Toro,J.R., Matrosova,V., Glenn,G.,
            Turner,M.L., Duray,P., Merino,M., Choyke,P., Pavlovich,C.P.,
            Sharma,N., Walther,M., Munroe,D., Hill,R., Maher,E., Greenberg,C.,
            Lerman,M.I., Linehan,W.M., Zbar,B. and Schmidt,L.S.
  TITLE     Mutations in a novel gene lead to kidney tumors, lung wall defects,
            and benign tumors of the hair follicle in patients with the
            Birt-Hogg-Dube syndrome
  JOURNAL   Cancer Cell 2 (2), 157-164 (2002)
   PUBMED   12204536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085848.1.
            
            On Nov 15, 2004 this sequence version replaced NM_199390.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085848.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2987
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2987
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /note="folliculin"
                     /db_xref="GeneID:303185"
                     /db_xref="RGD:735088"
     exon            1..278
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            279..396
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            397..667
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..2158
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /EC_number="2.7.1.21"
                     /note="birt-Hogg-Dube syndrome protein homolog"
                     /codon_start=1
                     /product="folliculin"
                     /protein_id="NP_955422.1"
                     /db_xref="GeneID:303185"
                     /db_xref="RGD:735088"
                     /translation="MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQ
                     AEEEEGGIQMSSRVRAHSPAEGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKET
                     SIKYVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKD
                     SLARGFQRWYSIIAIMMDRIYLINSWPFLLGKIRGIISELQGKALKVFEAEQFGCPQR
                     AQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSFAWLLKACGSRLTEKLLEG
                     APTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGRELASCPTESSFLSA
                     CGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHSAFEVLR
                     TMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSNPH
                     PAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLK
                     EEWMNKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLM
                     STVRSPTAAESRN"
     exon            668..814
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1036
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1197
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1289
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1480
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1594
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1718
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1850
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1956
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2966
                     /gene="Flcn"
                     /gene_synonym="Bhd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggactcttgg cttggaagag cgtaacgcag cacagcgtgg ctcggcgcat cctagtctcc
       61 tgtcggcgcc gcggcaccgc tcgccgtggc tagtctctgg cgttgccttc cctccgccag
      121 cctgcggatg gttcggtccg gctgggtcac gcgctagact cggtgcaagg gcctgcggaa
      181 cgggcgaggg gcagaacggt ggcgacagcc tcaggacagt tgcgagcggg ttccggccca
      241 gcatccggga gacggcggcg agcgccccag ctgagttgac aacctcaagc ctttgaattc
      301 gagtgcagtt tgcataccat acctgactca tccggcaggc ctcgtacacg ttctggtcta
      361 ggcaggatgg tgcagccgtg atctgtcaag cataaggcct cggccattct ccagcaccat
      421 gaacgccatt gtggctctct gccacttctg cgagctccat ggcccccgca cgctcttctg
      481 cacggaggtt ctacacgctc ccctgcccca gggtgccgga agtggggaca gtcctggcca
      541 ggttgagcag gctgaggaag aagagggcgg catccagatg agcagccgag tccgtgccca
      601 cagcccagcc gagggcgcca gcactgactc cagcagcccg gggcccaaga agtcagacat
      661 gtgcgagggc tgccgctcgc ttgctgtagg gcacccaggt tatatcagtc atgataagga
      721 gacctctatc aagtacgtca gccaccagca ccccaaccac ccacagctct tcagcattgt
      781 ccgccaggcc tgtgtccgca gcctgagctg tgaggtgtgc cctggtcgtg aaggccccat
      841 cttctttggt gatgagcaac atggctttgt gttcagccac accttcttca tcaaagacag
      901 cctggccaga ggcttccagc gctggtacag catcatcgcc atcatgatgg atcggatcta
      961 cctcatcaac tcctggccct tcctgctggg caagatccgc gggatcatca gcgagctcca
     1021 gggcaaggcc ctcaaggtgt ttgaggcaga acagtttgga tgtccacagc gtgcccagag
     1081 gatgaacact gccttcacac ccttcctgca ccagaggaac ggcaacgctg cccgctctct
     1141 gacctccttg accagtgatg acaacttgtg ggcctgtctg catacttcct ttgcctggct
     1201 cctgaaggca tgtggtagcc ggctgacaga aaagctctta gagggtgctc ccacagagga
     1261 caccctggtc cagatggaga agcttgctga cttagaggaa gaatcagaaa gttgggataa
     1321 ttcagaggct gaagaggagg agaaagcccc tgctacggca gagggtgctg aagggcgaga
     1381 gctggccagt tgcccaacag aatcatcctt tctctcagcc tgtgggagct ggcagccccc
     1441 aaagctttct gtcttcaagt cccttcgaca catgagacag gtcttgggag ccccatcttt
     1501 ccgaatgttg gcctggcatg tcctcatggg taatcaggtg atctggaaaa gcagagatgt
     1561 gaaccttgtc cattccgcat ttgaagtcct ccggaccatg ctgcctgtag gctgtgtgcg
     1621 aatcatccct tacagcagcc agtatgagga ggcctatcgc tgcaacttcc tagggctcag
     1681 ccctccggtg cctatccctg ctcatgtcct ggcctctgag ttcgtagttg tcgtggaggt
     1741 acacacagcc actcgctcaa acccgcaccc ggctggatgt gaggacgacc agtccctcag
     1801 caagtatgag tttgtggtga ccagcggtag ccctgtggct gcagacagag ttgggcccac
     1861 catcctgaat aaaatggagg cagctctgac caaccagaac ctgtctgtgg atgtggtgga
     1921 ccagtgcctc gtctgtctca aggaggagtg gatgaacaaa gtgaaagtcc tgttcaaatt
     1981 caccaaggtg gacagccgcc ccaaggagga cacccagaag ctcctgagcg tcctcggcgc
     2041 atcagaggag gacaacgtta agctactgaa gttctggatg acgggcctga gcaaaaccta
     2101 caagtcacac ctcatgtcca cagtccgaag cccgacagcc gcagagtcac ggaactgact
     2161 ccgagaacac cgtctggaag gtggtgtaca tcttagctct gtgggaaaga ctgcccttgg
     2221 gtttctgagt gctggcgtga gatcctgttt gaggagtgaa gacttacggg ctaggcctcg
     2281 ccctccttgt gaggctctct tagcccatgt tgaagtgtag gggacacagg gacagtggtc
     2341 ccactgcata aaattgctct gtcaggaact ggtgagatgt gctatgtgcc tcttgaggag
     2401 aaaggctggg agctgagagg agtctacgag ccagcctctg aggttttgtt gttgcaggat
     2461 gtcctcgtgg gcttaggaca acaccttccc accatggaag accaagcatc ctggatcgtt
     2521 tgtctttggg ttgatgactt ctcaggtcat gtgcacaccc gtggcctctg gacatcaaga
     2581 ccatggctgt tttgtttttg tttttttaat tttagtcttt gagtcagggt cttattctgt
     2641 ctcctatccc agtttagaac tcacggtgtg gcctatgcta cttccagact tgtagcagtc
     2701 ctcctgcctc agcttcccaa gtgctgggag tacagaactg agccatcaga accttacgtt
     2761 gctttcttct ctgttgctgc catagcatta accagcgact gtagactgtg gtggggttga
     2821 ggcggagtgc ctctcaccgt agcagcttag actccctgaa gctttcccaa tttgttcata
     2881 atttaacacg aagactacgt ttgtgtgtct tggtctctgt acagttgcaa gaatgttgaa
     2941 acacaataaa tctgtatttt tgtaaaaaaa aaaaaaaaaa aaaaaaa
//
