LOCUS       NM_001108667            3402 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fukutin (Fktn), mRNA.
ACCESSION   NM_001108667 XM_001057514 XM_342838
VERSION     NM_001108667.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3402)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3402)
  AUTHORS   Fortunato,M.J., Ball,C.E., Hollinger,K., Patel,N.B., Modi,J.N.,
            Rajasekaran,V., Nonneman,D.J., Ross,J.W., Kennedy,E.J., Selsby,J.T.
            and Beedle,A.M.
  TITLE     Development of rabbit monoclonal antibodies for detection of
            alpha-dystroglycan in normal and dystrophic tissue
  JOURNAL   PLoS One 9 (5), e97567 (2014)
   PUBMED   24824861
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3402)
  AUTHORS   Yis,U., Uyanik,G., Heck,P.B., Smitka,M., Nobel,H., Ebinger,F.,
            Dirik,E., Feng,L., Kurul,S.H., Brocke,K., Unalp,A., Ozer,E.,
            Cakmakci,H., Sewry,C., Cirak,S., Muntoni,F., Hehr,U. and
            Morris-Rosendahl,D.J.
  TITLE     Fukutin mutations in non-Japanese patients with congenital muscular
            dystrophy: less severe mutations predominate in patients with a
            non-Walker-Warburg phenotype
  JOURNAL   Neuromuscul Disord 21 (1), 20-30 (2011)
   PUBMED   20961758
REFERENCE   4  (bases 1 to 3402)
  AUTHORS   Chang,W., Winder,T.L., LeDuc,C.A., Simpson,L.L., Millar,W.S.,
            Dungan,J., Ginsberg,N., Plaga,S., Moore,S.A. and Chung,W.K.
  TITLE     Founder Fukutin mutation causes Walker-Warburg syndrome in four
            Ashkenazi Jewish families
  JOURNAL   Prenat Diagn 29 (6), 560-569 (2009)
   PUBMED   19266496
  REMARK    Erratum:[Prenat Diagn. 2012 Oct;32(10):1019]
REFERENCE   5  (bases 1 to 3402)
  AUTHORS   Puckett,R.L., Moore,S.A., Winder,T.L., Willer,T., Romansky,S.G.,
            Covault,K.K., Campbell,K.P. and Abdenur,J.E.
  TITLE     Further evidence of Fukutin mutations as a cause of childhood onset
            limb-girdle muscular dystrophy without mental retardation
  JOURNAL   Neuromuscul Disord 19 (5), 352-356 (2009)
   PUBMED   19342235
REFERENCE   6  (bases 1 to 3402)
  AUTHORS   Esapa,C.T., Benson,M.A., Schroder,J.E., Martin-Rendon,E.,
            Brockington,M., Brown,S.C., Muntoni,F., Kroger,S. and Blake,D.J.
  TITLE     Functional requirements for fukutin-related protein in the Golgi
            apparatus
  JOURNAL   Hum Mol Genet 11 (26), 3319-3331 (2002)
   PUBMED   12471058
REFERENCE   7  (bases 1 to 3402)
  AUTHORS   Hayashi,Y.K., Ogawa,M., Tagawa,K., Noguchi,S., Ishihara,T.,
            Nonaka,I. and Arahata,K.
  TITLE     Selective deficiency of alpha-dystroglycan in Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Neurology 57 (1), 115-121 (2001)
   PUBMED   11445638
REFERENCE   8  (bases 1 to 3402)
  AUTHORS   Saito,Y., Mizuguchi,M., Oka,A. and Takashima,S.
  TITLE     Fukutin protein is expressed in neurons of the normal developing
            human brain but is reduced in Fukuyama-type congenital muscular
            dystrophy brain
  JOURNAL   Ann Neurol 47 (6), 756-764 (2000)
   PUBMED   10852541
REFERENCE   9  (bases 1 to 3402)
  AUTHORS   Kondo-Iida,E., Kobayashi,K., Watanabe,M., Sasaki,J., Kumagai,T.,
            Koide,H., Saito,K., Osawa,M., Nakamura,Y. and Toda,T.
  TITLE     Novel mutations and genotype-phenotype relationships in 107
            families with Fukuyama-type congenital muscular dystrophy (FCMD)
  JOURNAL   Hum Mol Genet 8 (12), 2303-2309 (1999)
   PUBMED   10545611
REFERENCE   10 (bases 1 to 3402)
  AUTHORS   Kobayashi,K., Nakahori,Y., Miyake,M., Matsumura,K., Kondo-Iida,E.,
            Nomura,Y., Segawa,M., Yoshioka,M., Saito,K., Osawa,M., Hamano,K.,
            Sakakihara,Y., Nonaka,I., Nakagome,Y., Kanazawa,I., Nakamura,Y.,
            Tokunaga,K. and Toda,T.
  TITLE     An ancient retrotransposal insertion causes Fukuyama-type
            congenital muscular dystrophy
  JOURNAL   Nature 394 (6691), 388-392 (1998)
   PUBMED   9690476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474039.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342838.3, XM_001057514.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132271,
                              SAMD00132279 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3402
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3402
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="fukutin"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
     exon            1..232
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            233..435
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1716
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /note="Fukuyama type congenital muscular dystrophy
                     homolog; Fukuyama type congenital muscular dystrophy
                     (fukutin)"
                     /codon_start=1
                     /product="ribitol-5-phosphate transferase FKTN"
                     /protein_id="NP_001102137.1"
                     /db_xref="GeneID:362520"
                     /db_xref="RGD:1310087"
                     /translation="MSRVNKNVVLALLTLMSCAFLLFQLYYYKHYLSARNGTGSSKSK
                     GNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGSASECR
                     FFCVPRDFTAFALQYHLWKNEDGWFQMAENMGFQCLKIESKDPRLDGIDSLSGTEIPL
                     HYVCKLATHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRRLQFGRYPGAFDRPE
                     LQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYVDDNTVDAMAFRKR
                     AKELLQLAAKTLKALGVPFWLSSGTCLGWYRQCSIIPYSKDVDLGIFIQDYKPDIVLA
                     FQDAGLPLKHKFGKVEDSLELSFQGQADVKLDIFFFYEETDHMWNGGTQARTGKKFKY
                     LFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKAWKIPVKTWDWKSSPPNVQPNGVWP
                     ISEWDEVIQLY"
     exon            436..495
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            496..699
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            700..977
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1110
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1240
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1374
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1502
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..3402
                     /gene="Fktn"
                     /gene_synonym="Fcmd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttttccta aacctcaggc agcctcagga cgctgctgga gggatggctg actgcagatt
       61 tctaaaggcc agacaaatag aagggctccg agaacttggc agcagacgtt ggcaaacctg
      121 tacggccaaa ggctactcgg gctagcgaac gcagctgtgc gcttgacggt ttctttgcga
      181 cagtcgtcgt gactgccgta aagcgaggct tccgccgcag ctctagagtt agaagtacct
      241 ctgttgacag gaaacaagat tctgtttcat aaagaagatg aaaacaactg ggttcctgtt
      301 aacaaacacc caagagacca gcatagacca atgagcagag tcaataagaa cgtggtcttg
      361 gcccttctaa cactgatgag ctgtgccttc ctgctgtttc agctgtacta ctacaagcac
      421 tacttgtcag cacggaatgg aacgggttca tcaaaatcca aaggaaatcg agttggattt
      481 gatagcacac aatggcgtgc agttaagaaa tttattatgc tgacatccag ccaaaatgtg
      541 ccggtgttcc ttattgaccc ttggattctg gaatcaatta ataaaaattt cgaacaagtg
      601 aaaaatgcct ctcaaggctc ggcctcagaa tgcagatttt tctgtgttcc gagagacttc
      661 actgcgttcg cgctgcagta tcacctgtgg aagaatgagg atggatggtt tcagatggct
      721 gagaacatgg gattccagtg cctgaagatt gaaagcaaag atcctcggct ggatggaata
      781 gactcgcttt ccggaactga gatccctctg cactatgtct gtaagctggc cactcacgcc
      841 atccacttgg tcgtctttca cgagaggagt ggcaactacc tctggcatgg tcacctacga
      901 ctcaaagggc acatggatag gaagtttgtt ccttttcgaa ggctacaatt tggtcgttat
      961 cctggagcct ttgacaggcc ggagttacag caggttactg ttgatggact cgacatgctt
     1021 attccaaaag acccagggcg ctttctagaa gaagtacctc actccagatt tatcgagtgc
     1081 aggtataaag aagcccgggc attccttcag cagtacgtcg atgacaacac tgtggatgcc
     1141 atggcctttc ggaagagggc aaaggagtta ctgcaactag cggccaagac gctgaaggcg
     1201 ctgggagtgc ccttctggct gagcagtggg acgtgtctag gatggtatcg gcaatgcagt
     1261 atcattcctt atagcaaaga tgtcgaccta ggaattttca ttcaagatta caaacctgat
     1321 attgttttgg catttcagga tgcaggactt ccactcaaac acaagtttgg gaaggtggag
     1381 gacagcttgg aactctcctt ccagggacaa gctgatgtaa aacttgatat ttttttcttc
     1441 tatgaagaga ctgaccatat gtggaatgga ggcacgcagg ccagaacagg aaagaagttt
     1501 aagtatctgt tccccaagtt tacactgtgc tggacggagt ttgtagacat aaaagtccat
     1561 gttccctgtg aaacagttga ctacattgaa gccaactatg gcaaggcctg gaagatccct
     1621 gtcaagacct gggactggaa gagctcaccc ccgaatgtgc agcccaatgg ggtctggcct
     1681 atttcggagt gggatgaagt tatccagttg tactgagaac actgagctca tgtgggacgt
     1741 ttcccagaaa gaaggtaggc agctgttgaa agcactatgt tttctgcctg atgtgagagc
     1801 caaagaggag aaatgacgag ttggaagaca gaaaaggttt tctgactcat gggccatcta
     1861 atcagttctg ccactcagca tttactgagg agtttataca ccaggtgaag tactaggatc
     1921 tggtgaacag gcagagagga atgagaggcc agcttctctc ttgccctgtt ggtaagcact
     1981 acaattttat gttaagggaa actaacccac tctctgaaga ggtgtacagt agaatgtatt
     2041 ccataatgat ttttaaaatg ttaattaatg tttaaaccgg aaagtgagct catcagacaa
     2101 agctaacaaa ggatgtgtta gttgagagta gttcatttct gcctgccctc gggatttaag
     2161 ctgctgtgtt agtgttaagg ttgtgggata tgagttaata ttccagtgag tgattagact
     2221 ttgtctcaca gagaaaagac agtggccaac tcattttaca agcagtgtga tacacagttg
     2281 acttcaagca ctgggcattc tataagggag gatgagagcc gatagcagct cttgtcaaga
     2341 cgtacactgt tttcatcttt gagatgaaca tggatgctta gatggtgctt gaatccctga
     2401 catcataagg atattttcac tgacctgcag tagtacttcc tgataaatca ttcagtcgtg
     2461 ctatccaaaa gttgtgacat ctcaaagctt ccgttcctta tttcattctt agtcactctt
     2521 aaactcaaaa atggaagtta ctcatgaata tttttatatt ttatgaatgt ataacttttc
     2581 tgcctttaat tttaatattg acactaagta ataatagaca tacctcttaa ttttttaaaa
     2641 atacccttta tttatttatc aaccatagtt ccatgtgttt aatttatggc ctacacacta
     2701 atttatttag cacaagatat gcctgttctt ctatccaata ttacttcacg gttccaaaat
     2761 gaagggttaa cgtgaacctg gccattactc cttttcccag attactgtct ttaaagcctg
     2821 tgtccatctc tagattttca ttctgctgag tgtaataggg caagggcttc ctacccacaa
     2881 gtactgcaca agtgggaccc ttgacctaca ctcctgagtc cattgtagtg gctgcacata
     2941 agccatgcag tctcagagag agatgacaca gtgagtgcct gcctgccttg cctgggaggg
     3001 gagggtccac tccctgctgc ttagggatgt gcttcatggc aacctggcag atttcccttg
     3061 gcacgtgtag ttactacagc agaaaccagg atagatgaga gaatgggctg gcagaaagaa
     3121 aagaaaaaag aaagaaaaag aaaaacttgg aggaagtaac ttgaagccac ctatttccaa
     3181 atttaaactt caacatgaaa actgtctttg ttggatgata tgcagcagtc tccatgcagc
     3241 ctccaagtag gaatattgtc tctccataag catcatctaa tcagagtgtt acagttatta
     3301 gcacacatgt acccaaatga caaatcataa tcagctcttt cctagaaaat aagtccatag
     3361 aatacgtacc caagttgtag atacccaacc ctacatattt tt
//
