LOCUS       NM_001105922            1385 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus FKBP prolyl isomerase family member 6 (Fkbp6),
            mRNA.
ACCESSION   NM_001105922 XM_001071214 XM_222082
VERSION     NM_001105922.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1385)
  AUTHORS   Kasai,H., Kawakami,K., Yokoe,H., Yoshimura,K., Matsuda,M.,
            Yasumoto,J., Maekawa,S., Yamashita,A., Tanaka,T., Ikeda,M.,
            Kato,N., Okamoto,T., Matsuura,Y., Sakamoto,N., Enomoto,N.,
            Takeda,S., Fujii,H., Tsubuki,M., Kusunoki,M. and Moriishi,K.
  TITLE     Involvement of FKBP6 in hepatitis C virus replication
  JOURNAL   Sci Rep 5, 16699 (2015)
   PUBMED   26567527
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1385)
  AUTHORS   Xiol,J., Cora,E., Koglgruber,R., Chuma,S., Subramanian,S.,
            Hosokawa,M., Reuter,M., Yang,Z., Berninger,P., Palencia,A.,
            Benes,V., Penninger,J., Sachidanandam,R. and Pillai,R.S.
  TITLE     A role for Fkbp6 and the chaperone machinery in piRNA amplification
            and transposon silencing
  JOURNAL   Mol Cell 47 (6), 970-979 (2012)
   PUBMED   22902560
REFERENCE   3  (bases 1 to 1385)
  AUTHORS   Noguchi,J., Ozawa,M., Nakai,M., Somfai,T., Kikuchi,K., Kaneko,H.
            and Kunieda,T.
  TITLE     Affected homologous chromosome pairing and phosphorylation of
            testis specific histone, H2AX, in male meiosis under FKBP6
            deficiency
  JOURNAL   J Reprod Dev 54 (3), 203-207 (2008)
   PUBMED   18408354
  REMARK    GeneRIF: fundamental role of Fkbp6 in homologous chromosome
            synapsis during male meiosis
REFERENCE   4  (bases 1 to 1385)
  AUTHORS   Crackower,M.A., Kolas,N.K., Noguchi,J., Sarao,R., Kikuchi,K.,
            Kaneko,H., Kobayashi,E., Kawai,Y., Kozieradzki,I., Landers,R.,
            Mo,R., Hui,C.C., Nieves,E., Cohen,P.E., Osborne,L.R., Wada,T.,
            Kunieda,T., Moens,P.B. and Penninger,J.M.
  TITLE     Essential role of Fkbp6 in male fertility and homologous chromosome
            pairing in meiosis
  JOURNAL   Science 300 (5623), 1291-1295 (2003)
   PUBMED   12764197
  REMARK    GeneRIF: Fkbp6 is a component of the synaptonemal complex essential
            for sex-specific fertility and for the fidelity of homologous
            chromosome pairing in meiosis.
REFERENCE   5  (bases 1 to 1385)
  AUTHORS   Meng,X., Lu,X., Morris,C.A. and Keating,M.T.
  TITLE     A novel human gene FKBP6 is deleted in Williams syndrome
  JOURNAL   Genomics 52 (2), 130-137 (1998)
   PUBMED   9782077
REFERENCE   6  (bases 1 to 1385)
  AUTHORS   Coss,M.C., Winterstein,D., Sowder,R.C. 2nd and Simek,S.L.
  TITLE     Molecular cloning, DNA sequence analysis, and biochemical
            characterization of a novel 65-kDa FK506-binding protein (FKBP65)
  JOURNAL   J Biol Chem 270 (49), 29336-29341 (1995)
   PUBMED   7493967
REFERENCE   7  (bases 1 to 1385)
  AUTHORS   Atagi,Y., Ikadai,H., Kurohmaru,M. and Hayashi,Y.
  TITLE     Testicular disruption in the As (aspermia) mutant rat, with special
            reference to the aggregate of ribosomes
  JOURNAL   J Vet Med Sci 55 (2), 301-306 (1993)
   PUBMED   8513014
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473973.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_222082.3, XM_001071214.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1385
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..1385
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /note="FKBP prolyl isomerase family member 6"
                     /db_xref="GeneID:288597"
                     /db_xref="RGD:1308926"
     exon            1..91
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1018
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /EC_number="5.2.1.8"
                     /note="rotamase; 36 kDa FK506 binding protein;
                     immunophilin FKBP36; FK506 binding protein 6, 36kDa;
                     peptidyl-prolyl cis-trans isomerase FKBP6; inactive PPIase
                     FKBP6; FK506-binding protein 6; FKBP prolyl isomerase 6"
                     /codon_start=1
                     /product="inactive peptidyl-prolyl cis-trans isomerase
                     FKBP6"
                     /protein_id="NP_001099392.1"
                     /db_xref="GeneID:288597"
                     /db_xref="RGD:1308926"
                     /translation="MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIR
                     EGAGDPVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSM
                     RRGELARFLFKPTYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQE
                     QFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLAICEEQHLVEPAE
                     LLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYEQARDFL
                     VRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSGSSVGGN"
     exon            92..209
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            210..299
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            300..502
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            503..622
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            623..817
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            818..927
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1020
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1385
                     /gene="Fkbp6"
                     /gene_synonym="FKBP-36; PPiase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcgaggc ctctggcgac ggttgagcgg caagatgagt gtcttctcgc gcctcaggaa
       61 cggaatccca ccgtcgcgag acgactgcca gtctccctat gagcgattaa gtcaacgcat
      121 gttggacatt tctggggacc gaggtgtgct gaaagatatc atccgcgagg gcgctggcga
      181 tcctgtgaca cctgacgctt ctgtgctggt gaaatactct ggatacctgg agcacatgga
      241 taagcctttc gactccaatt gctttaggaa aacccctcgg ctgatgaaac ttggagaaga
      301 tattacactc tggggcatgg agctgggcct tctaagcatg cgcagagggg aactggccag
      361 gttcctgttc aagccaacct atgcttatgg taccctgggg tgcccgcccc tcatccctcc
      421 aaatgccact gtcctgtttg agatcgagct gattgacttc ctggactctg ccgagtcgga
      481 caagttttgt gcactctcag ctgagcagca agaacagttt ccactccaga aagtcctcaa
      541 ggtagcggca accgagaggg agtttggcaa ctaccttttc cgccagaatc gcttctgtga
      601 tgccaaagtg agatacaagc gggccttgtt gctgctccat cgacgcttgg ccatctgtga
      661 ggagcagcac ttggtagaac ctgctgagct cctagtcctc cttaaccttt catttgtgta
      721 cctgaagcta gaccgccctg ctatggccct gcgctatggg gagcaggctc tgctcattga
      781 caaaaggaac gccaaagccc tcttcaggtg tggacaggct tgcctcctcc tgaccgagta
      841 tgagcaggct cgggactttc tagtgagagc tcagaaggag cagccctgta accatgacat
      901 caataatgag ctgaagaagc tgtccagcca ctacagggac tatgtggaca gagagagaga
      961 gatgtgtcac cggatgtttg ctccctgtgg aagcggctct tcagtgggag gaaactgaag
     1021 ggtttcagct actgcaaaca caactggact cctccttcga actgtggctg gggatggatg
     1081 gagctcctag tgcagactgc tccagccacc cctggaagac agcgacgccc tgccagactg
     1141 tttctccagg ttcatacaca gtagcaaagg gtagtccctg acagcagaaa ccgctcagac
     1201 aagtaggttt tgtatgtgtg tcagttctcc gcttacctcc cagcctcacc cccacctcct
     1261 ttccaaatgc tgatgtcagt gggccagtac agatagaaat gcctttgtat attctgttgg
     1321 gttttttgaa gagaattatg ttacaattgt ttttgttgta aataaaacac attcttgtcc
     1381 tagca
//
