LOCUS       NM_001012174            3478 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus FKBP prolyl isomerase 5 (Fkbp5), mRNA.
ACCESSION   NM_001012174 XM_342103
VERSION     NM_001012174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3478)
  AUTHORS   Cattane,N., Di Benedetto,M.G., D'Aprile,I., Riva,M.A. and
            Cattaneo,A.
  TITLE     Dissecting the Long-Term Effect of Stress Early in Life on FKBP5:
            The Role of miR-20b-5p and miR-29c-3p
  JOURNAL   Biomolecules 14 (3), 371 (2024)
   PUBMED   38540789
  REMARK    GeneRIF: Dissecting the Long-Term Effect of Stress Early in Life on
            FKBP5: The Role of miR-20b-5p and miR-29c-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3478)
  AUTHORS   Rowson,S., Bekhbat,M., Kelly,S., Hyer,M.M., Dyer,S., Weinshenker,D.
            and Neigh,G.
  TITLE     Chronic adolescent stress alters GR-FKBP5 interactions in the
            hippocampus of adult female rats
  JOURNAL   Stress 27 (1), 2312467 (2024)
   PUBMED   38557197
  REMARK    GeneRIF: Chronic adolescent stress alters GR-FKBP5 interactions in
            the hippocampus of adult female rats.
REFERENCE   3  (bases 1 to 3478)
  AUTHORS   Maganga-Bakita,I., Aiken,A.A., Puracchio,M.J., Kentner,A.C. and
            Hunter,R.G.
  TITLE     Regulatory Effects of Maternal Immune Activation and Environmental
            Enrichment on Glucocorticoid Receptor and FKBP5 Expression in
            Stress-sensitive Regions of the Offspring Brain
  JOURNAL   Neuroscience 505, 51-58 (2022)
   PUBMED   36116554
  REMARK    GeneRIF: Regulatory Effects of Maternal Immune Activation and
            Environmental Enrichment on Glucocorticoid Receptor and FKBP5
            Expression in Stress-sensitive Regions of the Offspring Brain.
REFERENCE   4  (bases 1 to 3478)
  AUTHORS   Wanstrath,B.J., McLean,S.A., Zhao,Y., Mickelson,J., Bauder,M.,
            Hausch,F. and Linnstaedt,S.D.
  TITLE     Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via
            FKBP51 Inhibition Depends on Timing of Administration Relative to
            Traumatic Stress Exposure
  JOURNAL   J Pain 23 (7), 1256-1267 (2022)
   PUBMED   35296422
  REMARK    GeneRIF: Duration of Reduction in Enduring Stress-Induced
            Hyperalgesia Via FKBP51 Inhibition Depends on Timing of
            Administration Relative to Traumatic Stress Exposure.
REFERENCE   5  (bases 1 to 3478)
  AUTHORS   Kusumanchi,P., Liang,T., Zhang,T., Ross,R.A., Han,S., Chandler,K.,
            Oshodi,A., Jiang,Y., Dent,A.L., Skill,N.J., Huda,N., Ma,J., Yang,Z.
            and Liangpunsakul,S.
  TITLE     Stress-Responsive Gene FK506-Binding Protein 51 Mediates
            Alcohol-Induced Liver Injury Through the Hippo Pathway and
            Chemokine (C-X-C Motif) Ligand 1 Signaling
  JOURNAL   Hepatology 74 (3), 1234-1250 (2021)
   PUBMED   33710653
REFERENCE   6  (bases 1 to 3478)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 3478)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 3478)
  AUTHORS   Pratt,W.B., Morishima,Y., Murphy,M. and Harrell,M.
  TITLE     Chaperoning of glucocorticoid receptors
  JOURNAL   Handb Exp Pharmacol (172), 111-138 (2006)
   PUBMED   16610357
  REMARK    Review article
REFERENCE   9  (bases 1 to 3478)
  AUTHORS   Pirkl,F. and Buchner,J.
  TITLE     Functional analysis of the Hsp90-associated human peptidyl prolyl
            cis/trans isomerases FKBP51, FKBP52 and Cyp40
  JOURNAL   J Mol Biol 308 (4), 795-806 (2001)
   PUBMED   11350175
REFERENCE   10 (bases 1 to 3478)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001012174.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1523910.1,
                                           SRR26643292.63517.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                JAXUCZ010000020.1  6543469-6543555     c
            88-213              JAXUCZ010000020.1  6501117-6501242     c
            214-358             JAXUCZ010000020.1  6498134-6498278     c
            359-501             JAXUCZ010000020.1  6489368-6489510     c
            502-616             JAXUCZ010000020.1  6488516-6488630     c
            617-773             JAXUCZ010000020.1  6477046-6477202     c
            774-864             JAXUCZ010000020.1  6471788-6471878     c
            865-948             JAXUCZ010000020.1  6468812-6468895     c
            949-1134            JAXUCZ010000020.1  6464901-6465086     c
            1135-1374           JAXUCZ010000020.1  6462086-6462325     c
            1375-3478           JAXUCZ010000020.1  6458931-6461034     c
FEATURES             Location/Qualifiers
     source          1..3478
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3478
                     /gene="Fkbp5"
                     /note="FKBP prolyl isomerase 5"
                     /db_xref="GeneID:361810"
                     /db_xref="RGD:1309155"
     exon            1..87
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            88..213
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1479
                     /gene="Fkbp5"
                     /EC_number="5.2.1.8"
                     /note="FK506 binding protein 5"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP5"
                     /protein_id="NP_001012174.1"
                     /db_xref="GeneID:361810"
                     /db_xref="RGD:1309155"
                     /translation="MTTDEGTSNNEENPAATVVEQGEDITTKKDRGVLKIVKRVGTSE
                     ETPMIGDKVYVHYKGKLSNGKKFDSSRDRNEPFVFSLGKGQVIKAWDIGVSTMKKGEI
                     CHLLCKPEYAYGSAGSLPKIPSNATLFFEIELLDFKGEDLFEDSGIIRRIKRKGEGYS
                     NPNEGATVEVHLEGCCAGRVFDCRDVVFVIGEGEDHDIPIGIDKALEKMQREEQCILY
                     LGPQYGFGEAGKPKFGIEPNAELMYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGT
                     VYFKGGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLNLAMCYLKLREYT
                     KAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQIS
                     VCQRKAKEHNERDRRVYANMFKKFAEQDAKEEASKALSKKAVEGAAGKKHESQTMGEG
                     KAEGHV"
     exon            214..358
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            359..501
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            502..616
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            617..773
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            774..864
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            865..948
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1134
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1374
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..3478
                     /gene="Fkbp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcctg ctgggcgggc tgagcggcgc gcgcggcgga gagacgcgaa gcgagggacg
       61 cagtggcggc ggcggcggcg gcgacaggtt ttctacttac aaaggacaat gactactgat
      121 gagggcacca gtaacaatga agaaaaccca gcagccaccg tggttgagca gggagaagat
      181 atcactacga aaaaagatag aggagtatta aagattgtca aaagagtggg gactagtgag
      241 gagaccccaa tgattggtga caaggtttat gtccactaca aaggcaagtt gtcgaatgga
      301 aagaagtttg attccagtcg tgacagaaac gagccgtttg tctttagcct tggcaaaggc
      361 caggttatca aagcctggga tattggggtg tctaccatga agaaaggcga gatctgccac
      421 ttattatgta aaccagaata cgcttacggc tctgctggca gcctcccgaa aattccctcg
      481 aacgcaactc tctttttcga gattgaactc cttgacttca aaggcgagga tctatttgaa
      541 gattcaggca ttatccggag aatcaaacga aaaggagaag gctactcaaa ccccaatgaa
      601 ggagccacgg tggaagtcca cctggaaggc tgctgtgctg gaagggtgtt tgactgccgg
      661 gatgtggtgt tcgtcattgg cgaaggagaa gaccacgaca ttccaattgg gatcgacaag
      721 gccctggaga agatgcagag ggaagagcag tgcattttgt atcttggacc acaatatggt
      781 tttggagaag cggggaaacc taaatttggc atcgaaccca atgctgagct tatgtatgaa
      841 gtcacactga agagcttcga aaaggccaaa gaatcctggg agatggacac caaagaaaaa
      901 ctggagcagg ctgccattgt caaagaaaag ggaacggtgt acttcaaggg aggcaagtac
      961 atgcaggccg tgattcagta cgggaagata gtgtcctggc tggagatgga gtacggcttg
     1021 tcagaaaagg agtccaaagc ttcggagtcc ttcctgctcg cagccttcct caacctggcc
     1081 atgtgctacc tgaagctcag agagtacacc aaagctgtcg agtgctgtga caaggccctt
     1141 ggactggaca gcgccaacga gaaaggcttg tacaggaggg gcgaagccca gctgctcatg
     1201 aacgagttcg agtcggccaa aggggacttt gagaaagtac tggaggtgaa ccctcagaac
     1261 aaggcagcga gactgcagat ctccgtgtgc cagaggaagg cgaaggaaca caacgagcgg
     1321 gaccgcaggg tgtacgccaa catgttcaag aagttcgcag agcaggatgc caaggaagag
     1381 gccagcaaag cattgagcaa gaaggcagta gaaggagcgg ccggcaagaa acacgagagt
     1441 cagaccatgg gagaagggaa ggccgaaggc cacgtatgac gccacgacaa ggagggaaga
     1501 gagtcctaat gaactcggcc ctcctcactg ggctcgcccc caactcagga ctgaacagtg
     1561 tttagtgtaa ggtttgttac agtctctgtg attctggaag ccaatggcaa gccagtagct
     1621 tcccaaccaa ccacagctgc tgccgggggt gggcggggac tgccggggaa acagcagaga
     1681 aggccgctgg tgtggagaga ccaagccagc agctcagtcc tgctcatttc agtctgtcac
     1741 cttttgatgt ccagcgcagc atcccttgtg accctggggc ccagctgctg tgggttcttc
     1801 actatggtca ctgcagaaac cgttgagaaa ataaactcag tggatctctg ctttcctatt
     1861 ggtgggcatg gcagggatct ctgctttcct attagtgggc atggcagggc aggcgatgag
     1921 atctcctgtg gcactgactc gcctgacaca agcccacaca aggggcgccc aggtccacag
     1981 ctgaatctcg gactgcttgc ctgccctcca agctcccctc tcagacttga gtgtggcttt
     2041 ctgtcctctc cagcatgtcc atgggctctg tcgttcctct acacccttca ctagtgacag
     2101 caggtggggc tttcctggtc agttttctgt ttcgggtgaa tttctgaggt gtggggagca
     2161 gtcggagtga gttatcttcc ccgctgcccc tcttcagaat gttagctctg ctcggctcct
     2221 ccccgttctc tgccctgcag tgaagagcct aaggcttgct cttgtcctag gcctagagtg
     2281 gacgacttcc gtctccgtct ccagctaaga ctgatgagtt actctttatt actatggtta
     2341 cctccttgtc agcgtgtgta ccacttttga gaaggaactt cacactcctc tatcgtgcaa
     2401 acatattttt caatttttac tttgtagctt gggttttgaa aggcaaactc tgggaggttt
     2461 aaagcaggca actaattact cttcagagtg aggtacctgg aggtggacag gcagatacct
     2521 cgctcatcct gcgcctcagc ttcttgttct ggtgggagcg gtgagcctgt atactacatc
     2581 agccaaagtc tccagaactt gggcactgaa ttagggcaaa tcttaagtag ttttggagtt
     2641 ggattttagt cctacaggtg agttatgggt ttgagcaggg cttgctcctc acccctgtgg
     2701 ggaacaccca ccagcccaag gatccatgca cagccctctc cccgccctaa ggaccaccgc
     2761 actcaagacg tgtggctgta gtaagtcggt cagtcatcac gtcaggacct taccaccaac
     2821 gggtcacttg tttcccggag ttgagtttta gtctgcatgc agcaggtggg atagagctgt
     2881 gcagagtctg tgacgtggct gagaccctcg agttcacact ttgcacttct gcctccttgc
     2941 gttgttttag agccctggct cccccaggag gtactgagcc ggagccgact tggtgtgcag
     3001 tgcagtgtcg gcagttgtat tgaccagaat tgcaggccag ggaggctgtg ctggaatttg
     3061 agcctaacta gttaggtttt tacaggaaaa cttgttctaa cttgggcgac cctcaccagc
     3121 tgtctccaag tgtatactgt gggcctagga gactggtgtg ggacgggagg gtggtcaggg
     3181 ttccgagcca gaagtggcaa agtgcccagc ccactggatt gtgcatgctc ttgactcagt
     3241 cattcagaca cttagtacag aaatcagaag atgtcttcac accctgagcc tggagagagt
     3301 ggtgggtaag cagatgacat tgaaattttg gtttttaaaa aatcacttag actctgcgag
     3361 taatggcgac acacaccttt gatcccatga cttgggagac cctatctcaa aacaaaacaa
     3421 aaaaaaaaaa ttacttagat gcattttgtg ttccttaaat aaatttttta aaaagtaa
//
