LOCUS       NP_001012174             456 aa            linear   ROD 23-APR-2024
DEFINITION  peptidyl-prolyl cis-trans isomerase FKBP5 [Rattus norvegicus].
ACCESSION   NP_001012174 XP_342104
VERSION     NP_001012174.1
DBSOURCE    REFSEQ: accession NM_001012174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Cattane,N., Di Benedetto,M.G., D'Aprile,I., Riva,M.A. and
            Cattaneo,A.
  TITLE     Dissecting the Long-Term Effect of Stress Early in Life on FKBP5:
            The Role of miR-20b-5p and miR-29c-3p
  JOURNAL   Biomolecules 14 (3), 371 (2024)
   PUBMED   38540789
  REMARK    GeneRIF: Dissecting the Long-Term Effect of Stress Early in Life on
            FKBP5: The Role of miR-20b-5p and miR-29c-3p.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Rowson,S., Bekhbat,M., Kelly,S., Hyer,M.M., Dyer,S., Weinshenker,D.
            and Neigh,G.
  TITLE     Chronic adolescent stress alters GR-FKBP5 interactions in the
            hippocampus of adult female rats
  JOURNAL   Stress 27 (1), 2312467 (2024)
   PUBMED   38557197
  REMARK    GeneRIF: Chronic adolescent stress alters GR-FKBP5 interactions in
            the hippocampus of adult female rats.
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Maganga-Bakita,I., Aiken,A.A., Puracchio,M.J., Kentner,A.C. and
            Hunter,R.G.
  TITLE     Regulatory Effects of Maternal Immune Activation and Environmental
            Enrichment on Glucocorticoid Receptor and FKBP5 Expression in
            Stress-sensitive Regions of the Offspring Brain
  JOURNAL   Neuroscience 505, 51-58 (2022)
   PUBMED   36116554
  REMARK    GeneRIF: Regulatory Effects of Maternal Immune Activation and
            Environmental Enrichment on Glucocorticoid Receptor and FKBP5
            Expression in Stress-sensitive Regions of the Offspring Brain.
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Wanstrath,B.J., McLean,S.A., Zhao,Y., Mickelson,J., Bauder,M.,
            Hausch,F. and Linnstaedt,S.D.
  TITLE     Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via
            FKBP51 Inhibition Depends on Timing of Administration Relative to
            Traumatic Stress Exposure
  JOURNAL   J Pain 23 (7), 1256-1267 (2022)
   PUBMED   35296422
  REMARK    GeneRIF: Duration of Reduction in Enduring Stress-Induced
            Hyperalgesia Via FKBP51 Inhibition Depends on Timing of
            Administration Relative to Traumatic Stress Exposure.
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Kusumanchi,P., Liang,T., Zhang,T., Ross,R.A., Han,S., Chandler,K.,
            Oshodi,A., Jiang,Y., Dent,A.L., Skill,N.J., Huda,N., Ma,J., Yang,Z.
            and Liangpunsakul,S.
  TITLE     Stress-Responsive Gene FK506-Binding Protein 51 Mediates
            Alcohol-Induced Liver Injury Through the Hippo Pathway and
            Chemokine (C-X-C Motif) Ligand 1 Signaling
  JOURNAL   Hepatology 74 (3), 1234-1250 (2021)
   PUBMED   33710653
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Pratt,W.B., Morishima,Y., Murphy,M. and Harrell,M.
  TITLE     Chaperoning of glucocorticoid receptors
  JOURNAL   Handb Exp Pharmacol (172), 111-138 (2006)
   PUBMED   16610357
  REMARK    Review article
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Pirkl,F. and Buchner,J.
  TITLE     Functional analysis of the Hsp90-associated human peptidyl prolyl
            cis/trans isomerases FKBP51, FKBP52 and Cyp40
  JOURNAL   J Mol Biol 308 (4), 795-806 (2001)
   PUBMED   11350175
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Feb 11, 2005 this sequence version replaced XP_342104.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1523910.1,
                                           SRR26643292.63517.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     Protein         1..456
                     /product="peptidyl-prolyl cis-trans isomerase FKBP5"
                     /EC_number="5.2.1.8"
                     /note="FK506 binding protein 5"
                     /calculated_mol_wt=50834
     Region          44..135
                     /region_name="FKBP_C"
                     /note="FKBP-type peptidyl-prolyl cis-trans isomerase;
                     pfam00254"
                     /db_xref="CDD:459735"
     Region          266..>438
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          268..296
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          319..345
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(321..322,325..326,328,352,355..356,359..360,
                     362..363,386,389..390,393..394,397)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          350..380
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..456
                     /gene="Fkbp5"
                     /coded_by="NM_001012174.2:109..1479"
                     /db_xref="GeneID:361810"
                     /db_xref="RGD:1309155"
ORIGIN      
        1 mttdegtsnn eenpaatvve qgedittkkd rgvlkivkrv gtseetpmig dkvyvhykgk
       61 lsngkkfdss rdrnepfvfs lgkgqvikaw digvstmkkg eichllckpe yaygsagslp
      121 kipsnatlff eielldfkge dlfedsgiir rikrkgegys npnegatvev hlegccagrv
      181 fdcrdvvfvi gegedhdipi gidkalekmq reeqcilylg pqygfgeagk pkfgiepnae
      241 lmyevtlksf ekakeswemd tkekleqaai vkekgtvyfk ggkymqaviq ygkivswlem
      301 eyglsekesk asesfllaaf lnlamcylkl reytkavecc dkalgldsan ekglyrrgea
      361 qllmnefesa kgdfekvlev npqnkaarlq isvcqrkake hnerdrrvya nmfkkfaeqd
      421 akeeaskals kkavegaagk khesqtmgeg kaeghv
//
