LOCUS       NM_001191863            2845 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus FKBP prolyl isomerase 4 (Fkbp4), mRNA.
ACCESSION   NM_001191863 XM_342763
VERSION     NM_001191863.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2845)
  AUTHORS   Bandleon,S., Strunz,P.P., Pickel,S., Tiapko,O., Cellini,A.,
            Miranda-Laferte,E. and Eder-Negrin,P.
  TITLE     FKBP52 regulates TRPC3-dependent Ca2+ signals and the hypertrophic
            growth of cardiomyocyte cultures
  JOURNAL   J Cell Sci 132 (20) (2019)
   PUBMED   31540954
  REMARK    GeneRIF: data demonstrate that FKBP52 associates with TRPC3 via an
            as-yet-undescribed binding site in the C-terminus of TRPC3 and
            modulates TRPC3-dependent Ca(2+) signals in a PPIase-dependent
            manner. This functional interaction might be crucial for limiting
            TRPC3-dependent signaling during chronic hypertrophic stimulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2845)
  AUTHORS   Song,S. and Tan,Y.
  TITLE     Expression of FKBP52 in the ovaries of PCOS rats
  JOURNAL   Int J Mol Med 43 (2), 868-878 (2019)
   PUBMED   30483787
  REMARK    GeneRIF: the upregulation of cochaperone FKBP52 may mediate the
            activation of AR through the MAPK/ERK pathway.
REFERENCE   3  (bases 1 to 2845)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2845)
  AUTHORS   Yang,J. and Fuller,P.J.
  TITLE     Interactions of the mineralocorticoid receptor--within and without
  JOURNAL   Mol Cell Endocrinol 350 (2), 196-205 (2012)
   PUBMED   21784126
  REMARK    Review article
REFERENCE   5  (bases 1 to 2845)
  AUTHORS   Quinta,H.R., Maschi,D., Gomez-Sanchez,C., Piwien-Pilipuk,G. and
            Galigniana,M.D.
  TITLE     Subcellular rearrangement of hsp90-binding immunophilins
            accompanies neuronal differentiation and neurite outgrowth
  JOURNAL   J Neurochem 115 (3), 716-734 (2010)
   PUBMED   20796173
REFERENCE   6  (bases 1 to 2845)
  AUTHORS   Young,J.C., Obermann,W.M. and Hartl,F.U.
  TITLE     Specific binding of tetratricopeptide repeat proteins to the
            C-terminal 12-kDa domain of hsp90
  JOURNAL   J Biol Chem 273 (29), 18007-18010 (1998)
   PUBMED   9660753
REFERENCE   7  (bases 1 to 2845)
  AUTHORS   Schmitt,J., Pohl,J. and Stunnenberg,H.G.
  TITLE     Cloning and expression of a mouse cDNA encoding p59, an
            immunophilin that associates with the glucocorticoid receptor
  JOURNAL   Gene 132 (2), 267-271 (1993)
   PUBMED   7693550
REFERENCE   8  (bases 1 to 2845)
  AUTHORS   Alnemri,E.S., Fernandes-Alnemri,T., Nelki,D.S., Dudley,K.,
            DuBois,G.C. and Litwack,G.
  TITLE     Overexpression, characterization, and purification of a recombinant
            mouse immunophilin FKBP-52 and identification of an associated
            phosphoprotein
  JOURNAL   Proc Natl Acad Sci U S A 90 (14), 6839-6843 (1993)
   PUBMED   8341706
REFERENCE   9  (bases 1 to 2845)
  AUTHORS   Tai,P.K., Albers,M.W., Chang,H., Faber,L.E. and Schreiber,S.L.
  TITLE     Association of a 59-kilodalton immunophilin with the glucocorticoid
            receptor complex
  JOURNAL   Science 256 (5061), 1315-1318 (1992)
   PUBMED   1376003
REFERENCE   10 (bases 1 to 2845)
  AUTHORS   Kuhner,M.K. and Goodenow,R.S.
  TITLE     DNA sequences of mouse H-2 and Qa genes
  JOURNAL   Immunogenetics 30 (6), 458-464 (1989)
   PUBMED   2592022
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 17, 2010 this sequence version replaced XM_342763.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.14283.1,
                                           SRR26643298.25532.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000004.1  163397649-163397918 c
            271-415             JAXUCZ010000004.1  163395799-163395943 c
            416-558             JAXUCZ010000004.1  163395090-163395232 c
            559-679             JAXUCZ010000004.1  163394294-163394414 c
            680-836             JAXUCZ010000004.1  163393847-163394003 c
            837-927             JAXUCZ010000004.1  163393215-163393305 c
            928-1011            JAXUCZ010000004.1  163393037-163393120 c
            1012-1197           JAXUCZ010000004.1  163392633-163392818 c
            1198-1437           JAXUCZ010000004.1  163391953-163392192 c
            1438-2845           JAXUCZ010000004.1  163389464-163390871 c
FEATURES             Location/Qualifiers
     source          1..2845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2845
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /note="FKBP prolyl isomerase 4"
                     /db_xref="GeneID:260321"
                     /db_xref="RGD:628729"
     exon            1..270
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1542
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /EC_number="5.2.1.8"
                     /note="HBI; FKBP59; rotamase; FKBP52 protein; HSP-binding
                     immunophilin; 52 kDa FK506-binding protein; 52 kDa FKBP;
                     PPIase FKBP4; 59 kDa immunophilin; immunophilin FKBP52;
                     FK506 binding protein 52; FK506-binding protein 4"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP4"
                     /protein_id="NP_001178792.1"
                     /db_xref="GeneID:260321"
                     /db_xref="RGD:628729"
                     /translation="MTAEEMKVAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGT
                     ETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEV
                     CHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEDEDGGIIRRIRTRGEG
                     YARPNDGAMVEVALEGYYNDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSI
                     VYLKPSYAFGSVGKERFQIPPHAELRYEVHLKSFEKAKASWEMNSEEKLEQSNIVKER
                     GTVYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQA
                     FSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQ
                     LAVCQQRTRRQLAREKKLYANMFERLAEEEHKAKTEVAAGDHPTDAEMKGEPNNVAGN
                     QAQVKTEA"
     exon            271..415
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            416..558
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            559..679
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            680..836
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            837..927
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1011
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1197
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1437
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..2845
                     /gene="Fkbp4"
                     /gene_synonym="FKBP-4; FKBP-52; p59"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccggcgag cgcgcggaga gcccggtgcg cgagcctgga gcgcggttcg aggtgggcag
       61 cgctgccttc cgctgcacgc caccccgccg ctcatcccgg tcggcggcca gagtgccggg
      121 ctcgcgctcg ccccactccc gcagccaacg gtgcgcccag cggccatgac cgccgaggag
      181 atgaaggtgg cggagaacgg ggcgcaatcg gcgcccctgc ctctcgaagg agtggacatc
      241 agccccaagc aggacgaggg cgtgctcaag gtcatcaaga gagagggtac aggcacagag
      301 acagccatga ttggggaccg agtctttgtc cactacactg gctggctgct agatggcaca
      361 aagtttgact ccagtttgga ccgcaaggac aaattctcct ttgacctggg aaaaggggag
      421 gtcatcaagg cttgggatat tgctgtggca accatgaaag tgggggaagt gtgccacatc
      481 acctgcaagc cagaatacgc ctacggttca gcaggcagcc ctccaaagat tcccccaaat
      541 gccacacttg tatttgaggt ggagctgttt gagttcaaag gagaagatct tacagaagat
      601 gaagatggtg ggatcatccg cagaatacgg actcgggggg aaggctatgc caggcccaat
      661 gatggcgcta tggtagaagt ggcactagaa ggctactata atgaccggct gtttgaccag
      721 cgggagctct gctttgaagt cggggaaggg gaaagcctgg atctgccctg tgggctggag
      781 gaggccattc agcgcatgga gaaaggagaa cattccattg tgtacctcaa acctagctat
      841 gcttttggca gtgttgggaa ggaaaggttc cagatcccac cacatgctga gctgaggtat
      901 gaagtacatc tgaagagttt tgagaaggcc aaggcatctt gggagatgaa ctctgaggag
      961 aagctggagc agagcaacat agtgaaagaa aggggcaccg tgtacttcaa ggaaggcaag
     1021 tacaagcaag ccttactgca gtacaagaag attgtgtctt ggctagaata cgagtctagt
     1081 ttttccggtg aggaaatgca aaaggtccat gcgctccgac tggcctcaca tctcaatctg
     1141 gccatgtgtc acctgaaact gcaggccttc tcagctgcca tcgaaagctg taacaaggcc
     1201 ttggagctgg acagcaacaa tgagaagggc ctgtttcgcc ggggagaggc acacctggcc
     1261 gtgaatgact ttgacctggc acgagctgac ttccaaaagg tcctgcagct ctatcccagc
     1321 aacaaagccg ccaagaccca gctggctgtg tgccagcagc ggacccgcag gcagcttgcc
     1381 cgggaaaaga agctctatgc caacatgttt gagaggctgg ctgaggagga acataaggcc
     1441 aagacagaag tggctgcagg agaccatccc actgatgctg agatgaaggg tgagccgaac
     1501 aatgtggcag gcaaccaggc tcaggtgaag acagaagcat agcctgcctc tccgcctacc
     1561 cacccctgcg gctgcctccc tgctcccttc cctactccac cctgttagtt ttgtaaaaac
     1621 tgaagaattt tgagtgaatt agacctttat ttttctatct gtttggatga tggctttggg
     1681 ggagaaggga gaagagcagg ctgagggtga aatggggggt agttttagat ggtgtcaact
     1741 cctcttttct tccccgttat acatgagtgt atatccttcc acacatacat cagaatgtta
     1801 atttattttg ctccctctgt ttgctccatt ttcaagtggt tgaaggggct gtgtgatagg
     1861 gatggggtct gataagccag ggtggagaag actcctgggc agccattttt cccatccctt
     1921 ccctctgtgg ttgttttcca agcctgcggt ctccatgaag gtgctagggg catgggaaaa
     1981 ccactgttgt gtccattacc tctcttgcct tgctctcctg agatggtatt cccggtaaca
     2041 tcccccggta tcacagtgat cgcctctaga cagctcctac cagtacttcc cctttcctcc
     2101 cctcctctca gtttcctcat ccaggtcatc cctgtcccca tcccctcagc ctctttaatg
     2161 cacgctgaag gtccaggcac acctcaagtc ctgtgcttga gcaataaagt ggaaaccaca
     2221 aaacctgggt gtcaggcaac cctttatgtt gagctctcgg gtggggcatg gtggggatat
     2281 gggcggggca ggatgaataa ggtcccactc tgctccatcg ttaaagtgtg ggatgtggtg
     2341 cagactgtgg caaggcagga aacagctgct gtgctcatac accctgagct ctgatataga
     2401 ctacagcagt agaatgctgg ggtggttccc ctcaacaaga agaggaagag tttataaaca
     2461 gtggttttga aactggcttc ttgtactact gcctccctgt tctagtagac atctggggtg
     2521 ttatagctga atgtatctaa gcaccatgtc cattctggat gcctgtggag accagactac
     2581 ggcatcaagt ccctcagact ggagagaatt gagagtcact agttgggtgc ctggaatcac
     2641 acctgggtcc ttgtccgatg atataaaaac actatcacta ggctggcctt gtgtgtcaca
     2701 tctttaatgc cagcactctg gaattggggt cgggtggatc tctggtcaag gccagcttga
     2761 tctacagaat gagtccagga cagccagggc tctttataca gagaaacact gtctcaaaga
     2821 ccttcagtgt tgctggcttt tgttg
//
