LOCUS       NM_022675                960 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus FKBP prolyl isomerase 1B (Fkbp1b), transcript
            variant 1, mRNA.
ACCESSION   NM_022675
VERSION     NM_022675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 960)
  AUTHORS   Gant,J.C., Blalock,E.M., Chen,K.C., Kadish,I., Thibault,O.,
            Porter,N.M. and Landfield,P.W.
  TITLE     FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+],
            Rescues Memory and Restores Genomic Regulation in the Hippocampus
            of Aging Rats
  JOURNAL   J Neurosci 38 (4), 1030-1041 (2018)
   PUBMED   29255009
  REMARK    GeneRIF: a previously unrecognized genomic network modulating
            diverse brain structural processes is dysregulated by aging and
            restored by FKBP1b overexpression
REFERENCE   2  (bases 1 to 960)
  AUTHORS   Liu,X.H., Harlow,L., Graham,Z.A., Bauman,W.A. and Cardozo,C.
  TITLE     Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of
            Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation
            of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4
  JOURNAL   J Neurotrauma 34 (12), 2069-2074 (2017)
   PUBMED   27998200
REFERENCE   3  (bases 1 to 960)
  AUTHORS   Gant,J.C., Chen,K.C., Kadish,I., Blalock,E.M., Thibault,O.,
            Porter,N.M. and Landfield,P.W.
  TITLE     Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive
            Impairment by Delivery of a Transgene Encoding FK506-Binding
            Protein 12.6/1b to the Hippocampus
  JOURNAL   J Neurosci 35 (30), 10878-10887 (2015)
   PUBMED   26224869
  REMARK    GeneRIF: raising FKBP1b reversed calcium dysregulation and memory
            impairment in aging rats, allowing them to perform a memory task as
            well as young rats
REFERENCE   4  (bases 1 to 960)
  AUTHORS   Du,Y., Zhao,J., Li,X., Jin,S., Ma,W.L., Mu,Q., Xu,S., Yang,J.,
            Rao,S., Zhu,L., Xin,J., Cai,P.C., Su,Y. and Ye,H.
  TITLE     Dissociation of FK506-binding protein 12.6 kD from ryanodine
            receptor in bronchial smooth muscle cells in airway
            hyperresponsiveness in asthma
  JOURNAL   Am J Respir Cell Mol Biol 50 (2), 398-408 (2014)
   PUBMED   24053175
  REMARK    GeneRIF: Dissociation of FK506-binding protein 12.6 kD from
            ryanodine receptor 2 in bronchial smooth muscle cells is
            responsible for the increased calcium response contributing to AHR
            in asthma
REFERENCE   5  (bases 1 to 960)
  AUTHORS   Galfre,E., Pitt,S.J., Venturi,E., Sitsapesan,M., Zaccai,N.R.,
            Tsaneva-Atanasova,K., O'Neill,S. and Sitsapesan,R.
  TITLE     FKBP12 activates the cardiac ryanodine receptor Ca2+-release
            channel and is antagonised by FKBP12.6
  JOURNAL   PLoS One 7 (2), e31956 (2012)
   PUBMED   22363773
  REMARK    GeneRIF: The effects of FKBP12.6 and another structurally similar
            molecule, FKBP12, which is far more abundant in heart, on the
            gating of single sheep RyR2 channels, were investigated.
REFERENCE   6  (bases 1 to 960)
  AUTHORS   Marx,S.O., Reiken,S., Hisamatsu,Y., Jayaraman,T., Burkhoff,D.,
            Rosemblit,N. and Marks,A.R.
  TITLE     PKA phosphorylation dissociates FKBP12.6 from the calcium release
            channel (ryanodine receptor): defective regulation in failing
            hearts
  JOURNAL   Cell 101 (4), 365-376 (2000)
   PUBMED   10830164
REFERENCE   7  (bases 1 to 960)
  AUTHORS   Gold,B.G., Zeleny-Pooley,M., Chaturvedi,P. and Wang,M.S.
  TITLE     Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds
            nerve regeneration
  JOURNAL   Neuroreport 9 (3), 553-558 (1998)
   PUBMED   9512405
REFERENCE   8  (bases 1 to 960)
  AUTHORS   Noguchi,N., Takasawa,S., Nata,K., Tohgo,A., Kato,I., Ikehata,F.,
            Yonekura,H. and Okamoto,H.
  TITLE     Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release
            Ca2+ from islet microsomes
  JOURNAL   J Biol Chem 272 (6), 3133-3136 (1997)
   PUBMED   9013543
REFERENCE   9  (bases 1 to 960)
  AUTHORS   Lam,E., Martin,M.M., Timerman,A.P., Sabers,C., Fleischer,S.,
            Lukas,T., Abraham,R.T., O'Keefe,S.J., O'Neill,E.A. and
            Wiederrecht,G.J.
  TITLE     A novel FK506 binding protein can mediate the immunosuppressive
            effects of FK506 and is associated with the cardiac ryanodine
            receptor
  JOURNAL   J Biol Chem 270 (44), 26511-26522 (1995)
   PUBMED   7592869
REFERENCE   10 (bases 1 to 960)
  AUTHORS   Arakawa,H., Nagase,H., Hayashi,N., Fujiwara,T., Ogawa,M., Shin,S.
            and Nakamura,Y.
  TITLE     Molecular cloning and expression of a novel human gene that is
            highly homologous to human FK506-binding protein 12kDa (hFKBP-12)
            and characterization of two alternatively spliced transcripts
  JOURNAL   Biochem Biophys Res Commun 200 (2), 836-843 (1994)
   PUBMED   7513996
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 7, 2022 this sequence version replaced NM_022675.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.3915331.1, CB556548.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840105 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               JAXUCZ010000006.1  33567956-33568129   c
            175-222             JAXUCZ010000006.1  33563824-33563871   c
            223-335             JAXUCZ010000006.1  33560148-33560260   c
            336-960             JAXUCZ010000006.1  33558517-33559141   c
FEATURES             Location/Qualifiers
     source          1..960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..960
                     /gene="Fkbp1b"
                     /gene_synonym="FKBP-12.6; FKBP-1B"
                     /note="FKBP prolyl isomerase 1B"
                     /db_xref="GeneID:58950"
                     /db_xref="RGD:61835"
     exon            1..174
                     /gene="Fkbp1b"
                     /gene_synonym="FKBP-12.6; FKBP-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            175..222
                     /gene="Fkbp1b"
                     /gene_synonym="FKBP-12.6; FKBP-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            223..335
                     /gene="Fkbp1b"
                     /gene_synonym="FKBP-12.6; FKBP-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            336..960
                     /gene="Fkbp1b"
                     /gene_synonym="FKBP-12.6; FKBP-1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gactccagcc gcacctcctc cggctctgca gtggcggcaa gaagacgagc cggagcgcct
       61 gcggggtccg gcctgagcag agccggggtc ggggcagccg cgaggacccc cttggaggcg
      121 gggcctgtgg gaccgcgatg ggcgtggaga tcgagaccat ctccccggga gacggaagga
      181 cattccctaa gaagggtcag atatgcgtgg tgcactacac agggatgctc cagaatggca
      241 agaaattcga ttcgtccaga gacagaaaca aacccttcaa gttcagaatt ggcaagcagg
      301 aagtcatcaa aggttttgaa gaaggcgctg cccagatgag cttggggcag agggcgaagc
      361 tgacctgcac ccctgatgtg gcatatggag ctactggcca ccccggtgtc atccctccca
      421 atgccaccct catctttgac gtggagctgc tcaacttaga gtgaaggcag gaaggaagtc
      481 gaggtggctg gagaaggctc ctgctctgtc ctagcctgct ctctctgcca ctgggacggc
      541 tcctccaatg tagggctctt gatcagtgtg ctgaccccac cgccccttga cattatctgt
      601 tctttctgcc caacttgctc tgtatgtgtc ggccacttaa ccgtccccat acatctttgc
      661 ttgaggaaac ttttagttgc agatccaaac atttcagact gcattttgtg tgatgcatgt
      721 ggtagccatt cctgatcata ggacacagat ctcgtttgca caatctatat tgccttacct
      781 gcacttaagc cagatataca aggtgctcag acatgcgctg tacatggtta cctggaggga
      841 cttgagccag ttacctttgc tgtcactttc ttatcttctg ttggctgctc actttaagca
      901 ctgccctctt tggaaatact atgtaaaata aaggctctgt gcttggcatc ttcctgtcca
//
