LOCUS       NM_013102               1522 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus FKBP prolyl isomerase 1A (Fkbp1a), mRNA.
ACCESSION   NM_013102 NM_053308 XM_001053006 XM_001053007
VERSION     NM_013102.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Caraveo,G., Soste,M., Cappelleti,V., Fanning,S., van Rossum,D.B.,
            Whitesell,L., Huang,Y., Chung,C.Y., Baru,V., Zaichick,S.,
            Picotti,P. and Lindquist,S.
  TITLE     FKBP12 contributes to alpha-synuclein toxicity by regulating the
            calcineurin-dependent phosphoproteome
  JOURNAL   Proc Natl Acad Sci U S A 114 (52), E11313-E11322 (2017)
   PUBMED   29229832
  REMARK    GeneRIF: FKBP12 can endogenously regulate calcineurin activity with
            therapeutic implications for the treatment of Parkinson's Disease.
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Weingarten,J., Lassek,M., Mueller,B.F., Rohmer,M., Lunger,I.,
            Baeumlisberger,D., Dudek,S., Gogesch,P., Karas,M. and Volknandt,W.
  TITLE     The proteome of the presynaptic active zone from mouse brain
  JOURNAL   Mol Cell Neurosci 59, 106-118 (2014)
   PUBMED   24534009
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Liu,F.L., Liu,T.Y. and Kung,F.L.
  TITLE     FKBP12 regulates the localization and processing of amyloid
            precursor protein in human cell lines
  JOURNAL   J Biosci 39 (1), 85-95 (2014)
   PUBMED   24499793
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Spiekerkoetter,E., Tian,X., Cai,J., Hopper,R.K., Sudheendra,D.,
            Li,C.G., El-Bizri,N., Sawada,H., Haghighat,R., Chan,R.,
            Haghighat,L., de Jesus Perez,V., Wang,L., Reddy,S., Zhao,M.,
            Bernstein,D., Solow-Cordero,D.E., Beachy,P.A., Wandless,T.J., Ten
            Dijke,P. and Rabinovitch,M.
  TITLE     FK506 activates BMPR2, rescues endothelial dysfunction, and
            reverses pulmonary hypertension
  JOURNAL   J Clin Invest 123 (8), 3600-3613 (2013)
   PUBMED   23867624
REFERENCE   5  (bases 1 to 1522)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   6  (bases 1 to 1522)
  AUTHORS   Wang,T., Donahoe,P.K. and Zervos,A.S.
  TITLE     Specific interaction of type I receptors of the TGF-beta family
            with the immunophilin FKBP-12
  JOURNAL   Science 265 (5172), 674-676 (1994)
   PUBMED   7518616
REFERENCE   7  (bases 1 to 1522)
  AUTHORS   Nelson,P.A., Lippke,J.A., Murcko,M.A., Rosborough,S.L. and
            Peattie,D.A.
  TITLE     cDNA encoding murine FK506-binding protein (FKBP): nucleotide and
            deduced amino acid sequence
  JOURNAL   Gene 109 (2), 255-258 (1991)
   PUBMED   1722474
REFERENCE   8  (bases 1 to 1522)
  AUTHORS   Siekierka,J.J., Wiederrecht,G., Greulich,H., Boulton,D., Hung,S.H.,
            Cryan,J., Hodges,P.J. and Sigal,N.H.
  TITLE     The cytosolic-binding protein for the immunosuppressant FK-506 is
            both a ubiquitous and highly conserved peptidyl-prolyl cis-trans
            isomerase
  JOURNAL   J Biol Chem 265 (34), 21011-21015 (1990)
   PUBMED   1701173
REFERENCE   9  (bases 1 to 1522)
  AUTHORS   Standaert,R.F., Galat,A., Verdine,G.L. and Schreiber,S.L.
  TITLE     Molecular cloning and overexpression of the human FK506-binding
            protein FKBP
  JOURNAL   Nature 346 (6285), 671-674 (1990)
   PUBMED   1696686
REFERENCE   10 (bases 1 to 1522)
  AUTHORS   Harding,M.W., Galat,A., Uehling,D.E. and Schreiber,S.L.
  TITLE     A receptor for the immunosuppressant FK506 is a cis-trans
            peptidyl-prolyl isomerase
  JOURNAL   Nature 341 (6244), 758-760 (1989)
   PUBMED   2477715
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC070519.1.
            
            On Aug 31, 2012 this sequence version replaced NM_013102.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070519.1, CF110710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1522              BC070519.1         4-1525
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1522
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /note="FKBP prolyl isomerase 1A"
                     /db_xref="GeneID:25639"
                     /db_xref="RGD:2617"
     exon            1..110
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..400
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /EC_number="5.2.1.8"
                     /note="FKBP-12; FKBP-1A; rotamase; 12 kDa FKBP; PPIase
                     FKBP1A; 12 kDa FK506-binding protein; FK506 binding
                     protein 2 (13 kDa); FK506-binding protein 1 (12kD);
                     immunophilin FKBP12; FK506-binding protein 1A; FK506
                     binding protein 1a"
                     /codon_start=1
                     /product="peptidyl-prolyl cis-trans isomerase FKBP1A"
                     /protein_id="NP_037234.2"
                     /db_xref="GeneID:25639"
                     /db_xref="RGD:2617"
                     /translation="MGVQVETISSGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRN
                     KPFKFTLGKQEVIRGWEEGVAQMSVGQRAKLIISPDYAYGATGHPGIIPPHATLVFDV
                     ELLKLE"
     exon            111..158
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            159..271
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..434
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..1498
                     /gene="Fkbp1a"
                     /gene_synonym="FKBP12; Fkbp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccacgccg cccgtcgcgc ctccacccgc gtccttctcc tccgccaacg ccgccgccgc
       61 cgccgccgcc gccatgggag tgcaggtgga gaccatctct tctggagacg ggcgcacctt
      121 cccgaagcgc ggccagacct gcgtggtaca ctacacgggg atgcttgaag atgggaagaa
      181 atttgactcc tctcgggaca gaaacaagcc ttttaagttt acactaggca agcaggaggt
      241 gatccgaggc tgggaagaag gggtagccca gatgagtgtg ggccagagag ccaaactgat
      301 aatctcccca gactatgcct atggagccac cgggcaccca ggcatcatcc caccacatgc
      361 tactcttgtt tttgatgtgg agcttctaaa actggaatga cagaagtggc ctcctccctt
      421 agctctgcac atggatctgc catggaggaa tctggtacct ccagatgggt gcacatgaat
      481 ccatgggagc ttttcctgat gtcccaccac tctttgtata gacacctact gactgaatgt
      541 gttccgtcac tcagctttgc ttcggacacc tccatgtcct cttccccctt ctgtatgtgt
      601 gttgacctaa actgtatgcc ataaacctca agttactttg ttttggggtg aagactcagt
      661 ttctgtcttt gagatctaag tttccaatga agtatattat caagtgttaa cagcacaagc
      721 aatggattaa ctctagaata ggaattggtg ttgggggtgg gatttgcaag aatttttatt
      781 ttattttatt tttatttttt ggatgaaaat tttatctatt atatattaag acattctgct
      841 actgtgctgc aaagccatag cagattcgag atgctgttgg gggctggatt tttctccagt
      901 gagggaagtc ctgttaaacc gaaagcccta cccaaactga agtgggaagg gagggagagc
      961 ctttgcttct gacaggcctt ccacctaaaa ctgactgcct tttaaagcag gtcccttcac
     1021 tgctgtgttg aacactacaa tatctgtccc tgggtcggca gggacctctg aagccttctt
     1081 tgtgacctgg cttaatttgt ttttcatcct atggtttttc taatggattt tctggacttt
     1141 tgtaatcttg taactatcac gctccactta ctaaattcta gaacttcggt ggaaagttta
     1201 aactgaaggt gctgtttgta gactcaccac ccagtggatg cccagccacc acaacaaatc
     1261 cttgagtgtt ctctaagaaa atgatgctgg tcatcacagc ttcagcatct cccaggtttt
     1321 gatgcttggc tctctgctga tcccagcttc ctggcttttc ctccttcagt tccttttcac
     1381 cctctgctgt cccgtgtagt gatttggtga gagaaagctt ttgtcccctg cctctgcact
     1441 acatatgcgg ttcaagtttt attattgcaa taaaagtgct ttatgctggc ttttctcaaa
     1501 aaaaaaaaaa aaaaaaaaaa aa
//
