LOCUS       NM_001107799            4462 bp    mRNA    linear   ROD 12-JUN-2023
DEFINITION  Rattus norvegicus fat storage-inducing transmembrane protein 2
            (Fitm2), mRNA.
ACCESSION   NM_001107799 XM_001070393 XM_230827
VERSION     NM_001107799.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4462)
  AUTHORS   Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD,
            Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther
            TC and Farese RV Jr.
  TITLE     FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic
            reticulum homeostasis
  JOURNAL   J Cell Biol 219 (10) (2020)
   PUBMED   32915949
REFERENCE   2  (bases 1 to 4462)
  AUTHORS   Choudhary V, Ojha N, Golden A and Prinz WA.
  TITLE     A conserved family of proteins facilitates nascent lipid droplet
            budding from the ER
  JOURNAL   J Cell Biol 211 (2), 261-271 (2015)
   PUBMED   26504167
REFERENCE   3  (bases 1 to 4462)
  AUTHORS   Miranda DA, Kim JH, Nguyen LN, Cheng W, Tan BC, Goh VJ, Tan JS,
            Yaligar J, Kn BP, Velan SS, Wang H and Silver DL.
  TITLE     Fat storage-inducing transmembrane protein 2 is required for normal
            fat storage in adipose tissue
  JOURNAL   J Biol Chem 289 (14), 9560-9572 (2014)
   PUBMED   24519944
REFERENCE   4  (bases 1 to 4462)
  AUTHORS   Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V,
            Suryavanshi N, Bechtel S, Wiemann S, Baum B and Ridley AJ.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4462)
  AUTHORS   Gross DA, Snapp EL and Silver DL.
  TITLE     Structural insights into triglyceride storage mediated by fat
            storage-inducing transmembrane (FIT) protein 2
  JOURNAL   PLoS One 5 (5), e10796 (2010)
   PUBMED   20520733
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4462)
  AUTHORS   Kadereit B, Kumar P, Wang WJ, Miranda D, Snapp EL, Severina N,
            Torregroza I, Evans T and Silver DL.
  TITLE     Evolutionarily conserved gene family important for fat storage
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 94-99 (2008)
   PUBMED   18160536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_230827.4, XM_001070393.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK602480.1, CB785193.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..4462
                     /gene="Fitm2"
                     /gene_synonym="Fit2; RGD1307696"
                     /note="fat storage-inducing transmembrane protein 2"
                     /db_xref="GeneID:311617"
                     /db_xref="RGD:1307696"
     exon            1..302
                     /gene="Fitm2"
                     /gene_synonym="Fit2; RGD1307696"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..918
                     /gene="Fitm2"
                     /gene_synonym="Fit2; RGD1307696"
                     /note="fat-inducing transcript 2"
                     /codon_start=1
                     /product="acyl-coenzyme A diphosphatase FITM2"
                     /protein_id="NP_001101269.1"
                     /db_xref="GeneID:311617"
                     /db_xref="RGD:1307696"
                     /translation="MEHLERCAWFLRGTLVRAAVRRHLPWVLVAAMLVGSALKELSPL
                     PESYLSNKRNVLNVYFVKLAWAWTVCLLLPFIALTNYHLTGKTSLVLRRLSTLLVGTA
                     IWYMCTALFSNIEHYTGSCYQSPALEGIRQEHRTKQQCHREGGFWYGFDISGHSFLLT
                     FCALMIVEEMAVLHEVKTDRSHHLHVAITTLVVALGFLTFIWVWMFLCTAVYFHDLIQ
                     KVFGTMFGLLGWYGTYGYWYLKSFSPGLPPQSSSLTLKQDTYKK"
     exon            303..4462
                     /gene="Fitm2"
                     /gene_synonym="Fit2; RGD1307696"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccttagggg gcggagcttg cgggaagcgc gcatgctccc agagggatgt gtcggtacca
       61 gctcgggcga agggcaagac ggtggccgag aaggctccga gaggcggacg gtggccgaga
      121 aggaccggca tggagcacct ggagcgctgt gcgtggtttc tccgcgggac gctcgtgagg
      181 gcggcggtgc ggcgccacct gccctgggtg ctcgtggccg ccatgctggt gggctcggcc
      241 ctcaaggagc tgtccccgct gcccgaaagc tacctcagca acaagcgcaa cgtcctcaac
      301 gtgtattttg ttaaattggc ctgggcctgg acagtctgtc tcctcctgcc tttcattgcc
      361 ctcaccaact accacctgac gggcaagacc agcctggtcc tgcggcggct gagcaccctc
      421 ctcgtgggca cggccatctg gtatatgtgc acagccctct tctccaacat tgagcactac
      481 acaggcagtt gctaccagtc cccggccctg gagggcatca gacaggaaca ccggaccaag
      541 cagcagtgcc accgggaagg gggcttctgg tacggctttg acatctcagg ccactccttc
      601 ctactgacct tctgcgcgct catgatcgtg gaggagatgg ccgtgctgca cgaggtgaag
      661 acagatcgca gccaccacct ccatgttgcc atcaccaccc tggttgtcgc cctgggcttc
      721 ctgaccttca tctgggtgtg gatgtttctg tgcacggccg tctatttcca cgacttgatc
      781 cagaaagtgt tcggcaccat gtttggcttg ttgggctggt acgggacata cggctactgg
      841 tatctgaagt ctttctctcc cgggcttcct ccccagagct ccagtttgac tttgaagcaa
      901 gatacttaca agaaatgaaa gagagggaca tagggacagg aggacaatgg ctaatagaat
      961 cctcacctac tttgtccagt gactggctga attatccatc ccattccaga gagagccttt
     1021 tctaggtacc tttggagtgg gggacgtctg gggaacaagt ttagtcctca gactctgctg
     1081 gtggtgccac catgttccca acagcgctat tcctgttgga ttcttctcat ctctggcaag
     1141 atgtgacctt aatctgttcc cagagggagg gcgaaggctc ggcagagggt ctagtggaca
     1201 gcctcatcat gtgggtcaag ggaaaaccag ggtttcaggg ctctctgctg tggcctccct
     1261 ggctcttctt ctctttagag tctagcggcc acagtaatgc tgttcattta acagcatttc
     1321 cccgtggctg actctgagat aagcatttgt ctctggcagg ttctttagta aataccccag
     1381 tgtctaaagg acactttctg gctgtagcat ccagtcctct gcctggaacc tggcggtgat
     1441 tcccaacagg ggtccacgac cctgcagtgc ctggatgatt gttggtggtg gtaattttgt
     1501 ttctctgtgt agccctgtgt gtcctggaac tcgctctata gatcaggctg atctcaaact
     1561 cagaggtcgg cctgtgcctg cctcccgagt gctggattta ggtgcacact gcctcggcac
     1621 gctcggatgt tttctgtttt gttttttttg tttttgtttt tgtttttttc tgtccacact
     1681 gtgtatcgtc cattatgtgt tggtttttgg agtggtaaca gaaaacccca ttttctccct
     1741 tctctcctga gtgagtgctc tctggtttta atcattacga cgccatttgt tctttgttgg
     1801 caaatccccg gccctacacc ttgacatgtg aagactgttt ggaggggttt ttgtttttta
     1861 gaacactaac tttttctaag acaaattctt ggcttgttgt attaaatccc acctcatcgg
     1921 attgttcctc tcttaggaat acaactggag ccaggaggcg tggtgctgcg tgcctttaat
     1981 cctagcacca ggaaggcaga ggcaggcaga tctctgtgag tttgaggtta ccctgccagg
     2041 ggtgctctgt gagatcctga ctcaaaaaaa aaaaagaggg gttggggatt tagctcagtg
     2101 gtagagcgtt tgcctagcaa acgcaaggcc ctgggttcgg tccccagctc cgaaaaaaaa
     2161 aaaaaaaaaa aaagaaagac agactaaaac tgaacagcag acttttatta cttgatgcat
     2221 tttaagctga gagagtgatt cagtcaagtg ctcatttggc taagtctttc ctgcccactg
     2281 accggtgata gaggcagaat tgggtttggg gacctcatag gaccatagga caagggccac
     2341 agcctaaggg attcttacct ttggaggtta tgatcattta gaagtgagat aaaatgtctc
     2401 cctctgacgc aggaagccag ctggcataca aagccaccca tgttacatag cgccatgact
     2461 ttggccccac ctcttcttcc tcatctcacc aaaagaacaa ccttaggagg cagcgttcag
     2521 tggccatgag agtctttctt tgcagctctt cctggctgct agccatctcg ttctgtcgcc
     2581 ttcaccgtga ctgtcaggat aagaagccct ttcacccaca tcctacgtgg caggcctcca
     2641 gtctgatgag agggcccttt cctctcctgg gtaatctcct tacgcctgtc acagctgagc
     2701 ccctggcctt ttggatgatg atccttgaag ctgccttggt gcctcctccc cagcagagct
     2761 ggctaatgat gttaactgat aagctttggc ctgactggcc tgactgaagc tcgggttggt
     2821 aggcacctgg taaattaaga gtaatcgctt tcttttttta aattttagta tttttttaaa
     2881 ttttgaatta tttaatcttt tgagccaggg tcttactatg cagccctgac tgatctggaa
     2941 ctcactatgt agaccaggct ggtctcaaac tcacagagtt ctacctgcct gcctctgttt
     3001 cctaagtgct gggataaaag gtatactaag attaaagcca ccaaatctgg ctactgagta
     3061 atttttttaa atataataat ctatttaaaa tatgtatttt aggggttggg gatttagctc
     3121 agtggtagag cgcttgccta gcaaacgcaa tgccctgggt tctgtcccca gctccgaaaa
     3181 aaagaaaaaa aatatgtatt ttatatcctg ttgagctaca gatgtcaact tgacccatta
     3241 ctatttaaga tgtgagatgt tgtcacaaag ggcacgaaag ggaggcagta aggagtcacc
     3301 acgatgcttt gctgagttga cagtggtcta aaaggatgtt tgaccttctg ggagtttcca
     3361 ccgtctctcc agggtaggaa tgggcctggg gatgatgggg ctggtccctg ggtaaagtct
     3421 ctctttaaca acagaaggga caggatgcgg ccaaaagctc attgtcacag aggctccagg
     3481 cagtattctt tttttttttt tttttttttt tttttttggg ggtctttttt tcggagctgg
     3541 ggaccgaacc cagggccttg tgcttcctag gcaagcgctc taccactgag ctaaatcccc
     3601 agcccctcca ggcagtattc ttgtgtggtc tgaccaggtt taacattaaa ttggcaacac
     3661 atgggaactc tcagttgctc agcgttctct acatgtttga tggattcaat cacacgtgct
     3721 tacacttgat gctctaccct tcctgctctg ggtggggtgg tggggtggag ccaagggttc
     3781 tgtgcatgct gggcaagccc tctatccctg agctacacca caagttcctc agcgcccttg
     3841 ccttctcagg agcgtgcctt ccctcctgtg tgaggaagca tggcatgggt gagtgtttgg
     3901 gcttgggcag tcatgaggtg tgaatgttag catcaccccc agagcacctg agcagtgcaa
     3961 gccttgttgg ccttgtctgc aaagcagcgg ccattctctc agtacctaaa ggagatggcg
     4021 tgtaggatgc tgagcgtgtg ctgctaggtt atctccccag cttcctcctg acagcattta
     4081 gagcgttctg gctccttcag agaaagtcga gaaaccagta tcttctgagg agacactcag
     4141 agcctgggtc gctcatgtca tctttcaaag tgtctgtcgt cccttggtgg tggccaaccc
     4201 gaggctttgg gagcatctga ctggagtcac tccatgcatt cttcttcacc agcttccgtg
     4261 cgcatccgtt accgtctggg taccagcttg tagttaggga atacctcatg ccactgtcac
     4321 ctacgcacag tccacgtgta aacaagcaaa ttaaaaagca cttgaggtat ggagtccaca
     4381 ttccagagtt tggtgtgttc ctttctgtat gtttttaatt taaaatttta acttcaactt
     4441 ttaaaaggtg tgtgtgtatc tg
//
