LOCUS       NM_001047096            3181 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus FIG4 phosphoinositide 5-phosphatase (Fig4), mRNA.
ACCESSION   NM_001047096 XM_001064428 XM_228301
VERSION     NM_001047096.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3181)
  AUTHORS   Vaccari I, Dina G, Tronchere H, Kaufman E, Chicanne G, Cerri F,
            Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH and
            Bolino A.
  TITLE     Genetic interaction between MTMR2 and FIG4 phospholipid
            phosphatases involved in Charcot-Marie-Tooth neuropathies
  JOURNAL   PLoS Genet 7 (10), e1002319 (2011)
   PUBMED   22028665
REFERENCE   2  (bases 1 to 3181)
  AUTHORS   Yuan Y, Gao X, Guo N, Zhang H, Xie Z, Jin M, Li B, Yu L and Jing N.
  TITLE     rSac3, a novel Sac domain phosphoinositide phosphatase, promotes
            neurite outgrowth in PC12 cells
  JOURNAL   Cell Res 17 (11), 919-932 (2007)
   PUBMED   17909536
REFERENCE   3  (bases 1 to 3181)
  AUTHORS   Sbrissa D, Ikonomov OC, Fu Z, Ijuin T, Gruenberg J, Takenawa T and
            Shisheva A.
  TITLE     Core protein machinery for mammalian phosphatidylinositol
            3,5-bisphosphate synthesis and turnover that regulates the
            progression of endosomal transport. Novel Sac phosphatase joins the
            ArPIKfyve-PIKfyve complex
  JOURNAL   J Biol Chem 282 (33), 23878-23891 (2007)
   PUBMED   17556371
REFERENCE   4  (bases 1 to 3181)
  AUTHORS   Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K,
            Shy ME, Li J, Zhang X, Lupski JR, Weisman LS and Meisler MH.
  TITLE     Mutation of FIG4 causes neurodegeneration in the pale tremor mouse
            and patients with CMT4J
  JOURNAL   Nature 448 (7149), 68-72 (2007)
   PUBMED   17572665
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ666853.1.
            
            On or before Sep 7, 2006 this sequence version replaced
            XM_228301.4, XM_001064428.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ666853.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3181
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..3181
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /note="FIG4 phosphoinositide 5-phosphatase"
                     /db_xref="GeneID:309855"
                     /db_xref="RGD:1311375"
     exon            1..69
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..2727
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /note="Sac domain-containing inositol phosphatase 3"
                     /codon_start=1
                     /product="polyphosphoinositide phosphatase"
                     /protein_id="NP_001040561.1"
                     /db_xref="GeneID:309855"
                     /db_xref="RGD:1311375"
                     /translation="MPTAAAPIISSVQKLVLYETRARYFLVGSNHAETKFRVLKIDRT
                     EPKDLVVIDDRHVYTQQEVRELLGRLDLGNRTKLSQKGSSGLFRAVSAFGVVGFVRFL
                     EGYYIVLITKRRKMADIGGHAIYKIEDTSMIYIPNDSVRITHPDEARYLRIFQNVDLS
                     SNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSETSKTCQESFDIFEDEGLTTQGGSGVF
                     GISSEPYMKYVWNGELLDIIKNSVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRS
                     SRFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLFWSQ
                     DISTMMPKPPITLDQADPFAHIAALHFDQMLQRFGSPIIILNLVKEREKRKHERILSE
                     ELVAAVTYLNQFLPPEHSIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNR
                     PDSYCSVLRPDEKWNELGGRVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQ
                     LYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQH
                     SKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKNTMSL
                     LPPKRSYTHWWTPEVVKHLPLPYDEVICAANLKKLTVKKFHRWEEEIDIHNEFFRPYE
                     LSSFDDTFCLAMTSSARDFMPKTIGIDPSPFTVRKPDETGKSVLGNKSNREEAVLQRK
                     TAASAPPPPSEEAVSSSSEDDSGTDREDEGSISQRSTPVKMTDTGDSAKVTESVAQPM
                     KEVYGVSLSRSLSEEDHSIYARFVQLGQSQHRQDWSSPQMCARCSDGVIKLTPISAFS
                     QDNIYEVQPPRVDRKSTEIFQAHIQASQGIMQPLGKEDTAIYREYIRNRYL"
     exon            70..168
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            169..292
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            293..449
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            450..500
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..649
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..778
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..879
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1042
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1140
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1274
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1391
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1437
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1586
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1753
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1892
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1951
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2099
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2183
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2379
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2462
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2549
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..3140
                     /gene="Fig4"
                     /gene_synonym="Kiaa0274; RGD1311375; Sac3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatgccca cggccgctgc ccccatcatc agttcggtcc agaagctggt gctctatgag
       61 actagagcta gatactttct agtcgggagc aatcatgcgg aaacaaagtt ccgagtcctg
      121 aagattgata gaacagaacc aaaggatttg gtggtgattg acgataggca cgtgtacacg
      181 caacaggaag tgcgggaact tcttggccgc ctggatctgg gaaacagaac aaagctgagc
      241 cagaaaggat cctccgggtt gtttcgagcc gtctccgcgt ttggtgtcgt aggttttgtc
      301 aggttcttag aaggctacta tatcgtatta ataactaagc ggaggaagat ggcggatatc
      361 ggaggccatg caatatataa gattgaagat acaagtatga tttatatccc caatgactct
      421 gttcggatta ctcaccccga cgaagctagg tacctaagga tattccaaaa tgtggatctg
      481 tccagcaatt tttactttag ttacagctat gatctgtccc actcccttca gtacaatctt
      541 accgtcctgc gaatgcccct ggagatgtta aagtcggaaa catccaagac ctgccaggag
      601 agcttcgaca tctttgaaga tgaagggtta actacgcagg gcggcagtgg cgtatttggg
      661 atctctagtg agccttacat gaagtatgtc tggaacggcg aacttctgga tataattaaa
      721 aacagcgtgc atcgcgactg gctactgtat atcattcatg ggttctgcgg gcagtcaaag
      781 cttctgatct atggacgacc agtgtatgtg accctaatag ccagaagatc cagtaggttt
      841 gctgggacgc gctttctcaa gagaggtgca aactgtgagg gagatgttgc caacgaggtg
      901 gagacggagc agatcctctg tgatgcctcg gtgatgtctt ttaccgcagg cagttactct
      961 tcttacgtac aagtcagagg ctctgttccc ttattctggt cccaagacat ctcaaccatg
     1021 atgccgaaac cacccattac actggaccag gcagatccct tcgcacacat agccgctctt
     1081 cactttgacc agatgctgca gaggtttggc tcccccatca tcatcctgaa cttagtgaag
     1141 gagagagaga agagaaagca cgaaaggatt ctgagcgagg agctggtggc cgcggttact
     1201 taccttaacc agttcctgcc cccggagcac agcattgtat acattccctg ggatatggcc
     1261 aagtacacca agagtaagct gtgtaacgtt ctcgatcgtc tgaacgtgat tgcagaaagc
     1321 gtggtaaaga agacaggctt cttcgtcaac cgccctgatt cttactgcag cgttttacgg
     1381 ccagatgaga agtggaacga actaggaggt cgtgtgattc ccactggtcg gctccagacc
     1441 ggcatccttc gaaccaactg cgtggactgt ttggatcgta ccaacacggc gcagttcatg
     1501 gtgggcaagt gcgccctggc ttaccagctg tactccttag ggctgattga caagcccaac
     1561 ctgcagttcg atacggacgc agtgaggtta tttgaggaac tctatgaaga ccatggagac
     1621 accctttccc tgcagtacgg aggctctcag ctggttcatc gggtgaagac ctacagaaag
     1681 atagcgccgt ggacccagca ctccaaggac atcatgcaga cgctgtctcg gtactacagc
     1741 aatgcctttt cagatgcgga cagacaagat tccatcaacc tgttcttggg tgttttccac
     1801 cccacagaag ggaaacctca tctctgggaa cttcccacgg acttttacct gcatcacaaa
     1861 aacaccatga gccttttacc ccccaaaagg agttatactc actggtggac accagaggtg
     1921 gtgaagcatt tgccgctgcc ttacgacgaa gttatctgtg ctgcaaactt aaagaagttg
     1981 acggtgaaga agtttcacag atgggaagag gagattgata ttcacaatga gttcttccgg
     2041 ccgtatgaat tgagtagttt tgatgacacc ttttgcctgg ccatgacaag ttcagcacgt
     2101 gattttatgc ctaaaactat tggcattgac ccaagtccat tcaccgtgcg aaaaccagac
     2161 gaaaccggga aatctgtact ggggaacaaa agcaacagag aggaggccgt cctgcaacgg
     2221 aaaacggcag ccagcgcccc gccacccccc agcgaggagg ccgtgtccag cagctccgag
     2281 gacgactctg gtactgaccg ggaagacgaa ggttccatct cgcagcgatc cactcctgtg
     2341 aagatgactg acaccggaga cagcgccaaa gtgactgaga gtgtggccca acccatgaag
     2401 gaagtgtacg gagttagcct ctcacgtagc ctgtccgagg aggatcactc catttatgcc
     2461 aggtttgttc aactggggca gagtcagcat agacaggact ggagcagccc gcagatgtgt
     2521 gcccggtgct cagacggagt tatcaaacta acccccatct cagctttctc gcaagacaac
     2581 atttatgaag ttcagccccc gagagtagac agaaagtcca cagagatctt ccaggcccac
     2641 atccaggcca gccaaggtat catgcagccc cttggcaaag aggacactgc catataccgg
     2701 gagtacatca gaaaccgcta cttataacga cggccccgag gacagtgggg ttagcttctt
     2761 ttcagtgttg tctgcgagaa ggaattccca ggacctggag atgcagctca gtagtaaagg
     2821 acacgtactt ccagaggctc ggaacctggt ccccagcacc cgtatcacaa ccttcggtaa
     2881 ctccagctac aaagaatcca atgttgtctt ctgtattttg tacacaccta tactcaagtg
     2941 ggtgcctgtg tgtgtacacc catgcacagg cgaacatgca tatgcgtgca catgcttgca
     3001 cacacacaca cacacacact aaaaatacta gaagtgaaat ccttaataac caattcatcc
     3061 aaatcatgga tctgaagctt ttcacccctt tgaaccatgc aaattactaa ctacaggtaa
     3121 taaagaagtg tctgcctctg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3181 a
//
