LOCUS       NM_001010946            1965 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus FIC domain protein adenylyltransferase (Ficd),
            mRNA.
ACCESSION   NM_001010946 XM_222280
VERSION     NM_001010946.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1965)
  AUTHORS   Sanyal,A., Chen,A.J., Nakayasu,E.S., Lazar,C.S., Zbornik,E.A.,
            Worby,C.A., Koller,A. and Mattoo,S.
  TITLE     A novel link between Fic (filamentation induced by cAMP)-mediated
            adenylylation/AMPylation and the unfolded protein response
  JOURNAL   J Biol Chem 290 (13), 8482-8499 (2015)
   PUBMED   25601083
REFERENCE   2  (bases 1 to 1965)
  AUTHORS   Bunney,T.D., Cole,A.R., Broncel,M., Esposito,D., Tate,E.W. and
            Katan,M.
  TITLE     Crystal structure of the human, FIC-domain containing protein HYPE
            and implications for its functions
  JOURNAL   Structure 22 (12), 1831-1843 (2014)
   PUBMED   25435325
REFERENCE   3  (bases 1 to 1965)
  AUTHORS   Engel,P., Goepfert,A., Stanger,F.V., Harms,A., Schmidt,A.,
            Schirmer,T. and Dehio,C.
  TITLE     Adenylylation control by intra- or intermolecular active-site
            obstruction in Fic proteins
  JOURNAL   Nature 482 (7383), 107-110 (2012)
   PUBMED   22266942
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1965)
  AUTHORS   Worby,C.A., Mattoo,S., Kruger,R.P., Corbeil,L.B., Koller,A.,
            Mendez,J.C., Zekarias,B., Lazar,C. and Dixon,J.E.
  TITLE     The fic domain: regulation of cell signaling by adenylylation
  JOURNAL   Mol Cell 34 (1), 93-103 (2009)
   PUBMED   19362538
REFERENCE   5  (bases 1 to 1965)
  AUTHORS   Faber,P.W., Barnes,G.T., Srinidhi,J., Chen,J., Gusella,J.F. and
            MacDonald,M.E.
  TITLE     Huntingtin interacts with a family of WW domain proteins
  JOURNAL   Hum Mol Genet 7 (9), 1463-1474 (1998)
   PUBMED   9700202
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079197.1.
            
            On Jan 28, 2005 this sequence version replaced XM_222280.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079197.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760434, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1965
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..1965
                     /gene="Ficd"
                     /note="FIC domain protein adenylyltransferase"
                     /db_xref="GeneID:288741"
                     /db_xref="RGD:1359391"
     exon            1..704
                     /gene="Ficd"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1780
                     /gene="Ficd"
                     /EC_number="2.7.7.108"
                     /note="adenosine monophosphate-protein transferase FICD;
                     huntingtin interactor protein E; AMPylator FICD; FIC
                     domain-containing protein; de-AMPylase FICD; FIC domain
                     containing"
                     /codon_start=1
                     /product="protein adenylyltransferase FICD"
                     /protein_id="NP_001010946.1"
                     /db_xref="GeneID:288741"
                     /db_xref="RGD:1359391"
                     /translation="MILMPMASVVAVAEPKWVSVWGRFLWMTLLSMALGSLLALLLPL
                     GAVEEQCLAVLRGFHLLRSKLDRAQHVVTKCTSPSTELSVTSRDAGLLTVKTKASPAG
                     KLEAKAALNQALEMKRQGKRGKAHKLFLHALKMDPGFVDALNELGIFSEEDKDIIQAD
                     YLYTRALTISPFHEKALINRDRTLPLVEEIDQRYFSVLDSKVRKVMSIPKGSSALRRV
                     MEETYYHHIYHTVAIEGNTLTLAEIRHILETRYAVPGKSLEEQNEVIGMHAAMKYINS
                     TLVSRIGSVTIDHMLEIHRRVLGYVDPVEAGRFRRTQVLVGHHIPPHPRDVEKQMQEF
                     TQWLNSEDAMNLHPVEFAALAHYKLVYIHPFIDGNGRTSRLLMNLILMQAGYPPITIR
                     KEQRSEYYHVLEVANEGDVRPFIRFIAKCTEVTLDTLLLATTEYSAALPEAQPNHSGF
                     KETLPVRP"
     exon            705..1926
                     /gene="Ficd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagggctga caagtccctg acttcacttt tctgagctct tactgcatct ggagagagcg
       61 ctgtggaaac atcacctcct cgggttgtag tctgagatta tggacgttaa tgtatgtagg
      121 aagtgctctg taaacgcctt agatttctat cttgctaccc aggagcagct aggagttagt
      181 taggatgagt ctttccacca tgagagctct caccttcccc ctttccctgg tccctagtga
      241 attagaaggt gtggagattc tccatgttgg tctctccatc tgaaatcaca gttactggga
      301 gcaggtccac tctcctccct cattctttcc gacgcttggt tcctcgtaga ttctgctttc
      361 ctctgagacg ggatatgcgc cctgggcccg gcccttagtc cagatgatac tcatgccgat
      421 ggcgtcagtg gtggcagtgg ctgaacccaa atgggtctca gtctggggcc gtttcctgtg
      481 gatgacactg ctgagcatgg ctctggggtc actgctggcc ctgctgctgc cactgggagc
      541 tgtggaagaa cagtgtctgg ctgtgctcag aggcttccac ctgctcagga gcaaactgga
      601 cagggcacag catgtggtca ccaagtgcac cagcccatct acggagctca gtgtcacctc
      661 cagggacgca gggctgctga cggtcaagac taaggcgtct ccagcaggga aactggaagc
      721 caaggccgca ctaaaccaag ccctagagat gaagcgccaa ggcaagaggg gcaaagcgca
      781 caagctcttc ctgcatgccc tcaagatgga ccctggcttc gtagacgccc tcaatgagct
      841 cggcatcttc tcagaagagg acaaggacat catccaggca gattacctct acactagggc
      901 cctgaccatt tcgcccttcc acgagaaagc actgatcaac cgggaccgga cgctgccact
      961 ggtggaggaa atcgaccaga ggtacttcag cgtccttgac agcaaagtga ggaaggtaat
     1021 gtccatccct aaggggagct cagcgctccg cagggtcatg gaggagacct actaccatca
     1081 catctaccac actgtggcta tcgagggcaa caccctcact ctcgcagaga tcaggcacat
     1141 cctggagaca cgctatgccg tgccagggaa gagcttggag gagcaaaacg aggtgatcgg
     1201 catgcacgcg gccatgaagt acatcaacag taccctggtc tcccgcatcg ggtccgtcac
     1261 cattgaccac atgctggaga tccacaggag ggtcctgggg tacgtggacc cagtggaggc
     1321 gggcaggttt cggaggaccc aggtcctggt gggacaccac atcccacccc acccccggga
     1381 cgtggagaag cagatgcagg agttcacaca gtggctcaat tcggaggacg ccatgaacct
     1441 gcacccggtt gagttcgcag ccttagccca ttacaaactg gtgtacatcc accctttcat
     1501 cgatggcaat gggaggacct cccgcctgct gatgaacctg atcctgatgc aggcagggta
     1561 cccgcccatc accatacgca aggagcagag gtcagagtac taccatgtgc tggaagtcgc
     1621 caacgagggt gacgtgcggc cattcatccg cttcatagcc aagtgtacgg aagtcacact
     1681 ggacacattg ctcctcgcca ccaccgagta ctctgcagca ctgccagaag cccagcccaa
     1741 ccactctggg ttcaaggaga cacttcctgt gaggccttaa ccaccagccc tcccatggcg
     1801 ccctgagaag gcctttctag aaacagttct ccccagtagc aaaaggagac ccttaaacat
     1861 tctttacctc caggtgtttt tcagttgaga aagaaaacta aattattaag cctgtcttta
     1921 ggataaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
