LOCUS       NM_001415720            5409 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus formin homology 2 domain containing 3 (Fhod3),
            transcript variant 4, mRNA.
ACCESSION   NM_001415720 XM_017600803
VERSION     NM_001415720.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5409)
  AUTHORS   Monzo,P., Chong,Y.K., Guetta-Terrier,C., Krishnasamy,A.,
            Sathe,S.R., Yim,E.K., Ng,W.H., Ang,B.T., Tang,C., Ladoux,B.,
            Gauthier,N.C. and Sheetz,M.P.
  TITLE     Mechanical confinement triggers glioma linear migration dependent
            on formin FHOD3
  JOURNAL   Mol Biol Cell 27 (8), 1246-1261 (2016)
   PUBMED   26912794
  REMARK    GeneRIF: FHOD3 played a role in glioma linear migration.
REFERENCE   2  (bases 1 to 5409)
  AUTHORS   Iskratsch,T., Reijntjes,S., Dwyer,J., Toselli,P., Degano,I.R.,
            Dominguez,I. and Ehler,E.
  TITLE     Two distinct phosphorylation events govern the function of muscle
            FHOD3
  JOURNAL   Cell Mol Life Sci 70 (5), 893-908 (2013)
   PUBMED   23052206
  REMARK    GeneRIF: Following myofibril disassembly, such as that in
            dedifferentiating adult rat cardiomyocytes in culture, the
            expression of non-muscle Fhod3 is up-regulated, which is reversed
            once the myofibrils are reassembled.
REFERENCE   3  (bases 1 to 5409)
  AUTHORS   Arimura,T., Takeya,R., Ishikawa,T., Yamano,T., Matsuo,A.,
            Tatsumi,T., Nomura,T., Sumimoto,H. and Kimura,A.
  TITLE     Dilated cardiomyopathy-associated FHOD3 variant impairs the ability
            to induce activation of transcription factor serum response factor
  JOURNAL   Circ J 77 (12), 2990-2996 (2013)
   PUBMED   24088304
  REMARK    GeneRIF: DCM-associated FHOD3 variant may cause DCM by interfering
            with actin filament assembly.
REFERENCE   4  (bases 1 to 5409)
  AUTHORS   Kan-O,M., Takeya,R., Abe,T., Kitajima,N., Nishida,M., Tominaga,R.,
            Kurose,H. and Sumimoto,H.
  TITLE     Mammalian formin Fhod3 plays an essential role in cardiogenesis by
            organizing myofibrillogenesis
  JOURNAL   Biol Open 1 (9), 889-896 (2012)
   PUBMED   23213483
REFERENCE   5  (bases 1 to 5409)
  AUTHORS   Kan-o,M., Takeya,R., Taniguchi,K., Tanoue,Y., Tominaga,R. and
            Sumimoto,H.
  TITLE     Expression and subcellular localization of mammalian formin Fhod3
            in the embryonic and adult heart
  JOURNAL   PLoS One 7 (4), e34765 (2012)
   PUBMED   22509354
REFERENCE   6  (bases 1 to 5409)
  AUTHORS   Taniguchi,K., Takeya,R., Suetsugu,S., Kan-O,M., Narusawa,M.,
            Shiose,A., Tominaga,R. and Sumimoto,H.
  TITLE     Mammalian formin fhod3 regulates actin assembly and sarcomere
            organization in striated muscles
  JOURNAL   J Biol Chem 284 (43), 29873-29881 (2009)
   PUBMED   19706596
  REMARK    GeneRIF: actin dynamics regulated by Fhod3 are critical for
            sarcomere organization in striated muscle cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 27, 2022 this sequence version replaced XM_017600803.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.37341.1,
                                           SRR26643289.40943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               JAXUCZ010000018.1  16268011-16268305
            296-402             JAXUCZ010000018.1  16311148-16311254
            403-467             JAXUCZ010000018.1  16327834-16327898
            468-535             JAXUCZ010000018.1  16454005-16454072
            536-641             JAXUCZ010000018.1  16460098-16460203
            642-736             JAXUCZ010000018.1  16528873-16528967
            737-848             JAXUCZ010000018.1  16544819-16544930
            849-943             JAXUCZ010000018.1  16551568-16551662
            944-1087            JAXUCZ010000018.1  16558962-16559105
            1088-1329           JAXUCZ010000018.1  16565420-16565661
            1330-1422           JAXUCZ010000018.1  16585171-16585263
            1423-1779           JAXUCZ010000018.1  16587145-16587501
            1780-1884           JAXUCZ010000018.1  16592872-16592976
            1885-2019           JAXUCZ010000018.1  16624394-16624528
            2020-2070           JAXUCZ010000018.1  16628485-16628535
            2071-2282           JAXUCZ010000018.1  16634176-16634387
            2283-2561           JAXUCZ010000018.1  16651614-16651892
            2562-3439           JAXUCZ010000018.1  16657243-16658120
            3440-3598           JAXUCZ010000018.1  16668587-16668745
            3599-3781           JAXUCZ010000018.1  16676972-16677154
            3782-3901           JAXUCZ010000018.1  16679861-16679980
            3902-4063           JAXUCZ010000018.1  16681003-16681164
            4064-4254           JAXUCZ010000018.1  16684273-16684463
            4255-4447           JAXUCZ010000018.1  16688828-16689020
            4448-4471           JAXUCZ010000018.1  16693084-16693107
            4472-4646           JAXUCZ010000018.1  16694497-16694671
            4647-4808           JAXUCZ010000018.1  16697570-16697731
            4809-5409           JAXUCZ010000018.1  16699908-16700508
FEATURES             Location/Qualifiers
     source          1..5409
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..5409
                     /gene="Fhod3"
                     /note="formin homology 2 domain containing 3"
                     /db_xref="GeneID:100360334"
                     /db_xref="RGD:2322319"
     exon            1..295
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..4891
                     /gene="Fhod3"
                     /note="isoform 4 is encoded by transcript variant 4;
                     FH1/FH2 domain-containing protein 3"
                     /codon_start=1
                     /product="FH1/FH2 domain-containing protein 3 isoform 4"
                     /protein_id="NP_001402649.1"
                     /db_xref="GeneID:100360334"
                     /db_xref="RGD:2322319"
                     /translation="MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLA
                     GVHRLLRAPHKLDDCTLQLSHNGAYLDLEATLAEQRDELEGFQDDTGRGKKNSIILRT
                     QLSVRVHACIEKLYNSTGRDLRRALFSLKQIFQDDKDLVHEFVIAEGLTCLIKVGAEA
                     DQNYQNYILRALGQIMLYVDGMNGVINHSETIQWLYTLVGSKFRLVVKTALKLLLVFV
                     EYSESNAPLLIQAVSAVDTKRGVKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLAGL
                     PDQDTFYDVVDCLEELGIAAVSQRHLNKKGTDLDLLEQFNIYEVALRHEDGDETAEPP
                     PSGHRDRRRASMCSGGTVGEQQGLDRRRSRRHSIQNIKSPLSAPTSPCSQTVPAFKPS
                     QVRDLCEKDEEEEEEEQPITEPNSEEEREDDAQCQGKDSKASSASKQSPPEKDATPES
                     STLRTTSSPTSQGRWLPANPAAQSPVLAGTSGPEASRPAARLPPPSPVLAPRPSTAPK
                     VSPTIDKLPYVPHSPFHLFSYDFEDSPLLTKDKGGDSQTENRYSNFSSSSFQSSRPSP
                     GPSVSPSSASSFSSPQDTRSSPSGLLTSSFRQHQESLAAERERRRQEREERLQRIERE
                     ERNKFNREYLDKREEQRQARGERYKYLEHLAAEAHEKEQRSRSASRGRADLSLDLSLP
                     AAPASPSPSSPSPDSADSQEALTVPSTPPTLQYPQVSGKDREPELEAEAGQGADEASR
                     DIASAHREAGSQEEPALELEPEERASLSEKERQNEEVNERDNCSASSISSSSSTLERE
                     EKEDKLSGDRPTGLWSASLQDVGVNGQCGDILTSKRFMLDMLYAHNRKSTEDEEKGDG
                     EPGRSAQEVEAVASLATRISTLQANSQAPEESIKRVDIGCLDNRGSVKAFAEKFNSGE
                     VGRGSVSPDAESQDKVPDTPPAQLKTESDYIWDQLMANPRELRIQDMDFTDLGEEDDI
                     DVLDVDLGHREAPGPPPPPPPTFLGLPPPPPPPLLDSVPPPPVPGNLLASPVFNTPQG
                     LGWSQVPKGQPAFTKKKKTIRLFWNEVRPFEWPSKNNRRCREFLWSKLEPIKVDTSRL
                     EHLFESKSKELSVTKKTAADGKRQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFD
                     EYALNKEGIEKILTMIPTEEEKQKIQEAQLANPEVPLGSAEQFLLTLSSISELSARLH
                     LWAFKMDYETTEKEVAEPLLDLKEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFE
                     LSYLEKVPEVKDTVHKQSLLHHVCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDN
                     LCQMERRCKASWDHLKAIAKHEMKPVLKQRMSELLKDCAERIIILKIVHRRIINRFHS
                     FLLFMGHPPYAIREVNINKFCRIISEFALEYRTTRERVLQQKQKRANHRERNKTRGKM
                     ITDTDDEDDTESGKFSGSSPAAPSQPQGLSYAEDAAEHENMKAVLKTSSPALEDATPM
                     LGVRTRSRASRGSTSSWTMGTEESPSVPDDAADEIMDRIVKSATQVPSQRVVPRERKR
                     SRANRKSLRRTLKSGLTPEEARALGLVGTSELQL"
     exon            296..402
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            403..467
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            468..535
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            536..641
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..736
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            737..848
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..943
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1087
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1329
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1422
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1779
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1884
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2019
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2070
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2282
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2561
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..3439
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3598
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            3599..3781
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3901
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            3902..4063
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4254
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4447
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            4448..4471
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4646
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            4647..4808
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
     exon            4809..5409
                     /gene="Fhod3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctgctag cccgcgagcc tgttagcggc ggcggcggcg gcggcggcag cttctccgca
       61 cacacccggc gcccccgcct gcgcggcccg ctgaccccgg ggcccgtgcc ccacggggca
      121 gggatgcatc atggccacgc tggcttgtcg cgtgcagttc ttggacgaca ccgatccttt
      181 caacagcacc aacttcccag agcccagccg gccaccgctg ttcacattcc gcgaggacct
      241 ggctctgggc acccagttgg ccggggtcca tcggctgctg agggcgccac acaagctcga
      301 tgactgtacc ctgcagctgt cccacaatgg tgcctacctc gatctggagg ccacgctggc
      361 ggaacagcgg gatgagctgg aaggcttcca ggatgacaca gggcggggca agaagaacag
      421 cattatcctg aggacacagc tgtctgtgag ggtccatgct tgcattgaaa agctgtacaa
      481 ctccaccggc cgagatctaa gaagggccct tttctcgctg aagcagatat ttcaggatga
      541 caaggatttg gtgcatgaat tcgtcatagc tgaaggtctg acatgtttga tcaaagtggg
      601 agccgaggcg gatcagaact atcagaacta catcctgagg gcactgggtc agattatgct
      661 gtatgtggat gggatgaatg gcgtcatcaa ccacagcgag accatccagt ggctttacac
      721 tcttgttggc tcaaagttcc gcctggtggt gaagacggcc ctgaagcttc tgctggtctt
      781 tgtggagtat tctgagtcca atgcaccgct tctcattcag gctgtttctg ctgttgacac
      841 caaaagaggt gtcaaaccct ggtccaacat catggaaatc ttggaggaaa aagatggagt
      901 tgacacagaa ctcttggttt atgcaatgac tctagtaaac aagacactgg caggactgcc
      961 agatcaagac accttctatg acgtagtaga ctgcctggag gagctgggca ttgctgctgt
     1021 gtcccaaagg cacttgaaca agaaagggac ggacctggac ttgctggagc agtttaatat
     1081 ctatgaggtg gcactgaggc atgaagatgg tgatgagacc gccgaaccac ctcccagtgg
     1141 gcaccgggac cggaggaggg ccagcatgtg ttctggtggc actgtgggcg agcagcaagg
     1201 ccttgaccgc agaaggagcc gtagacactc aatccagaat atcaagagcc cactgtccgc
     1261 tcccaccagc ccctgctccc agacggttcc tgccttcaaa cccagccaag ttcgagacct
     1321 ctgtgaaaag gatgaggagg aggaagaaga agaacagcca atcacggagc ccaattcaga
     1381 ggaagagaga gaggacgatg cccagtgtca gggcaaggac agcaaagcca gctctgcctc
     1441 caagcagagc cctcctgaga aggatgctac tccagagagt tctacactcc gtaccacctc
     1501 aagtcccacc tcacagggaa ggtggcttcc ggccaaccca gcagcacaga gcccggtgct
     1561 tgctgggacc tctgggcctg aggccagccg gcctgccgct cgcttaccac ctcccagccc
     1621 tgtcttggct cctcggccgt ccaccgcacc aaaggtgtct cccaccatag acaagctgcc
     1681 ctacgtgccc cacagcccct tccacctctt ctcctatgac tttgaagatt cacctctcct
     1741 cactaaggac aagggaggag actctcagac ggaaaacaga tacagcaact tcagcagcag
     1801 ctctttccag tcctccagac cctctcctgg acctagtgtg tctccatctt ccgcatcgtc
     1861 cttctcatcc ccacaggata ccaggtcatc gccaagtggc cttctcacat cctcctttag
     1921 acagcaccaa gagtcactgg cagcggagag agagcggagg cggcaagaga gagaagaaag
     1981 actgcagagg atagaacggg aagaaaggaa caaattcaac cgggagtatc tagacaaaag
     2041 ggaggagcaa aggcaagcga gaggagaaag atacaaatac ttggagcact tggcagccga
     2101 ggcgcacgag aaggagcaga gaagccggag cgcgagccgg ggcagagctg acctctcctt
     2161 ggacctgagc ttgccagcag cccctgcctc accttcccca tcaagcccga gtcctgactc
     2221 tgctgactca caagaggctc tcacggtgcc ctcaacccca cccaccctgc agtacccaca
     2281 agtaagtggt aaggaccgag agcctgaact ggaggcggaa gctgggcagg gtgctgatga
     2341 agccagccgg gacatagcgt ctgcccacag ggaagcagga agccaagaag agccagcgct
     2401 ggagctagag cctgaggaaa gagcgtcact gagtgagaaa gagaggcaaa acgaagaggt
     2461 gaatgagagg gacaactgtt ctgcctccag catctcgtcc tccagcagca ccttggagag
     2521 ggaagagaag gaggacaaac tgtctggaga cagaccaact ggtttgtggt ctgccagcct
     2581 tcaggatgtg ggtgtaaatg gacagtgtgg tgacatcctt accagcaaaa ggttcatgct
     2641 ggacatgctg tatgcccata acagaaagtc cacagaagac gaagagaaag gtgatggcga
     2701 acctgggagg tctgcacagg aggtggaagc ggtggccagc ctcgccacca ggatctccac
     2761 tctgcaggcc aactctcagg ccccggagga gagcatcaag agggtggaca ttggctgctt
     2821 ggacaaccgg ggcagcgtga aggcatttgc cgagaaattc aacagtggag aagtagggag
     2881 aggctccgtc tctcctgatg ctgagtctca ggacaaggtc ccggatacac caccagcaca
     2941 gctgaaaact gagtctgatt acatctggga ccagctcatg gccaatccaa gggagctcag
     3001 aatccaagac atggatttta cagacctggg ggaggaggat gatatcgatg ttctggacgt
     3061 ggatctcggc caccgggaag ccccaggacc accccctcca cctcctccca ccttcctggg
     3121 tttgccaccc ccaccccctc cacccctatt ggacagtgtg cctcccccac cagtccccgg
     3181 taatttattg gcttctcctg tgttcaacac tcctcagggc ttagggtggt cccaggtacc
     3241 caagggtcag ccagcattca ccaagaaaaa gaagacgatc cgactgttct ggaatgaagt
     3301 ccggcccttt gagtggccaa gtaagaacaa tcgacggtgc agggaattcc tgtggtcaaa
     3361 actggaaccc attaaggtgg acacttccag actagagcac ctgtttgagt ccaagtccaa
     3421 ggagctgtct gtcaccaaga aaacagctgc agatggtaaa aggcaggaga tcattgttct
     3481 ggattccaag aggagcaacg ccatcaacat tggcctgact gtactgcccc ctccaaggac
     3541 gattaagata gccattttga actttgatga gtatgcctta aacaaagaag ggatcgagaa
     3601 aattctgacc atgattccaa ctgaagagga gaagcagaaa atccaggagg ctcagctggc
     3661 aaacccggaa gtacccctgg gcagtgcaga acagttcctt ctcaccctct cttccatcag
     3721 cgagctttca gctcggctgc acctgtgggc attcaaaatg gattatgaaa ccacagaaaa
     3781 ggaagtggct gaaccactgt tggacctgaa ggaaggaata gaccagttgg agaacaataa
     3841 gactctgggc ttcatcctgt ctactctcct tgccattggg aactttctaa atggaactaa
     3901 cgccaaagca tttgagttaa gctacctcga gaaggttcca gaagtcaaag atacagtgca
     3961 caagcagtct ctcctccacc acgtgtgcac catggtagtg gaaaactttc cggacagctc
     4021 ggatctgtac tcagagattg gggccatcac taggtcagcc aaggttgact ttgatcaact
     4081 tcaggataat ttgtgtcaga tggagagacg atgcaaagct tcgtgggacc acctcaaggc
     4141 cattgcaaaa catgaaatga aaccagtttt aaaacagcgg atgtcagagc tcttaaaaga
     4201 ttgtgcagag cgaattataa ttttaaagat cgtccatcgg agaataatta acagatttca
     4261 ctcgttttta ctgttcatgg gccatccccc ttacgcgatt cgggaggtga acatcaacaa
     4321 gttctgcagg atcatcagcg agtttgctct ggagtaccgc acgaccaggg aaagggttct
     4381 gcagcagaag cagaaacgag ccaaccacag agagagaaat aagacgagag gaaagatgat
     4441 cactgacact gatgacgagg atgacactga gtctggcaag ttctcgggca gctctccagc
     4501 agcaccgagc cagccccagg gtctgagcta tgctgaggat gcagcggaac atgagaacat
     4561 gaaggctgtg ctgaaaacct cgtctcctgc tctggaggat gccaccccca tgcttggtgt
     4621 ccgcactcgc agccgggcaa gccgaggatc cactagttca tggactatgg gaactgagga
     4681 gtcacctagt gtccctgatg atgcagctga tgagatcatg gaccgcatcg tcaaatcagc
     4741 cacccaagtg cccagccagc gagtggtgcc acgggagaga aagcgttcca gagccaaccg
     4801 caaatctctg cgaaggacct tgaagagtgg cctgactcca gaagaagcaa gagccttggg
     4861 cctggttggc acatctgaac tgcaactgtg acttttgtag gccctcagaa gtgtgcagag
     4921 cagaggacca gctctggcta gcaccacccc tttcagaagg ggcagggaga cttgacccga
     4981 gtatctgatg gttagaactg agtgttcatt ctgggtacca cactgcttgt gccactgctg
     5041 cgcattgaca tggatctcca gaaatctcct gcatgtattt tatctaaagt caactgtgtt
     5101 tctcttgttt ccttgatacc cggtttatta gccccatgtg tgacaccttt tctaggaagc
     5161 aacgatcctt gtaaggaaca catcacttct gtcacagttg ttaaggtaac acggagcaat
     5221 gtgattagac tcagagactg ggtctccaca acaacaaaac gtccagatat aaatgccaat
     5281 gttgtacaca aatgcaagca cagattgttt accaattgtg gattttagat gtactaaatg
     5341 tttatataaa actcatcaat gtacaccatg tttcaatgac taaataaata gagattaatg
     5401 tcatcataa
//
