LOCUS       NM_001395129            3829 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus formin homology 2 domain containing 1 (Fhod1),
            mRNA.
ACCESSION   NM_001395129 XM_008772484
VERSION     NM_001395129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3829)
  AUTHORS   Chen,Y., Yuan,Y., Chen,Y., Jiang,X., Hua,X., Chen,Z., Wang,J.,
            Liu,H., Zhou,Q., Yu,Y., Yang,Z., Yu,Y., Wang,Y., Wang,Q., Li,Y.,
            Chen,J. and Wang,Y.
  TITLE     Novel signaling axis of FHOD1-RNF213-Col1alpha/Col3alpha in the
            pathogenesis of hypertension-induced tunica media thickening
  JOURNAL   J Mol Cell Cardiol 182, 57-72 (2023)
   PUBMED   37482037
  REMARK    GeneRIF: Novel signaling axis of FHOD1-RNF213-Col1alpha/Col3alpha
            in the pathogenesis of hypertension-induced tunica media
            thickening.
REFERENCE   2  (bases 1 to 3829)
  AUTHORS   Al Haj,A., Mazur,A.J., Radaszkiewicz,K., Radaszkiewicz,T.,
            Makowiecka,A., Stopschinski,B.E., Schonichen,A., Geyer,M. and
            Mannherz,H.G.
  TITLE     Distribution of formins in cardiac muscle: FHOD1 is a component of
            intercalated discs and costameres
  JOURNAL   Eur J Cell Biol 94 (2), 101-113 (2015)
   PUBMED   25555464
REFERENCE   3  (bases 1 to 3829)
  AUTHORS   Dwyer,J., Pluess,M., Iskratsch,T., Dos Remedios,C.G. and Ehler,E.
  TITLE     The formin FHOD1 in cardiomyocytes
  JOURNAL   Anat Rec (Hoboken) 297 (9), 1560-1570 (2014)
   PUBMED   25125170
REFERENCE   4  (bases 1 to 3829)
  AUTHORS   Kutscheidt,S., Zhu,R., Antoku,S., Luxton,G.W., Stagljar,I.,
            Fackler,O.T. and Gundersen,G.G.
  TITLE     FHOD1 interaction with nesprin-2G mediates TAN line formation and
            nuclear movement
  JOURNAL   Nat Cell Biol 16 (7), 708-715 (2014)
   PUBMED   24880667
REFERENCE   5  (bases 1 to 3829)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3829)
  AUTHORS   Takeya,R., Taniguchi,K., Narumiya,S. and Sumimoto,H.
  TITLE     The mammalian formin FHOD1 is activated through phosphorylation by
            ROCK and mediates thrombin-induced stress fibre formation in
            endothelial cells
  JOURNAL   EMBO J 27 (4), 618-628 (2008)
   PUBMED   18239683
REFERENCE   7  (bases 1 to 3829)
  AUTHORS   Schonichen,A., Alexander,M., Gasteier,J.E., Cuesta,F.E.,
            Fackler,O.T. and Geyer,M.
  TITLE     Biochemical characterization of the diaphanous autoregulatory
            interaction in the formin homology protein FHOD1
  JOURNAL   J Biol Chem 281 (8), 5084-5093 (2006)
   PUBMED   16361249
REFERENCE   8  (bases 1 to 3829)
  AUTHORS   Madrid,R., Gasteier,J.E., Bouchet,J., Schroder,S., Geyer,M.,
            Benichou,S. and Fackler,O.T.
  TITLE     Oligomerization of the diaphanous-related formin FHOD1 requires a
            coiled-coil motif critical for its cytoskeletal and transcriptional
            activities
  JOURNAL   FEBS Lett 579 (2), 441-448 (2005)
   PUBMED   15642356
REFERENCE   9  (bases 1 to 3829)
  AUTHORS   Westendorf,J.J. and Koka,S.
  TITLE     Identification of FHOD1-binding proteins and mechanisms of
            FHOD1-regulated actin dynamics
  JOURNAL   J Cell Biochem 92 (1), 29-41 (2004)
   PUBMED   15095401
REFERENCE   10 (bases 1 to 3829)
  AUTHORS   Lake,S., Gullberg,H., Wahlqvist,J., Sjogren,A.M., Kinhult,A.,
            Lind,P., Hellstrom-Lindahl,E. and Stjernschantz,J.
  TITLE     Cloning of the rat and human prostaglandin F2 alpha receptors and
            the expression of the rat prostaglandin F2 alpha receptor
  JOURNAL   FEBS Lett 355 (3), 317-325 (1994)
   PUBMED   7988697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jun 4, 2021 this sequence version replaced XM_008772484.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.76106.1,
                                           SRR26643429.55742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000019.1  50135061-50135330   c
            271-377             JAXUCZ010000019.1  50125923-50126029   c
            378-442             JAXUCZ010000019.1  50125497-50125561   c
            443-510             JAXUCZ010000019.1  50125111-50125178   c
            511-616             JAXUCZ010000019.1  50124935-50125040   c
            617-711             JAXUCZ010000019.1  50124761-50124855   c
            712-823             JAXUCZ010000019.1  50124398-50124509   c
            824-918             JAXUCZ010000019.1  50124215-50124309   c
            919-1062            JAXUCZ010000019.1  50123978-50124121   c
            1063-1220           JAXUCZ010000019.1  50123731-50123888   c
            1221-1397           JAXUCZ010000019.1  50123478-50123654   c
            1398-1513           JAXUCZ010000019.1  50121919-50122034   c
            1514-2160           JAXUCZ010000019.1  50120169-50120815   c
            2161-2316           JAXUCZ010000019.1  50119411-50119566   c
            2317-2499           JAXUCZ010000019.1  50119009-50119191   c
            2500-2619           JAXUCZ010000019.1  50118803-50118922   c
            2620-2781           JAXUCZ010000019.1  50118562-50118723   c
            2782-2972           JAXUCZ010000019.1  50117618-50117808   c
            2973-3165           JAXUCZ010000019.1  50117326-50117518   c
            3166-3328           JAXUCZ010000019.1  50117079-50117241   c
            3329-3529           JAXUCZ010000019.1  50116806-50117006   c
            3530-3829           JAXUCZ010000019.1  50116415-50116714   c
FEATURES             Location/Qualifiers
     source          1..3829
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11-q12"
     gene            1..3829
                     /gene="Fhod1"
                     /note="formin homology 2 domain containing 1"
                     /db_xref="GeneID:291964"
                     /db_xref="RGD:1589776"
     exon            1..270
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..3612
                     /gene="Fhod1"
                     /codon_start=1
                     /product="FH1/FH2 domain-containing protein 1"
                     /protein_id="NP_001382058.1"
                     /db_xref="GeneID:291964"
                     /db_xref="RGD:1589776"
                     /translation="MAGEEERGDGDPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCS
                     LDGALPLSAQIPALHRLLGAPLKLEDCALQVSPSGYYLDPELSLEEQREMLEGFYEEI
                     SKGRKPTLILRTQLSVRVNAILEKLYGSSGPELRRSLFSLKQIFQEDKDLVPEFVHSE
                     GLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSETVQWLYTLCASLSRLV
                     VKTALKLLLVFVEYSENNAPLFIQAVNAVASNTGTLPWANLVSILEEKNGVDPELLVY
                     TVTLINKTLAALPDQDSFYDVTDAFEQQGMEALVQRLLGTAGTDVDLRTQLTLYESAL
                     RLEDGDMEEAAAAAAAGGRRERRKPSSEEGKRSRRSLEGGGCPVRTPEPGPTGSASPV
                     GSASFTDSTSPTSSAFSPTGPASGLHTSVNLFPTISVGPSVDTSCERSVYKARFLENV
                     AAAETEKQAALAQGRAETLAGATVDETDESSGTRELWDSSEPASAPRPPQSPVSPIVL
                     RTQRSLEPEPKEPVSPRSPKTEPVQELPTHVPKLCIGDLDFSDLGEDEDQDTLNVESV
                     EAGKASLVLSLPPSSFSGGPPPPPPPPPPIIVSCPPPPPPPPPPIMGSCLPPPPLAAP
                     FPHSALDGPRHPTKRKTVKLFWRELKPTGSPGCSRSRFGPCPTLWASLEPVSVDTARL
                     EHLFESRAKDVLPTKKAGEGRRTMTIVLDPKRSNAINIGLTTLPPVHVIKAALLNFDE
                     FAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAENFLMTLASIGGLAARLQL
                     WAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNFLNGSQSSGFEL
                     SYLEKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQLTENL
                     GQLECRSQAAEDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAF
                     LLYLGYTAQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMI
                     TETEKFSGVAGEVPSNLSVPVAVGSGPGRGDADNHASMKSLLTSRPEDATHSRRSRGM
                     VQSSSPVTHTTVGPFTASPEETAASGLPSDTSDEIMDLLVQSVTKSSPRALAARERKR
                     SRGNRKSLRRTLKSGLGDDLVQALGLSKAPGLEV"
     exon            271..377
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..442
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..510
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..616
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            617..711
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            712..823
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..918
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1062
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1220
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1397
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1513
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..2160
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2316
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2499
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2619
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            2620..2781
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2972
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3165
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3328
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3529
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3829
                     /gene="Fhod1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccagttg aagttgcagc attgcaggga cacagaggcg tccgtccagt ggcagccgga
       61 ggcagagcca tggcgggcga ggaagagcgc ggggatgggg acccagtatc agtggtgact
      121 gtgagagtgc agtacctgga agacaccgac cctttcgctt gtgccaactt cccggaacca
      181 cgccgggccc ccacctgcag cttggacggg gctctgcccc tgagtgcgca gatccctgct
      241 ctgcaccgac tcctgggagc gcctctcaag ctggaggact gtgcgttgca agtgtcgccc
      301 tctggatact acctggaccc ggagctgtcc ctagaagaac agcgggagat gctggagggc
      361 ttctatgaag agatcagcaa agggcggaag cccacattga tcctgcggac ccagctctct
      421 gtgagggtca atgctatctt ggaaaagctg tatggctcca gtggccccga gctccgccga
      481 tccctctttt cattaaagca gatattccag gaagacaagg acctggtgcc tgaatttgta
      541 cactcagagg ggttgagttg cctgatccgc gtgggtgctg ctgctgacca caactatcag
      601 agctacatcc ttcgagccct gggccagctg atgctttttg tggatgggat gctaggggtg
      661 gtggcgcaca gtgagaccgt gcaatggctg tatacactgt gtgcaagcct gtcccgcttg
      721 gtggtaaaga cagccctgaa gctgctgctg gtgtttgtgg agtattctga gaacaatgca
      781 ccgctcttca tccaggcagt caacgctgta gccagcaaca ccggtactct tccctgggcc
      841 aacttggtgt ccatcctgga ggagaagaat ggagttgatc cagagctgtt ggtgtacacg
      901 gtcactctca ttaacaagac actggcggcg ctcccagacc aggactcctt ctatgatgtg
      961 acagatgctt ttgagcagca gggcatggaa gcgctggtcc aacgtctctt gggcactgct
     1021 ggcactgatg ttgacctgcg aacacagcta acgctctatg agagcgccct tcggttagag
     1081 gatggagata tggaagaggc tgcagctgct gcagctgcag gtggccgacg agagcgacgg
     1141 aagccatcct cagaggaggg caaaaggagc cgaagatcac tagaaggtgg aggctgtcct
     1201 gtgcgtaccc cagaacctgg cccaacaggc tctgcctctc cagtaggctc cgcctccttc
     1261 actgactcca cctcgcctac aagttcggcc ttcagcccta ctggcccagc ctctggtctt
     1321 catacctcag tgaacctctt tcctaccatt tctgtggggc cctcagtgga cacttcctgt
     1381 gagagaagtg tctacaaagc ccggtttctg gagaatgtgg cagcagcaga gacagagaag
     1441 caggctgctc tggcccaagg ccgagcagag acgctggcag gggcaacagt ggatgagaca
     1501 gatgagtcat caggcaccag ggaactgtgg gactcttcag agccagcctc tgcacccaga
     1561 ccacctcaga gccctgtttc cccaatcgtg ctgcggaccc agagaagtct tgagcctgag
     1621 cccaaggagc cagtgtcacc acgaagccct aagactgagc ctgtccagga gcttcctact
     1681 cacgtaccca agctctgcat tggagacttg gacttctcag atctagggga ggatgaagac
     1741 caggacacat tgaatgtgga atctgtggag gctggaaaag catccctggt cctgtcactt
     1801 ccaccgtctt cattctctgg gggtccccct cctccccccc cacctccccc acccatcata
     1861 gtctcctgtc caccacctcc acccccacct cccccaccca tcatgggctc ctgcctacca
     1921 cctccacccc tggctgctcc ttttccccac tcagcccttg acggcccaag gcaccccacc
     1981 aaaaggaaga ctgtaaaact tttctggcgg gaactaaagc cgactgggag ccctgggtgt
     2041 tctagaagcc gctttgggcc ttgtcctacc ttgtgggcct ctctggaacc tgtctcggtg
     2101 gacacagccc ggctggaaca cctatttgag tcccgagcca aggatgtgct acccaccaag
     2161 aaagctggtg agggccgccg gacaatgacc atagttctgg accccaagcg cagcaatgcc
     2221 atcaacattg gcctaaccac tctgccacct gtgcatgtca tcaaggctgc tctgctcaac
     2281 tttgatgaat ttgctgtcag caaggatggt attgagaaac tgctgaccat gatgcccacg
     2341 gaggaagagc gacagaagat tgaggaagcc cagctggcca accctgatgt gcccctcggc
     2401 ccagctgaga atttcctgat gactcttgct tccattggag gcctggccgc gcgcctgcaa
     2461 ctctgggctt tcaagctgga ctatgaaagc atggagcggg aaattgcaga gccactgttt
     2521 gatctgaaag tgggcatgga acagttggtg cacaatgcca ccttccgttg cattctggct
     2581 acccttttgg ctgtgggcaa cttcctcaat ggctcccaga gcagtggctt tgagctgagc
     2641 tacctggaga aggtgtcaga agtaaaggac acagtgcgcc ggcagtcact gctgtatcat
     2701 ctctgttccc tggtgctcca gacccgacct gattcctctg acctctactc agaaattcct
     2761 gccctcaccc gctgtgccaa ggtggacttt gagcagctga ctgagaacct agggcagctg
     2821 gagtgccgga gccaggctgc tgaggacagc ctccggagct tggcaaagca tgagctatcc
     2881 ccagctctgc gtgcccgcct tacccacttc ctggcccaat gtacccgccg agtagccatg
     2941 ctaagagtag tacaccgtcg agtctgcaac aggttccacg ccttccttct ctacttgggc
     3001 tacaccgcac aggcagcaag ggaagtacgc atcatgcagt tctgtcacac gctcagagag
     3061 tttgcacttg agtatcggac ttgtcgggag cgggtactgc agcagcagca gaaacgggct
     3121 acataccgcg aacgcaacaa gacccggggt cgcatgatta ctgagacaga gaagttctcg
     3181 ggtgtggctg gggaggtccc cagtaacctg tctgtcccag tggctgtggg cagcgggcca
     3241 ggtcggggtg atgctgacaa tcatgccagt atgaagagtt tgcttaccag caggccagaa
     3301 gacgccacac acagccgacg tagcagaggt atggtccaga gtagttcccc cgtcacacac
     3361 acaacagtag ggcccttcac tgcatcccct gaggagactg cagcctctgg tttacctagt
     3421 gacacatcag atgagataat ggacctgctg gtgcagtcag tcaccaagag cagtcctaga
     3481 gccttggctg ctcgggagag gaagcgctct cgtggcaacc ggaagtcctt gaggcggaca
     3541 ttgaagagtg gacttggaga tgacctggtg caggcactgg gactaagcaa agctcctggc
     3601 ctagaggtgt aagggtgctg ccacacctgg agctgagcag agagggcgca gagcacaaac
     3661 ctggtttcag aagcttgcac ccagaaacca gcattgtgaa cagtattagg ggtgtgtgtg
     3721 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtaca catacatgta tttcgcatat
     3781 gtgagttccc tattcggaac aaaataaagt ttacctagct aatccaaaa
//
