LOCUS       NM_001033926            2333 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus four and a half LIM domains 1 (Fhl1), transcript
            variant 1, mRNA.
ACCESSION   NM_001033926
VERSION     NM_001033926.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Li,Y., Pu,G., Chen,C. and Yang,L.
  TITLE     Inhibition of FHL1 inhibits cigarette smoke extract-induced
            proliferation in pulmonary arterial smooth muscle cells
  JOURNAL   Mol Med Rep 12 (3), 3801-3808 (2015)
   PUBMED   25975448
  REMARK    GeneRIF: FHL1 may be involved in excessive cell proliferation and
            may represent a potential therapeutic target for pulmonary
            hypertension.
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Wang,L., Miao,J., Li,L., Wu,D., Zhang,Y., Peng,Z., Zhang,L.,
            Yuan,Z. and Sun,K.
  TITLE     Identification of an FHL1 protein complex containing gamma-actin
            and non-muscle myosin IIB by analysis of protein-protein
            interactions
  JOURNAL   PLoS One 8 (11), e79551 (2013)
   PUBMED   24265776
  REMARK    GeneRIF: FHL1 exists as part of a complex, which binds gamma-actin
            and non-muscle myosin IIB
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Yue,J., Guan,J., Wang,X., Zhang,L., Yang,Z., Ao,Q., Deng,Y., Zhu,P.
            and Wang,G.
  TITLE     MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension
            through targeting of the HIF-1alpha/Fhl-1 pathway
  JOURNAL   Lab Invest 93 (7), 748-759 (2013)
   PUBMED   23628900
  REMARK    GeneRIF: Hypoxia-induced downregulation of miR-206 promotes
            pulmonary hypertension by targeting the HIF-1alpha/Fhl-1 pathway in
            pulmonary artery smooth muscle cells.
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Niu,C., Liang,C., Guo,J., Cheng,L., Zhang,H., Qin,X., Zhang,Q.,
            Ding,L., Yuan,B., Xu,X., Li,J., Lin,J. and Ye,Q.
  TITLE     Downregulation and growth inhibitory role of FHL1 in lung cancer
  JOURNAL   Int J Cancer 130 (11), 2549-2556 (2012)
   PUBMED   21702045
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Wang,L.L., Qiu,G.R., Fu,W.N., Yuan,Z.W. and Sun,K.L.
  TITLE     Transcriptional regulation of Fhl1 by estradiol in rat
            myoblastocytes
  JOURNAL   Steroids 75 (4-5), 368-372 (2010)
   PUBMED   20149813
  REMARK    GeneRIF: These data indicate that estradiol down-regulates Fhl1
            expression through its binding to the ERbeta.
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Chen,C.N., Ferrington,D.A. and Thompson,L.V.
  TITLE     Carbonic anhydrase III and four-and-a-half LIM protein 1 are
            preferentially oxidized with muscle unloading
  JOURNAL   J Appl Physiol (1985) 105 (5), 1554-1561 (2008)
   PUBMED   18756007
  REMARK    GeneRIF: Carbonic anhydrase III and four-and-a-half LIM protein 1
            are preferentially oxidized with muscle unloading.
REFERENCE   8  (bases 1 to 2333)
  AUTHORS   Yang,Z., Browning,C.F., Hallaq,H., Yermalitskaya,L., Esker,J.,
            Hall,M.R., Link,A.J., Ham,A.J., McGrath,M.J., Mitchell,C.A. and
            Murray,K.T.
  TITLE     Four and a half LIM protein 1: a partner for KCNA5 in human atrium
  JOURNAL   Cardiovasc Res 78 (3), 449-457 (2008)
   PUBMED   18281375
REFERENCE   9  (bases 1 to 2333)
  AUTHORS   Kang,M.A., Jeoung,N.H., Kim,J.Y., Lee,J.E., Jung,U.J., Choi,M.S.,
            Lee,W.H., Kwon,O.S., Lee,H. and Park,Y.B.
  TITLE     Up-regulation of skeletal muscle LIM protein 1 gene by
            25-hydroxycholesterol may mediate morphological changes of rat
            aortic smooth muscle cells
  JOURNAL   Life Sci 80 (5), 460-467 (2007)
   PUBMED   17161435
  REMARK    GeneRIF: Over-production of SLIM1 in the cells resulted in a change
            in the cell-shape into a spindle-like form.
REFERENCE   10 (bases 1 to 2333)
  AUTHORS   Lim,D.S., Roberts,R. and Marian,A.J.
  TITLE     Expression profiling of cardiac genes in human hypertrophic
            cardiomyopathy: insight into the pathogenesis of phenotypes
  JOURNAL   J Am Coll Cardiol 38 (4), 1175-1180 (2001)
   PUBMED   11583900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ119120.1, BC061782.1 and CK840296.1.
            
            On Sep 7, 2012 this sequence version replaced NM_001033926.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061782.1, FQ121693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                FQ119120.1         1-49
            50-1748             BC061782.1         1-1699
            1749-2314           BC061782.1         1701-2266
            2315-2333           CK840296.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..2333
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /note="four and a half LIM domains 1"
                     /db_xref="GeneID:25177"
                     /db_xref="RGD:2615"
     exon            1..105
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..974
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /note="isoform 1 is encoded by transcript variant 1; four
                     and a half LIM domains protein 1; skeletal muscle
                     LIM-protein 1; FHL-1"
                     /codon_start=1
                     /product="four and a half LIM domains protein 1 isoform 1"
                     /protein_id="NP_001029098.1"
                     /db_xref="GeneID:25177"
                     /db_xref="RGD:2615"
                     /translation="MASQRHSGPSSYKVGTMSEKFDCHYCRDPLQGKKYVQKDGRHCC
                     LKCFDKFCANTCVECRKPISADAKEVHYKNRYWHDTCFRCAKCLHPLASETFVSKDGK
                     ILCNKCATREDSPRCKGCFKAIVAGDQNVEYKGTIWHKDCFTCSNCKQVIGTGSFFPK
                     GEDFYCVTCHETKFAKHCVKCNKAITSGGITYQDQPWHAECFVCVTCSKKLAGQRFTA
                     VEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLA
                     NKRFVFHNEQVYCPDCAKKL"
     exon            106..287
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..462
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..632
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..819
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..2319
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2297..2302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
     polyA_site      2319
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
ORIGIN      
        1 atgtatgttc acaaatgagc ctcatcatct gggcttgaga gaagacgggt gtaggtgccg
       61 ctcctgaact tggcctctga gccatggctt ctcaaagaca ctcaggtccc tccagctata
      121 aggtgggcac catgtctgag aagttcgact gtcactactg cagggacccc ttgcagggga
      181 agaagtatgt gcagaaggat ggccgtcact gctgcctgaa gtgctttgac aagttctgcg
      241 ccaacacctg cgtggaatgc cgcaagccca taagcgctga tgctaaggag gtgcactata
      301 agaatcgcta ctggcacgac acctgcttcc gctgtgccaa gtgccttcac cccttggcca
      361 gtgagacctt tgtgtccaag gatggcaaga tcctgtgcaa caagtgcgcc actcgggagg
      421 actcccccag gtgcaaaggg tgcttcaagg ccattgtggc aggagaccag aatgtggagt
      481 acaagggcac catctggcat aaagactgct tcacctgcag caactgcaag caagtcattg
      541 ggaccggaag cttcttcccg aaaggggagg acttctactg tgtgacttgc catgagacca
      601 agtttgccaa gcattgcgtg aaatgcaaca aggccatcac atctggagga atcacttacc
      661 aggatcagcc ctggcatgcc gagtgctttg tgtgtgttac ctgctctaag aagctggcgg
      721 ggcagcgttt caccgctgtg gaggaccagt attactgcgt ggattgctac aagaactttg
      781 tggccaagaa gtgtgctgga tgcaagaacc ccatcactgg gtttggtaaa ggctccagtg
      841 tggtggccta tgaaggacaa tcctggcacg actactgctt ccactgcaaa aaatgctccg
      901 tgaatctggc caacaagcgc tttgtctttc ataatgagca ggtgtattgt cctgactgtg
      961 ccaaaaagct gtaacttgac aggggctcct gtcctgtaaa atggcatttg aagcatactt
     1021 tgtgtccttt gctcactctc tctgcaccat ccatagggca agagtgggct ttcacctctt
     1081 tcaaattgct ctttctgtct ttgctctcat tttacagtat taatcaaccg aggacacaca
     1141 gtgatcatat tagaatttag aaaagagcaa cctcgcagca aaaataattt ctctgttgct
     1201 gcaatggcaa aacaaaaacg tagactgact cttctgcatg tttcccatag agcagaaaag
     1261 tgctaaccat gtagccactt catgatgcaa gcaaaaagca taggcgacaa agttcccact
     1321 gagatgcctt tggggctcag tcgggacgca ctgtgcggtc acgtgactgc tgtgcaggag
     1381 ttgcagcggc tgctccaact ccctcctcgc ctttttaaga acttgccaga atgcatggtt
     1441 taacttcctt atcaaaactc tgacctccct tctgttcttt tgtgctttca cacgactaac
     1501 acagatttcc agagaactaa cattttgaac tttgctgtaa ttctcaagtg actttccccc
     1561 cctactaatg tttgactccc ctatgtggcg tgttctctga gcgttcctac tttaaaccat
     1621 ggaacacagg tgatttggag cacctaagca gatctgagca aacaagcctg tttcagaaca
     1681 aactcgccac ggtgactact tctggaagct taacaagact aactctcctg tcctttttca
     1741 ttttttttaa aaattttgtt ttaatgagta gtaaaatagt ttatggagtt ggaaacttgc
     1801 atgacaatat atgagcctcc tcaaacgttc ctgcagtttt gcgattgatc ctgtagaagt
     1861 gacaaaagct ctagagtggc agctgagcag gcacagggct gtcatcaaca agaatacgtt
     1921 tcaaagtagt gacaaggtga agtccttgta gcataaccat tgtctgctct ttgtctgcgt
     1981 tcaggaagag tgcagagtcc ctttccttgt gattcctaga gaactttccc tgcagagttg
     2041 agttagatct ctggggctgt cagggtagcc ctcacccttt acaggcaggg ctgggtttcc
     2101 tcctcctctg aaatgcagga ttgcctccct gatcgtactc tccattatac cacatgtata
     2161 acgagccaat atcaaagtaa agatgtaatg aaaatacact catatattac tgtaggagtg
     2221 cttctagatg cccacacctc atttccatat ttgtcattag ctgtttccat cgaatgtttc
     2281 aatgtatcct tacaaaaata aagcagcata gaaagaacaa aaaaaaaaaa aaa
//
