LOCUS       NP_001029098             296 aa            linear   ROD 28-APR-2025
DEFINITION  four and a half LIM domains protein 1 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001029098
VERSION     NP_001029098.1
DBSOURCE    REFSEQ: accession NM_001033926.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 296)
  AUTHORS   Li,Y., Pu,G., Chen,C. and Yang,L.
  TITLE     Inhibition of FHL1 inhibits cigarette smoke extract-induced
            proliferation in pulmonary arterial smooth muscle cells
  JOURNAL   Mol Med Rep 12 (3), 3801-3808 (2015)
   PUBMED   25975448
  REMARK    GeneRIF: FHL1 may be involved in excessive cell proliferation and
            may represent a potential therapeutic target for pulmonary
            hypertension.
REFERENCE   2  (residues 1 to 296)
  AUTHORS   Wang,L., Miao,J., Li,L., Wu,D., Zhang,Y., Peng,Z., Zhang,L.,
            Yuan,Z. and Sun,K.
  TITLE     Identification of an FHL1 protein complex containing gamma-actin
            and non-muscle myosin IIB by analysis of protein-protein
            interactions
  JOURNAL   PLoS One 8 (11), e79551 (2013)
   PUBMED   24265776
  REMARK    GeneRIF: FHL1 exists as part of a complex, which binds gamma-actin
            and non-muscle myosin IIB
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 296)
  AUTHORS   Yue,J., Guan,J., Wang,X., Zhang,L., Yang,Z., Ao,Q., Deng,Y., Zhu,P.
            and Wang,G.
  TITLE     MicroRNA-206 is involved in hypoxia-induced pulmonary hypertension
            through targeting of the HIF-1alpha/Fhl-1 pathway
  JOURNAL   Lab Invest 93 (7), 748-759 (2013)
   PUBMED   23628900
  REMARK    GeneRIF: Hypoxia-induced downregulation of miR-206 promotes
            pulmonary hypertension by targeting the HIF-1alpha/Fhl-1 pathway in
            pulmonary artery smooth muscle cells.
REFERENCE   4  (residues 1 to 296)
  AUTHORS   Niu,C., Liang,C., Guo,J., Cheng,L., Zhang,H., Qin,X., Zhang,Q.,
            Ding,L., Yuan,B., Xu,X., Li,J., Lin,J. and Ye,Q.
  TITLE     Downregulation and growth inhibitory role of FHL1 in lung cancer
  JOURNAL   Int J Cancer 130 (11), 2549-2556 (2012)
   PUBMED   21702045
REFERENCE   5  (residues 1 to 296)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (residues 1 to 296)
  AUTHORS   Wang,L.L., Qiu,G.R., Fu,W.N., Yuan,Z.W. and Sun,K.L.
  TITLE     Transcriptional regulation of Fhl1 by estradiol in rat
            myoblastocytes
  JOURNAL   Steroids 75 (4-5), 368-372 (2010)
   PUBMED   20149813
  REMARK    GeneRIF: These data indicate that estradiol down-regulates Fhl1
            expression through its binding to the ERbeta.
REFERENCE   7  (residues 1 to 296)
  AUTHORS   Chen,C.N., Ferrington,D.A. and Thompson,L.V.
  TITLE     Carbonic anhydrase III and four-and-a-half LIM protein 1 are
            preferentially oxidized with muscle unloading
  JOURNAL   J Appl Physiol (1985) 105 (5), 1554-1561 (2008)
   PUBMED   18756007
  REMARK    GeneRIF: Carbonic anhydrase III and four-and-a-half LIM protein 1
            are preferentially oxidized with muscle unloading.
REFERENCE   8  (residues 1 to 296)
  AUTHORS   Yang,Z., Browning,C.F., Hallaq,H., Yermalitskaya,L., Esker,J.,
            Hall,M.R., Link,A.J., Ham,A.J., McGrath,M.J., Mitchell,C.A. and
            Murray,K.T.
  TITLE     Four and a half LIM protein 1: a partner for KCNA5 in human atrium
  JOURNAL   Cardiovasc Res 78 (3), 449-457 (2008)
   PUBMED   18281375
REFERENCE   9  (residues 1 to 296)
  AUTHORS   Kang,M.A., Jeoung,N.H., Kim,J.Y., Lee,J.E., Jung,U.J., Choi,M.S.,
            Lee,W.H., Kwon,O.S., Lee,H. and Park,Y.B.
  TITLE     Up-regulation of skeletal muscle LIM protein 1 gene by
            25-hydroxycholesterol may mediate morphological changes of rat
            aortic smooth muscle cells
  JOURNAL   Life Sci 80 (5), 460-467 (2007)
   PUBMED   17161435
  REMARK    GeneRIF: Over-production of SLIM1 in the cells resulted in a change
            in the cell-shape into a spindle-like form.
REFERENCE   10 (residues 1 to 296)
  AUTHORS   Lim,D.S., Roberts,R. and Marian,A.J.
  TITLE     Expression profiling of cardiac genes in human hypertrophic
            cardiomyopathy: insight into the pathogenesis of phenotypes
  JOURNAL   J Am Coll Cardiol 38 (4), 1175-1180 (2001)
   PUBMED   11583900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FQ119120.1, BC061782.1 and CK840296.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061782.1, FQ121693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..296
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     Protein         1..296
                     /product="four and a half LIM domains protein 1 isoform 1"
                     /note="four and a half LIM domains protein 1; skeletal
                     muscle LIM-protein 1; FHL-1"
                     /calculated_mol_wt=33448
     Region          <21..49
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     Region          56..109
                     /region_name="LIM1_FHL1"
                     /note="The first LIM domain of Four and a half LIM domains
                     protein 1; cd09344"
                     /db_xref="CDD:188730"
     Site            order(56,59,78,81,84,87,105,108)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188730"
     Region          117..174
                     /region_name="LIM2_FHL1"
                     /note="The second LIM domain of Four and a half LIM
                     domains protein 1 (FHL1); cd09424"
                     /db_xref="CDD:188808"
     Site            order(117,120,139,142,145,148,166,169)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188808"
     Region          178..230
                     /region_name="LIM3_FHL1"
                     /note="The third LIM domain of Four and a half LIM domains
                     protein 1 (FHL1); cd09429"
                     /db_xref="CDD:188813"
     Site            order(178,181,198,201,204,207,225,228)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188813"
     Region          233..296
                     /region_name="LIM4_FHL1"
                     /note="The fourth LIM domain of Four and a half LIM
                     domains protein 1 (FHL1); cd09348"
                     /db_xref="CDD:188734"
     Site            order(237,240,262,265,268,271,289,292)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188734"
     CDS             1..296
                     /gene="Fhl1"
                     /gene_synonym="SLIM1"
                     /coded_by="NM_001033926.2:84..974"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:25177"
                     /db_xref="RGD:2615"
ORIGIN      
        1 masqrhsgps sykvgtmsek fdchycrdpl qgkkyvqkdg rhcclkcfdk fcantcvecr
       61 kpisadakev hyknrywhdt cfrcakclhp lasetfvskd gkilcnkcat redsprckgc
      121 fkaivagdqn veykgtiwhk dcftcsnckq vigtgsffpk gedfycvtch etkfakhcvk
      181 cnkaitsggi tyqdqpwhae cfvcvtcskk lagqrftave dqyycvdcyk nfvakkcagc
      241 knpitgfgkg ssvvayegqs whdycfhckk csvnlankrf vfhneqvycp dcakkl
//
