LOCUS       NM_021774                620 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus fragile histidine triad diadenosine
            triphosphatase (Fhit), mRNA.
ACCESSION   NM_021774
VERSION     NM_021774.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   Xu,T., Li,Z.Y., Liu,M., Zhang,S.B., Ding,H.H., Wu,J.Y., Lin,S.Y.,
            Liu,J., Wei,J.Y., Zhang,X.Q. and Xin,W.J.
  TITLE     CircFhit Modulates GABAergic Synaptic Transmission via Regulating
            the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a
            Rat Model of Neuropathic Pain
  JOURNAL   Neurosci Bull 39 (6), 947-961 (2023)
   PUBMED   36637791
  REMARK    GeneRIF: CircFhit Modulates GABAergic Synaptic Transmission via
            Regulating the Parental Gene Fhit Expression in the Spinal Dorsal
            Horn in a Rat Model of Neuropathic Pain.
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Dannewitz Prosseda,S., Tian,X., Kuramoto,K., Boehm,M.,
            Sudheendra,D., Miyagawa,K., Zhang,F., Solow-Cordero,D.,
            Saldivar,J.C., Austin,E.D., Loyd,J.E., Wheeler,L., Andruska,A.,
            Donato,M., Wang,L., Huebner,K., Metzger,R.J., Khatri,P. and
            Spiekerkoetter,E.
  TITLE     FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension
  JOURNAL   Am J Respir Crit Care Med 199 (1), 83-98 (2019)
   PUBMED   30107138
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Buttitta,F., Marchetti,A., Radi,O., Bertacca,G., Pellegrini,S.,
            Gadducci,A., Genazzani,A.R. and Bevilacqua,G.
  TITLE     Evaluation of FHIT gene alterations in ovarian cancer
  JOURNAL   Br J Cancer 77 (7), 1048-1051 (1998)
   PUBMED   9569038
REFERENCE   7  (bases 1 to 620)
  AUTHORS   Chu,T.Y., Shen,C.Y., Chiou,Y.S., Lu,J.J., Perng,C.L., Yu,M.S. and
            Liu,H.S.
  TITLE     HPV-associated cervical cancers show frequent allelic loss at 3p14
            but no apparent aberration of FHIT mRNA
  JOURNAL   Int J Cancer 75 (2), 199-204 (1998)
   PUBMED   9462708
REFERENCE   8  (bases 1 to 620)
  AUTHORS   Lima,C.D., Klein,M.G. and Hendrickson,W.A.
  TITLE     Structure-based analysis of catalysis and substrate definition in
            the HIT protein family
  JOURNAL   Science 278 (5336), 286-290 (1997)
   PUBMED   9323207
REFERENCE   9  (bases 1 to 620)
  AUTHORS   Lima,C.D., D'Amico,K.L., Naday,I., Rosenbaum,G., Westbrook,E.M. and
            Hendrickson,W.A.
  TITLE     MAD analysis of FHIT, a putative human tumor suppressor from the
            HIT protein family
  JOURNAL   Structure 5 (6), 763-774 (1997)
   PUBMED   9261067
REFERENCE   10 (bases 1 to 620)
  AUTHORS   Barnes,L.D., Garrison,P.N., Siprashvili,Z., Guranowski,A.,
            Robinson,A.K., Ingram,S.W., Croce,C.M., Ohta,M. and Huebner,K.
  TITLE     Fhit, a putative tumor suppressor in humans, is a dinucleoside
            5',5''-P1,P3-triphosphate hydrolase
  JOURNAL   Biochemistry 35 (36), 11529-11535 (1996)
   PUBMED   8794732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF170064.1.
            
            [WARNING] On Jul 15, 2024 this sequence was replaced by
            NM_021774.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF170064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p15"
     gene            1..620
                     /gene="Fhit"
                     /note="fragile histidine triad diadenosine triphosphatase"
                     /db_xref="GeneID:60398"
                     /db_xref="RGD:620448"
     exon            1..48
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     exon            49..137
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     exon            138..249
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..599
                     /gene="Fhit"
                     /EC_number="3.6.1.29"
                     /EC_number="3.6.2.1"
                     /EC_number="2.7.7.51"
                     /note="AP3Aase; AP3A hydrolase;
                     dinucleosidetriphosphatase; diadenosine
                     5',5'''-P1,P3-triphosphate hydrolase; fragile histidine
                     triad protein; adenylylsulfatase; adenosine
                     5'-monophosphoramidase FHIT; adenylylsulfate-ammonia
                     adenylyltransferase"
                     /codon_start=1
                     /product="bis(5'-adenosyl)-triphosphatase"
                     /protein_id="NP_068542.1"
                     /db_xref="GeneID:60398"
                     /db_xref="RGD:620448"
                     /translation="MSFKFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLMCPLRPV
                     ERFRDLRPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHVHVHILPR
                     KSGDFRRNDNIYDELQKHDREEEDSPAFWRSEEEMAAEAEVLRAYFQA"
     exon            250..395
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     exon            396..425
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     exon            426..494
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     exon            495..593
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
     exon            594..620
                     /gene="Fhit"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttgaagccc agcaaagaag ggaaatccac tgagaagagt ctggaaaggt gtcctaggac
       61 aacctgcttg gtcacttgct ctgcaaaaac tctccatctt gcactgagga tctgaaggag
      121 gtatactcat ctacacgtgt gagaccatgt catttaaatt cggccaacat ctcatcaagc
      181 cctctgtggt tttcctcaaa accgaactgt cctttgccct ggtgaatagg aaacccgttg
      241 tacctggcca tgtcctcatg tgtccactta ggccagtgga gcgcttccgt gacttacgtc
      301 ctgatgaagt ggccgatttg tttcaagtaa cacagagagt tgggacagtg gtggagaagc
      361 atttccaggg gacctccatc accttctcca tgcaagatgg tcctgaagct ggacagactg
      421 tgaagcatgt acatgtccac attcttccca ggaagtcagg agacttccgc aggaatgaca
      481 acatctatga tgagcttcaa aaacatgaca gagaagaaga ggactcacca gccttttgga
      541 gatctgagga ggagatggct gcagaggcgg aagttctgag ggcctacttt caggcatgag
      601 agaaatgcaa acaaatccca
//
