LOCUS       NM_017005               1603 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus fumarate hydratase (Fh), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_017005
VERSION     NM_017005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Rodriguez-Rivera,C., Gonzalez-Martin,C., Fernandez-Millan,E.,
            Alvarez,C., Escriva,F. and Alguacil,L.F.
  TITLE     Perinatal undernourishment provokes long-lasting alterations of
            clusterin and fumarate hydratase expression in the rat nucleus
            accumbens
  JOURNAL   Nutr Neurosci 25 (9), 1796-1800 (2022)
   PUBMED   33755527
  REMARK    GeneRIF: Perinatal undernourishment provokes long-lasting
            alterations of clusterin and fumarate hydratase expression in the
            rat nucleus accumbens.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Zheng,X., Chen,M., Li,X., Yang,P., Zhao,X., Ouyang,Y., Yang,Z.,
            Liang,M., Hou,E. and Tian,Z.
  TITLE     Insufficient fumarase contributes to hypertension by an imbalance
            of redox metabolism in Dahl salt-sensitive rats
  JOURNAL   Hypertens Res 42 (11), 1672-1682 (2019)
   PUBMED   31235845
  REMARK    GeneRIF: Insufficient fumarase contributes to hypertension by an
            imbalance of redox metabolism in Dahl salt-sensitive rats.
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Ajalla Aleixo,M.A., Rangel,V.L., Rustiguel,J.K., de Padua,R.A.P.
            and Nonato,M.C.
  TITLE     Structural, biochemical and biophysical characterization of
            recombinant human fumarate hydratase
  JOURNAL   FEBS J 286 (10), 1925-1940 (2019)
   PUBMED   30761759
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Kulkarni,R.A., Bak,D.W., Wei,D., Bergholtz,S.E., Briney,C.A.,
            Shrimp,J.H., Alpsoy,A., Thorpe,A.L., Bavari,A.E., Crooks,D.R.,
            Levy,M., Florens,L., Washburn,M.P., Frizzell,N., Dykhuizen,E.C.,
            Weerapana,E., Linehan,W.M. and Meier,J.L.
  TITLE     A chemoproteomic portrait of the oncometabolite fumarate
  JOURNAL   Nat Chem Biol 15 (4), 391-400 (2019)
   PUBMED   30718813
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Bulku,A., Weaver,T.M. and Berkmen,M.B.
  TITLE     Biochemical Characterization of Two Clinically-Relevant Human
            Fumarase Variants Defective for Oligomerization
  JOURNAL   Open Biochem J 12, 1-15 (2018)
   PUBMED   29456767
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Wei,M.H., Toure,O., Glenn,G.M., Pithukpakorn,M., Neckers,L.,
            Stolle,C., Choyke,P., Grubb,R., Middelton,L., Turner,M.L.,
            Walther,M.M., Merino,M.J., Zbar,B., Linehan,W.M. and Toro,J.R.
  TITLE     Novel mutations in FH and expansion of the spectrum of phenotypes
            expressed in families with hereditary leiomyomatosis and renal cell
            cancer
  JOURNAL   J Med Genet 43 (1), 18-27 (2006)
   PUBMED   15937070
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Bourgeron,T., Chretien,D., Poggi-Bach,J., Doonan,S., Rabier,D.,
            Letouze,P., Munnich,A., Rotig,A., Landrieu,P. and Rustin,P.
  TITLE     Mutation of the fumarase gene in two siblings with progressive
            encephalopathy and fumarase deficiency
  JOURNAL   J Clin Invest 93 (6), 2514-2518 (1994)
   PUBMED   8200987
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Suzuki,T., Sato,M., Yoshida,T. and Tuboi,S.
  TITLE     Rat liver mitochondrial and cytosolic fumarases with identical
            amino acid sequences are encoded from a single gene
  JOURNAL   J Biol Chem 264 (5), 2581-2586 (1989)
   PUBMED   2914923
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Lai,J.C. and Clark,J.B.
  TITLE     Preparation and properties of mitochondria derived from
            synaptosomes
  JOURNAL   Biochem J 154 (2), 423-432 (1976)
   PUBMED   938457
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087598.1.
            
            On Oct 12, 2007 this sequence version replaced NM_017005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087598.1, J04473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..1603
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /note="fumarate hydratase"
                     /db_xref="GeneID:24368"
                     /db_xref="RGD:2614"
     exon            1..137
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1538
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /EC_number="4.2.1.2"
                     /note="fumarate hydratase, mitochondrial; fumarase;
                     fumarate hydratase 1"
                     /codon_start=1
                     /product="fumarate hydratase, mitochondrial precursor"
                     /protein_id="NP_058701.2"
                     /db_xref="GeneID:24368"
                     /db_xref="RGD:2614"
                     /translation="MNRAFCLLARSRRFPRVPSAGAVLSGEAATLPRCAPNVVRMASQ
                     NSFRIEYDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIKAFGILKRAAAE
                     VNQEYGLDPKIASAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIE
                     MLGGELGSKKPVHPNDHVNKSQSSNDTFPTAMHIAAALEVHQVLLPGLQKLHDALSAK
                     SKEFAQVIKIGRTHTQDAVPLTLGQEFSGYVQQVQYAMERIKAAMPRIYELAAGGTAV
                     GTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMK
                     IANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVT
                     VGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESL
                     MLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGPK"
     exon            138..272
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..383
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..560
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..743
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..909
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1113
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1241
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1395
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1579
                     /gene="Fh"
                     /gene_synonym="Fh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtacagcag caccatgaac cgcgcattct gtctcctcgc tcgctcgcgt cgcttcccgc
       61 gggtcccctc cgccggtgct gtattgtcag gggaagcggc caccctccca cggtgtgctc
      121 cgaacgtcgt gcgaatggca agccaaaatt ccttccgtat agaatacgac acctttggtg
      181 aactgaaggt cccaaccgat aagtattatg gtgctcagac tgtaagatct acgatgaact
      241 ttaagattgg aggtgcgacg gagagaatgc caatcccagt cattaaagca tttggcatct
      301 tgaagcgagc tgctgctgaa gtgaaccagg agtatggtct cgatcccaag attgctagtg
      361 caataatgaa ggccgcagat gaggtagctg aaggtaaatt aaacgatcac tttcctctgg
      421 tggtatggca gactgggtca ggaacccaga cgaacatgaa tgtaaatgaa gtcattagca
      481 acagggcaat cgaaatgcta ggaggtgaac ttggcagcaa gaagcccgtg caccccaatg
      541 atcacgttaa caaaagccag agctcgaatg acaccttccc cacagcaatg cacattgctg
      601 ctgcactgga agttcaccag gtcctgttgc caggattaca gaagctgcac gatgccctca
      661 gtgcaaaatc caaagagttc gcgcaggtca taaaaattgg gcggactcat acgcaggacg
      721 ctgtccctct tactcttgga caggagttca gtggttatgt tcagcaagtc cagtatgcga
      781 tggagaggat aaaagctgcc atgcccagaa tctacgagct cgctgctggc ggcactgccg
      841 tcggcacggg actaaacacc aggatcggct tcgcagaaaa ggtggctgca aaagtcgcag
      901 cactcacagg tttgcctttt gtcactgccc cgaataagtt tgaagctctg gccgctcatg
      961 atgctctggt ggagcttagt ggagccatga acactacggc ctgcagtctg atgaagattg
     1021 ccaatgacat tcgcttcctc ggttctggtc ctcggtccgg tttgggggag ctgatcttgc
     1081 ctgaaaatga gccagggagc agcataatgc caggaaaggt gaaccctact cagtgtgagg
     1141 cgatgaccat ggttgcagcc caagtcatgg ggaatcatgt cgctgttact gttggaggca
     1201 gcaatggaca tttcgaactg aatgttttta aaccgatgat gattaagaat gtgttgcact
     1261 cagccaggct actgggagat gcttcagtgt ccttcacaga gaactgtgtg gtagggatcc
     1321 aggccaacac agagaggatc aacaagctaa tgaacgagtc tttaatgttg gttacagctc
     1381 ttaatccgca tatagggtat gacaaagcag cgaagattgc caagactgca cacaagaacg
     1441 gatcaacctt aaaggaaacg gctattgaac ttggctatct cacagcagag cagtttgatg
     1501 agtgggtgaa acccaaggac atgctgggtc caaagtgact taaatttata ttaaaataaa
     1561 catgtatgaa atttaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
