LOCUS       NM_024145               2499 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus FGR proto-oncogene, Src family tyrosine kinase
            (Fgr), mRNA.
ACCESSION   NM_024145
VERSION     NM_024145.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2499)
  AUTHORS   Shen,K., Moroco,J.A., Patel,R.K., Shi,H., Engen,J.R., Dorman,H.R.
            and Smithgall,T.E.
  TITLE     The Src family kinase Fgr is a transforming oncoprotein that
            functions independently of SH3-SH2 domain regulation
  JOURNAL   Sci Signal 11 (553) (2018)
   PUBMED   30352950
  REMARK    GeneRIF: Fgr is a transforming oncoprotein that functions
            independently of SH3-SH2 domain regulation
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2499)
  AUTHORS   Lee,J.H., Kim,J.W., Kim,D.K., Kim,H.S., Park,H.J., Park,D.K.,
            Kim,A.R., Kim,B., Beaven,M.A., Park,K.L., Kim,Y.M. and Choi,W.S.
  TITLE     The Src family kinase Fgr is critical for activation of mast cells
            and IgE-mediated anaphylaxis in mice
  JOURNAL   J Immunol 187 (4), 1807-1815 (2011)
   PUBMED   21746961
REFERENCE   3  (bases 1 to 2499)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 2499)
  AUTHORS   Mehlitz,A., Banhart,S., Maurer,A.P., Kaushansky,A., Gordus,A.G.,
            Zielecki,J., Macbeath,G. and Meyer,T.F.
  TITLE     Tarp regulates early Chlamydia-induced host cell survival through
            interactions with the human adaptor protein SHC1
  JOURNAL   J Cell Biol 190 (1), 143-157 (2010)
   PUBMED   20624904
REFERENCE   5  (bases 1 to 2499)
  AUTHORS   Abe,K., Fuchs,H., Lisse,T., Hans,W. and Hrabe de Angelis,M.
  TITLE     New ENU-induced semidominant mutation, Ali18, causes inflammatory
            arthritis, dermatitis, and osteoporosis in the mouse
  JOURNAL   Mamm Genome 17 (9), 915-926 (2006)
   PUBMED   16964445
REFERENCE   6  (bases 1 to 2499)
  AUTHORS   Brunati,A.M., Ruzzene,M., James,P., Guerra,B. and Pinna,L.A.
  TITLE     Hierarchical phosphorylation of a 50-kDa protein by protein
            tyrosine kinases TPK-IIB and C-Fgr, and its identification as HS1
            hematopoietic-lineage cell-specific protein
  JOURNAL   Eur J Biochem 229 (1), 164-170 (1995)
   PUBMED   7744027
REFERENCE   7  (bases 1 to 2499)
  AUTHORS   Berton,G., Fumagalli,L., Laudanna,C. and Sorio,C.
  TITLE     Beta 2 integrin-dependent protein tyrosine phosphorylation and
            activation of the FGR protein tyrosine kinase in human neutrophils
  JOURNAL   J Cell Biol 126 (4), 1111-1121 (1994)
   PUBMED   7519620
REFERENCE   8  (bases 1 to 2499)
  AUTHORS   Lowell,C.A., Soriano,P. and Varmus,H.E.
  TITLE     Functional overlap in the src gene family: inactivation of hck and
            fgr impairs natural immunity
  JOURNAL   Genes Dev 8 (4), 387-398 (1994)
   PUBMED   8125254
REFERENCE   9  (bases 1 to 2499)
  AUTHORS   Inoue,K., Yamamoto,T. and Toyoshima,K.
  TITLE     Specific expression of human c-fgr in natural immunity effector
            cells
  JOURNAL   Mol Cell Biol 10 (4), 1789-1792 (1990)
   PUBMED   2181286
REFERENCE   10 (bases 1 to 2499)
  AUTHORS   Leibovitch,S.A., Leibovitch,M.P., Guillier,M., Hillion,J. and
            Harel,J.
  TITLE     Differential expression of protooncogenes related to transformation
            and cancer progression in rat myoblasts
  JOURNAL   Cancer Res 46 (8), 4097-4103 (1986)
   PUBMED   2425941
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_024145.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062025.1, SRR26643284.8070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               JAXUCZ010000005.1  150473797-150473984
            189-260             JAXUCZ010000005.1  150484234-150484305
            261-463             JAXUCZ010000005.1  150485978-150486180
            464-566             JAXUCZ010000005.1  150487285-150487387
            567-665             JAXUCZ010000005.1  150488590-150488688
            666-769             JAXUCZ010000005.1  150495257-150495360
            770-919             JAXUCZ010000005.1  150495494-150495643
            920-1075            JAXUCZ010000005.1  150498000-150498155
            1076-1255           JAXUCZ010000005.1  150498272-150498451
            1256-1332           JAXUCZ010000005.1  150498873-150498949
            1333-1486           JAXUCZ010000005.1  150499219-150499372
            1487-1618           JAXUCZ010000005.1  150500181-150500312
            1619-2499           JAXUCZ010000005.1  150500400-150501280
FEATURES             Location/Qualifiers
     source          1..2499
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2499
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /note="FGR proto-oncogene, Src family tyrosine kinase"
                     /db_xref="GeneID:79113"
                     /db_xref="RGD:621319"
     exon            1..188
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            189..260
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            261..463
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1827
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /EC_number="2.7.10.2"
                     /note="proto-oncogene tyrosine-protein kinase Fgr;
                     Gardner-Rasheed feline sarcoma viral (Fgr) oncogene
                     homolog; proto-oncogene c-Fgr; Gardner-Rasheed feline
                     sarcoma viral (v-fgr) oncogene homolog; feline
                     Gardner-Rasheed sarcoma viral oncogene"
                     /codon_start=1
                     /product="tyrosine-protein kinase Fgr"
                     /protein_id="NP_077059.2"
                     /db_xref="GeneID:79113"
                     /db_xref="RGD:621319"
                     /translation="MGCVFCKKLEPAPKEDVGLEGDFRSQGAEERYYPDPTQGRSSSI
                     SPQPISPAFLNVGNIRSVSGTGVTIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDW
                     WEARSLSSGRTGYVPSNYVAPVDSIQAEEWYFGKISRKDAERQLLSDGNPQGAFLIRE
                     SETTKGAYSLSIRDWDQNRGDHIKHYKIRKLDMGGYYITTRAQFESVQDLVRHYMEVN
                     DGLCYLLTAPCMVMKPQTLGLAKDAWEIDRNSIALDRRLGTGCFGDVWLGTWNCSTKV
                     AVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFL
                     KDRKGHNLMLPNLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEHLICKIADFGLA
                     RLIVDDEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGM
                     NNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPEERPTFEYLQSFLEDYFTSTE
                     PQYQPGDQT"
     exon            464..566
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            567..665
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            666..769
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            770..919
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1075
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1255
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1332
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1486
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1618
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..2499
                     /gene="Fgr"
                     /gene_synonym="p55-Fgr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacaggggc gggtagcact tcactttccc ctcacatcgt tcctgaaaat tagggttggc
       61 tcgccccaga tcgggtcacc agcagctggc tcccttgaga ccaggtaggc ggccaaacca
      121 ggaggaggct gacccggcag gtgtcgcccc gcccctgtcc gtcctcgccc tggaaggaag
      181 atttagaggt ttccggcacc cccccccgcc cccagggacc atgcatcagt cctactgacc
      241 caggagtagg ggcctgtggg caggacacct ggaatgggct gtgtgttctg caagaagtta
      301 gagcctgcac ccaaggagga tgttggcctg gaaggggact tccggagcca aggcgctgaa
      361 gaacgctatt accctgaccc tactcaaggc cggtcttcgt ccatctcgcc tcagcccatc
      421 agccctgctt tccttaatgt tggcaacata agaagcgtct ctgggacggg agtgaccata
      481 ttcgtcgccc tgtatgacta tgaggccagg acaggggatg acctcacctt caccaaaggc
      541 gagaagttcc acatcctgaa caatacggag tatgactggt gggaggctag gtccctgagc
      601 tccggacgca cgggctatgt tcccagcaac tatgtggctc ccgtggattc catccaggct
      661 gaagagtggt acttcggaaa gatcagcaga aaggatgcag agaggcagct tctctccgat
      721 ggcaaccctc aaggggcctt tctcattcgg gaaagcgaga ccaccaaagg tgcctactcc
      781 ctgtccatcc gtgactggga ccagaacaga ggcgaccaca taaagcatta caagatccga
      841 aagctggaca tgggtggcta ctacatcacc acgcgggccc agttcgaatc cgtgcaggac
      901 ctggtgcggc actacatgga agtgaatgac ggtctatgct acttgctcac ggcaccctgt
      961 atggtcatga agccccagac tctaggcctg gctaaggatg cctgggagat cgaccgtaac
     1021 tccatagcac ttgaccgcag gctgggcacc ggctgctttg gagacgtgtg gctgggcacg
     1081 tggaactgta gcacaaaggt ggcagtgaaa acgctgaagc caggcaccat gtcgccgaag
     1141 gccttcctgg aggaggcaca gatcatgaaa ctgctgaggc acgacaagct ggtgcagctg
     1201 tacgcggtgg tgtcagagga acccatttat attgtgacag agttcatgtg ctatggtagc
     1261 ttgctggatt tcctaaagga tcgaaagggt cacaacttga tgctgcccaa tctagtggac
     1321 atggctgccc aggtagcaga gggcatggcc tacatggagc gcatgaacta tatccaccga
     1381 gacctgagag cagccaacat cctggtgggg gaacatctaa tatgcaagat cgctgacttt
     1441 gggttggcac gcctcatagt ggatgatgag tacaaccccc aacaaggaac caagtttccc
     1501 atcaagtgga cagccccaga ggctgctctc tttggcagat tcactgtcaa atcagacgtg
     1561 tggtcctttg ggattctgct cactgaactg atcaccaagg gcagagttcc atacccaggt
     1621 atgaacaacc gggaagtgtt ggaacaggta gagcacggct accacatgcc atgccctccg
     1681 ggatgcccag tatccctgta tgaggtcatg gagcagacct ggcgtctgga tccagaggag
     1741 aggcccacct ttgagtacct gcagtctttc ctggaagact atttcacctc cacagaacca
     1801 cagtatcagc ccggagacca gacatagcct gactgggtat cagtgaccct ctgagactat
     1861 gtactaaccc ttgccaatcc ccagggcact ctggtcccag tgccccgaga cttggaaccc
     1921 tgtggaatcc tagcacgtcg gaaaaagtcc gaagctctga agccatttta tagagggtgc
     1981 aaatggagac tagaaattca tctcttacct tcgctggccc caagcactct ttcttccctt
     2041 cccacccatg ccccatgcaa aaatctaggg cacccagtca tttcacagac ggagtaaatg
     2101 gatgctcaga gttcatctct cgtacactct gaccccagta ccatttttcc tgtcccatta
     2161 ggctcctacg taccgttagt ccccccccca tctcctaaaa atactcatac attgtgtagt
     2221 tatttataaa attgtatttc tcttcttcca cttacctctt atccctgctt tctaacctcc
     2281 tgtcagcccg ctccagccca gaccttaaga gtttaattct gaggttctct tgggtttctc
     2341 tacgttacaa aggcagggga cgtctctgct tgattccccg tcttcagact ggatgctgtg
     2401 gtccaggccc aggtctgaag gagagagcca ttgaaggctc accatctctc tgagtggtct
     2461 gaatgtgttt attcgttata aacgaacagt gatgatcga
//
