LOCUS       NM_053455               3720 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus fibrinogen-like 2 (Fgl2), mRNA.
ACCESSION   NM_053455
VERSION     NM_053455.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3720)
  AUTHORS   Shao W, Huang Y, Wang L, Li P, Jia Y and Zhang J.
  TITLE     Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like
            receptor 9 (TLR9) expression in autoimmune myelitis
  JOURNAL   Int Immunopharmacol 114, 109539 (2023)
   PUBMED   36508913
  REMARK    GeneRIF: Expression of fibrinogen-like protein 2 (Fgl2) on
            Toll-like receptor 9 (TLR9) expression in autoimmune myelitis.
REFERENCE   2  (bases 1 to 3720)
  AUTHORS   Luft O, Khattar R, Farrokhi K, Ferri D, Yavorska N, Zhang J,
            Sadozai H, Adeyi O, Chruscinski A, Levy GA and Selzner N.
  TITLE     Inhibition of the Fibrinogen-Like Protein 2:FcgammaRIIB/RIII
            immunosuppressive pathway enhances antiviral T-cell and B-cell
            responses leading to clearance of lymphocytic choriomeningitis
            virus clone 13
  JOURNAL   Immunology 154 (3), 476-489 (2018)
   PUBMED   29341118
REFERENCE   3  (bases 1 to 3720)
  AUTHORS   Zheng Z, Yu L, Wu Y and Wu H.
  TITLE     FGL2 knockdown improves heart function through regulation of TLR9
            signaling in the experimental autoimmune myocarditis rats
  JOURNAL   Immunol Res 66 (1), 52-58 (2018)
   PUBMED   29128901
  REMARK    GeneRIF: this study shows that FGL2 knockdown improves heart
            function through regulation of TLR9 signaling in the experimental
            autoimmune myocarditis rats
REFERENCE   4  (bases 1 to 3720)
  AUTHORS   Zheng Z, Yu Y, Potla R, Wu Y and Wu H.
  TITLE     Fibrinogen-like protein-2 causes deterioration in cardiac function
            in experimental autoimmune myocarditis rats through regulation of
            programmed death-1 and inflammatory cytokines
  JOURNAL   Immunology 153 (2), 246-252 (2018)
   PUBMED   28892130
  REMARK    GeneRIF: FGL2 plays an important role in the pathogenesis of
            autoimmune myocarditis that also involves the PD-1/PD-L1 pathway.
            Our findings may provide novel therapeutic targets for the
            treatment of immune-induced heart injury.
REFERENCE   5  (bases 1 to 3720)
  AUTHORS   Long R, You Y, Li W, Jin N, Huang S, Li T, Liu K and Wang Z.
  TITLE     Sodium tanshinone IIA sulfonate ameliorates experimental coronary
            no-reflow phenomenon through down-regulation of FGL2
  JOURNAL   Life Sci 142, 8-18 (2015)
   PUBMED   26482204
  REMARK    GeneRIF: STS is able to ameliorate CNR through inhibition of FGL2
            expression mediated by Akt and NF-kappaB pathways as well as
            prevention of MVO by suppressing fibrin deposition and
            inflammation.
REFERENCE   6  (bases 1 to 3720)
  AUTHORS   Shao L, Wu D, Zhang P, Li W, Wang J, Su G, Liao Y, Wang Z and Liu
            K.
  TITLE     The significance of microthrombosis and fgl2 in no-reflow
            phenomenon of rats with acute myocardial ischemia/reperfusion
  JOURNAL   Clin Appl Thromb Hemost 19 (1), 19-28 (2013)
   PUBMED   22387586
  REMARK    GeneRIF: microthrombosis is involved in cardiac microvascular
            dysfunction or disturbance of rats with acute MI/R as one cause,
            and fgl2 may emerge as a predictor of the occurrence of no-reflow
            phenomenon.
REFERENCE   7  (bases 1 to 3720)
  AUTHORS   Chen T, Ye X, Huang Z, Chen R, Zhuge X, Chen X and Du Y.
  TITLE     Fgl2 prothrombinase is involved in severe acute
            pancreatitis-associated liver injury
  JOURNAL   Hepatogastroenterology 59 (116), 1225-1229 (2012)
   PUBMED   22456282
  REMARK    GeneRIF: Fgl2 prothrombinase is involved in severe acute
            pancreatitis-associated liver injury.
REFERENCE   8  (bases 1 to 3720)
  AUTHORS   Ding Y, Liu K, Wang Y, Su G, Deng H, Zeng Q, Liao Y and Wang Z.
  TITLE     Expression and significance of fgl2 prothrombinase in cardiac
            microvascular endothelial cells of rats with type 2 diabetes
  JOURNAL   J Huazhong Univ Sci Technolog Med Sci 30 (5), 575-581 (2010)
   PUBMED   21063837
  REMARK    GeneRIF: In rats with type 2 diabetes, microthrombosis due to fgl2
            contributes to the impairment of cardiac diastolic or systolic
            function and morphological changes.
REFERENCE   9  (bases 1 to 3720)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   10 (bases 1 to 3720)
  AUTHORS   Rychlik DF, Chien EK, Wolff D, Phillippe S and Phillippe M.
  TITLE     Cloning and tissue expression of the tissue prothrombinase Fgl-2 in
            the Sprague-Dawley rat
  JOURNAL   J Soc Gynecol Investig 10 (2), 67-73 (2003)
   PUBMED   12593995
  REMARK    GeneRIF: studies confirmed the expression of Fgl-2 mRNA in several
            rat tissues, including the pregnant uterus, where it could play a
            key role in the initiation of parturition especially in response to
            local or systemic infection
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB582252.1 and BC072502.1.
            
            On Oct 3, 2005 this sequence version replaced NM_053455.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107665.1, BC085357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680421, SAMN12840131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB582252.1         12-62
            52-2654             BC072502.1         1-2603
            2655-3720           BC072502.1         2605-3670
FEATURES             Location/Qualifiers
     source          1..3720
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..3720
                     /gene="Fgl2"
                     /note="fibrinogen-like 2"
                     /db_xref="GeneID:84586"
                     /db_xref="RGD:620170"
     exon            1..606
                     /gene="Fgl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1313
                     /gene="Fgl2"
                     /note="fibroleukin"
                     /codon_start=1
                     /product="fibroleukin precursor"
                     /protein_id="NP_445907.2"
                     /db_xref="GeneID:84586"
                     /db_xref="RGD:620170"
                     /translation="MRLPGWLWLSSAVLAACRAAEKHNLTEGLEDASAQAACPARLEG
                     SGRCEGSQCPFQLTLPTLTLQLPQQFGSMEEVLKEVRTLQEAVDSLKKSCQDCKLQAD
                     EHPDPGGNGAETAEDNRVQELESQVNKLSSELKNAKEEIQGLQGRLESLQLVNMNNIE
                     NYVDNKVANLTSVVNSLDSKCFKCPSQEHNQPNPVQHLIYKDCSDYYVLGKRSSGTYR
                     VTPDHRNSSFEVYCDMETTGGGWTVLQARLDGSTNFTRGWKDYKAGFGNLEREFWLGN
                     DKIHLLTKSKEMILRIDLEDFNGLTLYAVYDQFYVANEFLKYRLHLGNYNGTAGDALR
                     FSRHYNHDLRFFTTPDRDNDRYPSGNCGLYYSSGWWFDACLSANLNGKYYHQRYKGVR
                     NGIFWGTWPGVSQAHPGGYKFSFKKAKMMIRPKSFKP"
     exon            607..3695
                     /gene="Fgl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgggctg ctgcactgca aggatgaggc ttcctggctg gttgtggctg agctccgcgg
       61 tcctcgctgc ctgccgagcg gcggagaagc acaacctgac tgaagggctg gaggatgcga
      121 gcgcccaggc tgcctgcccc gcgaggctgg agggcagcgg gaggtgcgag ggcagccagt
      181 gccccttcca gctcaccctg cccacgctga ccctccagct cccgcagcag ttcggcagca
      241 tggaggaggt gctcaaagaa gtgcggaccc tccaggaagc tgtggacagt ctgaagaaat
      301 cctgccagga ctgcaagttg caggctgatg aacatccaga ccctggcggg aatggagcag
      361 agacggccga ggacaatcga gtccaggaac tggagagtca ggtgaacaag ctgtcctcag
      421 agctgaagaa tgcaaaggag gagatccagg ggctgcaggg gcgcctggag tcgctccaac
      481 tggtaaatat gaacaacatc gagaactacg tggacaacaa agtggcaaat ctaacctctg
      541 tggtcaacag tttggatagc aagtgtttca agtgccccag ccaagaacac aaccagccaa
      601 atccagttca acatctaata tacaaagatt gctctgacta ctacgtgtta gggaagagaa
      661 gcagtgggac ctacagagtt acgcctgatc acaggaacag cagctttgag gtctactgcg
      721 acatggagac cacgggtgga ggctggacag tgctgcaggc tcgccttgat gggagcacca
      781 acttcaccag agggtggaag gactacaaag ccggcttcgg gaaccttgaa cgagaatttt
      841 ggctgggcaa cgataaaatt catcttctga ccaagagtaa ggaaatgatt ttgagaatag
      901 atctcgaaga ctttaatggt ctcacacttt acgccgtgta cgatcagttt tatgtggcta
      961 acgagtttct caaataccgg ttacacctcg gtaactataa tggcacggca ggggatgcct
     1021 tgcgttttag ccgacattac aaccacgacc tgaggttttt caccacccca gacagagaca
     1081 atgatcggta cccctctggg aactgtgggc tctattacag ctcaggctgg tggtttgatg
     1141 catgtctctc tgccaactta aatggcaaat attatcacca gagatacaaa ggggtccgta
     1201 atgggatttt ctggggcacc tggcctggtg taagtcaggc acacccaggg ggctacaagt
     1261 tctccttcaa gaaggccaag atgatgataa gacccaagag ttttaagcca taaattcatg
     1321 ctcgtttctc tgggcactca ctatctaaga ggacagtgca ttcctccagc cttgactgta
     1381 tgcctcagtt tatatcccct tcctgtggct aaacactccc ttttaagctt tacagcttta
     1441 aaataaagct ggaaatgtct aaaacagact ctttggtggc tgttatatga ggaatgctcg
     1501 aaagcactgg aaatagtgac gattatacat tataattgca agacttttca tttttattag
     1561 ttgaaaagtt tcctactatt tttattattt tttataataa aaaactaaat tattcagcaa
     1621 gctaaattct gtatactcaa gttttatttt cactagggct aaacgcacac atttgaaaat
     1681 acaccagtct ttttcagggt acagacgctc gtgtatctgg agctaagaac tatagtattt
     1741 tctttggtcc aagaaatagt ttagttctca aaaagaaagt cagggatggg gttttggtgg
     1801 gcagggatta aatagctaaa tttatttatc taatgcaaaa tatggcatta aaatgcctta
     1861 aaatacagta gcataatata tgtctttttc ctctccaaaa ttggaaaata ctgctaccct
     1921 ggagattgtg gtttcgtggt gacccacgta ctgtttatag cctgttagac cctgatacag
     1981 aagctgcttt gtcatctcct ctctgtgcac gatagtgttt agtgtaaggt gcgagactac
     2041 tgtaaggctt ccttggagaa aggcatggta agggaaaaca gcgtttaatt atactttgaa
     2101 ggccaatgct agacccaaag caagacttga gttgttgagg aatcaacttc ctaggaagca
     2161 gacttttcta gaacaaatat atttattgtg atacattttg atagagtagt tcaaatatta
     2221 ttcattttaa tcctaagtcg tcaactgctt atttcattct cagaaattca cagaaaaact
     2281 atatataatt ttagtccagt gtaagtgcct ggagttcctt gattgtggaa tgctgagggc
     2341 catgttaaaa ggcttgggag gaagtttcat ttatcactgt agaaaaggat cacttcagag
     2401 aggaaagatg ctcttcagtg gaatctgagg aactgtacgc ggtcagtcat aggaggaggt
     2461 gatcagacag ggcgcagtgt ttaagcaaaa actttgatct ttaagttttg gtagatttct
     2521 aatatactaa ccaagccttt gaaatataag cacaaagatt ctattttagt tagtctttaa
     2581 atataactag gaaggacagt tattgacttg actacttaaa ttttcaaata cgtagccgct
     2641 gtaaaaaaaa aaaactttaa aaagagcaag atattatttt aaaaatatgc aacatgaagt
     2701 tttcagctga atacaatgac aattaaagta ttaataacat aattaaatta ccagagtaag
     2761 gtgaatgcac gctgaattaa atgaccaaaa tataaaatat agatttccaa gactgtttac
     2821 ctgcttggca aaatattgaa tgtaagtagc aataattagt tttatttctc ctttgctttt
     2881 taaaaaagaa aaagaagatt ttgatattat acaattgatg tgtttcaaat tctgtttgtt
     2941 atatgtaacc atagaagtgt aatgacattt ccgtcatgaa aatggattta ttatagcaaa
     3001 acccctatgc attcctcttt agtgtgtctt tttcagtgta acaatgaagc catgtgaatg
     3061 ctctatcttt gcacgtccaa tggattcaaa tgatgttttc tattatactc tagagatttt
     3121 tctaatgaac tctttaacac agaaatttat ttttggaatc cctttctgtc acttatttaa
     3181 gaatatattg taggctttga taacctttaa cctgtttgtt ggaatagtcc ttggccttaa
     3241 ctattcacta atgtatgcca gtcctcatag gtggacacta ttggcaagtc tgtgttttag
     3301 agtcttggct tcatctcggt ggctaacgct ggtcttaact atcgcttttt ggctgaacat
     3361 tcttatcctt taaaatgctg agtggaacta atttcttagg aatctggttg agtcacccat
     3421 caccgaatga gaaagccatt tttctgaaaa gtaataatgc agcaaatgtc ttcagcctct
     3481 gatggacaga acttgtgtac aaagcacagg atgcatggga gtcacacaca gtgctggctg
     3541 gtccggggct cttaatagct gcccctcgcc cctcagaaag ttttcaagct ggaatggata
     3601 tgtgtgatta caataaactc tcgtttagga tttcttttca ttgatgtata attaatgtta
     3661 catttcatgt ctcattaaag ccttgtaaaa taaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
