LOCUS       NM_172010               1100 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus fibrinogen-like 1 (Fgl1), mRNA.
ACCESSION   NM_172010
VERSION     NM_172010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1100)
  AUTHORS   Wang,J., Sanmamed,M.F., Datar,I., Su,T.T., Ji,L., Sun,J., Chen,L.,
            Chen,Y., Zhu,G., Yin,W., Zheng,L., Zhou,T., Badri,T., Yao,S.,
            Zhu,S., Boto,A., Sznol,M., Melero,I., Vignali,D.A.A., Schalper,K.
            and Chen,L.
  TITLE     Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of
            LAG-3
  JOURNAL   Cell 176 (1-2), 334-347 (2019)
   PUBMED   30580966
REFERENCE   2  (bases 1 to 1100)
  AUTHORS   Zou,Z., Cai,Y., Chen,Y., Chen,S., Liu,L., Shen,Z., Zhang,S., Xu,L.
            and Chen,Y.
  TITLE     Bone marrow-derived mesenchymal stem cells attenuate acute liver
            injury and regulate the expression of fibrinogen-like-protein 1 and
            signal transducer and activator of transcription 3
  JOURNAL   Mol Med Rep 12 (2), 2089-2097 (2015)
   PUBMED   25901902
  REMARK    GeneRIF: The expression of FGL1 and p-STAT3 were elevated
            concurrently with the improvement of liver function.
REFERENCE   3  (bases 1 to 1100)
  AUTHORS   Demchev,V., Malana,G., Vangala,D., Stoll,J., Desai,A., Kang,H.W.,
            Li,Y., Nayeb-Hashemi,H., Niepel,M., Cohen,D.E. and Ukomadu,C.
  TITLE     Targeted deletion of fibrinogen like protein 1 reveals a novel role
            in energy substrate utilization
  JOURNAL   PLoS One 8 (3), e58084 (2013)
   PUBMED   23483972
REFERENCE   4  (bases 1 to 1100)
  AUTHORS   Li,C.Y., Cao,C.Z., Xu,W.X., Cao,M.M., Yang,F., Dong,L., Yu,M.,
            Zhan,Y.Q., Gao,Y.B., Li,W., Wang,Z.D., Ge,C.H., Wang,Q.M.,
            Peng,R.Y. and Yang,X.M.
  TITLE     Recombinant human hepassocin stimulates proliferation of
            hepatocytes in vivo and improves survival in rats with fulminant
            hepatic failure
  JOURNAL   Gut 59 (6), 817-826 (2010)
   PUBMED   19880967
REFERENCE   5  (bases 1 to 1100)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   6  (bases 1 to 1100)
  AUTHORS   Yan,J., Ying,H., Gu,F., He,J., Li,Y.L., Liu,H.M. and Xu,Y.H.
  TITLE     Cloning and characterization of a mouse liver-specific gene
            mfrep-1, up-regulated in liver regeneration
  JOURNAL   Cell Res 12 (5-6), 353-361 (2002)
   PUBMED   12528893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Nov 30, 2020 this sequence version replaced NM_172010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF508020.1, BC088107.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000016.1  57824200-57824273
            75-145              JAXUCZ010000016.1  57834989-57835059
            146-332             JAXUCZ010000016.1  57835593-57835779
            333-492             JAXUCZ010000016.1  57844380-57844539
            493-590             JAXUCZ010000016.1  57845068-57845165
            591-679             JAXUCZ010000016.1  57849208-57849296
            680-867             JAXUCZ010000016.1  57849454-57849641
            868-1100            JAXUCZ010000016.1  57854176-57854408
FEATURES             Location/Qualifiers
     source          1..1100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..1100
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /note="fibrinogen-like 1"
                     /db_xref="GeneID:246186"
                     /db_xref="RGD:620169"
     exon            1..74
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..145
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1027
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /note="fibrinogen-like protein 1; fibronigen-like protein
                     1; fibrinogen-related protein 1; liver fibrinogen-related
                     protein 1"
                     /codon_start=1
                     /product="fibrinogen-like protein 1 precursor"
                     /protein_id="NP_742007.2"
                     /db_xref="GeneID:246186"
                     /db_xref="RGD:620169"
                     /translation="MGEIRSFVLITVALILGKESWVLGDENCLQEQVRLRAQVRQLET
                     RVKQQQVVIAQLLHEKEVQFLDRGQEDSFIDLGGKRHYADCSEIYNDGFKHSGFYKIK
                     PLQSLAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWNDYENGFGNFVQSNGEYWLGN
                     KNINLLTMQGDYTLKIDLTDFEKNSRFAQYEKFKVGDEKSFYELNIGEYSGTAGDSLS
                     GTFHPEVQWWASHQTMKFSTRDRDNDNYNGNCAEEEQSGWWFNRCHSANLNGVYYQGP
                     YRAETDNGVVWYTWRGWWYSLKSVVMKIRPSDFIPNIV"
     exon            146..332
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..492
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..590
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..679
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..867
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1100
                     /gene="Fgl1"
                     /gene_synonym="Frep1; Lfire1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttcagtt agaagttcct gggaggccct gtgtagaccc agcctagctg agtactgatt
       61 cattttgatg tgagtgggaa gaatggggga gattcgcagc tttgtcctca tcactgttgc
      121 tctgattctg ggcaaggaga gctgggtcct cggagatgag aactgtttgc aggagcaggt
      181 caggctcagg gctcaggtgc gccagcttga gacccgggtc aaacaacaac aggtggtgat
      241 tgcacagctc ttgcacgaga aggaggtcca gttcctggat agaggacagg aggacagctt
      301 cattgacctt ggaggcaaga ggcattacgc agattgttca gagatttaca atgatggatt
      361 taaacatagt gggttttaca aaatcaaacc tcttcagagt ctggcagaat tctctgttta
      421 ttgtgatatg tctgatggag gaggatggac tgtaattcag agacgatctg acggcagtga
      481 gaactttaac aggggttgga acgactatga aaatggcttt ggaaactttg tccaaagcaa
      541 tggtgaatac tggctgggta acaaaaacat taacttgctg actatgcaag gagactacac
      601 tttaaaaatc gacctgacag actttgagaa aaacagccgc ttcgcacaat acgaaaaatt
      661 taaagttggc gatgaaaagt ctttttacga actgaatatt ggagaatatt ctggcaccgc
      721 cggagactcc ctgtcgggaa catttcaccc tgaagtgcag tggtgggcta gtcaccaaac
      781 aatgaagttc agcacacggg acagagacaa cgacaactac aacgggaact gtgctgagga
      841 ggaacagtct ggctggtggt ttaacaggtg tcactctgca aacctgaacg gcgtgtacta
      901 ccaaggtccc tacagagcag aaaccgataa tggtgttgtc tggtacacct ggcgtgggtg
      961 gtggtattcc ttgaaatctg tggttatgaa aattaggccc agtgatttta ttccaaatat
     1021 cgtttagttg tcccattggg atctgctttc tgtgattcat cttggttttt aaatgtttga
     1081 aaaaaatata caattctgaa
//
