LOCUS       NM_012559               1554 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Rattus norvegicus fibrinogen gamma chain (Fgg), mRNA.
ACCESSION   NM_012559
VERSION     NM_012559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Wang,J., Zhang,Y., Liu,Y.M., Yang,X.C., Chen,Y.Y., Wu,G.J.,
            He,X.H., Duan,L., Dong,Y. and Ma,R.F.
  TITLE     Uncovering the protective mechanism of Huoxue Anxin Recipe against
            coronary heart disease by network analysis and experimental
            validation
  JOURNAL   Biomed Pharmacother 121, 109655 (2020)
   PUBMED   31734577
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Tsai,J.J., Kuo,H.C., Lee,K.F. and Tsai,T.H.
  TITLE     Proteomic analysis of plasma from rats following total parenteral
            nutrition-induced liver injury
  JOURNAL   Proteomics 15 (22), 3865-3874 (2015)
   PUBMED   26314240
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Asselta,R., Robusto,M., Braidotti,P., Peyvandi,F., Nastasio,S.,
            D'Antiga,L., Perisic,V.N., Maggiore,G., Caccia,S. and Duga,S.
  TITLE     Hepatic fibrinogen storage disease: identification of two novel
            mutations (p.Asp316Asn, fibrinogen Pisa and p.Gly366Ser, fibrinogen
            Beograd) impacting on the fibrinogen gamma-module
  JOURNAL   J Thromb Haemost 13 (8), 1459-1467 (2015)
   PUBMED   26039544
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Asselta,R., Robusto,M., Plate,M., Santoro,C., Peyvandi,F. and
            Duga,S.
  TITLE     Molecular characterization of 7 patients affected by dys- or
            hypo-dysfibrinogenemia: Identification of a novel mutation in the
            fibrinogen Bbeta chain causing a gain of glycosylation
  JOURNAL   Thromb Res 136 (1), 168-174 (2015)
   PUBMED   26006300
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Longstaff,C. and Kolev,K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Courtney,M.A., Stoler,M.H., Marder,V.J. and Haidaris,P.J.
  TITLE     Developmental expression of mRNAs encoding platelet proteins in rat
            megakaryocytes
  JOURNAL   Blood 77 (3), 560-568 (1991)
   PUBMED   1991167
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Morgan,J.G., Holbrook,N.J. and Crabtree,G.R.
  TITLE     Nucleotide sequence of the gamma chain gene of rat fibrinogen:
            conserved intronic sequences
  JOURNAL   Nucleic Acids Res 15 (6), 2774-2776 (1987)
   PUBMED   3562236
REFERENCE   8  (bases 1 to 1554)
  AUTHORS   Fowlkes,D.M., Mullis,N.T., Comeau,C.M. and Crabtree,G.R.
  TITLE     Potential basis for regulation of the coordinately expressed
            fibrinogen genes: homology in the 5' flanking regions
  JOURNAL   Proc Natl Acad Sci U S A 81 (8), 2313-2316 (1984)
   PUBMED   6232608
REFERENCE   9  (bases 1 to 1554)
  AUTHORS   Hawiger,J., Timmons,S., Kloczewiak,M., Strong,D.D. and
            Doolittle,R.F.
  TITLE     gamma and alpha chains of human fibrinogen possess sites reactive
            with human platelet receptors
  JOURNAL   Proc Natl Acad Sci U S A 79 (6), 2068-2071 (1982)
   PUBMED   6281794
REFERENCE   10 (bases 1 to 1554)
  AUTHORS   Olexa,S.A. and Budzynski,A.Z.
  TITLE     Localization of a fibrin polymerization site
  JOURNAL   J Biol Chem 256 (7), 3544-3549 (1981)
   PUBMED   6451630
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078893.1.
            
            On Mar 13, 2005 this sequence version replaced NM_012559.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078893.1, FQ219511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..1554
                     /gene="Fgg"
                     /note="fibrinogen gamma chain"
                     /db_xref="GeneID:24367"
                     /db_xref="RGD:2613"
     exon            1..101
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1340
                     /gene="Fgg"
                     /note="fibrinogen, gamma polypeptide"
                     /codon_start=1
                     /product="fibrinogen gamma chain precursor"
                     /protein_id="NP_036691.2"
                     /db_xref="GeneID:24367"
                     /db_xref="RGD:2613"
                     /translation="MNWSLQLRSFILCWALLLLSPTGLAQYTATRDNCCILDERFGSY
                     CPTTCGISDFLNSYQTDVDTDLQTLENILQRAENRTTEAKELIKAIQVYYNPDQPPKP
                     GMIEGATQKSKKMVEEILKYEALLLTHESSIRYLQDIYTSNKQKITNLKQKVAQLEAQ
                     CQEPCKDSVRIHDTTGKDCQDIANKGAKESGLYFIRPLKATQQFLVYCEIDGSGNGWT
                     VLQKRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISMQSTIPYALRIQL
                     KDWSGRTSTADYAMFRVGPESDKYRLTYAYFIGGDAGDAFDGYDFGDDPSDKFFTSHN
                     GMHFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYYQGGTYSKSSTPNGYDNG
                     IIWATWKTRWYSMKETTMKIIPFNRLSIGDGQQHHMGGSKQVGDM"
     exon            102..149
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            150..333
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            334..427
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            428..558
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            559..692
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            693..877
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1155
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1325
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1529
                     /gene="Fgg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggagcac cggtcaccca gacactatga attggtcctt gcaactccgg agtttcattc
       61 tatgctgggc gcttttacta ctttctccaa cgggcctggc acagtacact gctactagag
      121 ataactgttg catcctagat gagagattcg gtagttactg cccaaccact tgtggcatct
      181 cagacttcct gaattcttac caaaccgacg tggacactga cctccagact ctggaaaaca
      241 tcttacaacg agctgaaaac agaaccacag aagccaagga actgattaaa gccatccagg
      301 tttactacaa cccagaccaa cccccaaagc cgggtatgat agagggtgcc actcagaagt
      361 ctaagaagat ggtagaagaa atcttgaagt acgaagcact gttactaacc catgagtcga
      421 gtatccggta tttacaggac atctatactt caaataagca gaagatcacg aacctgaaac
      481 agaaggtggc ccagcttgaa gctcagtgcc aggagccttg caaggactct gtgcgaatcc
      541 atgacacaac cggaaaagat tgtcaggata tcgccaacaa gggtgccaaa gaaagtggac
      601 tttacttcat tcggcctttg aaagccacgc agcagttctt agtgtactgt gaaatcgacg
      661 gatctggaaa tggctggacc gtattgcaga agaggcttga tggcagtgtg gatttcaaga
      721 agaactggat tcagtataaa gaaggatttg gacacctgtc acctactggc accacagagt
      781 tttggctggg caatgagaag attcatctga taagcatgca gtccaccatc ccatacgcac
      841 tgagaataca gctcaaagac tggagtggca ggaccagcac cgcggactat gccatgttca
      901 gggtgggtcc tgaatccgac aaataccgcc tgacctatgc ctacttcatt ggcggagatg
      961 ccggggatgc cttcgacggc tacgattttg gtgatgatcc cagtgacaag tttttcacat
     1021 cccacaacgg catgcacttc agtacctggg acaatgacaa cgacaagttc gaaggcaact
     1081 gtgctgagca ggatggatct ggctggtgga tgaacaagtg tcacgctggc cacctcaatg
     1141 gagtttatta ccaaggtggc acttactcca agtcatctac tcctaacggt tatgacaatg
     1201 gcattatttg ggccacctgg aaaacccgct ggtattccat gaaggaaacc accatgaaga
     1261 taattccctt caacagactc tccattggag atgggcagca acatcacatg ggaggatcca
     1321 aacaggttgg agacatgtaa agaacatttc caaggtgatt tgctctttta acggacttta
     1381 tccaagcaga gagatatatt tttcctatga gaccatggaa cctcacttcc tttacagagt
     1441 taatgggatc catgatgcaa actccattag cagttttatg ctggcgataa tttatctaca
     1501 tgcatttcaa taaacatttt gtttcctaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
