LOCUS       NM_199114               2351 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor receptor-like 1
            (Fgfrl1), mRNA.
ACCESSION   NM_199114 XM_341178
VERSION     NM_199114.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2351)
  AUTHORS   Dingemann,J., Doi,T., Ruttenstock,E.M. and Puri,P.
  TITLE     Downregulation of FGFRL1 contributes to the development of the
            diaphragmatic defect in the nitrofen model of congenital
            diaphragmatic hernia
  JOURNAL   Eur J Pediatr Surg 21 (1), 46-49 (2011)
   PUBMED   20938900
  REMARK    GeneRIF: downregulation of the FGFRL1 gene during the late stages
            of gestation may contribute to the development of the diaphragmatic
            defect in nitrofen-induced CDH
            Erratum:[Eur J Pediatr Surg. 2014 Aug;24(4):e5]
REFERENCE   2  (bases 1 to 2351)
  AUTHORS   Catela,C., Bilbao-Cortes,D., Slonimsky,E., Kratsios,P.,
            Rosenthal,N. and Te Welscher,P.
  TITLE     Multiple congenital malformations of Wolf-Hirschhorn syndrome are
            recapitulated in Fgfrl1 null mice
  JOURNAL   Dis Model Mech 2 (5-6), 283-294 (2009)
   PUBMED   19383940
REFERENCE   3  (bases 1 to 2351)
  AUTHORS   Rieckmann,T., Kotevic,I. and Trueb,B.
  TITLE     The cell surface receptor FGFRL1 forms constitutive dimers that
            promote cell adhesion
  JOURNAL   Exp Cell Res 314 (5), 1071-1081 (2008)
   PUBMED   18061161
REFERENCE   4  (bases 1 to 2351)
  AUTHORS   Baertschi,S., Zhuang,L. and Trueb,B.
  TITLE     Mice with a targeted disruption of the Fgfrl1 gene die at birth due
            to alterations in the diaphragm
  JOURNAL   FEBS J 274 (23), 6241-6253 (2007)
   PUBMED   17986259
REFERENCE   5  (bases 1 to 2351)
  AUTHORS   Baier,P., Wolf-Vorbeck,G., Hempel,S., Hopt,U.T. and von
            Dobschuetz,E.
  TITLE     Effect of liver regeneration after partial hepatectomy and
            ischemia-reperfusion on expression of growth factor receptors
  JOURNAL   World J Gastroenterol 12 (24), 3835-3840 (2006)
   PUBMED   16804967
  REMARK    GeneRIF: EGFR, FGFR and TNFR1 mRNA expression was equal or lower
            than in resting liver, HGFR expression after I/R was stronger than
            in the control.
REFERENCE   6  (bases 1 to 2351)
  AUTHORS   Antoine,M., Wirz,W., Tag,C.G., Mavituna,M., Emans,N., Korff,T.,
            Stoldt,V., Gressner,A.M. and Kiefer,P.
  TITLE     Expression pattern of fibroblast growth factors (FGFs), their
            receptors and antagonists in primary endothelial cells and vascular
            smooth muscle cells
  JOURNAL   Growth Factors 23 (2), 87-95 (2005)
   PUBMED   16019430
  REMARK    GeneRIF: Analysis of Fgf18 and Fgfr5 (Fgfrl1) expression in primary
            endothelial cells and vascular smooth muscle cells.
REFERENCE   7  (bases 1 to 2351)
  AUTHORS   Trueb,B., Zhuang,L., Taeschler,S. and Wiedemann,M.
  TITLE     Characterization of FGFRL1, a novel fibroblast growth factor (FGF)
            receptor preferentially expressed in skeletal tissues
  JOURNAL   J Biol Chem 278 (36), 33857-33865 (2003)
   PUBMED   12813049
REFERENCE   8  (bases 1 to 2351)
  AUTHORS   Sleeman,M., Fraser,J., McDonald,M., Yuan,S., White,D.,
            Grandison,P., Kumble,K., Watson,J.D. and Murison,J.G.
  TITLE     Identification of a new fibroblast growth factor receptor, FGFR5
  JOURNAL   Gene 271 (2), 171-182 (2001)
   PUBMED   11418238
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ536020.1.
            
            On Jan 1, 2004 this sequence version replaced XM_341178.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ536020.1, BC097261.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132297,
                                           SAMEA5756307 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2351
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /note="fibroblast growth factor receptor-like 1"
                     /db_xref="GeneID:360903"
                     /db_xref="RGD:735156"
     exon            1..209
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1732
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /EC_number="3.2.1.76"
                     /function="putative role in fibroblast growth factor
                     signaling"
                     /note="fibroblast growth factor receptor 5; fibroblast
                     growth factor receptor-like protein; FGF receptor-like
                     protein 1; alpha-L-iduronidase"
                     /codon_start=1
                     /product="fibroblast growth factor receptor-like 1
                     precursor"
                     /protein_id="NP_954545.1"
                     /db_xref="GeneID:360903"
                     /db_xref="RGD:735156"
                     /translation="MTRSPALLLLLLGALPSAEAARGPPRMADKVVPRQVARLGRTVR
                     LQCPVEGDPPPLTMWTKDGRTIHSGWSRFRVLPQGLKVKEVEAEDAGVYVCKATNGFG
                     SLSVNYTLIIMDDISPGKENPGPGGSSGGQEDPVSQQWARPRFTQPSKMRRRVIARPV
                     GSSVRLKCVASGHPRPDIMWMKDDQTLTRLEASEHRKKKWTLSLKNLKPEDSGKYTCR
                     VSNRAGAINATYKVDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDVKPVIQW
                     LKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRARQDDAGMYIC
                     LGANTMGYSFRSAFLTVLPDPKPPGPPVAHSSSTTSLPWPVVIGIPAGAVFILGTVLL
                     WLCQTKKKPCAPASTLPVPGHRPPGTSRERSGDKDLPSLAVGICEEHGSTMAPQHILA
                     PGSTAGPKLYPKLYTDVHTHTHTHTCTHTLSCGGQGSSAPACPLSVLNTANLQALCPE
                     VGVWGPRQQVGRIENNGGRVS"
     exon            210..482
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /inference="alignment:Splign:2.1.0"
     exon            483..563
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /inference="alignment:Splign:2.1.0"
     exon            564..848
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1202
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..2351
                     /gene="Fgfrl1"
                     /gene_synonym="Fgfr5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcctttgc ctggagctcg gcgccgaggg gggccggacc ctggctctgt ggccgcgacc
       61 tgggtcttgc gggcctgagc cctgagtggc gtccagtcca gctcccagtg accgcgcccc
      121 tactagaggt ccgaacggcg agatgacgcg gagccccgcg ctgctgctgc tgctattggg
      181 ggccctcccg tcggctgagg cggcgcgagg acccccaaga atggcagaca aagtggtccc
      241 acggcaggtg gcccgcctgg gccgcactgt gcggctacag tgcccagtgg agggggaccc
      301 accaccgttg accatgtgga ccaaagatgg ccgcacgatc cacagtggct ggagccgctt
      361 ccgtgtgctg ccccaggggc tgaaggtgaa ggaggtggag gccgaggatg ccggtgttta
      421 tgtgtgcaag gccaccaatg gcttcggcag cctcagcgtc aactatactc tcatcatcat
      481 ggatgacatt agtccaggga aggagaaccc tggaccaggt ggctcttctg ggggccagga
      541 agacccagtc agccagcagt gggcacggcc tcgcttcaca cagccctcca agatgaggcg
      601 ccgagtgatt gcacggcccg tgggtagctc tgtgcggctc aagtgtgtgg ccagtgggca
      661 cccacggcct gacatcatgt ggatgaagga tgaccagacc ttgacacgtc tagaggccag
      721 tgaacacaga aagaagaagt ggacgctgag cttgaagaac ctgaagcctg aagacagtgg
      781 caagtacacg tgccgtgtat ccaaccgggc aggtgccatc aacgccacct acaaagtgga
      841 tgtaatccag cgtactcgtt ccaagcctgt gctcacgggg acacaccctg tgaacacaac
      901 ggtggacttc ggtgggacaa cgtccttcca gtgcaaggtg cgcagcgacg tgaagcctgt
      961 gatccaatgg ctaaagcggg tggagtacgg ctctgagggt cgccacaact ccaccattga
     1021 tgtgggtggc cagaagtttg tggtgttgcc cacgggtgat gtgtggtcac ggcctgacgg
     1081 ctcctacctc aacaagctgc tcatctctcg ggcccgccag gatgatgctg gcatgtacat
     1141 ctgcctgggt gcaaacacca tgggctacag tttccgtagc gccttcctca ctgtattacc
     1201 agaccccaaa cctccagggc ctcctgtggc tcattcatcc tcaaccacca gcctgccgtg
     1261 gcctgtggtg atcggcatcc cagcaggtgc tgtcttcatc ctaggcacgg tgttgctctg
     1321 gctttgccag actaagaaga agccatgtgc ccctgcatcc acacttcctg tgcctgggca
     1381 tcgtccccca gggacatccc gagaacgcag tggtgacaag gacctgccct cattggctgt
     1441 gggcatatgt gaggagcatg gatccaccat ggccccccag cacatcctgg ccccaggctc
     1501 aactgccggc cccaagctgt accctaagct gtacacagat gtgcacacgc acacgcatac
     1561 gcacacatgc acacacacgc tctcatgtgg agggcaaggc tcatcagcac cagcatgtcc
     1621 actatcagtg ctaaatacag ccaatctcca agcactgtgt cccgaggtgg gcgtatgggg
     1681 gccaaggcag caggttggga ggattgagaa caatggagga agagtatctt agggtgccct
     1741 gcgtgcagta ggcactcaca agcttggcca tataggtgga tggatgtact accagatgaa
     1801 ccgacagcca gacccacacg cacatattta aagtgtaaat gtgtgcacac gtgcacacac
     1861 aacctgagaa acctccagga ggatttatgg tgtgactttg tagtgacatg tagcgatggc
     1921 tagttgaagg acgactctcc ctcaagtctt agtggtcatg gccacttccc caccccctac
     1981 ccacctgtgc tcctgccctc catggtgtac ctggtgtacc tccatgtgcc ctgggtgtcc
     2041 aggagcctac cagcaacctg actggggtga gctgtgcagc catgcctgga ggtttgagcc
     2101 acacgcccct tgctagagag aagggcctcg atatttatat ttaagaatga aataatatta
     2161 ataataatgt aaggagggct gggacacagg aattctggcc ttccctgggg cctgggacct
     2221 gcctggcctt gtggttacat tgggtatcct cactgtccat ggctgcctgg tctctgtaat
     2281 tttatataga gtttgagctg aagcctcgta tatttaattt attttgttaa acaagaaagt
     2341 gcctcctttt t
//
