LOCUS       NM_001109904            3164 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus fibroblast growth factor receptor 4 (Fgfr4),
            mRNA.
ACCESSION   NM_001109904 XM_001066753 XM_001066809 XM_344570
VERSION     NM_001109904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Sootome,H., Fujita,H., Ito,K., Ochiiwa,H., Fujioka,Y., Ito,K.,
            Miura,A., Sagara,T., Ito,S., Ohsawa,H., Otsuki,S., Funabashi,K.,
            Yashiro,M., Matsuo,K., Yonekura,K. and Hirai,H.
  TITLE     Futibatinib Is a Novel Irreversible FGFR 1-4 Inhibitor That Shows
            Selective Antitumor Activity against FGFR-Deregulated Tumors
  JOURNAL   Cancer Res 80 (22), 4986-4997 (2020)
   PUBMED   32973082
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Yamauchi,M., Ono,A., Ishikawa,A., Kodama,K., Uchikawa,S.,
            Hatooka,H., Zhang,P., Teraoka,Y., Morio,K., Fujino,H., Nakahara,T.,
            Murakami,E., Miki,D., Kawaoka,T., Tsuge,M., Hiramatsu,A.,
            Imamura,M., Hayes,C.N., Fujita,M., Nakagawa,H., Yasui,W., Aikata,H.
            and Chayama,K.
  TITLE     Tumor Fibroblast Growth Factor Receptor 4 Level Predicts the
            Efficacy of Lenvatinib in Patients With Advanced Hepatocellular
            Carcinoma
  JOURNAL   Clin Transl Gastroenterol 11 (5), e00179 (2020)
   PUBMED   32677805
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Quintanal-Villalonga,A., Ojeda-Marquez,L., Marrugal,A., Yague,P.,
            Ponce-Aix,S., Salinas,A., Carnero,A., Ferrer,I., Molina-Pinelo,S.
            and Paz-Ares,L.
  TITLE     The FGFR4-388arg Variant Promotes Lung Cancer Progression by
            N-Cadherin Induction
  JOURNAL   Sci Rep 8 (1), 2394 (2018)
   PUBMED   29402970
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Leifheit-Nestler,M., Grabner,A., Hermann,L., Richter,B.,
            Schmitz,K., Fischer,D.C., Yanucil,C., Faul,C. and Haffner,D.
  TITLE     Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and
            hypertrophy in uremic rats
  JOURNAL   Nephrol Dial Transplant 32 (9), 1493-1503 (2017)
   PUBMED   28339837
  REMARK    GeneRIF: High FGFr4 expression is associated with cardiac
            hypertrophy.
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Shi,S., Li,X., You,B., Shan,Y., Cao,X. and You,Y.
  TITLE     High Expression of FGFR4 Enhances Tumor Growth and Metastasis in
            Nasopharyngeal Carcinoma
  JOURNAL   J Cancer 6 (12), 1245-1254 (2015)
   PUBMED   26535066
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   Xie,M.H., Holcomb,I., Deuel,B., Dowd,P., Huang,A., Vagts,A.,
            Foster,J., Liang,J., Brush,J., Gu,Q., Hillan,K., Goddard,A. and
            Gurney,A.L.
  TITLE     FGF-19, a novel fibroblast growth factor with unique specificity
            for FGFR4
  JOURNAL   Cytokine 11 (10), 729-735 (1999)
   PUBMED   10525310
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Weinstein,M., Xu,X., Ohyama,K. and Deng,C.X.
  TITLE     FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in
            the murine lung
  JOURNAL   Development 125 (18), 3615-3623 (1998)
   PUBMED   9716527
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Horlick,R.A., Stack,S.L. and Cooke,G.M.
  TITLE     Cloning, expression and tissue distribution of the gene encoding
            rat fibroblast growth factor receptor subtype 4
  JOURNAL   Gene 120 (2), 291-295 (1992)
   PUBMED   1398143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB743466.1 and BC100260.1.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_344570.3, XM_001066753.1, XM_001066809.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC100260.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMD00132261,
                                    SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-397               CB743466.1         53-449
            398-3164            BC100260.1         490-3256
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..3164
                     /gene="Fgfr4"
                     /note="fibroblast growth factor receptor 4"
                     /db_xref="GeneID:25114"
                     /db_xref="RGD:2612"
     exon            1..123
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            124..257
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..2578
                     /gene="Fgfr4"
                     /EC_number="2.7.10.1"
                     /note="FGFR-4"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 4 precursor"
                     /protein_id="NP_001103374.1"
                     /db_xref="GeneID:25114"
                     /db_xref="RGD:2612"
                     /translation="MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTV
                     ALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARG
                     SMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPA
                     GNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTY
                     TCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPH
                     IQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNS
                     IGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQA
                     IHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSL
                     DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNAS
                     DKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPP
                     GPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVM
                     KIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFT
                     LGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEA
                     LDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQ
                     TT"
     exon            258..521
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            522..599
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            600..766
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..890
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1081
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1220
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1420
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1566
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1688
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1799
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1990
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2113
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2184
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2322
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2428
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..3142
                     /gene="Fgfr4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtagttgc agggacattc ctggctcttc ggcccggggc ggaggagctc caggcgggtg
       61 agtgtgccag ccctgccggg atcgtgaccc ccgagcacgg gaaccgggtg gcggaggagc
      121 caggaaggtg gtcagcggga agtctggcct gggtcccgag aacagctgga aggaaatgtg
      181 gctgctgttg gctttgttga gcatctttca ggagacacca gccttctccc ttgaggcctc
      241 tgaggaaatg gaacaggagc cctgcccagc cccaatctcg gagcagcaag agcaggtgtt
      301 gactgtggcc cttgggcagc ctgtgcggct atgctgtggc cgcactgagc gtggtcgtca
      361 ttggtacaag gagggcagcc gtttagcatc tgctgggaga gtacggggct ggagaggccg
      421 cctggagatc gccagcttcc ttcctgagga tgctggccgg tacctctgcc tggcccgtgg
      481 ctccatgact gtcgtacaca atcttacttt gattatggat gactccttac cctccatcaa
      541 taacgaggac cccaagaccc tcagcagctc ctcgagtggg cactcctacc tgcagcaagc
      601 accttactgg acacaccccc aacgcatgga gaagaaactg cacgcggtac ctgccgggaa
      661 cactgtcaaa ttccgctgtc cagctgcagg gaaccccatg cccaccatcc actggctcaa
      721 gaacggacag gccttccacg gagagaatcg tatcggaggc attcggctgc gtcaccaaca
      781 ctggagcctc gtgatggaga gcgtggtgcc ctcagaccgt ggcacgtaca cgtgtcttgt
      841 ggagaactct ctgggtagca ttcgctacag ctatctgctg gatgtgctgg agcggtcccc
      901 gcaccggccc atcctgcagg cgggactccc agccaacacc acggctgtgg ttggcagcaa
      961 cgtggagctg ctgtgcaagg tgtacagtga cgcccagccg cacatccagt ggctgaagca
     1021 catcgttatc aacggcagca gtttcggcgc tgatggtttc ccctacgtac aagtcctgaa
     1081 gacaacagac atcaatagct cagaggtgga ggtgctgtat ctgaggaacg tgtcggctga
     1141 ggatgcaggg gagtacacct gcctggcggg caactccatc ggcctctcct accagtcagc
     1201 gtggctcaca gtgctacccg cagaggaaga agacctcgcg tggacaacag caacatcgga
     1261 ggccagatat acagatatta tcctatatgt atctggctca ctggctttgg ttttgctcct
     1321 gctgctggcc ggggtgtatc accgacaagc aatccacggc caccactctc gacagcctgt
     1381 cactgtacag aagctgtccc ggttcccttt ggcccggcag ttctccttgg agtcgaggtc
     1441 ctctggcaag tcaagtttgt ccctggtgcg aggtgtccgg ctctcctcca gtggcccgcc
     1501 cttgctcacg ggccttgtga gtctagacct acctctcgat ccactttggg agttcccccg
     1561 ggacaggctg gtgctcggaa agcccctggg tgagggctgc tttgggcaag tggttcgtgc
     1621 agaagccctt ggcatggatt cctcccggcc agaccaaacc agcaccgtgg ctgtgaagat
     1681 gctgaaagac aatgcctccg acaaggattt ggcagacctg atctctgaga tggagatgat
     1741 gaagctaatc ggaagacaca agaacatcat taacctgctg ggtgtctgca ctcaggaagg
     1801 gcccctgtat gtgattgtgg aatatgcggc caagggaaac cttcgggaat tcctccgtgc
     1861 ccggcgtccc ccaggccctg atctcagccc tgatgggcct cggagcagcg aaggaccgct
     1921 ctccttcccg gccctggtct cctgtgccta ccaggtggcc cgaggcatgc agtatctgga
     1981 gtctcggaag tgcatccacc gggacctggc tgcccgaaac gtgctggtga ccgaggatga
     2041 cgtgatgaag atcgctgact ttggtctggc ccgtggtgtc caccacatcg actactataa
     2101 gaaaaccagc aatggccgcc tgccagtcaa gtggatggct cctgaggcgt tgtttgaccg
     2161 tgtatacaca caccagagtg acgtgtggtc cttcgggatc ctgctgtggg aaatcttcac
     2221 cctcgggggc tccccatacc ccggcatccc agtggaggag ctgttctcac tgctgcgaga
     2281 ggggcacagg atggagcggc ccccaaactg cccctcagag ctgtatgggc taatgaggga
     2341 gtgttggcac gcagctcctt ctcagaggcc gacttttaag cagctggtgg aagctctgga
     2401 caaggtcctg ctggctgtct ctgaagagta ccttgacctc cgcctgacct ttggacccta
     2461 ttcccccaac aatggggatg ccagcagcac gtgctcctcc agcgactcgg ttttcagcca
     2521 cgaccctttg cccctcgagc caagcccctt cccatttcct gaggcgcaga ccacatgagc
     2581 ctgggaacga tgttgcatgg gctcgtaggc ccgtggccgt gggactccaa cctgtttcat
     2641 cagcatttga cgttggcact gtcatcaggc ctctgactcg aggctactgc tggcccagat
     2701 cctctctctg gccctgtttt ggggaggccc attcttggtc ttggggttca cagttgaggc
     2761 cttctgttcc aaacttatgt tcccagctca gagttcaact cctcgtctca agatcatggt
     2821 cgtgcccttg gactcatcct caaaggagcg aagcattaag gccttgacac ttagcctcca
     2881 ccccaggggc tctccgggcc tgactgcaaa tctttggtcc taaacatttc tagctcccca
     2941 aacaacctag aggcctcggg acttcactgc acccccgccc ccgcagccca caagcctcgc
     3001 caccctggtc cccaactccc cactgcttgt tctagcatct tgttgaagga gcctcagctc
     3061 tggtgtcctt gagagacgag aagcctgtgg aaaagacaga agaacaaggc attttataaa
     3121 ttattattat tttttgaaat aaaaaaaaaa aaaaaaaaaa aaaa
//
