LOCUS       NM_053429               4203 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor receptor 3 (Fgfr3),
            mRNA.
ACCESSION   NM_053429 XM_006251396
VERSION     NM_053429.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4203)
  AUTHORS   Li,A., Tian,J., Yang,J., Ren,X., Zhou,Z. and Zhou,W.
  TITLE     Expression of fibroblast growth factor 9 and its receptors in the
            dentate gyrus of hippocampus in poststroke depression rats
  JOURNAL   Neuroreport 32 (4), 321-325 (2021)
   PUBMED   33470768
  REMARK    GeneRIF: Expression of fibroblast growth factor 9 and its receptors
            in the dentate gyrus of hippocampus in poststroke depression rats.
REFERENCE   2  (bases 1 to 4203)
  AUTHORS   Gillison,M.L., Akagi,K., Xiao,W., Jiang,B., Pickard,R.K.L., Li,J.,
            Swanson,B.J., Agrawal,A.D., Zucker,M., Stache-Crain,B., Emde,A.K.,
            Geiger,H.M., Robine,N., Coombes,K.R. and Symer,D.E.
  TITLE     Human papillomavirus and the landscape of secondary genetic
            alterations in oral cancers
  JOURNAL   Genome Res 29 (1), 1-17 (2019)
   PUBMED   30563911
REFERENCE   3  (bases 1 to 4203)
  AUTHORS   Bersani,C., Haeggblom,L., Ursu,R.G., Giusca,S.E., Marklund,L.,
            Ramqvist,T., Nasman,A. and Dalianis,T.
  TITLE     Overexpression of FGFR3 in HPV-positive Tonsillar and Base of
            Tongue Cancer Is Correlated to Outcome
  JOURNAL   Anticancer Res 38 (8), 4683-4690 (2018)
   PUBMED   30061236
REFERENCE   4  (bases 1 to 4203)
  AUTHORS   Liu,H., Fang,Q., Wang,M., Wang,W., Zhang,M., Zhang,D., He,Y.,
            Zhang,Y., Wang,H., Otero,M., Ma,T. and Chen,J.
  TITLE     FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes:
            Association with chondrocyte death in deep zone of Kashin-Beck
            disease
  JOURNAL   Biochem Biophys Res Commun 500 (2), 184-190 (2018)
   PUBMED   29626475
  REMARK    GeneRIF: FGF8 and FGFR3 may therefore play an important role in the
            onset of deep zone necrosis and pathogenesis in Kashin-Beck disease
            in adolescent children.
REFERENCE   5  (bases 1 to 4203)
  AUTHORS   Robinson,J.W., Egbert,J.R., Davydova,J., Schmidt,H., Jaffe,L.A. and
            Potter,L.R.
  TITLE     Dephosphorylation is the mechanism of fibroblast growth factor
            inhibition of guanylyl cyclase-B
  JOURNAL   Cell Signal 40, 222-229 (2017)
   PUBMED   28964968
  REMARK    GeneRIF: We conclude that FGF rapidly inactivates GC-B by a
            reversible dephosphorylation mechanism, which may contribute to the
            signaling network by which activated FGFR3 causes dwarfism.
REFERENCE   6  (bases 1 to 4203)
  AUTHORS   Delezoide,A.L., Lasselin-Benoist,C., Legeai-Mallet,L., Brice,P.,
            Senee,V., Yayon,A., Munnich,A., Vekemans,M. and Bonaventure,J.
  TITLE     Abnormal FGFR 3 expression in cartilage of thanatophoric dysplasia
            fetuses
  JOURNAL   Hum Mol Genet 6 (11), 1899-1906 (1997)
   PUBMED   9302269
REFERENCE   7  (bases 1 to 4203)
  AUTHORS   Miyake,A., Hattori,Y., Ohta,M. and Itoh,N.
  TITLE     Rat oligodendrocytes and astrocytes preferentially express
            fibroblast growth factor receptor-2 and -3 mRNAs
  JOURNAL   J Neurosci Res 45 (5), 534-541 (1996)
   PUBMED   8875318
REFERENCE   8  (bases 1 to 4203)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   9  (bases 1 to 4203)
  AUTHORS   Meyers,G.A., Orlow,S.J., Munro,I.R., Przylepa,K.A. and Jabs,E.W.
  TITLE     Fibroblast growth factor receptor 3 (FGFR3) transmembrane mutation
            in Crouzon syndrome with acanthosis nigricans
  JOURNAL   Nat Genet 11 (4), 462-464 (1995)
   PUBMED   7493034
REFERENCE   10 (bases 1 to 4203)
  AUTHORS   Rousseau,F., Bonaventure,J., Legeai-Mallet,L., Pelet,A.,
            Rozet,J.M., Maroteaux,P., Le Merrer,M. and Munnich,A.
  TITLE     Mutations in the gene encoding fibroblast growth factor receptor-3
            in achondroplasia
  JOURNAL   Nature 371 (6494), 252-254 (1994)
   PUBMED   8078586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_006251396.4, NM_053429.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.35198.1,
                                           SRR26643429.47120.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000014.1  81227031-81227209   c
            180-371             JAXUCZ010000014.1  81226484-81226675   c
            372-641             JAXUCZ010000014.1  81220834-81221103   c
            642-695             JAXUCZ010000014.1  81220478-81220531   c
            696-865             JAXUCZ010000014.1  81218943-81219112   c
            866-989             JAXUCZ010000014.1  81218735-81218858   c
            990-1180            JAXUCZ010000014.1  81218462-81218652   c
            1181-1325           JAXUCZ010000014.1  81216562-81216706   c
            1326-1516           JAXUCZ010000014.1  81215894-81216084   c
            1517-1662           JAXUCZ010000014.1  81215402-81215547   c
            1663-1784           JAXUCZ010000014.1  81215077-81215198   c
            1785-1895           JAXUCZ010000014.1  81214885-81214995   c
            1896-2086           JAXUCZ010000014.1  81214619-81214809   c
            2087-2209           JAXUCZ010000014.1  81214380-81214502   c
            2210-2280           JAXUCZ010000014.1  81214226-81214296   c
            2281-2418           JAXUCZ010000014.1  81213891-81214028   c
            2419-2524           JAXUCZ010000014.1  81213654-81213759   c
            2525-4203           JAXUCZ010000014.1  81211800-81213478   c
FEATURES             Location/Qualifiers
     source          1..4203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..4203
                     /gene="Fgfr3"
                     /note="fibroblast growth factor receptor 3"
                     /db_xref="GeneID:84489"
                     /db_xref="RGD:620714"
     exon            1..179
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            180..371
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2671
                     /gene="Fgfr3"
                     /EC_number="2.7.10.1"
                     /note="tyrosine kinase receptor"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 3 precursor"
                     /protein_id="NP_445881.2"
                     /db_xref="GeneID:84489"
                     /db_xref="RGD:620714"
                     /translation="MVVPACVLVFCVAVVAGVTSEPPGPEQRVGRRAAEVPGPEPSQQ
                     EQVAFGSGDTVELSCHPPGGAPTGPTLWAKDGVGLVASHRILVGPQRLQVLNATHEDA
                     GVYSCQQRLTRRVLCHFSVRVTDAPSSGDDEDGEDVAEDTGAPYWTRPERMDKKLLAV
                     PAANTVRFRCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRG
                     NYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQ
                     PHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDRELEVLSLHNVTFEDAGEYTCL
                     AGNSIGFSHHSAWLVVLPAEEELMEVDEAGSVYAGVLSYGVGFFLFILVVAAVTLCRL
                     RSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRIARLSSGEGPVLANVSE
                     LELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDA
                     TDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP
                     PGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV
                     MKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF
                     TLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAVPSQRPTFKQLVE
                     DLDRILTVTSTDEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTHDLLPPGPPSNGGP
                     RT"
     exon            372..641
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            642..695
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..865
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..989
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1180
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1325
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1516
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1662
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1784
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1895
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2086
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2209
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2280
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2418
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2524
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..4203
                     /gene="Fgfr3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgagctgt ggcagcgggg gtggcgggag cagctggcgc cgtgcggtcc gctccggcga
       61 ggggactcac cggtggggtg ggcggccggc cactgggaca gaggagagcc tggaagagcc
      121 ggccgagagc cgaagccgga gccgcgagtg gtgagctggg ctctagcggc ggccgccagt
      181 ctccgcagcg gcgccggagc cgggtgtggg gggttgcagc atgcccgcgc gcatcgcttg
      241 aggacgccac ggccccagct ccggagccat ggtagtcccg gcctgcgtgc tagtgttctg
      301 cgtggcggtc gtggctggag ttacttccga gcctcccggt ccagagcagc gagttggtcg
      361 gagagcggca gaggttccag ggcctgaacc tagccagcag gagcaggtgg ccttcggcag
      421 tggggacact gtggagctga gctgccatcc gcctggaggt gcccccacag gccccactct
      481 ctgggctaag gacggtgtgg ggctggtggc ctcccaccgt atcctggtgg ggcctcagag
      541 gcttcaagtg ctaaacgcca cccatgagga tgctggggtc tacagctgcc agcagcggct
      601 aacccggcgt gtgctgtgcc actttagtgt gcgtgtgaca gatgctccgt cctcaggaga
      661 tgacgaagat ggggaggacg tggctgaaga cacaggggct ccttactgga ctcgaccgga
      721 gcgtatggat aagaaactgc tggctgtgcc agctgcaaac actgtacgct tccgctgccc
      781 agctgctggc aaccccaccc cctccatctc ctggctgaag aacggcaaag aattccgagg
      841 ggagcaccgc attgggggca ttaagctccg gcaccagcag tggagcttgg tcatggaaag
      901 tgtggtgccc tctgaccgcg gcaattacac ctgcgtggtt gagaacaagt ttggcagcat
      961 ccggcagacg tacaccctgg atgtgctgga gcgctcccca caccggccca tcctgcaggc
     1021 tgggctgcca gccaaccaga cagccgttct gggcagtgac gtggagttcc actgcaaggt
     1081 gtacagcgac gcacagccac acatccagtg gctgaagcac gtggaggtga atgggagcaa
     1141 ggtgggccct gacggcacgc cctacgtcac tgtactcaag actgcaggag ctaacaccac
     1201 cgacagggag ctagaggttc tgtccttgca caatgtcacc tttgaggatg cgggggagta
     1261 cacctgcctg gcgggcaatt ctatcgggtt ttcccatcac tctgcgtggc tggtggtgct
     1321 gccagccgag gaggagctga tggaagttga cgaggctggc agcgtgtacg cgggtgtcct
     1381 cagctacggg gtgggcttct tcctcttcat cctggtggtg gcggcagtga cgctctgccg
     1441 tctgcgcagt cccccaaaga agggcctggg ctcgcccacc gtgcacaagg tctctcgctt
     1501 cccgcttaag cgacaggtgt ccttggagtc taattcctct atgaactcca acacacctct
     1561 cgtccggatt gcccggctgt cctcaggaga aggtcctgtc ctggccaatg tttctgaact
     1621 tgagctgcct gctgacccca agtgggagct atccaggacc cggctgacac tcggtaagcc
     1681 tcttggagaa ggctgctttg gacaggttgt catggcagaa gctattggca tcgacaagga
     1741 ccgcactgcc aagcctgtca ccgtggccgt gaagatgctg aaagatgatg ccactgacaa
     1801 ggacctgtcg gacctggtgt ctgagatgga gatgatgaaa atgattggca agcacaagaa
     1861 catcattaac ctgttggggg cctgcaccca gggtgggccc ctgtatgtgc tggtggagta
     1921 tgcagccaag ggcaacctgc gagagttcct ccgggcacgg cggcctccag gcatggatta
     1981 ctcctttgat gcctgcaggc tgccagagga acagctcacc tgcaaggatc tggtgtcctg
     2041 tgcctaccag gtggcacggg gcatggagta cttggcttcc cagaagtgta ttcacagaga
     2101 cctggctgcc agaaacgtgc tggtgactga ggacaatgtg atgaagattg cagactttgg
     2161 cctggcccga gatgtgcaca acctggatta ctacaagaag accacaaatg gccggctacc
     2221 tgtgaagtgg atggcaccag aggccctttt tgaccgagtc tacacccatc agagtgatgt
     2281 ctggtccttt ggtgtcctcc tctgggagat ctttacactg ggtgggtcac catatcctgg
     2341 catcccagtg gaagagcttt tcaagctgtt gaaagagggc caccgcatgg acaagccagc
     2401 caactgcaca catgacctgt acatgatcat gcgggaatgt tggcatgcag tgccttcaca
     2461 gaggcccacc ttcaagcagt tggtagagga tttagaccgc atcctcacgg tgacatcaac
     2521 tgacgagtac ttggacctct cggtgccatt tgaacagtac tcgccaggtg gccaagatac
     2581 tcctagctcc agctcgtccg gggacgactc tgtgttcacc catgacctgc tacccccagg
     2641 cccacccagc aatgggggac ctcggacgtg aagggccgac agtcccacag accaagcccc
     2701 agccaatgtt tacgcggacc ctagcccgcc ctgctactgc tggtgtgcag tggaccctag
     2761 ccagcccagt gcaatgggcc agcaatagac aagacttcct gcgtgtttat ccttggctcc
     2821 tgggtgcaga ggcccctggg gaacatgtac tgctgtagaa tgatctcctg actggccagg
     2881 gccaggagca ccaaatgaga atgtaagagg gcccccccgc ccctgtgcga cagtggggtt
     2941 ctggctccct cactccccac tgctacctta cagggaccgt tgtagagagg gctggacttc
     3001 atgtccaggg tgggccttgg cctttttggt gcccaaagct gagcctgtag ggaggctctg
     3061 ctcttatgtg gcaagcctct ctcctacatg gcaccttgtg cctggggtga gtcatagctc
     3121 gacacctcca ggctgcccgc ttcccatcct gtccctcaaa ttacgggtac ctgaaggggg
     3181 ggtggccata acttctatca gaaaggttta ttccagagga aaatgtacat ttatataaat
     3241 agatgttgtg tatgatatat atagatatat acatacatat atataagaat atctatatgg
     3301 aaaaaggcaa agctgaggcc caagggagca agacacccca tggggctcac cagtgagatg
     3361 gcacaggcag gccgagaagc aggggccttt tctggcattg cagtgttgtt tgtatctgga
     3421 cctgtatatt tgtaaagcta tttatcaacc ctcggagctc cagtccccaa ccccaggttc
     3481 atagcgttta gtcccagggt attgcagaaa ttttaagttg taacttatta acagctgaag
     3541 aggtttatgc tgaatctagg gagttgctga gaatgtgcgt ctgtcctccc accaaggctg
     3601 gacgtggccc cgtggagctt gagtgactct cctagttagc catggctcca gtgaacatct
     3661 tttttttatt ttgtttcctt tggccctctt ctgtggggga ttagattata tagggacttt
     3721 ctttagaaga tttttaaaga tttcaaggtg aactggtatt tttcatacag attattctaa
     3781 ttgttatgtg ttccaggcag gggcctgtgc ccagggaggg gctggccctg caaagaaggt
     3841 tcagatgtta atagatgtct gttacaagtt tatctatcta taatttattg agtttctaca
     3901 agttgttttg ctgtaggctt aacacttcta tgcagtgatt ctagactttt tatagcctag
     3961 actgctacct ttcaaagctt gggagagagt gctgaatgca attttgttac agtttgtact
     4021 gttactgggc cctaggcttg ggtggctgtc ccttgcctgt cagccagcag ggtcaggaca
     4081 gtggctcagg gtgactttct tggggcctag catatggttt ttcagcccac actggcaaat
     4141 gtggttttgt taacacagcc aacttacttt ccaaaaaata aagataactg gttctgatat
     4201 cca
//
