LOCUS       NM_001109892            4651 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor receptor 2 (Fgfr2),
            transcript variant b, mRNA.
ACCESSION   NM_001109892 XM_001077699 XM_001077810 XM_001079420 XM_001079450
            XM_001079458 XM_001079467 XM_001079477 XM_001079488 XM_001079498
            XM_001079510 XM_001079521 XM_001079530 XM_341940
VERSION     NM_001109892.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4651)
  AUTHORS   Tian,M., Yang,J., Yan,X., Cao,Y., Liu,Y., Lei,Y. and Lv,H.
  TITLE     Knockdown of lncRNA TUG1 alleviates diabetic retinal vascular
            dysfunction through regulating miR-524-5p/FGFR2
  JOURNAL   Bioengineered 13 (5), 12661-12672 (2022)
   PUBMED   35599572
  REMARK    GeneRIF: Knockdown of lncRNA TUG1 alleviates diabetic retinal
            vascular dysfunction through regulating miR-524-5p/FGFR2.
REFERENCE   2  (bases 1 to 4651)
  AUTHORS   Kilcoyne,S., Potter,K.R., Gordon,Z., Overton,S., Brockbank,S.,
            Jayamohan,J., Magdum,S., Smith,M., Johnson,D., Wall,S. and
            Wilkie,A.O.M.
  TITLE     Feeding, Communication, Hydrocephalus, and Intracranial
            Hypertension in Patients With Severe FGFR2-Associated Pfeiffer
            Syndrome
  JOURNAL   J Craniofac Surg 32 (1), 134-140 (2021)
   PUBMED   33074973
REFERENCE   3  (bases 1 to 4651)
  AUTHORS   Zhu,M., Chen,G., Yang,Y., Yang,J., Qin,B. and Gu,L.
  TITLE     miR-217-5p regulates myogenesis in skeletal muscle stem cells by
            targeting FGFR2
  JOURNAL   Mol Med Rep 22 (2), 850-858 (2020)
   PUBMED   32626929
  REMARK    GeneRIF: miR2175p regulates myogenesis in skeletal muscle stem
            cells by targeting FGFR2.
REFERENCE   4  (bases 1 to 4651)
  AUTHORS   Xu,Z., Zhu,X., Wang,M., Lu,Y. and Dai,C.
  TITLE     FGF/FGFR2 Protects against Tubular Cell Death and Acute Kidney
            Injury Involving Erk1/2 Signaling Activation
  JOURNAL   Kidney Dis (Basel) 6 (3), 181-194 (2020)
   PUBMED   32523960
REFERENCE   5  (bases 1 to 4651)
  AUTHORS   Chen,P., Xu,B., Feng,Y., Li,K.X., Liu,Z., Sun,X., Lu,X.L.,
            Wang,L.Q., Chen,Y.W., Fan,X.X., Yang,X.L., Wang,N., Qiao,G.F. and
            Li,B.Y.
  TITLE     FGF-21 ameliorates essential hypertension of SHR via baroreflex
            afferent function
  JOURNAL   Brain Res Bull 154, 9-20 (2020)
   PUBMED   31626954
REFERENCE   6  (bases 1 to 4651)
  AUTHORS   Park,W.J., Theda,C., Maestri,N.E., Meyers,G.A., Fryburg,J.S.,
            Dufresne,C., Cohen,M.M. Jr. and Jabs,E.W.
  TITLE     Analysis of phenotypic features and FGFR2 mutations in Apert
            syndrome
  JOURNAL   Am J Hum Genet 57 (2), 321-328 (1995)
   PUBMED   7668257
REFERENCE   7  (bases 1 to 4651)
  AUTHORS   Schell,U., Hehr,A., Feldman,G.J., Robin,N.H., Zackai,E.H., de
            Die-Smulders,C., Viskochil,D.H., Stewart,J.M., Wolff,G., Ohashi,H.
            et al.
  TITLE     Mutations in FGFR1 and FGFR2 cause familial and sporadic Pfeiffer
            syndrome
  JOURNAL   Hum Mol Genet 4 (3), 323-328 (1995)
   PUBMED   7795583
REFERENCE   8  (bases 1 to 4651)
  AUTHORS   Jabs,E.W., Li,X., Scott,A.F., Meyers,G., Chen,W., Eccles,M.,
            Mao,J.I., Charnas,L.R., Jackson,C.E. and Jaye,M.
  TITLE     Jackson-Weiss and Crouzon syndromes are allelic with mutations in
            fibroblast growth factor receptor 2
  JOURNAL   Nat Genet 8 (3), 275-279 (1994)
   PUBMED   7874170
  REMARK    Erratum:[Nat Genet 1995 Apr;9(4):451]
REFERENCE   9  (bases 1 to 4651)
  AUTHORS   Reardon,W., Winter,R.M., Rutland,P., Pulleyn,L.J., Jones,B.M. and
            Malcolm,S.
  TITLE     Mutations in the fibroblast growth factor receptor 2 gene cause
            Crouzon syndrome
  JOURNAL   Nat Genet 8 (1), 98-103 (1994)
   PUBMED   7987400
REFERENCE   10 (bases 1 to 4651)
  AUTHORS   Savagner,P., Valles,A.M., Jouanneau,J., Yamada,K.M. and Thiery,J.P.
  TITLE     Alternative splicing in fibroblast growth factor receptor 2 is
            associated with induced epithelial-mesenchymal transition in rat
            bladder carcinoma cells
  JOURNAL   Mol Biol Cell 5 (8), 851-862 (1994)
   PUBMED   7803853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW531062.1, BF420170.1, L19105.1, L19104.1, CB777398.1, L19110.1,
            CB780941.1, CB716134.1, CO397781.1, CF109832.1, DV718561.1 and
            CB769194.1.
            
            On or before Oct 12, 2007 this sequence version replaced
            XM_001079521.1, XM_001079530.1, XM_001079420.1, XM_001079450.1,
            XM_001079488.1, XM_001079510.1, XM_001079477.1, XM_001079498.1,
            XM_001079458.1, XM_001079467.1, XM_341940.3, XM_001077699.1,
            XM_001077810.1.
            
            Transcript Variant: This variant (b) lacks an alternate internal
            exon and contains an alternate internal exon compared to variant a.
            The resulting isoform (b) has the same N- and C-termini but differs
            in an internal segment compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00155311, SAMD00155315
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AW531062.1         1-462               c
            463-599             BF420170.1         8-144
            600-1789            L19105.1           38-1227
            1790-1884           L19104.1           1229-1323
            1885-2029           CB777398.1         232-376
            2030-2583           L19110.1           171-724
            2584-2777           CB780941.1         158-351
            2778-2947           CB716134.1         102-271             c
            2948-3112           L19110.1           983-1147
            3113-3660           CO397781.1         78-625
            3661-4318           CF109832.1         194-851
            4319-4600           DV718561.1         275-556
            4601-4651           CB769194.1         56-106              c
FEATURES             Location/Qualifiers
     source          1..4651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..4651
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /note="fibroblast growth factor receptor 2"
                     /db_xref="GeneID:25022"
                     /db_xref="RGD:2611"
     exon            1..453
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            454..755
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             590..3112
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /EC_number="2.7.10.1"
                     /note="isoform b precursor is encoded by transcript
                     variant b"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 2 isoform b
                     precursor"
                     /protein_id="NP_001103362.1"
                     /db_xref="GeneID:25022"
                     /db_xref="RGD:2611"
                     /translation="MGLPSTWRYGTGPGIGTVTMVSWGRFICLVLVTMATLSLARPSF
                     SLVEDTTLEPEEPPTKYQISQPEACVVAPGESLELRCMLKDAAVISWTKDGVHLGPNN
                     RTVLIGEYLQIKGATPRDSGLYACAAARTVDSETLYFMVNVTDAISSGDDEDDTDSSE
                     DFVSENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFK
                     QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPI
                     LQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAA
                     GVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPVREKEITASP
                     DYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVS
                     AESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGE
                     GCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI
                     INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS
                     CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNG
                     RLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHR
                     MDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQY
                     SPSYPDTRSSCSSGDDSVFSPDPMPYDPCLPQYPHINGSVKT"
     exon            756..1022
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1100
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1270
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1394
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1585
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1730
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1933
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2085
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2207
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2318
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2509
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2632
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2703
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..2841
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2947
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..4626
                     /gene="Fgfr2"
                     /gene_synonym="KGFR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggagagg cgagcggcgg cggcgggcgc agagcgggcg cacggacgat cgagcgcgcg
       61 gctgccagag ctccggtgct gaggctgcct gtgtgtccct ggcccggcgt ggcgactgct
      121 ctccgggctg gcgggggccg ggcgtgagcc cccgggcctc agcgttcctg agcgctgcga
      181 gtgttcacca ctcgccagca aagtttggag taggcaacgc caagccccag ttctttcttc
      241 tgctgctgcc cagatccgag ggcagctccg gcgtcatgtc cgcgctgttc tgcgatcccc
      301 agcgcgcgtg aagcctcgga accttggcgc ccgcttccac ccaagggatc attctctttt
      361 tggagttttc ctccgagctc atcgcctgct ccatcccgac ccactcaggg cttcgacgcc
      421 aacaccgagc gcagaggagc gctgccattc aaggggcggc cgcagcagca gcagcagcga
      481 cagcagcagc aacaacagcc tgagcaagcc acagcagcgc cctggctcct gagccccccg
      541 tgggctgaag gcattgcagg tagcccatgg tccctgaaga agtgtgcaga tgggattacc
      601 gtccacatgg agatatggaa caggaccagg gattggcacc gtgaccatgg tcagctgggg
      661 gcgcttcatc tgcctggtct tggtcaccat ggcaaccttg tccctggccc ggccctcctt
      721 cagtttagtt gaagatacca ctttagaacc agaagagcca ccaaccaaat accaaatctc
      781 ccaaccagaa gcgtgcgtgg ttgcccccgg ggagtcgcta gagttgcgct gcatgttgaa
      841 agatgccgcc gtgatcagtt ggactaagga tggggtgcac ttggggccca acaataggac
      901 agtgcttatt ggggagtacc tccagataaa aggtgccaca cctagagact ccggcctcta
      961 tgcttgtgct gcagctagga cggtagacag tgaaactttg tacttcatgg tgaatgtcac
     1021 agatgccatc tcatctggag atgacgagga cgacacagat agctccgaag actttgtcag
     1081 tgagaacagg agcaaccaga gagcaccgta ctggaccaac accgaaaaga tggagaagcg
     1141 gctccatgct gtccctgccg ccaacactgt gaagttccgc tgtccagccg gggggaatcc
     1201 aacacccaca atgaggtggc taaaaaacgg gaaggagttt aagcaggagc atcgcatcgg
     1261 aggctataag gtacgaaacc agcactggag ccttattatg gaaagtgtgg tcccatcaga
     1321 caaaggcaat tacacctgcc tggtggagaa tgaatacggg tccatcaacc acacctacca
     1381 ccttgatgtt gttgagcgat caccacaccg gcccatcctc caagctggac tgcctgcaaa
     1441 tgcctccacg gtggtcggag gggacgtaga atttgtctgc aaggtttata gtgatgccca
     1501 gccccatatc cagtggatca aacatgtgga aaagaacggc agtaaatatg gacctgatgg
     1561 gctgccctac ctcaaggtcc tgaaggccgc cggtgttaac accacggaca aagaaattga
     1621 ggttctctat attcggaatg taacttttga ggatgctggg gaatatacgt gcttggcggg
     1681 taattctatc gggatatcct ttcactctgc atggttgaca gttctgccag cacctgtgag
     1741 agagaaggag atcacagctt ccccagatta cctggagata gctatttact gcataggggt
     1801 cttcttaatc gcctgcatgg tggtgacagt catcttttgc cgaatgaaga ccacgaccaa
     1861 gaagccagac ttcagcagcc agccagctgt gcacaagctg accaagcgca tccccctgcg
     1921 gagacaggta acagtttcgg ccgagtccag ctcgtccatg aactccaaca ccccactggt
     1981 gaggataacg acacgtctgt cctcaacggc ggacaccccg atgctagcag gggtctctga
     2041 gtacgagttg ccagaggatc caaagtggga attccccaga gataagctga cgctgggcaa
     2101 acccctgggg gaaggctgct tcgggcaagt agtcatggct gaagcggtgg gaatcgataa
     2161 ggacagaccc aaggaggcag tcaccgtggc ggtgaagatg ttgaaagatg acgccacaga
     2221 gaaggacctg tctgacctgg tgtcagagat ggagatgatg aagatgattg gtaaacataa
     2281 gaacatcatc aacctcctgg gggcctgcac ccaggatgga cccctctatg tcatagtcga
     2341 atacgcatcg aaaggcaacc tccgggaata cctccgggcc cggaggccac ctggcatgga
     2401 gtactcctat gacattaacc gagttcccga ggagcagatg accttcaagg acttggtgtc
     2461 ctgcacctac cagctggcga gaggcatgga gtacttggct tcccaaaaat gtatccatcg
     2521 agacttggca gccagaaatg tgctggtaac agaaaacaac gtgatgaaga tagcagactt
     2581 tggcctggcc agggatatca acaacataga ctattacaaa aagaccacga atgggcgact
     2641 tccagtcaag tggatggctc ctgaagccct ttttgataga gtttacactc atcagagtga
     2701 tgtctggtcc ttcggggtgt taatgtggga gatcttcact ttagggggtt caccctaccc
     2761 agggattccc gtggaggaac tttttaagct gctcaaagag ggccacagga tggacaagcc
     2821 caccaactgc accaatgaac tgtacatgat gatgagggac tgctggcatg ctgtaccctc
     2881 acagaggccc acgtttaagc agttggtgga agacttggat cgaattctga ctctcacaac
     2941 caatgaggaa tacttggacc tcacccagcc tctcgaacag tattctccta gttaccccga
     3001 cacaaggagc tcttgttctt caggggacga ttctgtgttt tctccagacc ccatgcctta
     3061 tgacccctgc ctgcctcagt atccacacat aaacggcagt gttaaaacat gagcgggtgt
     3121 gtcttcctgt ccccaaacag gacagcacca ggaacctact tacactgagc agagaggctg
     3181 tgcccccaaa gcgtgtggca tgcctccaca tgtatatatg gatcagagga gtaaatagtg
     3241 ggaagagtat ttgtcacgtg tgtgaagatt tatacagttg gaaacatgtt actttcccag
     3301 gaaaggaaga ctgtttcctg ataagtggac agccgcaagc caccgccacc ctctctgacc
     3361 taccatgtat gctggctgtg ccccagttgg actcaaggca gaccgctgtt ctgccttcct
     3421 tgttaatttt gtaataattg gagaagatat atgtcagcac atacttacag agcacaaatg
     3481 cagtatatag gtgctggatg tatgtaaata tattcaaatt atgtataaat atatattata
     3541 tatttacaag gaattatttt ttgtattgat cttaaatgga tgtcctgatg cacctagaaa
     3601 attggtctct ccattttttt taaatagata tttgctaaat gctgttctta gaatttctta
     3661 attttcaccg agcagaggtg ggaaaatact tttgctttca gggaaaatgg tgtcacatta
     3721 atttattaat gaattggtaa tatacgaaac aattaatcat ctatagtttg tttttttttt
     3781 gtaatttaag tggcatttct atgcagacag cacagaggac tagttaatct attgcttgga
     3841 cttaactggt tattggatcc tttgagaaga gaaatattta cgatatatga ctaatttggg
     3901 gggaaatgat gtcttgattt atttgtgttt caactctgct gtccgatgat tatgtctaaa
     3961 cacctcaatg cccacctttc aagaaacctt ttaaactctg tcaccccagt gtaataatta
     4021 accagacttc ccatgacaaa tggtaccaga gtcctcatcc caagatgcct taatcctctt
     4081 ctctggagaa cagactccca tcggagacgg cagggtgggt cttgtctggc agctggcctt
     4141 ctgcctgagt tacacacccg tcacattcgc cttgctccct ctccgtgagt tttgataaca
     4201 gcttcagatt cttcagcatc aaaaactctt tggggactct ccatcctctc ggagaatagt
     4261 gaaagcccag ggttattctg tcgagagttt gggacctcct tccatcttct gcagggtttg
     4321 cttctggctt ccacccactt ctgacaagac ctctcctcac taaaagatct ggcccgagag
     4381 ctacacccga caagagaacg cttaccattg atttccgtgt tcaagtcttg tgctttgctt
     4441 tggacacgcc cactcacctt gctaccgtca tgtgacagga gtgcagacta cactgatttt
     4501 atgtgttttg aaattggaga aagtatttaa taaaacctgt taatttttat actgacaata
     4561 aaaatgtttc tacagatatt aatgttaacg agacaaaaat aaatgtcgcg cagcttattt
     4621 ttttaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
