LOCUS       NM_024146               5336 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Fibroblast growth factor receptor 1 (Fgfr1),
            mRNA.
ACCESSION   NM_024146 XM_017600251 XM_346491
VERSION     NM_024146.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5336)
  AUTHORS   Srisakuldee,W., Nickel,B.E., Fandrich,R.R., Zhang,F.,
            Pasumarthi,K.B.S. and Kardami,E.
  TITLE     A Cardiac Mitochondrial FGFR1 Mediates the Antithetical Effects of
            FGF2 Isoforms on Permeability Transition
  JOURNAL   Cells 10 (10), 2735 (2021)
   PUBMED   34685716
  REMARK    GeneRIF: A Cardiac Mitochondrial FGFR1 Mediates the Antithetical
            Effects of FGF2 Isoforms on Permeability Transition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5336)
  AUTHORS   Li,A., Tian,J., Yang,J., Ren,X., Zhou,Z. and Zhou,W.
  TITLE     Expression of fibroblast growth factor 9 and its receptors in the
            dentate gyrus of hippocampus in poststroke depression rats
  JOURNAL   Neuroreport 32 (4), 321-325 (2021)
   PUBMED   33470768
  REMARK    GeneRIF: Expression of fibroblast growth factor 9 and its receptors
            in the dentate gyrus of hippocampus in poststroke depression rats.
REFERENCE   3  (bases 1 to 5336)
  AUTHORS   Zhang,M., Jin,F., Zhu,Y. and Qi,F.
  TITLE     Peripheral FGFR1 Regulates Myofascial Pain in Rats via the PI3K/AKT
            Pathway
  JOURNAL   Neuroscience 436, 1-10 (2020)
   PUBMED   32278061
  REMARK    GeneRIF: Peripheral FGFR1 Regulates Myofascial Pain in Rats via the
            PI3K/AKT Pathway.
REFERENCE   4  (bases 1 to 5336)
  AUTHORS   Hu,Y., Liu,H.X., Jena,P.K., Sheng,L., Ali,M.R. and Wan,Y.Y.
  TITLE     miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1
            induction
  JOURNAL   JHEP Rep 2 (2), 100093 (2020)
   PUBMED   32195457
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5336)
  AUTHORS   Lou,D., Han,J., Zhou,L., Ma,H., Xv,J., Shou,J., Xu,Z., Jiang,L. and
            Qian,Y.
  TITLE     Fibroblast growth factor receptor 1 antagonism attenuates
            lipopolysaccharide-induced activation of hepatic stellate cells via
            suppressing inflammation
  JOURNAL   Exp Ther Med 16 (4), 2909-2916 (2018)
   PUBMED   30250515
REFERENCE   6  (bases 1 to 5336)
  AUTHORS   Rider,V., Piva,M., Cohen,M.E. and Carlone,D.L.
  TITLE     Alternative splicing and differential targeting of fibroblast
            growth factor receptor 1 in the pregnant rat uterus
  JOURNAL   Endocrinology 136 (7), 3137-3145 (1995)
   PUBMED   7789341
REFERENCE   7  (bases 1 to 5336)
  AUTHORS   Muenke,M., Schell,U., Hehr,A., Robin,N.H., Losken,H.W.,
            Schinzel,A., Pulleyn,L.J., Rutland,P., Reardon,W., Malcolm,S. et
            al.
  TITLE     A common mutation in the fibroblast growth factor receptor 1 gene
            in Pfeiffer syndrome
  JOURNAL   Nat Genet 8 (3), 269-274 (1994)
   PUBMED   7874169
REFERENCE   8  (bases 1 to 5336)
  AUTHORS   Van Der Wal,E.A., Gomez-Pinilla,F. and Cotman,C.W.
  TITLE     Seizure-associated induction of basic fibroblast growth factor and
            its receptor in the rat brain
  JOURNAL   Neuroscience 60 (2), 311-323 (1994)
   PUBMED   8072686
REFERENCE   9  (bases 1 to 5336)
  AUTHORS   Kim,E.G., Kwon,H.M., Burrow,C.R. and Ballermann,B.J.
  TITLE     Expression of rat fibroblast growth factor receptor 1 as three
            splicing variants during kidney development
  JOURNAL   Am J Physiol 264 (1 Pt 2), F66-F73 (1993)
   PUBMED   8381605
REFERENCE   10 (bases 1 to 5336)
  AUTHORS   Mansukhani,A., Moscatelli,D., Talarico,D., Levytska,V. and
            Basilico,C.
  TITLE     A murine fibroblast growth factor (FGF) receptor expressed in CHO
            cells is activated by basic FGF and Kaposi FGF
  JOURNAL   Proc Natl Acad Sci U S A 87 (11), 4378-4382 (1990)
   PUBMED   2161540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On or before Aug 29, 2022 this sequence version replaced
            XM_017600251.2, NM_024146.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: D12498.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMN12840115
                                    [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-631               JAXUCZ010000016.1  73249225-73249855   c
            632-816             JAXUCZ010000016.1  73236206-73236390   c
            817-1083            JAXUCZ010000016.1  73213098-73213364   c
            1084-1173           JAXUCZ010000016.1  73211272-73211361   c
            1174-1346           JAXUCZ010000016.1  73210865-73211037   c
            1347-1470           JAXUCZ010000016.1  73208584-73208707   c
            1471-1661           JAXUCZ010000016.1  73207188-73207378   c
            1662-1806           JAXUCZ010000016.1  73204885-73205029   c
            1807-2009           JAXUCZ010000016.1  73202357-73202559   c
            2010-2155           JAXUCZ010000016.1  73201434-73201579   c
            2156-2277           JAXUCZ010000016.1  73200690-73200811   c
            2278-2388           JAXUCZ010000016.1  73200253-73200363   c
            2389-2579           JAXUCZ010000016.1  73199701-73199891   c
            2580-2702           JAXUCZ010000016.1  73198175-73198297   c
            2703-2773           JAXUCZ010000016.1  73197866-73197936   c
            2774-2911           JAXUCZ010000016.1  73197438-73197575   c
            2912-3017           JAXUCZ010000016.1  73197056-73197161   c
            3018-5336           JAXUCZ010000016.1  73194631-73196949   c
FEATURES             Location/Qualifiers
     source          1..5336
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.4"
     gene            1..5336
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /note="Fibroblast growth factor receptor 1"
                     /db_xref="GeneID:79114"
                     /db_xref="RGD:620713"
     exon            1..631
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            632..816
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             726..3194
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /EC_number="2.7.10.1"
                     /note="basic fibroblast growth factor receptor 1;
                     proto-oncogene c-Fgr; FGF receptor-1"
                     /codon_start=1
                     /product="fibroblast growth factor receptor 1 precursor"
                     /protein_id="NP_077060.2"
                     /db_xref="GeneID:79114"
                     /db_xref="RGD:620713"
                     /translation="MWGWRGLLFWAVLVTATLCTARPAPTLPEQAQPWGVPVEVESLL
                     VHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVRDSIPADSGLYACV
                     TNSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRRPVAPYWTSPEK
                     MEKKLHAVPAAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMD
                     SVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFM
                     CKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFE
                     DAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVG
                     SVIIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLS
                     SSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV
                     TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
                     GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDL
                     AARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD
                     VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAV
                     PSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSH
                     EPLPEEPCLPRHPTQLANGGLKRR"
     exon            817..1083
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1173
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1346
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1470
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1661
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1806
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..2009
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2155
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2277
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2388
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2579
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2702
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2773
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2911
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3017
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..5336
                     /gene="Fgfr1"
                     /gene_synonym="bFGF-R; bFGF-R-1; c-fgr; FGFR-1; MFR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacagcgct cggagcgctc ctgcgggaac ctttgcgggg ctctcggcag ccggtggcgc
       61 cgaacgcgag ccggaacgcc ggtgcagccg ctgcgtgccg aggatccggg ctgcgcaggg
      121 aacggggccg caacgtccgg actggacgga gactgtgctt agcgcattgc ggcgacctcg
      181 cctttcccgg ccgcgagcgc gcgccgcagc tggaaaagca gcggagaccg aggacttttc
      241 tcaggtccca gaggcgcacc acagccgtgc tgcagtcaat gcccgccgta gccctcggag
      301 gggcgatgga actcgggcta ccagaagcct gagacgacgc cgccgccgcg tactggagag
      361 cggggggcgc acgatctggg gacccccggc ggcggacccg agccctcccc cccgccccgc
      421 ctccggggca ccagcttcgg ctccattgtt cccgcccggg ctggaggcgc ccggctccga
      481 gtgccgccgg gagtcgtgcc tcggccgcgg agctctcgag accccaccag gacctgaacg
      541 gatcccaggg acgagctgct ggagcgcaag acacagacac ccgccgcgcc acggcgagct
      601 ctccagaggc gggaccgcag cgccaagtga gagtcagctt gcgaaggcag atcccgctca
      661 ccgcagcggc agagtatcca tggaggtgcg gagccttgtt accaacctct aactgcagaa
      721 ctgggatgtg gggctggagg ggcctcctct tctgggctgt gctggtcaca gccactctct
      781 gcactgccag accagcccca accttgcccg aacaagctca gccctgggga gtccctgtgg
      841 aagtggagtc tctcctggtc caccctggtg acctgctaca gcttcgctgc cggctgcgcg
      901 atgatgtgca gagcatcaac tggctgcggg atggggtgca gctggcggaa agcaaccgta
      961 cacgcatcac aggggaggag gtggaggtgc gggattccat ccccgctgac tctggcctct
     1021 acgcttgtgt gaccaacagc ccctctggca gcgataccac ctacttctcc gtcaatgtct
     1081 cagatgcact gccatcctcg gaggacgatg acgatgatga tgactcctcc tcagaggaga
     1141 aagagacaga caacaccaaa ccaaaccgta ggcctgtggc gccatactgg acatccccag
     1201 agaaaatgga gaagaaactg cacgcagtgc cagctgccaa gacggtgaaa ttcaaatgcc
     1261 cgtcgagtgg gacacccagc cccactttgc gctggttgaa aaatggcaag gaattcaaac
     1321 ctgaccaccg gatcggaggc tacaaggttc gttacgccac ttggagcatc ataatggact
     1381 ctgtggtgcc ttctgacaag ggcaactaca cctgcatcgt ggagaacgag tatgggagca
     1441 ttaaccacac ctaccagcta gacgttgtgg agcgatcccc tcaccggccc atccttcagg
     1501 cagggctacc agccaacaag accgtggccc tgggcagcaa cgtggagttc atgtgcaagg
     1561 tgtacagtga cccccagcct cacatccagt ggctgaagca catcgaggtg aatgggagta
     1621 agatcggtcc agacaacttg ccgtatgtcc agatcctgaa gactgctgga gttaatacca
     1681 ccgacaagga aatggaggtg cttcatctac ggaatgtctc ctttgaggat gcgggggagt
     1741 atacgtgctt ggcgggtaac tctatcggac tctcccatca ctctgcatgg ttgaccgttc
     1801 tggaagccct ggaagagaga ccagccgtga tgacctcacc tctgtacctg gaaatcatta
     1861 tctactgcac cggggccttc ctgatctcct gtatggtggg ctccgtcatc atctacaaga
     1921 tgaagagcgg caccaagaag agcgacttcc atagccagat ggctgtgcat aagctggcta
     1981 agagcatccc tctgcgcaga caggtaacag tgtcagctga ctccagcgca tccatgaact
     2041 ccggggttct cctggttcgg ccttcgcgac tgtcctccag cggaaccccc atgctagctg
     2101 gcgtctctga atatgagctc cctgaagatc cccgctggga gctgccccgg gacagactgg
     2161 tcttaggaaa accgcttggc gagggctgct tcgggcaggt ggtgttggcc gaagccatcg
     2221 gtctggataa ggacaaaccc aaccgcgtga ccaaagtggc cgtgaagatg ttgaagtctg
     2281 atgcgacaga gaaggacctg tcggacctga tctcggagat ggagatgatg aaaatgatcg
     2341 ggaagcacaa gaatatcatc aacctgctgg gggcgtgcac acaggatggt cctctctatg
     2401 tcattgtgga gtatgcctcc aaaggcaatc ttcgggagta tctgcaggcc cggaggcctc
     2461 ctgggctgga gtattgctac aaccccagcc acaaccctga ggaacagctg tcttccaaag
     2521 atctggtgtc ctgtgcctat caggtggccc ggggcatgga gtatcttgcc tcgaagaagt
     2581 gtatacaccg agacctggct gctaggaatg tcctggtgac agaggataat gtcatgaaga
     2641 tcgcagactt tggcctagct cgagacattc accatatcga ctactataag aaaaccacca
     2701 atggccggct gcctgtgaag tggatggcac ctgaggcatt gtttgaccgg atctacaccc
     2761 accagagtga tgtgtggtct tttggggtgc tcttatggga gatcttcact ctgggtggct
     2821 ccccataccc cggtgtgcct gtggaagaac ttttcaagct gctgaaggag ggtcatcgaa
     2881 tggacaagcc cagtaactgt accaatgagc tgtacatgat gatgcgggac tgctggcacg
     2941 cagtgccctc tcagagacct actttcaagc agttggtgga agacctggac cgcattgtgg
     3001 ccttgacctc caaccaggag tatctggacc tgtccatgcc actggaccag tactcgccaa
     3061 gctttccgga cacacggagc tctacctgct cttcagggga ggactctgtc ttctctcatg
     3121 agccattacc tgaggagccc tgtctgcccc gacaccccac ccagcttgca aatggtggac
     3181 tcaaacggcg ctgatgacca gccgtcccca gccttccccc attccatcat cacccgtgcc
     3241 cctcacctgc aactccccgt tggacacact gtctttctcc ttctcctttg tggctggcaa
     3301 gagccagtgc ctgactgagg ccttcctgtg tggcctaccc ttccatcacc cccaagaccc
     3361 ctctcttcct cttcttagcc tgctgtgtga gagaggagcc aagaggcagg tacttgctgg
     3421 tggccacttc ctccttccca agtgttggac caagacccac cctgctgcct ggcaactgct
     3481 gggaggtctc cagagtggaa gcaagtggca taggcgtgca agcaagagct tcctgggtgt
     3541 tcttgttgac ccatcagccc tttgtgttct ggtggcaggg gccttggggc tcctgaagca
     3601 gtgaggtttc tgtttaggcc ttaaccgaag gtggggcaac ctctgctcca gatggacggt
     3661 accagtagct tcttaattcc aatactaatt tgctttgctg accaaatacc tggtaccaga
     3721 agacagtgag tcagaggtcg ggagcaggga tgtgcccttg ggctgagccc tagacttggg
     3781 ggctctgtac atagctatga agaaaacaca aagtgtataa atctgagtat atatttacat
     3841 gtctttctaa aagggtcgtg actagagatt tacccgtcgg gtgagatgct cctggtggct
     3901 ggacctgagg catcagtagc tatatattaa aaacaaacaa acaaacaaaa aaaaaaggaa
     3961 aatgtttttt aaaaggtcat atattttttg ctacttttgc tgttttattt ttttaaatta
     4021 tgttttaaac ctattttcag tttaggtttc cctcaataaa aattgctgct gcttcatttt
     4081 tatcctgggc gtgtggaaag ggaggagatg tccactgcaa aggagggaga cagggactca
     4141 agggccatga gctgcccccc accccctcag ccccccaccc ccccaggccc atgacctctg
     4201 tctcctagat tgtgcaccaa gacctcccag acaatccttc tggctctgaa actttgggaa
     4261 agaagattga catcctgagg gcatagagcc aagcccatcc acttggttgt ttcctcagag
     4321 gagagggtga gggggggtga gactagctag agggtagaac tggacagaaa ctcaaaccct
     4381 ggaccctgtg tgggtgaatg tacgcatctc tgagagaaag tttgtcaccc gaagctagcg
     4441 gtgcattcag atgtcttgtc tgtctccccc aaccttctcc tcaatttcct ctcctgtaaa
     4501 taacctcccc gggcctctcc cggtctctgg gaaggccctg ttgggtctgt tcctgacctt
     4561 ggcttcctat agtttttcct ttacaaactc cacccatccc tgaggaaagg gaaaacaatc
     4621 tctttgggtc agcttctgcc acctgctggt tgttcgtggt accttagtcc acccagcgcc
     4681 atgctagcct cggtttgttt gcttgttttc cttgtgtctc tgctgaatac agaacggttc
     4741 aatctgattt catctgtagg ggttagggcc gcttctttaa atacagcttt gatggctgcg
     4801 gtttgggtca tcgtcatgag agttctttct tatcattgtt tccctctgtg cccgtgtaac
     4861 tgtcaaaata tcgcaagtgg ctttttgtgc caaaagaagg catcctttgc cagagagggc
     4921 caggaaatga aatttagcac ataactcgtt ttcttggaga ccgtatcgtc gtgttttcct
     4981 tttttcttgt ttaaaatggt gagcgccatt tctgcctcgg gtcttcttga ttcacggttg
     5041 tgtgaacgga aggagaacat agaggggctt tgtgtgactc aagaagagga accaggaact
     5101 caaggaactg aagtcccttc tgtcactatt caaattgccc acggatatcc ccagggacag
     5161 gggtggctat cgaataagag acagtgagat tgacacgaag gaaaatgaaa tggctatttc
     5221 acttcgaggg ccagattggg tctcctgggg aagggtaccc agctcacaga atgaagatgt
     5281 gccgtcagag cacagcgtcc gtctggtttc ctgagggata aaatatggcc aaggca
//
