LOCUS       NM_012952               1061 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 9 (Fgf9), mRNA.
ACCESSION   NM_012952
VERSION     NM_012952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Thummler,K., Wrzos,C., Franz,J., McElroy,D., Cole,J.J., Hayden,L.,
            Arseni,D., Schwarz,F., Junker,A., Edgar,J.M., Kugler,S., Neef,A.,
            Wolf,F., Stadelmann,C. and Linington,C.
  TITLE     Fibroblast growth factor 9 (FGF9)-mediated neurodegeneration:
            Implications for progressive multiple sclerosis?
  JOURNAL   Neuropathol Appl Neurobiol 49 (5), e12935 (2023)
   PUBMED   37705188
  REMARK    GeneRIF: Fibroblast growth factor 9 (FGF9)-mediated
            neurodegeneration: Implications for progressive multiple sclerosis?
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Fan,Q., Wu,M., Li,C. and Li,J.
  TITLE     MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation
            (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling
            Pathway by Targeting FGF9/FGF12 in PC12 Cells
  JOURNAL   J Stroke Cerebrovasc Dis 31 (4), 106295 (2022)
   PUBMED   35093630
  REMARK    GeneRIF: MiR-107 Aggravates Oxygen-Glucose
            Deprivation/Reoxygenation (OGD/R)-Induced Injury Through
            Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in
            PC12 Cells.
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Li,A., Tian,J., Yang,J., Ren,X., Zhou,Z. and Zhou,W.
  TITLE     Expression of fibroblast growth factor 9 and its receptors in the
            dentate gyrus of hippocampus in poststroke depression rats
  JOURNAL   Neuroreport 32 (4), 321-325 (2021)
   PUBMED   33470768
  REMARK    GeneRIF: Expression of fibroblast growth factor 9 and its receptors
            in the dentate gyrus of hippocampus in poststroke depression rats.
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Liang,Z., Xu,J., Ma,Z., Li,G. and Zhu,W.
  TITLE     MiR-187 suppresses non-small-cell lung cancer cell proliferation by
            targeting FGF9
  JOURNAL   Bioengineered 11 (1), 70-80 (2020)
   PUBMED   31884893
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Sun,J., Wang,Z., Shi,H., Gu,L., Wang,S., Wang,H., Li,Y., Wei,T.,
            Wang,Q. and Wang,L.
  TITLE     LncRNA FAF inhibits fibrosis induced by angiotensinogen II via the
            TGFbeta1-P-Smad2/3 signalling by targeting FGF9 in cardiac
            fibroblasts
  JOURNAL   Biochem Biophys Res Commun 521 (3), 814-820 (2020)
   PUBMED   31708099
  REMARK    GeneRIF: FGF9 Is the Target of LncRNA FAF.
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Schmahl,J., Kim,Y., Colvin,J.S., Ornitz,D.M. and Capel,B.
  TITLE     Fgf9 induces proliferation and nuclear localization of FGFR2 in
            Sertoli precursors during male sex determination
  JOURNAL   Development 131 (15), 3627-3636 (2004)
   PUBMED   15229180
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   Colvin,J.S., White,A.C., Pratt,S.J. and Ornitz,D.M.
  TITLE     Lung hypoplasia and neonatal death in Fgf9-null mice identify this
            gene as an essential regulator of lung mesenchyme
  JOURNAL   Development 128 (11), 2095-2106 (2001)
   PUBMED   11493531
REFERENCE   8  (bases 1 to 1061)
  AUTHORS   Tucker,A.S., Al Khamis,A., Ferguson,C.A., Bach,I., Rosenfeld,M.G.
            and Sharpe,P.T.
  TITLE     Conserved regulation of mesenchymal gene expression by Fgf-8 in
            face and limb development
  JOURNAL   Development 126 (2), 221-228 (1999)
   PUBMED   9847236
REFERENCE   9  (bases 1 to 1061)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   10 (bases 1 to 1061)
  AUTHORS   Miyamoto,M., Naruo,K., Seko,C., Matsumoto,S., Kondo,T. and
            Kurokawa,T.
  TITLE     Molecular cloning of a novel cytokine cDNA encoding the ninth
            member of the fibroblast growth factor family, which has a unique
            secretion property
  JOURNAL   Mol Cell Biol 13 (7), 4251-4259 (1993)
   PUBMED   8321227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012952.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            19 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14839.1, BC078699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-429               JAXUCZ010000015.1  36327358-36327786
            430-533             JAXUCZ010000015.1  36337944-36338047
            534-1061            JAXUCZ010000015.1  36367138-36367665
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..1061
                     /gene="Fgf9"
                     /gene_synonym="Fgf4b"
                     /note="fibroblast growth factor 9"
                     /db_xref="GeneID:25444"
                     /db_xref="RGD:2610"
     exon            1..429
                     /gene="Fgf9"
                     /gene_synonym="Fgf4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..779
                     /gene="Fgf9"
                     /gene_synonym="Fgf4b"
                     /note="glia-activating factor; GAF; FGF-9; HBGF-9;
                     fibroblast growth factor 4b"
                     /codon_start=1
                     /product="fibroblast growth factor 9"
                     /protein_id="NP_037084.1"
                     /db_xref="GeneID:25444"
                     /db_xref="RGD:2610"
                     /translation="MAPLGEVGSYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGG
                     LPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAV
                     GLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGR
                     RYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS"
     exon            430..533
                     /gene="Fgf9"
                     /gene_synonym="Fgf4b"
                     /inference="alignment:Splign:2.1.0"
     exon            534..1061
                     /gene="Fgf9"
                     /gene_synonym="Fgf4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttatgcatt ggatggattg aagaaaagaa ccctttttcc ctctctgtct gcaactgcag
       61 caagggaggg gagttggata tacctcgcct agtgtctcct ggttgatacc atcattattg
      121 tttattcttg tgattaaaag ccgagtcctc tgatggctcc cttaggtgaa gttgggagct
      181 atttcggtgt gcaggacgcg gtaccgttcg ggaacgtacc ggtgttgccg gtggacagtc
      241 cggtgttgct aagtgaccac ctgggtcagt ccgaagcagg ggggctgccc cggggacccg
      301 cagtcacgga cttggatcat ttaaagggga ttctcaggcg gaggcagctg tactgcagga
      361 ctggatttca cttagaaatc ttccccaacg gtactatcca gggaaccagg aaagaccaca
      421 gccgattcgg cattctggaa tttatcagta tagcagtggg cctggtcagc attcgtggtg
      481 tggacagtgg actctacctc ggcatgaacg agaaggggga gctgtatgga tcagaaaaac
      541 taacacagga gtgcgtgttc agagaacagt ttgaagaaaa ctggtacaac acctactctt
      601 ccaacctgta caagcacgtg gacaccggaa ggagatacta tgttgcatta aataaggatg
      661 ggactccaag agaagggacc aggactaaac ggcaccagaa atttacacat tttttaccta
      721 gaccagtgga ccctgacaaa gtacctgaac tatataagga tattctaagc caaagttgac
      781 aaagacagtg tcttcacttg agcccttaaa acataaccac tataaatgct ttcatgcggt
      841 gggttcttat tgattagcag tgccgtcacc tcagctccac tgttgccaaa ctttgtcgca
      901 tgcatatgta tgatgggagc ttggatgagg acttgccgat ttgctctgca cttactggct
      961 ggtcctcctg gagggctgcc tagggccact tgcttgattt attgtgaaag caggggagag
     1021 aggctgcggg agagggtgcg agtgcatgag tgagtagagg g
//
