LOCUS       NP_037084                208 aa            linear   ROD 05-MAY-2025
DEFINITION  fibroblast growth factor 9 [Rattus norvegicus].
ACCESSION   NP_037084
VERSION     NP_037084.1
DBSOURCE    REFSEQ: accession NM_012952.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 208)
  AUTHORS   Thummler,K., Wrzos,C., Franz,J., McElroy,D., Cole,J.J., Hayden,L.,
            Arseni,D., Schwarz,F., Junker,A., Edgar,J.M., Kugler,S., Neef,A.,
            Wolf,F., Stadelmann,C. and Linington,C.
  TITLE     Fibroblast growth factor 9 (FGF9)-mediated neurodegeneration:
            Implications for progressive multiple sclerosis?
  JOURNAL   Neuropathol Appl Neurobiol 49 (5), e12935 (2023)
   PUBMED   37705188
  REMARK    GeneRIF: Fibroblast growth factor 9 (FGF9)-mediated
            neurodegeneration: Implications for progressive multiple sclerosis?
REFERENCE   2  (residues 1 to 208)
  AUTHORS   Fan,Q., Wu,M., Li,C. and Li,J.
  TITLE     MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation
            (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling
            Pathway by Targeting FGF9/FGF12 in PC12 Cells
  JOURNAL   J Stroke Cerebrovasc Dis 31 (4), 106295 (2022)
   PUBMED   35093630
  REMARK    GeneRIF: MiR-107 Aggravates Oxygen-Glucose
            Deprivation/Reoxygenation (OGD/R)-Induced Injury Through
            Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in
            PC12 Cells.
REFERENCE   3  (residues 1 to 208)
  AUTHORS   Li,A., Tian,J., Yang,J., Ren,X., Zhou,Z. and Zhou,W.
  TITLE     Expression of fibroblast growth factor 9 and its receptors in the
            dentate gyrus of hippocampus in poststroke depression rats
  JOURNAL   Neuroreport 32 (4), 321-325 (2021)
   PUBMED   33470768
  REMARK    GeneRIF: Expression of fibroblast growth factor 9 and its receptors
            in the dentate gyrus of hippocampus in poststroke depression rats.
REFERENCE   4  (residues 1 to 208)
  AUTHORS   Liang,Z., Xu,J., Ma,Z., Li,G. and Zhu,W.
  TITLE     MiR-187 suppresses non-small-cell lung cancer cell proliferation by
            targeting FGF9
  JOURNAL   Bioengineered 11 (1), 70-80 (2020)
   PUBMED   31884893
REFERENCE   5  (residues 1 to 208)
  AUTHORS   Sun,J., Wang,Z., Shi,H., Gu,L., Wang,S., Wang,H., Li,Y., Wei,T.,
            Wang,Q. and Wang,L.
  TITLE     LncRNA FAF inhibits fibrosis induced by angiotensinogen II via the
            TGFbeta1-P-Smad2/3 signalling by targeting FGF9 in cardiac
            fibroblasts
  JOURNAL   Biochem Biophys Res Commun 521 (3), 814-820 (2020)
   PUBMED   31708099
  REMARK    GeneRIF: FGF9 Is the Target of LncRNA FAF.
REFERENCE   6  (residues 1 to 208)
  AUTHORS   Schmahl,J., Kim,Y., Colvin,J.S., Ornitz,D.M. and Capel,B.
  TITLE     Fgf9 induces proliferation and nuclear localization of FGFR2 in
            Sertoli precursors during male sex determination
  JOURNAL   Development 131 (15), 3627-3636 (2004)
   PUBMED   15229180
REFERENCE   7  (residues 1 to 208)
  AUTHORS   Colvin,J.S., White,A.C., Pratt,S.J. and Ornitz,D.M.
  TITLE     Lung hypoplasia and neonatal death in Fgf9-null mice identify this
            gene as an essential regulator of lung mesenchyme
  JOURNAL   Development 128 (11), 2095-2106 (2001)
   PUBMED   11493531
REFERENCE   8  (residues 1 to 208)
  AUTHORS   Tucker,A.S., Al Khamis,A., Ferguson,C.A., Bach,I., Rosenfeld,M.G.
            and Sharpe,P.T.
  TITLE     Conserved regulation of mesenchymal gene expression by Fgf-8 in
            face and limb development
  JOURNAL   Development 126 (2), 221-228 (1999)
   PUBMED   9847236
REFERENCE   9  (residues 1 to 208)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   10 (residues 1 to 208)
  AUTHORS   Miyamoto,M., Naruo,K., Seko,C., Matsumoto,S., Kondo,T. and
            Kurokawa,T.
  TITLE     Molecular cloning of a novel cytokine cDNA encoding the ninth
            member of the fibroblast growth factor family, which has a unique
            secretion property
  JOURNAL   Mol Cell Biol 13 (7), 4251-4259 (1993)
   PUBMED   8321227
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            19 bp suspected to be vector contamination from the 5' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D14839.1, BC078699.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..208
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     Protein         1..208
                     /product="fibroblast growth factor 9"
                     /note="glia-activating factor; GAF; FGF-9; HBGF-9;
                     fibroblast growth factor 4b"
                     /calculated_mol_wt=23282
     mat_peptide     4..208
                     /product="Fibroblast growth factor 9. /id=PRO_0000008978"
                     /note="propagated from UniProtKB/Swiss-Prot (P36364.2)"
                     /calculated_mol_wt=23114
     Region          49..208
                     /region_name="beta-trefoil_FGF9"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 9 (FGF9) and similar proteins; cd23325"
                     /db_xref="CDD:467011"
     Site            order(60..62,64,67,69,73,88,143..144,188..195,200..201,
                     204..205)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:467011"
     Site            79
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36364.2)"
     Site            order(137,154,161,163,173,177,180)
                     /site_type="other"
                     /note="putative heparin binding site [chemical binding]"
                     /db_xref="CDD:467011"
     CDS             1..208
                     /gene="Fgf9"
                     /gene_synonym="Fgf4b"
                     /coded_by="NM_012952.2:153..779"
                     /db_xref="GeneID:25444"
                     /db_xref="RGD:2610"
ORIGIN      
        1 maplgevgsy fgvqdavpfg nvpvlpvdsp vllsdhlgqs eagglprgpa vtdldhlkgi
       61 lrrrqlycrt gfhleifpng tiqgtrkdhs rfgilefisi avglvsirgv dsglylgmne
      121 kgelygsekl tqecvfreqf eenwyntyss nlykhvdtgr ryyvalnkdg tpregtrtkr
      181 hqkfthflpr pvdpdkvpel ykdilsqs
//
