LOCUS       NM_001414191            1234 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 8 (Fgf8), transcript
            variant 1, mRNA.
ACCESSION   NM_001414191 XM_039107315
VERSION     NM_001414191.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1234)
  AUTHORS   Liu,H., Fang,Q., Wang,M., Wang,W., Zhang,M., Zhang,D., He,Y.,
            Zhang,Y., Wang,H., Otero,M., Ma,T. and Chen,J.
  TITLE     FGF8 and FGFR3 are up-regulated in hypertrophic chondrocytes:
            Association with chondrocyte death in deep zone of Kashin-Beck
            disease
  JOURNAL   Biochem Biophys Res Commun 500 (2), 184-190 (2018)
   PUBMED   29626475
  REMARK    GeneRIF: FGF8 and FGFR3 may therefore play an important role in the
            onset of deep zone necrosis and pathogenesis in Kashin-Beck disease
            in adolescent children.
REFERENCE   2  (bases 1 to 1234)
  AUTHORS   Tabler,J.M., Rigney,M.M., Berman,G.J., Gopalakrishnan,S., Heude,E.,
            Al-Lami,H.A., Yannakoudakis,B.Z., Fitch,R.D., Carter,C., Vokes,S.,
            Liu,K.J., Tajbakhsh,S., Egnor,S.R. and Wallingford,J.B.
  TITLE     Cilia-mediated Hedgehog signaling controls form and function in the
            mammalian larynx
  JOURNAL   Elife 6, e19153 (2017)
   PUBMED   28177282
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1234)
  AUTHORS   Singla,R.D., Wang,J. and Singla,D.K.
  TITLE     Fibroblast growth factor-8 inhibits oxidative stress-induced
            apoptosis in H9c2 cells
  JOURNAL   Mol Cell Biochem 425 (1-2), 77-84 (2017)
   PUBMED   27804049
  REMARK    GeneRIF: data demonstrate that apoptotic inhibition by FGF-8 is
            consequent to FoxO-1 oxidative detoxification as well as
            augmentation to the PI3K/AKT cell survival pathway.
REFERENCE   4  (bases 1 to 1234)
  AUTHORS   Tabler,J.M., Rice,C.P., Liu,K.J. and Wallingford,J.B.
  TITLE     A novel ciliopathic skull defect arising from excess neural crest
  JOURNAL   Dev Biol 417 (1), 4-10 (2016)
   PUBMED   27395007
REFERENCE   5  (bases 1 to 1234)
  AUTHORS   Li,K., Leung,A.W., Guo,Q., Yang,W. and Li,J.Y.
  TITLE     Shp2-dependent ERK signaling is essential for induction of Bergmann
            glia and foliation of the cerebellum
  JOURNAL   J Neurosci 34 (3), 922-931 (2014)
   PUBMED   24431450
REFERENCE   6  (bases 1 to 1234)
  AUTHORS   Ericson,J., Norlin,S., Jessell,T.M. and Edlund,T.
  TITLE     Integrated FGF and BMP signaling controls the progression of
            progenitor cell differentiation and the emergence of pattern in the
            embryonic anterior pituitary
  JOURNAL   Development 125 (6), 1005-1015 (1998)
   PUBMED   9463347
REFERENCE   7  (bases 1 to 1234)
  AUTHORS   Xu,X., Weinstein,M., Li,C., Naski,M., Cohen,R.I., Ornitz,D.M.,
            Leder,P. and Deng,C.
  TITLE     Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal
            regulation loop between FGF8 and FGF10 is essential for limb
            induction
  JOURNAL   Development 125 (4), 753-765 (1998)
   PUBMED   9435295
REFERENCE   8  (bases 1 to 1234)
  AUTHORS   Neubuser,A., Peters,H., Balling,R. and Martin,G.R.
  TITLE     Antagonistic interactions between FGF and BMP signaling pathways: a
            mechanism for positioning the sites of tooth formation
  JOURNAL   Cell 90 (2), 247-255 (1997)
   PUBMED   9244299
REFERENCE   9  (bases 1 to 1234)
  AUTHORS   Ghosh,A.K., Shankar,D.B., Shackleford,G.M., Wu,K., T'Ang,A.,
            Miller,G.J., Zheng,J. and Roy-Burman,P.
  TITLE     Molecular cloning and characterization of human FGF8 alternative
            messenger RNA forms
  JOURNAL   Cell Growth Differ 7 (10), 1425-1434 (1996)
   PUBMED   8891346
REFERENCE   10 (bases 1 to 1234)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 16, 2022 this sequence version replaced XM_039107315.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN06680425, SAMN12840109
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               JAXUCZ010000001.1  254539355-254539605 c
            252-480             JAXUCZ010000001.1  254539026-254539254 c
            481-661             JAXUCZ010000001.1  254538192-254538372 c
            662-768             JAXUCZ010000001.1  254534868-254534974 c
            769-1234            JAXUCZ010000001.1  254533504-254533969 c
FEATURES             Location/Qualifiers
     source          1..1234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..1234
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /note="fibroblast growth factor 8"
                     /db_xref="GeneID:29349"
                     /db_xref="RGD:70891"
     exon            1..251
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1059
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fibroblast growth factor 8 (androgen-induced);
                     fibroblast growth factor 6c"
                     /codon_start=1
                     /product="fibroblast growth factor 8 isoform 1 precursor"
                     /protein_id="NP_001401120.1"
                     /db_xref="GeneID:29349"
                     /db_xref="RGD:70891"
                     /translation="MGSPRSALSCLLLHLLVLCLQAQVRSAAQKRGPGAGDPADTLGQ
                     GHEDRSFGQRSRAGKNFTNPAPNYPEEGSKEQRDSVLPKVTERVTVQSSPNFTQHVRE
                     QSLVTDQLSRRLIRTYQLYSRTSGKHVQVLANKRINAMAEDGDPFAKLIVETDTFGSR
                     VRVRGAETGLYICMNKKGKLIAKSNGKGKDCVFTEIVLENNYTALQNAKYEGWYMAFT
                     RKGRPRKGSKTRQHQREVHFMKRLPRGHHTTEQSLRFEFLNYPPFTRSLRGSQRTWAP
                     EPR"
     exon            252..480
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /inference="alignment:Splign:2.1.0"
     exon            481..661
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /inference="alignment:Splign:2.1.0"
     exon            662..768
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1234
                     /gene="Fgf8"
                     /gene_synonym="Fgf6c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcagccag cggcaccggc tccggcagcg gcgcagaggg aatcggcgcg cgcggcgagc
       61 acgacattcc acgggacccg ccgagccgcg tcgggatagc cgctgggctc ccgcaccccg
      121 accttcctcg gcctccgcac cttcggcctg tccccccgcg gcttccagtg ggacggcgtg
      181 accccgcccg ggctctcggt gctcccgggg ccgcgcgcca tgggcagccc ccgctccgcg
      241 ctgagctgcc tgctgttgca cttgctggtt ctctgcctcc aagcccaggt aaggagcgcc
      301 gcgcagaagc gggggccggg cgcgggggac ccagctgaca ctctcgggca gggacacgag
      361 gaccgatcct tcggccagcg cagcagggct ggaaagaact ttacaaatcc agccccaaac
      421 taccccgagg agggatctaa ggaacagaga gacagtgtcc tgcctaaagt cacagagcga
      481 gtaactgttc agtcctcacc taattttaca cagcatgtga gggagcagag cctggtgacg
      541 gatcagctca gccgccgcct catccggacc taccagctct acagccgcac cagcgggaag
      601 cacgtgcagg tcctggccaa caagcgcatc aacgccatgg cagaagacgg agaccccttc
      661 gcaaagctca ttgtggagac cgatactttt ggaagcagag tccgagtccg cggagcagag
      721 accggtctgt acatctgcat gaacaagaag gggaagctaa tcgccaagag caacggcaaa
      781 ggcaaggact gcgtgttcac ggagatcgtg ctggagaaca actacacggc gctgcagaac
      841 gccaagtacg agggctggta catggccttt acccgcaagg gccggccccg caagggttcc
      901 aagacgcgcc agcaccagcg cgaggtgcac ttcatgaagc gcctgccgcg gggccaccac
      961 accacagagc agagcctccg cttcgagttc ctcaactacc cgcccttcac gcgcagcctg
     1021 cgcggcagcc agaggacttg ggccccggag ccccgatagg cgctcgcccg gcccctccct
     1081 gcctgcctgc ggactccagg gagagctcgg ccgcactgcg aaggggagga gctggggagc
     1141 tgccttctag ttgtgcatat tgtttgctgt tgggtttttt gttttgtttt gttctgtttt
     1201 ttaaacaaaa gagaggctct atttttgtat tcca
//
