LOCUS       NM_022182                693 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 7 (Fgf7), mRNA.
ACCESSION   NM_022182 XM_346672
VERSION     NM_022182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Wang,X., Gao,Y. and Sun,X.
  TITLE     Effect of Taspine hydrochloride on the repair of rat skin wounds by
            regulating keratinocyte growth factor signal
  JOURNAL   Bioengineered 13 (1), 789-799 (2022)
   PUBMED   34898359
  REMARK    GeneRIF: Effect of Taspine hydrochloride on the repair of rat skin
            wounds by regulating keratinocyte growth factor signal.
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Zhou,L., Zhang,S., Zhang,L., Li,F., Sun,H. and Feng,J.
  TITLE     MiR-199a-3p inhibits the proliferation, migration, and invasion of
            endothelial cells and retinal pericytes of diabetic retinopathy
            rats through regulating FGF7 via EGFR/PI3K/AKT pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 19-31 (2021)
   PUBMED   32586178
  REMARK    GeneRIF: MiR-199a-3p inhibits the proliferation, migration, and
            invasion of endothelial cells and retinal pericytes of diabetic
            retinopathy rats through regulating FGF7 via EGFR/PI3K/AKT pathway.
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Zhang,C., Han,M. and Wu,S.
  TITLE     Silencing fibroblast growth factor 7 inhibits krypton laser-induced
            choroidal neovascularization in a rat model
  JOURNAL   J Cell Biochem 120 (8), 13792-13801 (2019)
   PUBMED   31017714
  REMARK    GeneRIF: Silencing fibroblast growth factor 7 inhibits krypton
            laser-induced choroidal neovascularization in a rat model.
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Peng,Y., Wu,S., Tang,Q., Li,S. and Peng,C.
  TITLE     KGF-1 accelerates wound contraction through the TGF-beta1/Smad
            signaling pathway in a double-paracrine manner
  JOURNAL   J Biol Chem 294 (21), 8361-8370 (2019)
   PUBMED   30894415
  REMARK    GeneRIF: findings demonstrate that KGF-1 promotes fibroblast
            contraction and accelerates wound contraction via the
            TGF-beta1/Smad signaling pathway in a double-paracrine manner.
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Zhou,C., Chen,Y., Kang,W., Lv,H., Fang,Z., Yan,F., Li,L., Zhang,W.
            and Shi,J.
  TITLE     Mir-455-3p-1 represses FGF7 expression to inhibit pulmonary
            arterial hypertension through inhibiting the RAS/ERK signaling
            pathway
  JOURNAL   J Mol Cell Cardiol 130, 23-35 (2019)
   PUBMED   30858037
  REMARK    GeneRIF: findings illustrate a role for miR-455-3p-1 in modulating
            FGF7-RAS/ERK signaling and suggest that an agomir of miR-455-3p-1
            could inhibit the proliferation of PASMCs and mitigate PAH in vivo.
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Siegfried,S., Pekonen,F., Nyman,T., Ammala,M. and Rutanen,E.M.
  TITLE     Distinct patterns of expression of keratinocyte growth factor and
            its receptor in endometrial carcinoma
  JOURNAL   Cancer 79 (6), 1166-1171 (1997)
   PUBMED   9070494
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Kitsberg,D.I. and Leder,P.
  TITLE     Keratinocyte growth factor induces mammary and prostatic
            hyperplasia and mammary adenocarcinoma in transgenic mice
  JOURNAL   Oncogene 13 (12), 2507-2515 (1996)
   PUBMED   9000125
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Yan,G., Fukabori,Y., Nikolaropoulos,S., Wang,F. and McKeehan,W.L.
  TITLE     Heparin-binding keratinocyte growth factor is a candidate
            stromal-to-epithelial-cell andromedin
  JOURNAL   Mol Endocrinol 6 (12), 2123-2128 (1992)
   PUBMED   1491693
REFERENCE   10 (bases 1 to 693)
  AUTHORS   Yan,G.C., Nikolaropoulos,S., Wang,F. and McKeehan,W.L.
  TITLE     Sequence of rat keratinocyte growth factor (heparin-binding growth
            factor type 7)
  JOURNAL   In Vitro Cell Dev Biol 27A (6), 437-438 (1991)
   PUBMED   1869483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X56551.1.
            
            On Jan 12, 2005 this sequence version replaced XM_346672.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56551.1, AF295300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..693
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="fibroblast growth factor 7"
                     /db_xref="GeneID:29348"
                     /db_xref="RGD:61805"
     exon            1..394
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..693
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /note="FGF-7; HBGF-7; heparin-binding growth factor 7;
                     Keratinocyte Growth Factor Fgf-7; fibroblast growth factor
                     5b"
                     /codon_start=1
                     /product="fibroblast growth factor 7 precursor"
                     /protein_id="NP_071518.1"
                     /db_xref="GeneID:29348"
                     /db_xref="RGD:61805"
                     /translation="MRKWILTRILPTPLYRPCFHLVCLVGTISLACNDMSPEQTATSV
                     NCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIMT
                     VAVGIVAIKGVESEYYLAMNKQGELYAKKECNEDCNFKELILENHYNTSASAKWTHSG
                     GEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT"
     exon            395..498
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="alignment:Splign:2.1.0"
     exon            499..693
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caatctacaa ttcacagata ggaggaggcc catgacctag gagtagcgat caactcaagg
       61 tccagttctc attatgttat tcatggacac ccggggcact gctctataat gcgcaaatgg
      121 atactgacac ggatcctgcc gactccgctc tacagaccgt gcttccacct cgtctgtctt
      181 gtgggcacca tatctttagc ttgcaatgac atgagtccag agcagacggc cacgagcgtg
      241 aactgttcta gccccgagcg acacacgaga agttatgact acatggaagg aggggatata
      301 agggtgagga gactgttctg tcgcacccag tggtacctga ggattgacaa acgaggcaaa
      361 gtgaaaggga cccaggagat gaggaacagc tacaacatca tggaaatcat gactgtggca
      421 gttggaattg tggcaatcaa aggggtggaa agtgaatact atcttgccat gaacaaacaa
      481 ggggaactct atgcaaagaa agaatgcaat gaggattgca acttcaaaga actgattctg
      541 gaaaaccatt acaacacctc tgcatcagct aaatggacac acagcggagg ggaaatgttc
      601 gtggccttaa atcaaaaggg gcttcctgtc aaagggaaga aaacgaagaa agaacaaaaa
      661 acggcccact ttcttcctat ggcaataact taa
//
