LOCUS       NP_071518                194 aa            linear   ROD 30-JUL-2024
DEFINITION  fibroblast growth factor 7 precursor [Rattus norvegicus].
ACCESSION   NP_071518 XP_346673
VERSION     NP_071518.1
DBSOURCE    REFSEQ: accession NM_022182.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 194)
  AUTHORS   Wang,X., Gao,Y. and Sun,X.
  TITLE     Effect of Taspine hydrochloride on the repair of rat skin wounds by
            regulating keratinocyte growth factor signal
  JOURNAL   Bioengineered 13 (1), 789-799 (2022)
   PUBMED   34898359
  REMARK    GeneRIF: Effect of Taspine hydrochloride on the repair of rat skin
            wounds by regulating keratinocyte growth factor signal.
REFERENCE   2  (residues 1 to 194)
  AUTHORS   Zhou,L., Zhang,S., Zhang,L., Li,F., Sun,H. and Feng,J.
  TITLE     MiR-199a-3p inhibits the proliferation, migration, and invasion of
            endothelial cells and retinal pericytes of diabetic retinopathy
            rats through regulating FGF7 via EGFR/PI3K/AKT pathway
  JOURNAL   J Recept Signal Transduct Res 41 (1), 19-31 (2021)
   PUBMED   32586178
  REMARK    GeneRIF: MiR-199a-3p inhibits the proliferation, migration, and
            invasion of endothelial cells and retinal pericytes of diabetic
            retinopathy rats through regulating FGF7 via EGFR/PI3K/AKT pathway.
REFERENCE   3  (residues 1 to 194)
  AUTHORS   Zhang,C., Han,M. and Wu,S.
  TITLE     Silencing fibroblast growth factor 7 inhibits krypton laser-induced
            choroidal neovascularization in a rat model
  JOURNAL   J Cell Biochem 120 (8), 13792-13801 (2019)
   PUBMED   31017714
  REMARK    GeneRIF: Silencing fibroblast growth factor 7 inhibits krypton
            laser-induced choroidal neovascularization in a rat model.
REFERENCE   4  (residues 1 to 194)
  AUTHORS   Peng,Y., Wu,S., Tang,Q., Li,S. and Peng,C.
  TITLE     KGF-1 accelerates wound contraction through the TGF-beta1/Smad
            signaling pathway in a double-paracrine manner
  JOURNAL   J Biol Chem 294 (21), 8361-8370 (2019)
   PUBMED   30894415
  REMARK    GeneRIF: findings demonstrate that KGF-1 promotes fibroblast
            contraction and accelerates wound contraction via the
            TGF-beta1/Smad signaling pathway in a double-paracrine manner.
REFERENCE   5  (residues 1 to 194)
  AUTHORS   Zhou,C., Chen,Y., Kang,W., Lv,H., Fang,Z., Yan,F., Li,L., Zhang,W.
            and Shi,J.
  TITLE     Mir-455-3p-1 represses FGF7 expression to inhibit pulmonary
            arterial hypertension through inhibiting the RAS/ERK signaling
            pathway
  JOURNAL   J Mol Cell Cardiol 130, 23-35 (2019)
   PUBMED   30858037
  REMARK    GeneRIF: findings illustrate a role for miR-455-3p-1 in modulating
            FGF7-RAS/ERK signaling and suggest that an agomir of miR-455-3p-1
            could inhibit the proliferation of PASMCs and mitigate PAH in vivo.
REFERENCE   6  (residues 1 to 194)
  AUTHORS   Siegfried,S., Pekonen,F., Nyman,T., Ammala,M. and Rutanen,E.M.
  TITLE     Distinct patterns of expression of keratinocyte growth factor and
            its receptor in endometrial carcinoma
  JOURNAL   Cancer 79 (6), 1166-1171 (1997)
   PUBMED   9070494
REFERENCE   7  (residues 1 to 194)
  AUTHORS   Kitsberg,D.I. and Leder,P.
  TITLE     Keratinocyte growth factor induces mammary and prostatic
            hyperplasia and mammary adenocarcinoma in transgenic mice
  JOURNAL   Oncogene 13 (12), 2507-2515 (1996)
   PUBMED   9000125
REFERENCE   8  (residues 1 to 194)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   9  (residues 1 to 194)
  AUTHORS   Yan,G., Fukabori,Y., Nikolaropoulos,S., Wang,F. and McKeehan,W.L.
  TITLE     Heparin-binding keratinocyte growth factor is a candidate
            stromal-to-epithelial-cell andromedin
  JOURNAL   Mol Endocrinol 6 (12), 2123-2128 (1992)
   PUBMED   1491693
REFERENCE   10 (residues 1 to 194)
  AUTHORS   Yan,G.C., Nikolaropoulos,S., Wang,F. and McKeehan,W.L.
  TITLE     Sequence of rat keratinocyte growth factor (heparin-binding growth
            factor type 7)
  JOURNAL   In Vitro Cell Dev Biol 27A (6), 437-438 (1991)
   PUBMED   1869483
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X56551.1.
            
            On Jan 12, 2005 this sequence version replaced XP_346673.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X56551.1, AF295300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..194
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     Protein         1..194
                     /product="fibroblast growth factor 7 precursor"
                     /note="FGF-7; HBGF-7; heparin-binding growth factor 7;
                     Keratinocyte Growth Factor Fgf-7; fibroblast growth factor
                     5b"
                     /calculated_mol_wt=18673
     sig_peptide     1..31
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3613
     mat_peptide     32..194
                     /product="Fibroblast growth factor 7. /id=PRO_0000008968"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02195.1)"
                     /calculated_mol_wt=18673
     Site            45
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q02195.1)"
     Region          57..192
                     /region_name="beta-trefoil_FGF7"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 7 (FGF7) and similar proteins; cd23319"
                     /db_xref="CDD:467005"
     Site            149
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q02195.1)"
     CDS             1..194
                     /gene="Fgf7"
                     /gene_synonym="Fgf5b; Kgf; KGF/FGF7"
                     /coded_by="NM_022182.1:109..693"
                     /db_xref="GeneID:29348"
                     /db_xref="RGD:61805"
ORIGIN      
        1 mrkwiltril ptplyrpcfh lvclvgtisl acndmspeqt atsvncsspe rhtrsydyme
       61 ggdirvrrlf crtqwylrid krgkvkgtqe mrnsynimei mtvavgivai kgveseyyla
      121 mnkqgelyak kecnedcnfk elilenhynt sasakwthsg gemfvalnqk glpvkgkktk
      181 keqktahflp mait
//
