LOCUS       NM_022211               2475 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 5 (Fgf5), transcript
            variant 1, mRNA.
ACCESSION   NM_022211
VERSION     NM_022211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Lee,D., Park,C., Lee,H., Lugus,J.J., Kim,S.H., Arentson,E.,
            Chung,Y.S., Gomez,G., Kyba,M., Lin,S., Janknecht,R., Lim,D.S. and
            Choi,K.
  TITLE     ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and
            vessel progenitor specification
  JOURNAL   Cell Stem Cell 2 (5), 497-507 (2008)
   PUBMED   18462699
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Reuss,B., Dono,R. and Unsicker,K.
  TITLE     Functions of fibroblast growth factor (FGF)-2 and FGF-5 in
            astroglial differentiation and blood-brain barrier permeability:
            evidence from mouse mutants
  JOURNAL   J Neurosci 23 (16), 6404-6412 (2003)
   PUBMED   12878680
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Ota,Y., Saitoh,Y., Suzuki,S., Ozawa,K., Kawano,M. and Imamura,T.
  TITLE     Fibroblast growth factor 5 inhibits hair growth by blocking dermal
            papilla cell activation
  JOURNAL   Biochem Biophys Res Commun 290 (1), 169-176 (2002)
   PUBMED   11779149
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Hattori,Y., Yamasaki,M. and Itoh,N.
  TITLE     The rat FGF-5 mRNA variant generated by alternative splicing
            encodes a novel truncated form of FGF-5
  JOURNAL   Biochim Biophys Acta 1306 (1), 31-33 (1996)
   PUBMED   8611621
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Clements,D.A., Wang,J.K., Dionne,C.A. and Goldfarb,M.
  TITLE     Activation of fibroblast growth factor (FGF) receptors by
            recombinant human FGF-5
  JOURNAL   Oncogene 8 (5), 1311-1316 (1993)
   PUBMED   8386828
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Zhan,X., Bates,B., Hu,X.G. and Goldfarb,M.
  TITLE     The human FGF-5 oncogene encodes a novel protein related to
            fibroblast growth factors
  JOURNAL   Mol Cell Biol 8 (8), 3487-3495 (1988)
   PUBMED   3211147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 29, 2022 this sequence version replaced NM_022211.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.42853.1,
                                           SRR26643295.48315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-516               JAXUCZ010000014.1  11649728-11650243   c
            517-620             JAXUCZ010000014.1  11642574-11642677   c
            621-2475            JAXUCZ010000014.1  11627906-11629760   c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..2475
                     /gene="Fgf5"
                     /gene_synonym="FGF-5; Fgf3a; HBGF-5"
                     /note="fibroblast growth factor 5"
                     /db_xref="GeneID:60662"
                     /db_xref="RGD:620129"
     exon            1..516
                     /gene="Fgf5"
                     /gene_synonym="FGF-5; Fgf3a; HBGF-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..968
                     /gene="Fgf5"
                     /gene_synonym="FGF-5; Fgf3a; HBGF-5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; heparin-binding growth factor 5; fibroblast
                     growth factor FGF-5; fibroblast growth factor 3a"
                     /codon_start=1
                     /product="fibroblast growth factor 5 isoform 1 precursor"
                     /protein_id="NP_071547.2"
                     /db_xref="GeneID:60662"
                     /db_xref="RGD:620129"
                     /translation="MSLSLLFLIFCSHLILSAPAQGEKRLTPEGQPAPPRNPGDSSGS
                     RGRSSATFASSSASSPVAASPGSQGSGSEHSSFQWSPSGRRTGSLYCRVGIGFHLQIY
                     PDGKVNGSHEASVLSILEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKF
                     RERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHVSTHFLPRFK
                     QSEQPELSFTVTVPEKKKPPSPVKPKVPLSPPRRSPSPVKYRLKFRFG"
     exon            517..620
                     /gene="Fgf5"
                     /gene_synonym="FGF-5; Fgf3a; HBGF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            621..2475
                     /gene="Fgf5"
                     /gene_synonym="FGF-5; Fgf3a; HBGF-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcgggtgg cccctctctc tctctccccc tctccctctc ccttccccga ggctatgtcc
       61 acccagtgcg gcgagggagg cagcgccaga ggctcgcagc cgcgcggggg ctacggagcc
      121 cggagccagc cctgcaagat gcacttagga cccccgcggc cggaagaatg agcctgtcct
      181 tgctcttcct catcttctgc agccacctga tcctcagcgc tccggctcaa ggggagaagc
      241 gtctcactcc cgaagggcaa cccgcgcctc ctaggaaccc gggagactcc agcggcagcc
      301 ggggcagaag tagcgcgacg tttgcttcgt cttctgcctc ttccccagtc gcagcttctc
      361 cgggcagcca aggaagcggc tcggagcaca gcagtttcca gtggagccct tcggggcgcc
      421 ggaccggcag cctgtactgc agagtgggca tcggtttcca tctgcagatc tacccggatg
      481 gcaaagtcaa tggatcccac gaagccagtg tgttaagtat tttggaaata tttgctgtgt
      541 ctcaggggat tgtaggaata cgaggagttt tcagcaacaa atttttagcg atgtcaaaaa
      601 aaggaaaact ccatgcaagt gccaaattta cagatgactg taagttcagg gagagattcc
      661 aagaaaacag ctataatacc tatgcgtcag cgattcacag aactgaaaag acaggccggg
      721 agtggtatgt ggccctgaac aagagaggga aagccaaaag aggctgcagc ccacgggtca
      781 aaccccagca cgtctccacc cacttcctac ccaggttcaa gcagtccgag caaccggaac
      841 tttccttcac cgtcactgtt ccagaaaaga aaaagccacc cagccccgtg aaaccaaagg
      901 ttcccctgtc gccacctcgc agaagcccca gcccagtgaa gtacagactg aagtttcgct
      961 ttggatgatg ctcgcccgga gccttgtggg aaaccactct tctcctcagg accttctgca
     1021 ggcatcctcg gagccctgaa ggaaatttcg gacacagtgt ccatccgctg tgcttgcacg
     1081 agtggaagtc aggtcacttg ttctgctttg actggaacta aactgctttc taaattttaa
     1141 atagaaacag aagtgggatt ctccgtagcg atccagggag cacatcccta cggatcacta
     1201 aggttataaa ggctgcgaga ttagaggatg tttagcatca tggattttca gaccgttcaa
     1261 taccccggac tgtgtatttt tctgactttt acagatcaac cgggaagaac acacatgata
     1321 catttttatt tttgttctcc aaagaatatt ttgatgcaga taaaatattt tataaacttt
     1381 tgggtttttt tttttaaggt acctcaacat tgagcatact ttcttacttc tattatttta
     1441 attaacgtga cacaagcagt tggtttgttg ccgttcgccg attgtaaaca ttttggtagc
     1501 ttgtgtggta ggatctggat ctccttcgag tttttctctc tctacagcat tgtttacttt
     1561 attttagcga tacctcaaat cgtataggtt tagttctacg ttttaagact tttttagaaa
     1621 atgtgctttc aaagcgccag aggctcggcg tggaggtgtg ttatttgtgt ataaagtcat
     1681 ggcattctac gtggaatctg gccacgttag cggctgggct ctcgattgga aggacgaaaa
     1741 tttgaggacg ttttgatgga ttgaaaggtt gggtataaag aaggacggag gcaaacacag
     1801 gctgagtgtg aagctttggc tgagatttga ctctgtcttt ggcttcctct ccttttatgt
     1861 gtgcccctcc cccccgccct gtcctcattc aagaacagct ggaagaataa gttttattct
     1921 gtccgtcaag catacactat gaaactggag gaaactggag tgcttaaaag tacttctacg
     1981 actcccagtc atccttactg tatgaaccca cagggagcag ctaatcagga tgcgcgcatg
     2041 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtagc tgaaggagaa
     2101 gaatcactaa ccaggttttc acgtcaagtc tcatgctcaa gcacacttct attattcagt
     2161 caaatacctg ttgagctttc tatcctaaag gtcacgacct cgatgagtgg gtccgctctg
     2221 ctctaagaaa acctgacacg ccccagaagc atctcgtgat gcaggagctt aatttgggaa
     2281 tttgatgaac tgagaatgac acttcatcct caactggaat tccaaacgct gggtggactt
     2341 cacaaatagt ttaacttatg aagagttact aaatttattt tcttggataa tcattttttt
     2401 tatggagatc tatggagtat aagtgttcac cttatgttcc taagtgttgc aataaagact
     2461 cagaggtgac catta
//
