LOCUS       NP_071547                266 aa            linear   ROD 31-MAR-2024
DEFINITION  fibroblast growth factor 5 isoform 1 precursor [Rattus norvegicus].
ACCESSION   NP_071547
VERSION     NP_071547.2
DBSOURCE    REFSEQ: accession NM_022211.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 266)
  AUTHORS   Lee,D., Park,C., Lee,H., Lugus,J.J., Kim,S.H., Arentson,E.,
            Chung,Y.S., Gomez,G., Kyba,M., Lin,S., Janknecht,R., Lim,D.S. and
            Choi,K.
  TITLE     ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and
            vessel progenitor specification
  JOURNAL   Cell Stem Cell 2 (5), 497-507 (2008)
   PUBMED   18462699
REFERENCE   2  (residues 1 to 266)
  AUTHORS   Reuss,B., Dono,R. and Unsicker,K.
  TITLE     Functions of fibroblast growth factor (FGF)-2 and FGF-5 in
            astroglial differentiation and blood-brain barrier permeability:
            evidence from mouse mutants
  JOURNAL   J Neurosci 23 (16), 6404-6412 (2003)
   PUBMED   12878680
REFERENCE   3  (residues 1 to 266)
  AUTHORS   Ota,Y., Saitoh,Y., Suzuki,S., Ozawa,K., Kawano,M. and Imamura,T.
  TITLE     Fibroblast growth factor 5 inhibits hair growth by blocking dermal
            papilla cell activation
  JOURNAL   Biochem Biophys Res Commun 290 (1), 169-176 (2002)
   PUBMED   11779149
REFERENCE   4  (residues 1 to 266)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   5  (residues 1 to 266)
  AUTHORS   Hattori,Y., Yamasaki,M. and Itoh,N.
  TITLE     The rat FGF-5 mRNA variant generated by alternative splicing
            encodes a novel truncated form of FGF-5
  JOURNAL   Biochim Biophys Acta 1306 (1), 31-33 (1996)
   PUBMED   8611621
REFERENCE   6  (residues 1 to 266)
  AUTHORS   Clements,D.A., Wang,J.K., Dionne,C.A. and Goldfarb,M.
  TITLE     Activation of fibroblast growth factor (FGF) receptors by
            recombinant human FGF-5
  JOURNAL   Oncogene 8 (5), 1311-1316 (1993)
   PUBMED   8386828
REFERENCE   7  (residues 1 to 266)
  AUTHORS   Zhan,X., Bates,B., Hu,X.G. and Goldfarb,M.
  TITLE     The human FGF-5 oncogene encodes a novel protein related to
            fibroblast growth factors
  JOURNAL   Mol Cell Biol 8 (8), 3487-3495 (1988)
   PUBMED   3211147
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 29, 2022 this sequence version replaced NP_071547.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.42853.1,
                                           SRR26643295.48315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09345238
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..266
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..266
                     /product="fibroblast growth factor 5 isoform 1 precursor"
                     /note="heparin-binding growth factor 5; fibroblast growth
                     factor FGF-5; fibroblast growth factor 3a"
                     /calculated_mol_wt=27199
     sig_peptide     1..17
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P48807.1)"
                     /calculated_mol_wt=1937
     mat_peptide     18..266
                     /product="Fibroblast growth factor 5. /id=PRO_0000008960"
                     /note="propagated from UniProtKB/Swiss-Prot (P48807.1)"
                     /calculated_mol_wt=27199
     Region          23..81
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48807.1)"
     Region          85..217
                     /region_name="beta-trefoil_FGF5"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 5 (FGF5) and similar proteins; cd23317"
                     /db_xref="CDD:467003"
     Site            108
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P48807.1)"
     CDS             1..266
                     /gene="Fgf5"
                     /gene_synonym="FGF-5; Fgf3a; HBGF-5"
                     /coded_by="NM_022211.2:168..968"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:60662"
                     /db_xref="RGD:620129"
ORIGIN      
        1 mslsllflif cshlilsapa qgekrltpeg qpapprnpgd ssgsrgrssa tfasssassp
       61 vaaspgsqgs gsehssfqws psgrrtgsly crvgigfhlq iypdgkvngs heasvlsile
      121 ifavsqgivg irgvfsnkfl amskkgklha sakftddckf rerfqensyn tyasaihrte
      181 ktgrewyval nkrgkakrgc sprvkpqhvs thflprfkqs eqpelsftvt vpekkkppsp
      241 vkpkvplspp rrspspvkyr lkfrfg
//
