LOCUS       NM_001389212            3055 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 4 (Fgf4), mRNA.
ACCESSION   NM_001389212 XM_006230640
VERSION     NM_001389212.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Zhao,X., Yang,W., Li,G., Dong,H., Hou,J., Cao,Z. and Guan,D.
  TITLE     Expression of Fibroblast Growth Factor 4 in a Rat Model of
            Polydactyly of the Thumb Induced by Cytarabine
  JOURNAL   Med Sci Monit 26, e926953 (2020)
   PUBMED   32788570
  REMARK    GeneRIF: Expression of Fibroblast Growth Factor 4 in a Rat Model of
            Polydactyly of the Thumb Induced by Cytarabine.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3055)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   Abell,A.N., Granger,D.A., Johnson,N.L., Vincent-Jordan,N.,
            Dibble,C.F. and Johnson,G.L.
  TITLE     Trophoblast stem cell maintenance by fibroblast growth factor 4
            requires MEKK4 activation of Jun N-terminal kinase
  JOURNAL   Mol Cell Biol 29 (10), 2748-2761 (2009)
   PUBMED   19289495
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Kettunen,P., Spencer-Dene,B., Furmanek,T., Kvinnsland,I.H.,
            Dickson,C., Thesleff,I. and Luukko,K.
  TITLE     Fgfr2b mediated epithelial-mesenchymal interactions coordinate
            tooth morphogenesis and dental trigeminal axon patterning
  JOURNAL   Mech Dev 124 (11-12), 868-883 (2007)
   PUBMED   17951031
REFERENCE   5  (bases 1 to 3055)
  AUTHORS   Bobick,B.E., Thornhill,T.M. and Kulyk,W.M.
  TITLE     Fibroblast growth factors 2, 4, and 8 exert both negative and
            positive effects on limb, frontonasal, and mandibular
            chondrogenesis via MEK-ERK activation
  JOURNAL   J Cell Physiol 211 (1), 233-243 (2007)
   PUBMED   17167778
REFERENCE   6  (bases 1 to 3055)
  AUTHORS   Kim,H.J., Rice,D.P., Kettunen,P.J. and Thesleff,I.
  TITLE     FGF-, BMP- and Shh-mediated signalling pathways in the regulation
            of cranial suture morphogenesis and calvarial bone development
  JOURNAL   Development 125 (7), 1241-1251 (1998)
   PUBMED   9477322
REFERENCE   7  (bases 1 to 3055)
  AUTHORS   Neubuser,A., Peters,H., Balling,R. and Martin,G.R.
  TITLE     Antagonistic interactions between FGF and BMP signaling pathways: a
            mechanism for positioning the sites of tooth formation
  JOURNAL   Cell 90 (2), 247-255 (1997)
   PUBMED   9244299
REFERENCE   8  (bases 1 to 3055)
  AUTHORS   Chen,Y., Bei,M., Woo,I., Satokata,I. and Maas,R.
  TITLE     Msx1 controls inductive signaling in mammalian tooth morphogenesis
  JOURNAL   Development 122 (10), 3035-3044 (1996)
   PUBMED   8898217
REFERENCE   9  (bases 1 to 3055)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   10 (bases 1 to 3055)
  AUTHORS   Grass,S., Arnold,H.H. and Braun,T.
  TITLE     Alterations in somite patterning of Myf-5-deficient mice: a
            possible role for FGF-4 and FGF-6
  JOURNAL   Development 122 (1), 141-150 (1996)
   PUBMED   8565825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced XM_006230640.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN09345238,
                              SAMN09345329 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-447               JAXUCZ010000001.1  209453229-209453675
            448-551             JAXUCZ010000001.1  209454073-209454176
            552-3055            JAXUCZ010000001.1  209454582-209457085
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3055
                     /gene="Fgf4"
                     /gene_synonym="Fgf7a; Hst; Hst1"
                     /note="fibroblast growth factor 4"
                     /db_xref="GeneID:116499"
                     /db_xref="RGD:620127"
     exon            1..447
                     /gene="Fgf4"
                     /gene_synonym="Fgf7a; Hst; Hst1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..728
                     /gene="Fgf4"
                     /gene_synonym="Fgf7a; Hst; Hst1"
                     /note="heparin-binding growth factor 1; fibroblast growth
                     factor 7a"
                     /codon_start=1
                     /product="fibroblast growth factor 4 precursor"
                     /protein_id="NP_001376141.1"
                     /db_xref="GeneID:116499"
                     /db_xref="RGD:620127"
                     /translation="MAKRGPTTGTLLPGVLLALVVALADRGTAAPNGTRHAELGHGWD
                     GLVARSLARLPVAAQPPQAAVRSGAGDYLLGLKRLRRLYCNVGIGFHLQVLPDGRIGG
                     VHADTRDSLLELSPVQRGVVSIFGVASRFFVAMSSRGKLFGVPFFTDECKFKEILLPN
                     NYNAYESYAYPGMFMALSKNGRTKKGNRVSPTMKVTHFLPRL"
     exon            448..551
                     /gene="Fgf4"
                     /gene_synonym="Fgf7a; Hst; Hst1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..3055
                     /gene="Fgf4"
                     /gene_synonym="Fgf7a; Hst; Hst1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcggggac tgtcccgcca ccggcgcttg cccgtttgct ctcgtggctt cgacttgcgc
       61 gcagcactca ccgaactcac ggcccgccgc tcgggctcac gcacggcccg cgggccggaa
      121 tggcgaagcg cgggccgact acagggacgc tgctgcccgg ggtcctgctg gccctggtgg
      181 tggccctggc ggaccgaggg accgccgcac ccaacggcac gcggcacgcc gaattggggc
      241 acggctggga cggcctggtg gcccgctcgc tggcacgctt gccggtggcc gcgcagcccc
      301 cgcaggcggc ggtccgcagc ggcgcagggg actacctgct gggcctcaaa aggctgcgga
      361 gactctactg caacgtgggc atcggattcc acctgcaggt gctgcccgac ggccgcatcg
      421 gcggtgtgca cgcggacacg agggacagcc ttctggagct ctctccggtg cagcggggtg
      481 tggtgagcat cttcggagtg gccagccggt tcttcgtggc catgagcagc aggggcaagc
      541 tcttcggtgt gcctttcttt accgacgagt gtaaattcaa agaaatactt ctccccaaca
      601 actacaatgc ctacgagtcc tacgcatacc cgggcatgtt catggccctc agtaagaacg
      661 ggcggaccaa gaaggggaac cgagtttcgc cgaccatgaa ggtaacccac ttccttccta
      721 gactgtgact ctccgaagcc ctgcctcagc ctcggaagca cacccgaccc ctcaggagga
      781 gcactttctc tcgatggata attgtttgca aaaacaagcc taagatattt aaattaatta
      841 tttaaatatg tatatatgga cagccaatta tttataagtc tatgtatttt cattttctgg
      901 cggaaaatga ccaaaagaac aaacaaatca aatgcagctc ggacctcttt ggtacagtgg
      961 gacaaacttt ttccttcact ctcaaagatc gggctgtgct gctgtttcat atgtgcctct
     1021 aaaacgtggt gacatcagat tccaagggtg cctggcccct ctgtctggaa aggcctgctt
     1081 gggtcctctg agtcagtgag aggaggaccc taagcttcct cctgtcccgg agcatcctgc
     1141 agcagccgct ccctcagctc cctttggtat gaaccctgtc ggatcggttt actccaggga
     1201 cagaagtgcg tcctggaagt cctcccgcct ctgtttttag atctccaaga ctgatctttg
     1261 aactctcttg cagtcaatct tcttggacct accggatggg agacccttag acaactttat
     1321 aaactcctgt ttgccttctt ttttactggc caacagggcg catggcttgt agccactgga
     1381 actttgtaaa ttccctggaa aaaggaacta ggaatggaca agatgcgtgt gccacaactc
     1441 caactctagg gatgaaattg ttttgtgata gaggatgaca tgtcggggat ataacaatgt
     1501 attttgcaaa aatcaaattg agaaaaacag gcttccctga atttgggggt cttttgtatt
     1561 gggactccat aatttaaagg tgagctgtcc ttcccatcgg ggcagccctt atgcaggcag
     1621 actgcaggag tccgcattcc agtgctgcgc caatgtgaaa cgcattctat tcccatctac
     1681 ctcagagttc ctgagtccct ggtggccaag ctggaggctc tgctgggtgc gtctgcctgt
     1741 ttctcttcca catgtagcat ctctcaaccc gctggtctct tgtcacgttt cagctatctt
     1801 tacccaatga tttactttta gtaaggggta ttcatggtga aaatatgcgc ggccagctgt
     1861 cggagtgcag tatatggtca ccaagtcaag taacccttat atttttcttt atatatttta
     1921 cgaatgtcac ccctgtcacc gagaccgaga tggaggagca gggtcggcgg catttaaaaa
     1981 aagggctgag gtgagggagg acatttaatt ttaatgaatg actttggagt ttatacaaaa
     2041 tgaccttcgc tcactacagc gaatgtctca aatgcttctc cccaagacgt taagactctg
     2101 ctgggaggct tctgagcctc ctcccgaatt aactttatga gagggtacag acagcaagac
     2161 gggaaaatct gattggcatt tttttttgtc tttcacattc ctttagaaga aaactctttg
     2221 tttgaatgct aatgggatac ttaaaatact attctgcagc gctgccctag aaggaagaag
     2281 ccacgcccca aagttgaggt gggagcatgt cccaaacttc cctttctgtc tggggctcac
     2341 aggctgatac agattttgtg ttttttaagc caggccctag actccaagag tgttggggag
     2401 aagatagttg aaggtctttt gtttttgtta ttttttaaag actgggtctc ttagcccagg
     2461 ctggccctga acttgctatg tcattaaaga tgaccttgaa tttctgatcc tcttgcccca
     2521 tttccaagtg ctaaggttac aggccttgcc caccacaccc actcattagg tgatgggaat
     2581 tgaaatcgag tgtgtgctag accactcagc agagctaagc ctccctcttt tttgtggggg
     2641 aggaaatgtg ggggtcttat tcggtagccc aggccagtct cctgcttgaa ttgtgttgag
     2701 actacaggta gaagactcct gctctgctct gatgggattc tctgctgcta tgttgcctca
     2761 ggctggctgt ggtcctacct gacacctatt acctgtttct tcagcctgtt agcttccttt
     2821 cctgtgccca gggacaagat tgtatctttg gaactttgtt actaaatgga tttgggtttc
     2881 tgtatccgcc cctgttaccg agtcggtctg tagttactac aggtgtcgac ccagagatgg
     2941 tatgtgctat gcacactgga tgctccatcc aagagaagca ttcaatcatg tatagagagc
     3001 ccccacggac tgggagtgac tgagaaagat attaaaatga caaacgtatc tggaa
//
