LOCUS       NM_130817               1189 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 3 (Fgf3), mRNA.
ACCESSION   NM_130817
VERSION     NM_130817.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1189)
  AUTHORS   Sautter,N.B., Delaney,K.L., Hausman,F.A. and Trune,D.R.
  TITLE     Tissue remodeling in the acute otitis media mouse model
  JOURNAL   Int J Pediatr Otorhinolaryngol 75 (11), 1368-1371 (2011)
   PUBMED   21889218
REFERENCE   2  (bases 1 to 1189)
  AUTHORS   Tirosh-Finkel,L., Zeisel,A., Brodt-Ivenshitz,M., Shamai,A., Yao,Z.,
            Seger,R., Domany,E. and Tzahor,E.
  TITLE     BMP-mediated inhibition of FGF signaling promotes cardiomyocyte
            differentiation of anterior heart field progenitors
  JOURNAL   Development 137 (18), 2989-3000 (2010)
   PUBMED   20702560
REFERENCE   3  (bases 1 to 1189)
  AUTHORS   Zelarayan,L.C., Vendrell,V., Alvarez,Y., Dominguez-Frutos,E.,
            Theil,T., Alonso,M.T., Maconochie,M. and Schimmang,T.
  TITLE     Differential requirements for FGF3, FGF8 and FGF10 during inner ear
            development
  JOURNAL   Dev Biol 308 (2), 379-391 (2007)
   PUBMED   17601531
REFERENCE   4  (bases 1 to 1189)
  AUTHORS   Aggarwal,V.S., Liao,J., Bondarev,A., Schimmang,T., Lewandoski,M.,
            Locker,J., Shanske,A., Campione,M. and Morrow,B.E.
  TITLE     Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS
            suggests functional redundancy
  JOURNAL   Hum Mol Genet 15 (21), 3219-3228 (2006)
   PUBMED   17000704
REFERENCE   5  (bases 1 to 1189)
  AUTHORS   Ladher,R.K., Wright,T.J., Moon,A.M., Mansour,S.L. and
            Schoenwolf,G.C.
  TITLE     FGF8 initiates inner ear induction in chick and mouse
  JOURNAL   Genes Dev 19 (5), 603-613 (2005)
   PUBMED   15741321
REFERENCE   6  (bases 1 to 1189)
  AUTHORS   Nakajima,A., Shimizu,S., Moriya,H. and Yamazaki,M.
  TITLE     Expression of fibroblast growth factor receptor-3 (FGFR3), signal
            transducer and activator of transcription-1, and cyclin-dependent
            kinase inhibitor p21 during endochondral ossification: differential
            role of FGFR3 in skeletal development and fracture repair
  JOURNAL   Endocrinology 144 (10), 4659-4668 (2003)
   PUBMED   12960068
  REMARK    GeneRIF: During fracture repair, strongly expressed in
            prehypertrophic chondrocytes, and expression level reached maximum
            on day 14. FGFR3-mediated STAT1-p21 signaling may have role in
            fracture repair.
REFERENCE   7  (bases 1 to 1189)
  AUTHORS   Wright,T.J. and Mansour,S.L.
  TITLE     Fgf3 and Fgf10 are required for mouse otic placode induction
  JOURNAL   Development 130 (15), 3379-3390 (2003)
   PUBMED   12810586
REFERENCE   8  (bases 1 to 1189)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   9  (bases 1 to 1189)
  AUTHORS   Hajitou,A. and Calberg-Bacq,C.M.
  TITLE     Fibroblast growth factor 3 is tumorigenic for mouse mammary cells
            orthotopically implanted in nude mice
  JOURNAL   Int J Cancer 63 (5), 702-709 (1995)
   PUBMED   7591288
REFERENCE   10 (bases 1 to 1189)
  AUTHORS   Venesio,T., Taverna,D., Hynes,N.E., Deed,R., MacAllan,D.,
            Ciardiello,F., Valverius,E.M., Salomon,D.S., Callahan,R. and
            Merlo,G.
  TITLE     The int-2 gene product acts as a growth factor and substitutes for
            basic fibroblast growth factor in promoting the differentiation of
            a normal mouse mammary epithelial cell line
  JOURNAL   Cell Growth Differ 3 (1), 63-71 (1992)
   PUBMED   1376141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 11, 2022 this sequence version replaced NM_130817.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB079262.1, BF386947.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMN06680417 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               JAXUCZ010000001.1  209430457-209430775
            320-423             JAXUCZ010000001.1  209432513-209432616
            424-1189            JAXUCZ010000001.1  209434067-209434832
FEATURES             Location/Qualifiers
     source          1..1189
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..1189
                     /gene="Fgf3"
                     /gene_synonym="Fgf5c; Int2"
                     /note="fibroblast growth factor 3"
                     /db_xref="GeneID:170633"
                     /db_xref="RGD:620126"
     exon            1..319
                     /gene="Fgf3"
                     /gene_synonym="Fgf5c; Int2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..837
                     /gene="Fgf3"
                     /gene_synonym="Fgf5c; Int2"
                     /note="interacting gene 2; fibroblast growth factor 5c"
                     /codon_start=1
                     /product="fibroblast growth factor 3 precursor"
                     /protein_id="NP_570830.1"
                     /db_xref="GeneID:170633"
                     /db_xref="RGD:620126"
                     /translation="MGLIWLLLLSLLEPGWPATGPGTRLRRDAGGRGGVYEHLGGAPR
                     RRKLYCATKYHLQLHPSGRVNGSLENSAYSILEITAVEVGVVAIKGLFSGRYLAMNKR
                     GRLYASEHYNAECEFVERIHELGYNTYASRLYRTGPSGPGARRQPGAQRPWYVSVNGK
                     GRPRRGFKTRRTQKSSLFLPRVLGHKDHEMVRLLQSGQPQAPGEGSQPRQRRQKKQSP
                     GDHGKMEHLPTKATTSAQLDTGGLAMA"
     exon            320..423
                     /gene="Fgf3"
                     /gene_synonym="Fgf5c; Int2"
                     /inference="alignment:Splign:2.1.0"
     exon            424..1189
                     /gene="Fgf3"
                     /gene_synonym="Fgf5c; Int2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcgagccg gcctggcgcg cgagcgtgtg ctccctgcgc cgcgccttcg tgagccccgc
       61 gctggcgcag ccgccgctgc gggcgggcgc gatgccggga tgggcctgat ctggcttctg
      121 ctgctcagct tgctggaacc cggctggcca gctacggggc ccgggacgcg acttcgacgc
      181 gatgcgggcg gccgtggcgg cgtttacgag cacctcggcg gggcgccccg gcgccgcaag
      241 ctctactgcg ctaccaagta ccacctccag cttcacccga gcggccgcgt gaacggcagc
      301 cttgagaaca gcgcctatag catcctggag attactgctg tggaggtggg cgtggtggcc
      361 atcaaagggc tcttttctgg gcggtacctg gccatgaaca agagaggacg gctgtatgct
      421 tcggagcact acaacgcaga gtgtgagttt gtggaacgga tccacgagct gggttacaat
      481 acatatgctt cccgcctata ccgcacgggg cccagtgggc caggggctcg acggcagcct
      541 ggtgcccaga gaccttggta cgtgtctgtg aacggcaagg gtcggccacg caggggcttc
      601 aagacccgcc gcacacagaa gtcttctctc ttcctgcccc gagtgctggg tcacaaggac
      661 catgagatgg tacggctgct gcagagtggc cagccacaag ccccaggaga gggcagccaa
      721 cccaggcagc ggaggcagaa gaagcagagc ccaggtgatc atggcaaaat ggagcatttg
      781 ccaaccaagg ccactacaag cgcccaactg gatacagggg gactggctat ggcttgagtg
      841 gccacttgga agccctctga gaccaacctc agcaagcacc caagatccac ttggagaccc
      901 agcctcccca cccttgtctg tggggtggct gcatggggga ccaagaactt gcatgccttt
      961 gggggctttt aaagagcaag tgccaactgc tgagggactt gggtcagaga ctctggaaga
     1021 ctcttcaaga tgtgtgtgga gttacatgag agggaattct aattacaggg gtcatcctaa
     1081 ccctgggtgg agcccagcca atggcagaca gtcctggcaa cctgaggcag tggagagtgg
     1141 aggggctgtg attcaaacat taaaggtgtc tgtctgtctt gctacttaa
//
