LOCUS       NM_130754               2630 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 23 (Fgf23), mRNA.
ACCESSION   NM_130754
VERSION     NM_130754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2630)
  AUTHORS   Li,J., Nie,J., Zhou,Z., Guo,M., Yang,Q., Yuan,D., Huang,J., Li,R.
            and Li,Q.
  TITLE     Changes of FGF23 and hearing in chronic renal failure and their
            correlation analysis
  JOURNAL   Cytokine 174, 156478 (2024)
   PUBMED   38134554
  REMARK    GeneRIF: Changes of FGF23 and hearing in chronic renal failure and
            their correlation analysis.
REFERENCE   2  (bases 1 to 2630)
  AUTHORS   Suito,H., Fujikawa,K. and Ohsako,M.
  TITLE     ENPP1 downregulation and FGF23 upregulation in growth-related
            calcification of the tibial tuberosity in rats
  JOURNAL   J Anat 244 (2), 333-342 (2024)
   PUBMED   37814911
  REMARK    GeneRIF: ENPP1 downregulation and FGF23 upregulation in
            growth-related calcification of the tibial tuberosity in rats.
REFERENCE   3  (bases 1 to 2630)
  AUTHORS   Radvanyi,Z., Yoo,E.J., Kandasamy,P., Salas-Bastos,A., Monnerat,S.,
            Refardt,J., Christ-Crain,M., Hayashi,H., Kondo,Y., Jantsch,J.,
            Rubio-Aliaga,I., Sommer,L., Wagner,C.A., Hediger,M.A., Kwon,H.M.,
            Loffing,J. and Pathare,G.
  TITLE     Extracellular sodium regulates fibroblast growth factor 23 (FGF23)
            formation
  JOURNAL   J Biol Chem 300 (1), 105480 (2024)
   PUBMED   37992803
  REMARK    GeneRIF: Extracellular sodium regulates fibroblast growth factor 23
            (FGF23) formation.
REFERENCE   4  (bases 1 to 2630)
  AUTHORS   Jia,Z., Liu,Q., Xie,Y., Wei,J., Sun,X., Meng,F., Zhao,B., Yu,Z.,
            Zhao,L. and Xing,Z.
  TITLE     Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine
            Release through ERK/MAPK Pathway
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 317-328 (2023)
   PUBMED   37704925
  REMARK    GeneRIF: Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and
            Cytokine Release through ERK/MAPK Pathway.
REFERENCE   5  (bases 1 to 2630)
  AUTHORS   Li,L. and Gan,H.
  TITLE     Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney
            Disease-Induced Myocardial Fibrosis by Activating the Sonic
            Hedgehog Signaling Pathway
  JOURNAL   J Am Heart Assoc 11 (18), e026365 (2022)
   PUBMED   36102251
  REMARK    GeneRIF: Intact Fibroblast Growth Factor 23 Regulates Chronic
            Kidney Disease-Induced Myocardial Fibrosis by Activating the Sonic
            Hedgehog Signaling Pathway.
REFERENCE   6  (bases 1 to 2630)
  AUTHORS   Larsson,T., Marsell,R., Schipani,E., Ohlsson,C., Ljunggren,O.,
            Tenenhouse,H.S., Juppner,H. and Jonsson,K.B.
  TITLE     Transgenic mice expressing fibroblast growth factor 23 under the
            control of the alpha1(I) collagen promoter exhibit growth
            retardation, osteomalacia, and disturbed phosphate homeostasis
  JOURNAL   Endocrinology 145 (7), 3087-3094 (2004)
   PUBMED   14988389
REFERENCE   7  (bases 1 to 2630)
  AUTHORS   Shimada,T., Hasegawa,H., Yamazaki,Y., Muto,T., Hino,R.,
            Takeuchi,Y., Fujita,T., Nakahara,K., Fukumoto,S. and Yamashita,T.
  TITLE     FGF-23 is a potent regulator of vitamin D metabolism and phosphate
            homeostasis
  JOURNAL   J Bone Miner Res 19 (3), 429-435 (2004)
   PUBMED   15040831
REFERENCE   8  (bases 1 to 2630)
  AUTHORS   Saito,H., Kusano,K., Kinosaki,M., Ito,H., Hirata,M., Segawa,H.,
            Miyamoto,K. and Fukushima,N.
  TITLE     Human fibroblast growth factor-23 mutants suppress Na+-dependent
            phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3
            production
  JOURNAL   J Biol Chem 278 (4), 2206-2211 (2003)
   PUBMED   12419819
REFERENCE   9  (bases 1 to 2630)
  AUTHORS   Bowe,A.E., Finnegan,R., Jan de Beur,S.M., Cho,J., Levine,M.A.,
            Kumar,R. and Schiavi,S.C.
  TITLE     FGF-23 inhibits renal tubular phosphate transport and is a PHEX
            substrate
  JOURNAL   Biochem Biophys Res Commun 284 (4), 977-981 (2001)
   PUBMED   11409890
REFERENCE   10 (bases 1 to 2630)
  CONSRTM   ADHR Consortium
  TITLE     Autosomal dominant hypophosphataemic rickets is associated with
            mutations in FGF23
  JOURNAL   Nat Genet 26 (3), 345-348 (2000)
   PUBMED   11062477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 6, 2022 this sequence version replaced NM_130754.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.20128.1,
                                           SRR26643295.19901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               JAXUCZ010000004.1  161600439-161600775
            338-441             JAXUCZ010000004.1  161605986-161606089
            442-2630            JAXUCZ010000004.1  161607803-161609991
FEATURES             Location/Qualifiers
     source          1..2630
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2630
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /note="fibroblast growth factor 23"
                     /db_xref="GeneID:170583"
                     /db_xref="RGD:620178"
     exon            1..337
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..882
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /note="FGF-23; fibroblast growth factor 8b"
                     /codon_start=1
                     /product="fibroblast growth factor 23 precursor"
                     /protein_id="NP_570110.1"
                     /db_xref="GeneID:170583"
                     /db_xref="RGD:620178"
                     /translation="MLGACLRLLVGALCTVCSLGTARAYSDTSPLLGSNWGSLTHLYT
                     ATARNSYHLQIHRDGHVDGTPHQTIYSALMITSEDAGSVVIIGAMTRRFLCMDLRGNI
                     FGSYHFSPENCRFRQWTLENGYDVYLSPKHHYLVSLGRSKRIFQPGTNPPPFSQFLAR
                     RNEVPLLHFYTARPRRHTRSAEDPPERDPLNVLKPRPRATPIPVSCSRELPSAEEGGP
                     AASDPLGVLRRGRGDARRGAGGTDRCRPFPRFV"
     exon            338..441
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /inference="alignment:Splign:2.1.0"
     exon            442..2630
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagcccagg atccccacct cagttctcag cttcttccta ggaagaagac agtaaggcca
       61 gcgaggtccc aggctgtctg ggagtgtcag atttcaacct cagcaatagc cactcagcgc
      121 tgtgcgatgc tgggggcctg cctcagactc ctggtgggcg ctctgtgcac cgtctgcagc
      181 ttgggcactg ctagagccta ttcagacact tccccactgc ttggctccaa ctgggggagc
      241 ctgacccacc tgtacacagc tacagccagg aacagctatc acctacagat ccatagggat
      301 ggccatgtag acggaacacc ccatcagact atctacagtg ccctgatgat cacatcagag
      361 gatgctggct ccgtagtgat aataggggcc atgaccagaa ggttcctttg tatggatctc
      421 cgcggcaaca tttttggatc gtatcacttc agcccggaga actgcagatt ccgccagtgg
      481 acgctagaga acggctacga cgtctacctg tcaccgaagc atcactacct ggtgagcttg
      541 ggccgctcca agcgcatctt ccagcccggt accaacccgc cgcccttctc gcagttcctg
      601 gcgcgcagga acgaggtccc gctgctgcac ttctacaccg cgcgcccacg gcgccacacg
      661 cgcagcgccg aggacccgcc cgagcgcgac ccgctgaatg tgctcaagcc gcggccccgc
      721 gctactccca taccggtatc ctgctcgcga gagctaccga gtgcagagga aggtggcccc
      781 gcggccagcg accccctggg agtgctgcgc agaggccgcg gggatgctcg ccggggcgcg
      841 ggaggcacgg atcggtgtcg cccctttccc aggttcgtct aggtccccag ccccggctgc
      901 ctccaccttc atcctccagt cggttcaccc cacgtggaga gctggggtac cctgaagatg
      961 tctgcttctc tcccttccct ttgggcctga gagtcacctg caaggttcca gccaggcacc
     1021 gctattcaga gccaacagtg ggaggctgga gaggtggccc agacaattct cagcacccac
     1081 aactacctgt aattctagct ccagggaaat ctgcactctc acacacatat ccacacatgc
     1141 atacatttaa ttttaaatgt tgatctattt tgaagacccc aacaggtaaa ctagacacga
     1201 ggctctttta attttacttt cctcagaggt aaactagacg cttagcccgt ctcttgccta
     1261 gcgttcttat cgatcagtta gcacgaggaa agagctcaca ccttgaacac agagaagagg
     1321 ccatctctgc agcttcttgt tactgttctg ggacccacat gagtttgagt ttgagtacct
     1381 tgaccttaat gtcttcactg ggcaagccga aggaagacat agatttcttc cctttgggaa
     1441 gagcttttgg aaaagattgg cgggaggctg acaaggagac ccaaaggcac ggtgaaccaa
     1501 agcccactcc acagagttca gcctcactac agaatgaaca ccctttgcca gcaagtgccg
     1561 aacctgctta cttcccagct ccctgcgata gaacgtgctt ttctgttggt agctttctga
     1621 atttaccctg gctcagcaaa gtctaccttg ctagggtgtt ttgcaaaatg caaaagcatg
     1681 aactctctct aaagaggcat tttagtaaaa gcttctgcta gccggtcgag ttgtaatata
     1741 ttctaagtga atgtgcctgg aggggaaggg tccttgagac ctgggattgt tccaggttag
     1801 ggtttctgtg aagtggaaag aaaaaaaaaa gttttttcct aagtgaaatg ggatccagga
     1861 cttactagct agagtcgggg ggtgggggtg ggggtctcct gcaggggtta accccacaat
     1921 ggcagctact cttgggaact tttagggcat taaaggaaga catctttcat ttgtcccaga
     1981 aaccccaggg ctgtcctggg gtgagcatag cctcacagtg aacagcaaga cgtgttaggc
     2041 aggctttgag gttgtccccc ctctgtacct tattagctgg tggtcgacct cgacgaaggg
     2101 cacctccttt ctacctctac ttaaatgaga actgaagggc acagtaatgg cccagtcctt
     2161 cagacaattc cgtgctttcc actgtcatca tgtacccact tagaaatgga cccactgttt
     2221 ttttgcttat cagaggaaca gcagccaatg tgaccacctc cacctctgag ttactaaatg
     2281 ctgtgcatag atagcagtag gtaccacgca ccccaaacct tttcttcgct ggctttcatt
     2341 cctgctgggg atcggtcagc acagcagcca ccggaagcct gcccactgag gcaactctgt
     2401 ggaaagccca gaaagaactt aactgggtgt aaactcaagc ccaacaccac cgagaggcct
     2461 tctttttggc ggagccgagg tcgtcttgta atttcttagg tccctttgca cgtggcgata
     2521 tttatttatt tatttgaaag attctgccta tcactctata tttatagtta tttatgaaat
     2581 gtaaccccac ttctgtcctt gagttttaaa taaaaataag atttctgtca
//
