LOCUS       NP_570110                251 aa            linear   ROD 31-MAR-2024
DEFINITION  fibroblast growth factor 23 precursor [Rattus norvegicus].
ACCESSION   NP_570110
VERSION     NP_570110.1
DBSOURCE    REFSEQ: accession NM_130754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 251)
  AUTHORS   Li,J., Nie,J., Zhou,Z., Guo,M., Yang,Q., Yuan,D., Huang,J., Li,R.
            and Li,Q.
  TITLE     Changes of FGF23 and hearing in chronic renal failure and their
            correlation analysis
  JOURNAL   Cytokine 174, 156478 (2024)
   PUBMED   38134554
  REMARK    GeneRIF: Changes of FGF23 and hearing in chronic renal failure and
            their correlation analysis.
REFERENCE   2  (residues 1 to 251)
  AUTHORS   Suito,H., Fujikawa,K. and Ohsako,M.
  TITLE     ENPP1 downregulation and FGF23 upregulation in growth-related
            calcification of the tibial tuberosity in rats
  JOURNAL   J Anat 244 (2), 333-342 (2024)
   PUBMED   37814911
  REMARK    GeneRIF: ENPP1 downregulation and FGF23 upregulation in
            growth-related calcification of the tibial tuberosity in rats.
REFERENCE   3  (residues 1 to 251)
  AUTHORS   Radvanyi,Z., Yoo,E.J., Kandasamy,P., Salas-Bastos,A., Monnerat,S.,
            Refardt,J., Christ-Crain,M., Hayashi,H., Kondo,Y., Jantsch,J.,
            Rubio-Aliaga,I., Sommer,L., Wagner,C.A., Hediger,M.A., Kwon,H.M.,
            Loffing,J. and Pathare,G.
  TITLE     Extracellular sodium regulates fibroblast growth factor 23 (FGF23)
            formation
  JOURNAL   J Biol Chem 300 (1), 105480 (2024)
   PUBMED   37992803
  REMARK    GeneRIF: Extracellular sodium regulates fibroblast growth factor 23
            (FGF23) formation.
REFERENCE   4  (residues 1 to 251)
  AUTHORS   Jia,Z., Liu,Q., Xie,Y., Wei,J., Sun,X., Meng,F., Zhao,B., Yu,Z.,
            Zhao,L. and Xing,Z.
  TITLE     Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine
            Release through ERK/MAPK Pathway
  JOURNAL   Cardiovasc Toxicol 23 (9-10), 317-328 (2023)
   PUBMED   37704925
  REMARK    GeneRIF: Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and
            Cytokine Release through ERK/MAPK Pathway.
REFERENCE   5  (residues 1 to 251)
  AUTHORS   Li,L. and Gan,H.
  TITLE     Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney
            Disease-Induced Myocardial Fibrosis by Activating the Sonic
            Hedgehog Signaling Pathway
  JOURNAL   J Am Heart Assoc 11 (18), e026365 (2022)
   PUBMED   36102251
  REMARK    GeneRIF: Intact Fibroblast Growth Factor 23 Regulates Chronic
            Kidney Disease-Induced Myocardial Fibrosis by Activating the Sonic
            Hedgehog Signaling Pathway.
REFERENCE   6  (residues 1 to 251)
  AUTHORS   Larsson,T., Marsell,R., Schipani,E., Ohlsson,C., Ljunggren,O.,
            Tenenhouse,H.S., Juppner,H. and Jonsson,K.B.
  TITLE     Transgenic mice expressing fibroblast growth factor 23 under the
            control of the alpha1(I) collagen promoter exhibit growth
            retardation, osteomalacia, and disturbed phosphate homeostasis
  JOURNAL   Endocrinology 145 (7), 3087-3094 (2004)
   PUBMED   14988389
REFERENCE   7  (residues 1 to 251)
  AUTHORS   Shimada,T., Hasegawa,H., Yamazaki,Y., Muto,T., Hino,R.,
            Takeuchi,Y., Fujita,T., Nakahara,K., Fukumoto,S. and Yamashita,T.
  TITLE     FGF-23 is a potent regulator of vitamin D metabolism and phosphate
            homeostasis
  JOURNAL   J Bone Miner Res 19 (3), 429-435 (2004)
   PUBMED   15040831
REFERENCE   8  (residues 1 to 251)
  AUTHORS   Saito,H., Kusano,K., Kinosaki,M., Ito,H., Hirata,M., Segawa,H.,
            Miyamoto,K. and Fukushima,N.
  TITLE     Human fibroblast growth factor-23 mutants suppress Na+-dependent
            phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3
            production
  JOURNAL   J Biol Chem 278 (4), 2206-2211 (2003)
   PUBMED   12419819
REFERENCE   9  (residues 1 to 251)
  AUTHORS   Bowe,A.E., Finnegan,R., Jan de Beur,S.M., Cho,J., Levine,M.A.,
            Kumar,R. and Schiavi,S.C.
  TITLE     FGF-23 inhibits renal tubular phosphate transport and is a PHEX
            substrate
  JOURNAL   Biochem Biophys Res Commun 284 (4), 977-981 (2001)
   PUBMED   11409890
REFERENCE   10 (residues 1 to 251)
  CONSRTM   ADHR Consortium
  TITLE     Autosomal dominant hypophosphataemic rickets is associated with
            mutations in FGF23
  JOURNAL   Nat Genet 26 (3), 345-348 (2000)
   PUBMED   11062477
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.20128.1,
                                           SRR26643295.19901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..251
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     Protein         1..251
                     /product="fibroblast growth factor 23 precursor"
                     /note="FGF-23; fibroblast growth factor 8b"
                     /calculated_mol_wt=25537
     sig_peptide     1..24
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2393
     mat_peptide     25..251
                     /product="Fibroblast growth factor 23. /id=PRO_0000009000"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI82.1)"
                     /calculated_mol_wt=25537
     Region          25..169
                     /region_name="beta-trefoil_FGF"
                     /note="FGF domain, beta-trefoil fold, found in acidic and
                     basic fibroblast growth factor (FGF) superfamily; cl00060"
                     /db_xref="CDD:469595"
     Site            171
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZV9; propagated from
                     UniProtKB/Swiss-Prot (Q8VI82.1)"
     Region          175..251
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VI82.1)"
     Site            178
                     /site_type="glycosylation"
                     /note="O-linked (GalNAc) threonine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZV9; propagated from
                     UniProtKB/Swiss-Prot (Q8VI82.1)"
     Site            180
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by FAM20C.
                     /evidence=ECO:0000250|UniProtKB:Q9GZV9; propagated from
                     UniProtKB/Swiss-Prot (Q8VI82.1)"
     CDS             1..251
                     /gene="Fgf23"
                     /gene_synonym="Fgf8b"
                     /coded_by="NM_130754.2:127..882"
                     /db_xref="GeneID:170583"
                     /db_xref="RGD:620178"
ORIGIN      
        1 mlgaclrllv galctvcslg taraysdtsp llgsnwgslt hlytatarns yhlqihrdgh
       61 vdgtphqtiy salmitseda gsvviigamt rrflcmdlrg nifgsyhfsp encrfrqwtl
      121 engydvylsp khhylvslgr skrifqpgtn pppfsqflar rnevpllhfy tarprrhtrs
      181 aedpperdpl nvlkprprat pipvscsrel psaeeggpaa sdplgvlrrg rgdarrgagg
      241 tdrcrpfprf v
//
