LOCUS       NM_130751               1290 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 22 (Fgf22), mRNA.
ACCESSION   NM_130751
VERSION     NM_130751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Xu,Y.H., Yu,M., Wei,H., Yao,S., Chen,S.Y., Zhu,X.L. and Li,Y.F.
  TITLE     Fibroblast growth factor 22 is a novel modulator of depression
            through interleukin-1beta
  JOURNAL   CNS Neurosci Ther 23 (11), 907-916 (2017)
   PUBMED   28948716
  REMARK    GeneRIF: This study showed that serum FGF22 levels in depressive
            patients were negatively correlated with serum IL-1beta levels. In
            animal and cell experiments, enhancing the levels of FGF22 in rat
            hippocampus was demonstrated to alleviate the chronic unpredictable
            mild stress-induced depression. The increase in FGF22 was found to
            be associated with reduced IL-1beta expression and hippocampal
            apoptosis.
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   Hu,H.T., Umemori,H. and Hsueh,Y.P.
  TITLE     Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for
            bidirectional synaptic formation
  JOURNAL   Sci Rep 6, 33592 (2016)
   PUBMED   27627962
  REMARK    GeneRIF: postsynaptic SDC2 uses its ectodomain to interact with and
            facilitate dendritic filopodial targeting of FGF22, triggering
            presynaptic maturation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Umemori,H., Linhoff,M.W., Ornitz,D.M. and Sanes,J.R.
  TITLE     FGF22 and its close relatives are presynaptic organizing molecules
            in the mammalian brain
  JOURNAL   Cell 118 (2), 257-270 (2004)
   PUBMED   15260994
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   Beyer,T.A., Werner,S., Dickson,C. and Grose,R.
  TITLE     Fibroblast growth factor 22 and its potential role during skin
            development and repair
  JOURNAL   Exp Cell Res 287 (2), 228-236 (2003)
   PUBMED   12837279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Oct 11, 2022 this sequence version replaced NM_130751.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1294723.1, AB078902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               JAXUCZ010000007.1  10600749-10600945   c
            198-301             JAXUCZ010000007.1  10599323-10599426   c
            302-1290            JAXUCZ010000007.1  10598254-10599242   c
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1290
                     /gene="Fgf22"
                     /gene_synonym="Fgf5d"
                     /note="fibroblast growth factor 22"
                     /db_xref="GeneID:170579"
                     /db_xref="RGD:620177"
     exon            1..197
                     /gene="Fgf22"
                     /gene_synonym="Fgf5d"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..499
                     /gene="Fgf22"
                     /gene_synonym="Fgf5d"
                     /note="fibroblast growth factor 5d"
                     /codon_start=1
                     /product="fibroblast growth factor 22 precursor"
                     /protein_id="NP_570107.1"
                     /db_xref="GeneID:170579"
                     /db_xref="RGD:620177"
                     /translation="MRRRLWLGLAWLLLARAPGAPGGYPHLEGDVRWRRLFSSTHFFL
                     RVDPGGRVQGTRWRHGQDSIVEIRSVRVGTVVIKAVYSGFYVAMNRRGRLYGSRVYSV
                     DCRFRERIEENGYNTYASRRWRHHGRPMFLALDSQGIPRQGRRTRRHQLSTHFLPVLV
                     SS"
     exon            198..301
                     /gene="Fgf22"
                     /gene_synonym="Fgf5d"
                     /inference="alignment:Splign:2.1.0"
     exon            302..1290
                     /gene="Fgf22"
                     /gene_synonym="Fgf5d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaggtcggg atgcgccgcc gcctctggct gggcctggcc tggctgctgc tggcgcgggc
       61 accgggagcc ccgggcgggt acccacatct ggagggcgac gtgcgctggc gccgcctctt
      121 ctcctccacc cactttttcc tgcgtgtgga tcctggtggt cgggtgcagg ggacgcgttg
      181 gcgacacggc caggacagta ttgttgagat ccgttctgtc cgtgtgggca ctgtggtgat
      241 caaagctgtg tactcaggct tctatgtggc catgaatcgc aggggccgcc tctatgggtc
      301 gcgggtctac tctgtggact gtaggttccg ggagcgcatc gaggagaacg gctacaacac
      361 atacgcctca cgacgttgga ggcaccacgg ccgacccatg ttcttggcac tggacagcca
      421 gggcattccc aggcaaggca gacggacgcg tcggcaccaa ctgtccacac acttcctacc
      481 agtactggtc tcatcttgaa gggcctggcg acagttcagg aggcgtgggt gacacacagg
      541 gccgggaaga tctggagttg agtagcaaag ggccaggcta gagaccctgg gcccacacac
      601 gtctttgtca caggttgggt acctgttggc tgtcaggcat ggagacctgg cagggtccct
      661 gcaggtgagg ccaacatttg gggatacaca gaactggcag tttccatcca tctagtttgg
      721 aggtgagagg cttggaaagt aaaaacaagg agaaccaggg agggtggaca cgtgcggagg
      781 gcagggccca ggtcagtggg aacacagaca tattagccca tgtggccaga gtagggtact
      841 ggagtcaaga gcacttcttg ctcttccaag gggcctgggt ttaggtcccc cacgtcagac
      901 tactcataac caccagtatc tcccacccca gaggatctga ctcccttttc tgttctctgc
      961 aggcacctgc actcatgtgc acgtaccctg cacccataca cataaaaaaa cggtttgggt
     1021 tttttttttg agacaaggtc tctacatcac cctgctgtcc tgaaattcac tatgcaggct
     1081 aggctgtcct ggaaagagat gcccatctct gcctcctgag tactggaatt aaagacatgc
     1141 accaccatgc caggttgaca tggggcctct gaacactgtg ttcaatgccc aacttgtctg
     1201 gagtcactgg gagggaccgg cctgagggta catatcacag tccgaggagg ccagtgtcag
     1261 gtggccaaca ataaacgttt ggagccttga
//
