LOCUS       NM_130752                935 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 21 (Fgf21), mRNA.
ACCESSION   NM_130752
VERSION     NM_130752.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 935)
  AUTHORS   Wu,K., Huang,S., Zheng,F. and Liu,Y.
  TITLE     The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway
  JOURNAL   Acta Diabetol 60 (11), 1491-1503 (2023)
   PUBMED   37392202
  REMARK    GeneRIF: The CEBPA-FGF21 regulatory network may participate in the
            T2DM-induced skeletal muscle atrophy by regulating the
            autophagy-lysosomal pathway.
REFERENCE   2  (bases 1 to 935)
  AUTHORS   Zheng,W., Li,W., Zeng,Y., Yuan,H., Yang,H., Chen,R., Zhu,A., Wu,J.,
            Song,Z. and Yan,W.
  TITLE     Endogenous FGF21 attenuates blood-brain barrier disruption in
            penumbra after delayed recanalization in MCAO rats through
            FGFR1/PI3K/Akt pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (5), 648-662 (2023)
   PUBMED   37539567
  REMARK    GeneRIF: Endogenous FGF21 attenuates blood-brain barrier disruption
            in penumbra after delayed recanalization in MCAO rats through
            FGFR1/PI3K/Akt pathway.
REFERENCE   3  (bases 1 to 935)
  AUTHORS   Kakoty,V., Kc,S., Yang,C.H., Dubey,S.K. and Taliyan,R.
  TITLE     Exploring the Epigenetic Regulated Modulation of Fibroblast Growth
            Factor 21 Involvement in High-Fat Diet Associated Parkinson's
            Disease in Rats
  JOURNAL   ACS Chem Neurosci 14 (4), 725-740 (2023)
   PUBMED   36694924
  REMARK    GeneRIF: Exploring the Epigenetic Regulated Modulation of
            Fibroblast Growth Factor 21 Involvement in High-Fat Diet Associated
            Parkinson's Disease in Rats.
REFERENCE   4  (bases 1 to 935)
  AUTHORS   Moro,J., Roisne-Hamelin,G., Chaumontet,C., Even,P.C., Blais,A.,
            Cansell,C., Piedcoq,J., Gaudichon,C., Tome,D. and
            Azzout-Marniche,D.
  TITLE     Lysine or Threonine Deficiency Decreases Body Weight Gain in
            Growing Rats despite an Increase in Food Intake without Increasing
            Energy Expenditure in Response to FGF21
  JOURNAL   Nutrients 15 (1), 197 (2022)
   PUBMED   36615854
  REMARK    GeneRIF: Lysine or Threonine Deficiency Decreases Body Weight Gain
            in Growing Rats despite an Increase in Food Intake without
            Increasing Energy Expenditure in Response to FGF21.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 935)
  AUTHORS   Yang,S., Zhang,Y., Lyu,X., Gu,Y., Zhang,G., Liu,P., Zheng,Y.,
            Guo,Z., Zhang,Y. and Hou,H.
  TITLE     The Association Between FGF21 and Diabetic Erectile Dysfunction:
            Evidence from Clinical and Animal Studies
  JOURNAL   Front Endocrinol (Lausanne) 13, 874796 (2022)
   PUBMED   36213282
  REMARK    GeneRIF: The Association Between FGF21 and Diabetic Erectile
            Dysfunction: Evidence from Clinical and Animal Studies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 935)
  AUTHORS   Johnson,C.L., Weston,J.Y., Chadi,S.A., Fazio,E.N., Huff,M.W.,
            Kharitonenkov,A., Koester,A. and Pin,C.L.
  TITLE     Fibroblast growth factor 21 reduces the severity of
            cerulein-induced pancreatitis in mice
  JOURNAL   Gastroenterology 137 (5), 1795-1804 (2009)
   PUBMED   19664632
REFERENCE   7  (bases 1 to 935)
  AUTHORS   Iizuka,K., Takeda,J. and Horikawa,Y.
  TITLE     Glucose induces FGF21 mRNA expression through ChREBP activation in
            rat hepatocytes
  JOURNAL   FEBS Lett 583 (17), 2882-2886 (2009)
   PUBMED   19660458
  REMARK    GeneRIF: These findings suggest that FGF21 expression in liver is
            regulated by ChREBP.
REFERENCE   8  (bases 1 to 935)
  AUTHORS   Suzuki,M., Uehara,Y., Motomura-Matsuzaka,K., Oki,J., Koyama,Y.,
            Kimura,M., Asada,M., Komi-Kuramochi,A., Oka,S. and Imamura,T.
  TITLE     betaKlotho is required for fibroblast growth factor (FGF) 21
            signaling through FGF receptor (FGFR) 1c and FGFR3c
  JOURNAL   Mol Endocrinol 22 (4), 1006-1014 (2008)
   PUBMED   18187602
REFERENCE   9  (bases 1 to 935)
  AUTHORS   Kurosu,H., Choi,M., Ogawa,Y., Dickson,A.S., Goetz,R.,
            Eliseenkova,A.V., Mohammadi,M., Rosenblatt,K.P., Kliewer,S.A. and
            Kuro-O,M.
  TITLE     Tissue-specific expression of betaKlotho and fibroblast growth
            factor (FGF) receptor isoforms determines metabolic activity of
            FGF19 and FGF21
  JOURNAL   J Biol Chem 282 (37), 26687-26695 (2007)
   PUBMED   17623664
REFERENCE   10 (bases 1 to 935)
  AUTHORS   Nishimura,T., Nakatake,Y., Konishi,M. and Itoh,N.
  TITLE     Identification of a novel FGF, FGF-21, preferentially expressed in
            the liver
  JOURNAL   Biochim Biophys Acta 1492 (1), 203-206 (2000)
   PUBMED   10858549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 11, 2022 this sequence version replaced NM_130752.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.1598.1, AB078901.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               JAXUCZ010000001.1  105220966-105221376 c
            412-515             JAXUCZ010000001.1  105220765-105220868 c
            516-935             JAXUCZ010000001.1  105219825-105220244 c
FEATURES             Location/Qualifiers
     source          1..935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..935
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /note="fibroblast growth factor 21"
                     /db_xref="GeneID:170580"
                     /db_xref="RGD:620175"
     exon            1..411
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..800
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /note="fibroblast growth factor 8c"
                     /codon_start=1
                     /product="fibroblast growth factor 21 precursor"
                     /protein_id="NP_570108.1"
                     /db_xref="GeneID:170580"
                     /db_xref="RGD:620175"
                     /translation="MDWMKSRVGAPGLWVCLLLPVFLLGVCEAYPISDSSPLLQFGGQ
                     VRQRYLYTDDDQDTEAHLEIREDGTVVGTAHRSPESLLELKALKPGVIQILGVKASRF
                     LCQQPDGTLYGSPHFDPEACSFRELLLKDGYNVYQSEAHGLPLRLPQKDSQDPATRGP
                     VRFLPMPGLPHEPQEQPGVLPPEPPDVGSSDPLSMVEPLQGRSPSYAS"
     exon            412..515
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /inference="alignment:Splign:2.1.0"
     exon            516..935
                     /gene="Fgf21"
                     /gene_synonym="Fgf8c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccttagtg tcttgtcagc tgggcattca acgcaggaga aacaggcatt cactttgcct
       61 gagccccagt ctgaacctga acctgttctg ctgggccacc ggagtcagaa gccaattcca
      121 gctgactcgc cttctcagac gctggccagg ggttctcaca gagcgcggca ttgatggact
      181 ggatgaaatc tagagttggg gccccgggac tgtgggtctg tctcctgctg cctgtcttcc
      241 tgctgggggt gtgcgaggca taccccatct ctgactccag ccccctcctc cagtttgggg
      301 gtcaagtccg acagaggtat ctctacacag atgacgacca ggacaccgaa gcccacctgg
      361 agatcaggga ggacggaaca gtggtgggca cagcacaccg cagtccagaa agtctcctgg
      421 agctcaaagc cttgaagcca ggggtcattc aaatcctggg tgtcaaagcc tctaggtttc
      481 tttgccaaca accagatgga actctctatg gatcgcctca ctttgatcct gaggcctgca
      541 gtttcagaga gctgctgctt aaggacggat acaatgtgta ccagtctgag gcccatggcc
      601 tgcccctgcg tctgccccag aaggactccc aggatccagc aacccgggga cctgtgcgct
      661 tcctgcccat gccaggcctg ccccacgagc cccaagagca accaggagtc cttcccccag
      721 agcccccaga tgtgggttcc tccgaccccc tgagcatggt agagcctttg caaggccgaa
      781 gccccagcta tgcatcttga atcttcccga ttctaggcat gtttctcttt aggtttcctc
      841 ttatttatta tgggtattta tcttatttat ttattttaaa gttttttttc ttacttggaa
      901 taataaagag tctgaaagaa aattttgttt gttaa
//
