LOCUS       NM_019305               1016 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 2 (Fgf2), mRNA.
ACCESSION   NM_019305
VERSION     NM_019305.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1016)
  AUTHORS   Zhou,C., Sun,J., Wu,L., Liu,C., Cheng,Q., Xie,S. and Zhang,J.
  TITLE     LTBP2 down-regulated FGF2 to repress vascular smooth muscle cell
            proliferation and vascular remodeling in a rat model of
            intracranial aneurysm
  JOURNAL   Neurosci Lett 842, 137988 (2024)
   PUBMED   39288883
  REMARK    GeneRIF: LTBP2 down-regulated FGF2 to repress vascular smooth
            muscle cell proliferation and vascular remodeling in a rat model of
            intracranial aneurysm.
REFERENCE   2  (bases 1 to 1016)
  AUTHORS   Li,Z., Liu,Y., Li,X., Yang,S., Feng,S., Li,G., Jin,F. and Nie,S.
  TITLE     Knockdown the moyamoya disease susceptibility gene, RNF213,
            upregulates the expression of basic fibroblast growth factor and
            matrix metalloproteinase-9 in bone marrow derived mesenchymal stem
            cells
  JOURNAL   Neurosurg Rev 47 (1), 246 (2024)
   PUBMED   38811382
  REMARK    GeneRIF: Knockdown the moyamoya disease susceptibility gene,
            RNF213, upregulates the expression of basic fibroblast growth
            factor and matrix metalloproteinase-9 in bone marrow derived
            mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1016)
  AUTHORS   Uzay,B., Bahadir-Varol,A., Hokelekli,F.O., Yilmaz,M., Esen,E.C.,
            Basar,K., Ayhan,Y., Dalkara,T. and Eren-Kocak,E.
  TITLE     FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by
            promoting inflammation and suppressing neurogenesis without
            altering FGF2 signalling
  JOURNAL   J Physiol 602 (7), 1427-1442 (2024)
   PUBMED   38468384
  REMARK    GeneRIF: FGF2 gene's antisense protein, NUDT6, plays a
            depressogenic role by promoting inflammation and suppressing
            neurogenesis without altering FGF2 signalling.
REFERENCE   4  (bases 1 to 1016)
  AUTHORS   Xie,X., Zhang,X., Li,S. and Du,W.
  TITLE     Involvement of Fgf2-mediated tau protein phosphorylation in
            cognitive deficits induced by sevoflurane in aged rats
  JOURNAL   Mol Med 30 (1), 39 (2024)
   PUBMED   38493090
  REMARK    GeneRIF: Involvement of Fgf2-mediated tau protein phosphorylation
            in cognitive deficits induced by sevoflurane in aged rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1016)
  AUTHORS   Grinchii,D., Levin-Greenwald,M., Lezmy,N., Gordon,T., Paliokha,R.,
            Khoury,T., Racicky,M., Herburg,L., Grothe,C., Dremencov,E. and
            Barak,S.
  TITLE     FGF2 activity regulates operant alcohol self-administration and
            mesolimbic dopamine transmission
  JOURNAL   Drug Alcohol Depend 248, 109920 (2023)
   PUBMED   37224676
  REMARK    GeneRIF: FGF2 activity regulates operant alcohol
            self-administration and mesolimbic dopamine transmission.
REFERENCE   6  (bases 1 to 1016)
  AUTHORS   el-Husseini,A.E., Paterson,J.A., Myal,Y. and Shiu,R.P.
  TITLE     PCR detection of the rat brain basic fibroblast growth factor
            (bFGF) mRNA containing a unique 3' untranslated region
  JOURNAL   Biochim Biophys Acta 1131 (3), 314-316 (1992)
   PUBMED   1378302
REFERENCE   7  (bases 1 to 1016)
  AUTHORS   Venesio,T., Taverna,D., Hynes,N.E., Deed,R., MacAllan,D.,
            Ciardiello,F., Valverius,E.M., Salomon,D.S., Callahan,R. and
            Merlo,G.
  TITLE     The int-2 gene product acts as a growth factor and substitutes for
            basic fibroblast growth factor in promoting the differentiation of
            a normal mouse mammary epithelial cell line
  JOURNAL   Cell Growth Differ 3 (1), 63-71 (1992)
   PUBMED   1376141
REFERENCE   8  (bases 1 to 1016)
  AUTHORS   Fujimoto,K., Ichimori,Y., Kakizoe,T., Okajima,E., Sakamoto,H.,
            Sugimura,T. and Terada,M.
  TITLE     Increased serum levels of basic fibroblast growth factor in
            patients with renal cell carcinoma
  JOURNAL   Biochem Biophys Res Commun 180 (1), 386-392 (1991)
   PUBMED   1718278
REFERENCE   9  (bases 1 to 1016)
  AUTHORS   Mansukhani,A., Moscatelli,D., Talarico,D., Levytska,V. and
            Basilico,C.
  TITLE     A murine fibroblast growth factor (FGF) receptor expressed in CHO
            cells is activated by basic FGF and Kaposi FGF
  JOURNAL   Proc Natl Acad Sci U S A 87 (11), 4378-4382 (1990)
   PUBMED   2161540
REFERENCE   10 (bases 1 to 1016)
  AUTHORS   Shimasaki,S., Emoto,N., Koba,A., Mercado,M., Shibata,F.,
            Cooksey,K., Baird,A. and Ling,N.
  TITLE     Complementary DNA cloning and sequencing of rat ovarian basic
            fibroblast growth factor and tissue distribution study of its mRNA
  JOURNAL   Biochem Biophys Res Commun 157 (1), 256-263 (1988)
   PUBMED   3196337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M22427.1 and JAXUCZ010000002.1.
            
            On Nov 2, 2007 this sequence version replaced NM_019305.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M22427.1, SRR26643294.8636.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               M22427.1           1-280
            281-282             JAXUCZ010000002.1  122164734-122164735
            283-1016            M22427.1           283-1016
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..1016
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a"
                     /note="fibroblast growth factor 2"
                     /db_xref="GeneID:54250"
                     /db_xref="RGD:2609"
     exon            1..707
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..997
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a"
                     /note="heparin-binding growth factor 2; HBGF-2; basic
                     fibroblast growth factor; angiogenesis promoting growth
                     factor; heparin binding growth factor; fibroblast growth
                     factor 2a"
                     /codon_start=1
                     /product="fibroblast growth factor 2"
                     /protein_id="NP_062178.1"
                     /db_xref="GeneID:54250"
                     /db_xref="RGD:2609"
                     /translation="MAAGSITSLPALPEDGGGAFPPGHFKDPKRLYCKNGGFFLRIHP
                     DGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFF
                     FERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS"
     exon            708..811
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1016
                     /gene="Fgf2"
                     /gene_synonym="bFGF; Fgf-2; Fgf2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaccccat tcctggcctc tgtctcccgc accctatccc ttcacagcct gtgctctagg
       61 ggactggaga tttccaaaac ctgacccgat ccctccccag ttcagttcct tctactgctt
      121 tgggtggaag gctggtcgtt gtgttaaaag gcaggaaggg agaaagttgc atttaaactt
      181 taggagctgc gtcacggcag tctcctggag aaagctccgc cgaacgggac agattctttt
      241 tgcaacttgg aggcgccggg cgtggggagg aggcggcgcg tggggcgggg gcgcgcgggg
      301 ccggggtgca ggcggggacg cggggtgacg cgggcccggg ccgctgtagc acacaggggc
      361 tcggtctctc ggcttcaggc ggagtccggc tgcactaggc tgggagcgcg gcgggacgcg
      421 aaccgggagg ctggcagccc gcgggcgagc cgcgctgggg ggccgaggcc ggggtcgggg
      481 ccggggagcc ccgagagctg ccgcagcggg gtcccggggc cgcggagggg ccatggctgc
      541 cggcagcatc acttcgcttc ccgcactgcc ggaggacggc ggcggcgcct tcccacccgg
      601 ccacttcaag gatcccaagc ggctctactg caagaacggc ggcttcttcc tgcgcatcca
      661 tccagacggc cgcgtggacg gcgtccggga gaagagcgac ccacacgtca aactacagct
      721 ccaagcagaa gagagaggag ttgtgtccat caagggagtg tgtgcgaacc ggtacctggc
      781 tatgaaggaa gatggacggc tgctggcttc taagtgtgtt acagaagagt gtttcttctt
      841 tgaacgcctg gagtccaata actacaacac ttaccggtca cggaaatact ccagttggta
      901 tgtggcactg aaacgaactg ggcagtataa actcggatcc aaaacggggc ctggacagaa
      961 ggccatactg tttcttccaa tgtctgctaa gagctgactc tctttagaca ctgtca
//
