LOCUS       NM_130753               1823 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 19 (Fgf19), mRNA.
ACCESSION   NM_130753
VERSION     NM_130753.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Lu,J., Liu,Z., Zhao,Y., Liu,X., He,W. and Zhang,L.
  TITLE     FGF19 improves sevoflurane-induced cognitive dysfunction in rats
            through the PGC-1alpha/BDNF/FNDC5 pathway
  JOURNAL   Tissue Cell 81, 102012 (2023)
   PUBMED   36608639
  REMARK    GeneRIF: FGF19 improves sevoflurane-induced cognitive dysfunction
            in rats through the PGC-1alpha/BDNF/FNDC5 pathway.
REFERENCE   2  (bases 1 to 1823)
  AUTHORS   Avalos-de Leon,C.G., Jimenez-Castro,M.B., Cornide-Petronio,M.E.,
            Gulfo,J., Rotondo,F., Gracia-Sancho,J., Casillas-Ramirez,A. and
            Peralta,C.
  TITLE     The Effect of Fibroblast Growth Factor 15 Signaling in
            Non-Steatotic and Steatotic Liver Transplantation from
            Cardiocirculatory Death
  JOURNAL   Cells 8 (12), 1640 (2019)
   PUBMED   31847428
  REMARK    GeneRIF: The Effect of Fibroblast Growth Factor 15 Signaling in
            Non-Steatotic and Steatotic Liver Transplantation from
            Cardiocirculatory Death.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1823)
  AUTHORS   Duan,Y., Zhang,F., Yuan,W., Wei,Y., Wei,M., Zhou,Y., Yang,Y.,
            Chang,Y. and Wu,X.
  TITLE     Hepatic cholesterol accumulation ascribed to the activation of
            ileum Fxr-Fgf15 pathway inhibiting hepatic Cyp7a1 in high-fat
            diet-induced obesity rats
  JOURNAL   Life Sci 232, 116638 (2019)
   PUBMED   31288013
  REMARK    GeneRIF: The increased CDCAs concentrations activated Fxr-Fgf15
            pathway in ileum to result in the mRNA expression of Cyp7a1 in
            liver down-regulation, which inhibited cholesterol metabolizing
            into primary BAs to contribute to the cholesterol level increase in
            liver tissue in HFD-induced obesity rats.
REFERENCE   4  (bases 1 to 1823)
  AUTHORS   Wang,F., Lu,Z., Wang,X. and Zhang,Y.
  TITLE     Impaired vagus function in rats suppresses bile acid synthesis in
            the liver by disrupting tight junctions and activating Fxr-Fgf15
            signaling in the intestine
  JOURNAL   Biochem Biophys Res Commun 495 (1), 1490-1496 (2018)
   PUBMED   29198707
  REMARK    GeneRIF: In summary, the present study provides the first
            comprehensive analysis of the critical role of the vagus nerve in
            regulating BA metabolism and signaling pathway.
REFERENCE   5  (bases 1 to 1823)
  AUTHORS   Yan,X., Li,P., Tang,Z. and Feng,B.
  TITLE     The relationship between bile acid concentration,
            glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid
            receptors in rats during progression of glucose intolerance
  JOURNAL   BMC Endocr Disord 17 (1), 60 (2017)
   PUBMED   28946907
  REMARK    GeneRIF: plasma level in glucose intolerance correlated with FXR
            mRNA expression in colon
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1823)
  AUTHORS   Vincentz,J.W., McWhirter,J.R., Murre,C., Baldini,A. and Furuta,Y.
  TITLE     Fgf15 is required for proper morphogenesis of the mouse cardiac
            outflow tract
  JOURNAL   Genesis 41 (4), 192-201 (2005)
   PUBMED   15789410
REFERENCE   7  (bases 1 to 1823)
  AUTHORS   Olsen,S.K., Garbi,M., Zampieri,N., Eliseenkova,A.V., Ornitz,D.M.,
            Goldfarb,M. and Mohammadi,M.
  TITLE     Fibroblast growth factor (FGF) homologous factors share structural
            but not functional homology with FGFs
  JOURNAL   J Biol Chem 278 (36), 34226-34236 (2003)
   PUBMED   12815063
REFERENCE   8  (bases 1 to 1823)
  AUTHORS   Holt,J.A., Luo,G., Billin,A.N., Bisi,J., McNeill,Y.Y.,
            Kozarsky,K.F., Donahee,M., Wang,D.Y., Mansfield,T.A., Kliewer,S.A.,
            Goodwin,B. and Jones,S.A.
  TITLE     Definition of a novel growth factor-dependent signal cascade for
            the suppression of bile acid biosynthesis
  JOURNAL   Genes Dev 17 (13), 1581-1591 (2003)
   PUBMED   12815072
REFERENCE   9  (bases 1 to 1823)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from
            zebrafish to human
  JOURNAL   Int J Mol Med 12 (1), 45-50 (2003)
   PUBMED   12792807
REFERENCE   10 (bases 1 to 1823)
  AUTHORS   Xie,M.H., Holcomb,I., Deuel,B., Dowd,P., Huang,A., Vagts,A.,
            Foster,J., Liang,J., Brush,J., Gu,Q., Hillan,K., Goddard,A. and
            Gurney,A.L.
  TITLE     FGF-19, a novel fibroblast growth factor with unique specificity
            for FGFR4
  JOURNAL   Cytokine 11 (10), 729-735 (1999)
   PUBMED   10525310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 11, 2022 this sequence version replaced NM_130753.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.5387.1, AB078900.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000001.1  209485813-209486195
            384-487             JAXUCZ010000001.1  209486378-209486481
            488-1823            JAXUCZ010000001.1  209488932-209490267
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..1823
                     /gene="Fgf19"
                     /gene_synonym="Fgf15; Fgf8a"
                     /note="fibroblast growth factor 19"
                     /db_xref="GeneID:170582"
                     /db_xref="RGD:620166"
     exon            1..383
                     /gene="Fgf19"
                     /gene_synonym="Fgf15; Fgf8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..787
                     /gene="Fgf19"
                     /gene_synonym="Fgf15; Fgf8a"
                     /note="fibroblast growth factor 15; fibroblast growth
                     factor 8a"
                     /codon_start=1
                     /product="fibroblast growth factor 19 precursor"
                     /protein_id="NP_570109.1"
                     /db_xref="GeneID:170582"
                     /db_xref="RGD:620166"
                     /translation="MARKWSGRIVARALVLATLWLAVSGRPLVQQSQSVSDEGPLFLY
                     GWGKITRLQYLYSAGPYVSNCFLRIRSDGSVDCEEDQNERNLLEFRAVALKTIAIKDV
                     SSVRYLCMSADGKIYGLIRYSEEDCTFREEMDCLGYNQYRSMKHHLHIIFIKAKPREQ
                     LQGQKPSNFIPIFHRSFFESTDQLRSKMFSLPLESDSMDPFRMVEDVDHLVKSPSFQK
                     "
     exon            384..487
                     /gene="Fgf19"
                     /gene_synonym="Fgf15; Fgf8a"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1823
                     /gene="Fgf19"
                     /gene_synonym="Fgf15; Fgf8a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgtcgaag cagcagcgcc ccgcgctgca agcgcccgat tgctttgtgg gctgtgcctg
       61 ccttgcgagt ccctgccgcg tcgcagtctc cgcgccacct ttgtagctgc cttcacgacc
      121 ccgaggtgcc atggcgagaa agtggagtgg gcgtattgtg gcccgagctc tggtcctggc
      181 cactctgtgg ctggccgtgt ctgggcgtcc cctggtccag caatcccagt ctgtgtcgga
      241 tgaaggtcca ctctttctct atggctgggg caagattacc cgcctgcagt acctgtactc
      301 tgctggtccc tacgtctcca actgcttcct gcgtatccgg agtgacggct ctgtggactg
      361 cgaggaggac cagaacgaac gaaatctgtt ggagttccgc gcggttgctc tgaagacaat
      421 tgccatcaag gacgtcagca gcgtgcggta cctctgcatg agcgccgacg gcaagatata
      481 cgggctgatt cgctactcgg aggaagactg taccttcagg gaggaaatgg actgtttggg
      541 ctacaaccag tacaggtcca tgaagcacca cctccacatc atcttcatca aggccaagcc
      601 cagagagcag ctccagggcc agaaaccttc aaactttatc cccatatttc accggtcttt
      661 ctttgaatcc acggaccagc tgaggtctaa aatgttctct ctgcccctgg agagcgacag
      721 catggatccg ttcagaatgg tggaggatgt ggaccaccta gtgaagagtc ccagcttcca
      781 gaaatgatgg ggttctgaca ggatggagaa aatccccaag atcctgtgtg cgtaccctta
      841 ggggagctgt acatagtctt acacggaccc tgtcgtgtta gtggctagac ttgatcatga
      901 gcctaagttg acaacctgcc tggctgccat ccgagcccca ctgactttgg aggttgccga
      961 catgtgccta ggttactcca gttctgtttg attatctcca ctaatgggga actcactcct
     1021 gtgaaacatt cttacttttg agccaaatcg gtgacttgga tggttttaag atggcagtca
     1081 gaggatatga agtctaatga caaaattcat gtagagaaag tgggctctga agtaaatgtt
     1141 cactatatgg accttgtggg atcttaactt gccccccaag tgtctcctgg ctaatggggg
     1201 ccacaaaggg tagcctagaa aaccttggga gccttgtagg atggttttag gattaagaat
     1261 tccagctgac cacatatgta gcttcccctt cccccacttg taagtcagat ggaaatgacc
     1321 cttagccagg ctcaagagtg agtggactcc tcggctgaat gcatagccaa gttgtcactt
     1381 gtgccctaag agcgtatctt ggtcctggga ctccagattt ccagggcctg gatctgctcc
     1441 tcagaccctt cccagagttc acctgggccc tccaacccca gagcaggtag cttatgggcc
     1501 atccacttgt gtccccagct cctggctctt agccctggtc accaaacatt gtgattccat
     1561 gtgtctctgc tgcctgtgtt aacctgtacc cctcataaac aagcgacagg aataggaagc
     1621 cccaaattct gcaggggagc tgtgaagtcc tttccccctc acccacctcc caccccccac
     1681 ccccgcactt acttggcagc gtgatatttg taagtaattt attgtgtgtg cgtcttctat
     1741 tttcttactt tatttatgcc ccagatcata tttatgtaca tgacttgttt tctacattaa
     1801 aaaggagttg gtttgtatca aaa
//
