LOCUS       NM_019199               1458 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 18 (Fgf18), mRNA.
ACCESSION   NM_019199
VERSION     NM_019199.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1458)
  AUTHORS   Yang,Q., Jia,C., Wang,P., Xiong,M., Cui,J., Li,L., Wang,W., Wu,Q.,
            Chen,Y. and Zhang,T.
  TITLE     MicroRNA-505 identified from patients with essential hypertension
            impairs endothelial cell migration and tube formation
  JOURNAL   Int J Cardiol 177 (3), 925-934 (2014)
   PUBMED   25449503
REFERENCE   2  (bases 1 to 1458)
  AUTHORS   Takahashi,H., Friedmacher,F., Fujiwara,N., Hofmann,A., Kutasy,B.,
            Gosemann,J.H. and Puri,P.
  TITLE     Pulmonary FGF-18 gene expression is downregulated during the
            canalicular-saccular stages in nitrofen-induced hypoplastic lungs
  JOURNAL   Pediatr Surg Int 29 (11), 1199-1203 (2013)
   PUBMED   23979401
  REMARK    GeneRIF: Downregulation of FGF-18 gene expression in
            nitrofen-induced hypoplastic lungs suggests that decreased FGF-18
            expression during the canalicular-saccular stages
REFERENCE   3  (bases 1 to 1458)
  AUTHORS   Liu,Z., Lavine,K.J., Hung,I.H. and Ornitz,D.M.
  TITLE     FGF18 is required for early chondrocyte proliferation, hypertrophy
            and vascular invasion of the growth plate
  JOURNAL   Dev Biol 302 (1), 80-91 (2007)
   PUBMED   17014841
REFERENCE   4  (bases 1 to 1458)
  AUTHORS   Antoine,M., Wirz,W., Tag,C.G., Gressner,A.M., Wycislo,M., Muller,R.
            and Kiefer,P.
  TITLE     Fibroblast growth factor 16 and 18 are expressed in human
            cardiovascular tissues and induce on endothelial cells migration
            but not proliferation
  JOURNAL   Biochem Biophys Res Commun 346 (1), 224-233 (2006)
   PUBMED   16756958
REFERENCE   5  (bases 1 to 1458)
  AUTHORS   Olsen,S.K., Li,J.Y., Bromleigh,C., Eliseenkova,A.V., Ibrahimi,O.A.,
            Lao,Z., Zhang,F., Linhardt,R.J., Joyner,A.L. and Mohammadi,M.
  TITLE     Structural basis by which alternative splicing modulates the
            organizer activity of FGF8 in the brain
  JOURNAL   Genes Dev 20 (2), 185-198 (2006)
   PUBMED   16384934
REFERENCE   6  (bases 1 to 1458)
  AUTHORS   Ellsworth,J.L., Garcia,R., Yu,J. and Kindy,M.S.
  TITLE     Fibroblast growth factor-18 reduced infarct volumes and behavioral
            deficits after transient occlusion of the middle cerebral artery in
            rats
  JOURNAL   Stroke 34 (6), 1507-1512 (2003)
   PUBMED   12738892
  REMARK    GeneRIF: FGF18 is an effective neuroprotective agent in a rat model
            of transient middle cerebral artery occlusion
REFERENCE   7  (bases 1 to 1458)
  AUTHORS   Ohbayashi,N., Shibayama,M., Kurotaki,Y., Imanishi,M., Fujimori,T.,
            Itoh,N. and Takada,S.
  TITLE     FGF18 is required for normal cell proliferation and differentiation
            during osteogenesis and chondrogenesis
  JOURNAL   Genes Dev 16 (7), 870-879 (2002)
   PUBMED   11937494
REFERENCE   8  (bases 1 to 1458)
  AUTHORS   Liu,Z., Xu,J., Colvin,J.S. and Ornitz,D.M.
  TITLE     Coordination of chondrogenesis and osteogenesis by fibroblast
            growth factor 18
  JOURNAL   Genes Dev 16 (7), 859-869 (2002)
   PUBMED   11937493
REFERENCE   9  (bases 1 to 1458)
  AUTHORS   Shimoaka,T., Ogasawara,T., Yonamine,A., Chikazu,D., Kawano,H.,
            Nakamura,K., Itoh,N. and Kawaguchi,H.
  TITLE     Regulation of osteoblast, chondrocyte, and osteoclast functions by
            fibroblast growth factor (FGF)-18 in comparison with FGF-2 and
            FGF-10
  JOURNAL   J Biol Chem 277 (9), 7493-7500 (2002)
   PUBMED   11741978
REFERENCE   10 (bases 1 to 1458)
  AUTHORS   Ohbayashi,N., Hoshikawa,M., Kimura,S., Yamasaki,M., Fukui,S. and
            Itoh,N.
  TITLE     Structure and expression of the mRNA encoding a novel fibroblast
            growth factor, FGF-18
  JOURNAL   J Biol Chem 273 (29), 18161-18164 (1998)
   PUBMED   9660775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 24, 2022 this sequence version replaced NM_019199.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AW530232.1, AB004638.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMN06621351 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000010.1  18240787-18240882   c
            97-133              JAXUCZ010000010.1  18240596-18240632   c
            134-314             JAXUCZ010000010.1  18227369-18227549   c
            315-421             JAXUCZ010000010.1  18218069-18218175   c
            422-1458            JAXUCZ010000010.1  18210497-18211533   c
FEATURES             Location/Qualifiers
     source          1..1458
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1458
                     /gene="Fgf18"
                     /note="fibroblast growth factor 18"
                     /db_xref="GeneID:29369"
                     /db_xref="RGD:2608"
     exon            1..96
                     /gene="Fgf18"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..688
                     /gene="Fgf18"
                     /note="FGF-18"
                     /codon_start=1
                     /product="fibroblast growth factor 18 precursor"
                     /protein_id="NP_062072.1"
                     /db_xref="GeneID:29369"
                     /db_xref="RGD:2608"
                     /translation="MYSAPSACTCLCLHFLLLCFQVQVLAAEENVDFRIHVENQTRAR
                     DDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGK
                     ETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPR
                     KGPKTRENQQDVHFMKRYPKGQTELQKPFKYTTVTKRSRRIRPTHPG"
     exon            97..133
                     /gene="Fgf18"
                     /inference="alignment:Splign:2.1.0"
     exon            134..314
                     /gene="Fgf18"
                     /inference="alignment:Splign:2.1.0"
     exon            315..421
                     /gene="Fgf18"
                     /inference="alignment:Splign:2.1.0"
     exon            422..1458
                     /gene="Fgf18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggg gagcggacat gtgcaggctg ggctaggagc cgccgcctcc ccccccgccc
       61 cgcgatgtat tcagcgccct ccgcctgcac ttgcctgtgt ttacactttc tactgctgtg
      121 cttccaggtt caggtgttgg cagccgagga gaacgtggac ttccgcatcc atgtggagaa
      181 ccagactcgg gctcgcgatg atgtgagtcg gaagcagctg cgcttgtacc agctctacag
      241 caggaccagt gggaagcaca ttcaagtcct gggccgtagg atcagtgccc gtggcgagga
      301 cggggacaag tatgcccagc tcctagtgga gacggatacc ttcgggagtc aagtccggat
      361 caagggcaaa gagacagagt tctacctgtg tatgaaccga aaaggcaagc tcgtggggaa
      421 gcctgatggt actagcaagg agtgcgtgtt cattgagaag gttctggaaa acaactacac
      481 ggccctgatg tcagccaagt actcaggctg gtacgtgggc ttcaccaaga aggggcggcc
      541 tcgcaagggt cccaagaccc gcgaaaacca gcaagatgtg cacttcatga agcgttaccc
      601 caagggacag actgagctgc agaagccctt caagtacacc acagttacta agcgatcccg
      661 gcggatccgc cccactcacc ccggctaggt ccggtcacac tcaccccccc agagaactac
      721 gtcagaggaa tatttttaca tgaaaaataa ggaaaaaaat ctctattttt gtacattgtg
      781 tttaaaagaa gacaaaaact gaacctaaaa gtcttggggg gaggggtgat atgattccac
      841 tgttgacctg aaccccatga cgaaggactc acacaagggg accactgtca acccacaggt
      901 gcttgcctct ctctaggagg tgacaattca aaactcaacc ccagaggagg acttgaacga
      961 gaaaactgac gctgcgagaa accaaagtcc tttccccccc aaaggttctg aaagcaaaca
     1021 aaacaaaaac aaaaacaaaa aaaaaaaaaa ggaaaagtag tgccctaccc ccaccccctc
     1081 cctgccccag actccaacaa gaatcgctct ctggtttgca gtcatttatt tattgtccac
     1141 tgcaagctgt cccgcgacac cgcgcaggga aggcgcccct gagaattctc cgcgcctcga
     1201 ccttccgacg acagacgcct cgtccaatca tggtggcctg ccttgcccgc agttctggag
     1261 gatgctgcta tggaccttcc gtgactcacg tgacctagta caccaatgat aagggaatat
     1321 tttaaaacca gctatattat atatattata tatataagct atttatttca cctctctgta
     1381 tattgcagtc tcatgaacca agtattactg ccccaacaat taaaaacaac ccacaaatta
     1441 tttaaaaaaa aaaaaaaa
//
