LOCUS       NP_062071                216 aa            linear   ROD 01-MAY-2025
DEFINITION  fibroblast growth factor 17 isoform 1 precursor [Rattus
            norvegicus].
ACCESSION   NP_062071
VERSION     NP_062071.1
DBSOURCE    REFSEQ: accession NM_019198.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 216)
  AUTHORS   Olsen,S.K., Li,J.Y., Bromleigh,C., Eliseenkova,A.V., Ibrahimi,O.A.,
            Lao,Z., Zhang,F., Linhardt,R.J., Joyner,A.L. and Mohammadi,M.
  TITLE     Structural basis by which alternative splicing modulates the
            organizer activity of FGF8 in the brain
  JOURNAL   Genes Dev 20 (2), 185-198 (2006)
   PUBMED   16384934
REFERENCE   2  (residues 1 to 216)
  AUTHORS   Xu,J., Lawshe,A., MacArthur,C.A. and Ornitz,D.M.
  TITLE     Genomic structure, mapping, activity and expression of fibroblast
            growth factor 17
  JOURNAL   Mech Dev 83 (1-2), 165-178 (1999)
   PUBMED   10381577
REFERENCE   3  (residues 1 to 216)
  AUTHORS   Hoshikawa,M., Ohbayashi,N., Yonamine,A., Konishi,M., Ozaki,K.,
            Fukui,S. and Itoh,N.
  TITLE     Structure and expression of a novel fibroblast growth factor,
            FGF-17, preferentially expressed in the embryonic brain
  JOURNAL   Biochem Biophys Res Commun 244 (1), 187-191 (1998)
   PUBMED   9514906
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB008682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050745 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..216
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p11"
     Protein         1..216
                     /product="fibroblast growth factor 17 isoform 1 precursor"
                     /note="FGF-17; fibroblast growth factor 6b"
                     /calculated_mol_wt=22541
     sig_peptide     1..22
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P63076.1)"
                     /calculated_mol_wt=2401
     mat_peptide     23..216
                     /product="Fibroblast growth factor 17. /id=PRO_0000008987"
                     /note="propagated from UniProtKB/Swiss-Prot (P63076.1)"
                     /calculated_mol_wt=22541
     Region          53..178
                     /region_name="beta-trefoil_FGF17"
                     /note="FGF domain, beta-trefoil fold, found in fibroblast
                     growth factor 17 (FGF17) and similar proteins; cd23323"
                     /db_xref="CDD:467009"
     Site            137
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P63076.1)"
     Region          195..216
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P63076.1)"
     CDS             1..216
                     /gene="Fgf17"
                     /gene_synonym="Fgf6b"
                     /coded_by="NM_019198.2:560..1210"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:29368"
                     /db_xref="RGD:2607"
ORIGIN      
        1 mgaarllpnl tlclqllilc cqtqgenhps pnfnqyvrdq gamtdqlsrr qireyqlysr
       61 tsgkhvqvtg rrisataedg nkfaklivet dtfgsrvrik gaesekyicm nkrgkligkp
      121 sgkskdcvft eivlennyta fqnarhegwf maftrqgrpr qasrsrqnqr eahfikrlyq
      181 gqlpfpnhae rqkqfefvgs aptrrtkrtr rpqsqt
//
