LOCUS       NM_021867               1644 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 16 (Fgf16), mRNA.
ACCESSION   NM_021867
VERSION     NM_021867.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Wang,J., Xiang,B., Dolinsky,V.W., Kardami,E. and Cattini,P.A.
  TITLE     Cardiac Fgf-16 Expression Supports Cardiomyocyte Survival and
            Increases Resistance to Doxorubicin Cytotoxicity
  JOURNAL   DNA Cell Biol 37 (11), 866-877 (2018)
   PUBMED   30230915
  REMARK    GeneRIF: Cardiac Fgf-16 expression supports cardiomyocyte survival
            and increases resistance to doxorubicin cytotoxicity.
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Lu,S.Y., Sontag,D.P., Detillieux,K.A. and Cattini,P.A.
  TITLE     FGF-16 is released from neonatal cardiac myocytes and alters
            growth-related signaling: a possible role in postnatal development
  JOURNAL   Am J Physiol Cell Physiol 294 (5), C1242-C1249 (2008)
   PUBMED   18337564
  REMARK    GeneRIF: Expression and release of FGF-16 in the neonatal
            myocardium interfere with cardiac myocyte proliferative potential
            by altering the local signaling environment via modulation of PKC
            activation and cell cycle-related gene expression.
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Antoine,M., Wirz,W., Tag,C.G., Gressner,A.M., Wycislo,M., Muller,R.
            and Kiefer,P.
  TITLE     Fibroblast growth factor 16 and 18 are expressed in human
            cardiovascular tissues and induce on endothelial cells migration
            but not proliferation
  JOURNAL   Biochem Biophys Res Commun 346 (1), 224-233 (2006)
   PUBMED   16756958
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Miyakawa,K. and Imamura,T.
  TITLE     Secretion of FGF-16 requires an uncleaved bipartite signal sequence
  JOURNAL   J Biol Chem 278 (37), 35718-35724 (2003)
   PUBMED   12851399
  REMARK    GeneRIF: FGF-16 employs a unique bipartite signal sequence that is
            not cleaved, although it shares the same secretory machinery used
            by secreted proteins with cleavable signal sequences.
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Konishi,M., Mikami,T., Yamasaki,M., Miyake,A. and Itoh,N.
  TITLE     Fibroblast growth factor-16 is a growth factor for embryonic brown
            adipocytes
  JOURNAL   J Biol Chem 275 (16), 12119-12122 (2000)
   PUBMED   10766846
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Miyake,A., Konishi,M., Martin,F.H., Hernday,N.A., Ozaki,K.,
            Yamamoto,S., Mikami,T., Arakawa,T. and Itoh,N.
  TITLE     Structure and expression of a novel member, FGF-16, on the
            fibroblast growth factor family
  JOURNAL   Biochem Biophys Res Commun 243 (1), 148-152 (1998)
   PUBMED   9473496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Aug 31, 2022 this sequence version replaced NM_021867.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085738.2, CK600063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               JAXUCZ010000021.1  74882995-74883530
            537-640             JAXUCZ010000021.1  74891130-74891233
            641-1644            JAXUCZ010000021.1  74892595-74893598
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..1644
                     /gene="Fgf16"
                     /note="fibroblast growth factor 16"
                     /db_xref="GeneID:60464"
                     /db_xref="RGD:71052"
     exon            1..536
                     /gene="Fgf16"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..886
                     /gene="Fgf16"
                     /note="FGF-16"
                     /codon_start=1
                     /product="fibroblast growth factor 16"
                     /protein_id="NP_068639.1"
                     /db_xref="GeneID:60464"
                     /db_xref="RGD:71052"
                     /translation="MAEVGGVFASLDWDLQGFSSSLGNVPLADSPGFLNERLGQIEGK
                     LQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHDHSRFGILEFISLAVG
                     LISIRGVDSGLYLGMNERGELFGSKKLTRECVFREQFEENWYNTYASTLYKHSDSERQ
                     YYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFRYR"
     exon            537..640
                     /gene="Fgf16"
                     /inference="alignment:Splign:2.1.0"
     exon            641..1644
                     /gene="Fgf16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaggccag gagagatgga tgcgaagggg aagccgcact ttaactgaga gcaaggtcag
       61 gagcgcgcta ccccacgctc cccgccgctg agaagttctt tggacgcgaa cagacgtgtg
      121 ctgcagctgg gcagagcgcg gagccgagca gcgagctagc gagcgccgcc gacccgcccg
      181 cccgcccgcc cgcgccagcc gggaggagag gcagttcgcg ccccggggcc ccggctcggc
      241 ccgcgccgcc gccggccccg ccatggcgga ggtcgggggc gtctttgcct ccttggactg
      301 ggacctgcaa ggcttctcct cctctctggg gaacgtgccc ttagctgact ccccgggttt
      361 cctgaacgag cgcctgggcc agatcgaggg gaagctgcag cgcggctcgc ccacagactt
      421 cgcccacctg aaggggatcc tgcggcgccg ccagctctac tgccgcacgg gcttccacct
      481 tgaaatcttc cccaatggca cggtgcatgg cacccgccac gaccacagcc gcttcggaat
      541 tctggaattt atcagcttgg ctgtggggct gatcagcatc cggggagtag actctggcct
      601 atacctagga atgaatgagc gaggagagct gtttggatcg aagaaactca cacgagaatg
      661 tgttttccgg gaacagtttg aagaaaactg gtacaacacc tatgcatcca ccttgtacaa
      721 acactcggac tcggagagac agtattatgt ggccctgaat aaagacggct caccccggga
      781 gggatacagg actaaacgac accagaaatt cactcacttt ttacccaggc cagtagatcc
      841 ttctaagttg ccctccatgt ccagagacct cttccgctat aggtaatgga cccctggtgc
      901 cacctctgtg acccatgtac tctgtgacca tggttggctc tgcaaacact atactcatag
      961 cttttcaacc cttccttcct atcaattaga taacagagaa gcacttactg ttcaacatga
     1021 cccagctgtc cccttgttca aagtgtatat caaggttggg ttattctggg gagggacgtg
     1081 gggggagggg ttgttccgag ggaatcttgt atatactttt tgttttactc atgttctttc
     1141 ccgggaggtg gcatgacaaa gaacaagggt tcccactaag ggccaaagct gtcttgcctc
     1201 acaatctacc cagatacctt gagatggggt acaaatgaaa gaccaaggaa tctgccacag
     1261 atgctaccta aagagctttg ggaaagtgtc atttggaaaa tcctaggggc tcccaccctg
     1321 ctgcaagcca tccctaccct agctctgtag atctctcatt cgtcctgaca tgcagttttc
     1381 ctgccaccag aaagtgggag atatggggta ggttgtaagg aaatgatatt aaaatgtaag
     1441 catggatact gtgcataagg acaaactatt tatgaaatgt atatgctatt tattttatat
     1501 atttatttat ttcaaaataa ttttattttt aatgagagat gctatgactg gattttcttc
     1561 agaaagaata aggtcctatt gaaacaggaa aaatgagtta ttaaaggctt ttatttggca
     1621 ataaaattgt ctttaattat aaaa
//
