LOCUS       NM_001411965            4510 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 14 (Fgf14), transcript
            variant 2, mRNA.
ACCESSION   NM_001411965 XM_017599795
VERSION     NM_001411965.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4510)
  AUTHORS   Martinez-Espinosa,P.L., Yang,C., Xia,X.M. and Lingle,C.J.
  TITLE     Nav1.3 and FGF14 are primary determinants of the TTX-sensitive
            sodium current in mouse adrenal chromaffin cells
  JOURNAL   J Gen Physiol 153 (4) (2021)
   PUBMED   33651884
  REMARK    GeneRIF: Nav1.3 and FGF14 are primary determinants of the
            TTX-sensitive sodium current in mouse adrenal chromaffin cells.
REFERENCE   2  (bases 1 to 4510)
  AUTHORS   Hsu,W.C., Nenov,M.N., Shavkunov,A., Panova,N., Zhan,M. and
            Laezza,F.
  TITLE     Identifying a kinase network regulating FGF14:Nav1.6 complex
            assembly using split-luciferase complementation
  JOURNAL   PLoS One 10 (2), e0117246 (2015)
   PUBMED   25659151
  REMARK    GeneRIF: identified the PI3K/Akt pathway, the cell-cycle regulator
            Wee1 kinase, and protein kinase C (PKC) as prospective regulatory
            nodes of neuronal excitability through modulation of the
            FGF14:Nav1.6 complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4510)
  AUTHORS   Yan,H., Pablo,J.L. and Pitt,G.S.
  TITLE     FGF14 regulates presynaptic Ca2+ channels and synaptic transmission
  JOURNAL   Cell Rep 4 (1), 66-75 (2013)
   PUBMED   23831029
  REMARK    GeneRIF: FGF14 regulates presynaptic Ca2+ channels in granule cell
            and EPSCs in Purkinje cells.
REFERENCE   4  (bases 1 to 4510)
  AUTHORS   Shavkunov,A.S., Wildburger,N.C., Nenov,M.N., James,T.F.,
            Buzhdygan,T.P., Panova-Elektronova,N.I., Green,T.A.,
            Veselenak,R.L., Bourne,N. and Laezza,F.
  TITLE     The fibroblast growth factor 14.voltage-gated sodium channel
            complex is a new target of glycogen synthase kinase 3 (GSK3)
  JOURNAL   J Biol Chem 288 (27), 19370-19385 (2013)
   PUBMED   23640885
  REMARK    GeneRIF: inhibition of GSK3 reduces the assembly of the FGF14.Nav
            channel complex, modifies FGF14-dependent regulation of Na(+)
            currents, and induces dissociation and subcellular redistribution
            of the native FGF14.Nav channel complex in hippocampal neurons.
REFERENCE   5  (bases 1 to 4510)
  AUTHORS   Goldfarb,M., Schoorlemmer,J., Williams,A., Diwakar,S., Wang,Q.,
            Huang,X., Giza,J., Tchetchik,D., Kelley,K., Vega,A., Matthews,G.,
            Rossi,P., Ornitz,D.M. and D'Angelo,E.
  TITLE     Fibroblast growth factor homologous factors control neuronal
            excitability through modulation of voltage-gated sodium channels
  JOURNAL   Neuron 55 (3), 449-463 (2007)
   PUBMED   17678857
REFERENCE   6  (bases 1 to 4510)
  AUTHORS   Olsen,S.K., Garbi,M., Zampieri,N., Eliseenkova,A.V., Ornitz,D.M.,
            Goldfarb,M. and Mohammadi,M.
  TITLE     Fibroblast growth factor (FGF) homologous factors share structural
            but not functional homology with FGFs
  JOURNAL   J Biol Chem 278 (36), 34226-34236 (2003)
   PUBMED   12815063
REFERENCE   7  (bases 1 to 4510)
  AUTHORS   Munoz-Sanjuan,I., Smallwood,P.M. and Nathans,J.
  TITLE     Isoform diversity among fibroblast growth factor homologous factors
            is generated by alternative promoter usage and differential
            splicing
  JOURNAL   J Biol Chem 275 (4), 2589-2597 (2000)
   PUBMED   10644718
REFERENCE   8  (bases 1 to 4510)
  AUTHORS   Yamamoto,S., Mikami,T., Ohbayashi,N., Ohta,M. and Itoh,N.
  TITLE     Structure and expression of a novel isoform of mouse FGF homologous
            factor (FHF)-4
  JOURNAL   Biochim Biophys Acta 1398 (1), 38-41 (1998)
   PUBMED   9602045
REFERENCE   9  (bases 1 to 4510)
  AUTHORS   Miyagawa,K., Kimura,S., Yoshida,T., Sakamoto,H., Takaku,F.,
            Sugimura,T. and Terada,M.
  TITLE     Structural analysis of a mature hst-1 protein with transforming
            growth factor activity
  JOURNAL   Biochem Biophys Res Commun 174 (1), 404-410 (1991)
   PUBMED   1824921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Sep 13, 2022 this sequence version replaced XM_017599795.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.58609.1,
                                           SRR26360194.2084289.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1011              JAXUCZ010000015.1  108085402-108086412 c
            1012-1122           JAXUCZ010000015.1  107619702-107619812 c
            1123-1226           JAXUCZ010000015.1  107616055-107616158 c
            1227-1425           JAXUCZ010000015.1  107457916-107458114 c
            1426-4510           JAXUCZ010000015.1  107451634-107454718 c
FEATURES             Location/Qualifiers
     source          1..4510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q25"
     gene            1..4510
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /note="fibroblast growth factor 14"
                     /db_xref="GeneID:63851"
                     /db_xref="RGD:620165"
     exon            1..1011
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /inference="alignment:Splign:2.1.0"
     CDS             804..1562
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /note="isoform 2 is encoded by transcript variant 2; FGF
                     homologus factor 4b; fibroblast growth factor homologous
                     factor 4"
                     /codon_start=1
                     /product="fibroblast growth factor 14 isoform 2"
                     /protein_id="NP_001398894.1"
                     /db_xref="GeneID:63851"
                     /db_xref="RGD:620165"
                     /translation="MVKPVPLFRRTDFKLLLCNHKGLFFLRVSKLLGCFSPKSMWFLW
                     NIFSKGTHMLQCLCGKSLKKNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDD
                     STNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYV
                     IYSSMLYRQQESGRAWFLGLNKEGQVMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHD
                     VGETVPKAGVTPSKSTSASAIMNGGKPVNKCKTT"
     exon            1012..1122
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1226
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1425
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..4510
                     /gene="Fgf14"
                     /gene_synonym="FGF-14; Fhf4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctctaa tgcctgtaac tcacagccga gactgggcga ggaatccgga ggggagcttt
       61 tcctcatgct ctcggtggct ggagactgga agcaagagtg tagggaagga ggaaggagat
      121 ttgtggcgct ttctacctac tacgagactg aaaaggggag ggggcaccta cattacatcg
      181 tctcttcgtg attgagaact gcaggttcag tccgacccta cggagctctg gcgattgctt
      241 atttaaaaaa gaaaagaaag aaagaaagaa aaaaaattga ccgcgggaga aagaaggctc
      301 agtttttggc agccagactc gtcttggagg tggtattggt gtgtgagtgt gtgcggtggt
      361 gttttatttt ttcttccttt tttctttctt tttatttttt ctttctttct ttcttttttc
      421 ttttttctcc ccttctctcc taggggctac acaatggcag tcttctctcg ctaagatgaa
      481 tccggctttg ccttctgcag atccgcccat cctcagttcc atttagtaaa aggctatgat
      541 tttctctttg gggatctttt gtgcattact gttctccctg gttagttctg gtctcggttg
      601 ggatttcttt gctatttttt gtttggcttc atgtgaaaac ggattttttt ctctccaacc
      661 ctttggtcat gatccagtgg tgatcaagag gggataaatc attcaccctg gccgagaaaa
      721 aacaatcgct gagaagtctc aaagagatat accacgtgag gggaaaaaac tgggagaaga
      781 tccggaatat taacgttttt cctatggtaa aaccggtgcc cctcttcagg agaactgatt
      841 tcaagttatt attatgcaac cacaagggcc tcttctttct cagggtgtct aagctgctgg
      901 gttgcttttc gcccaaatca atgtggtttc tttggaacat tttcagcaaa ggaacgcata
      961 tgctgcagtg tctttgtggc aagagtctta agaaaaacaa gaacccaact gatccccagc
     1021 tcaagggcat agtgaccagg ttatattgca ggcaaggtta ctacttgcag atgcaccccg
     1081 atggagctct cgatggaact aaggatgaca gcaccaattc cactctgttc aacctcatcc
     1141 cagtgggact gcgtgttgtt gccatccagg gagtgaagac agggttgtac atagcaatga
     1201 atggagaagg ttacctctac ccatcagaac tttttactcc tgaatgcaag tttaaagagt
     1261 ctgtttttga aaactattat gtaatctact catccatgct gtacaggcaa caggagtctg
     1321 gcagagcctg gtttttggga ttaaataagg aagggcaagt tatgaaagga aacagagtaa
     1381 agaaaaccaa accagcagct cattttctac ccaagccatt ggaagttgcc atgtaccgag
     1441 aaccatcttt gcatgatgtt ggtgaaacag tcccgaaagc tggggtgaca ccaagcaaaa
     1501 gtacaagtgc atctgcaata atgaatggag gcaaaccagt caacaagtgc aagaccacat
     1561 agccagatcc tcaggtgtcc tgactgactt atcccgagca cagtggagtg atttatcctt
     1621 actagacatt cctgctcctg tggcggaaaa gccccagcaa gcaagctgac gcttgtccta
     1681 tgctctctca gacctccttc gttgcaagtg gataaatctc aacctgtggc ccccctacac
     1741 caagaagaca cctggacaaa ccagctaaac tcagaccatg gaatgcccta ccagatatgg
     1801 aatgcctttt taatatcttt tctgtgactg tgacacttca tgtgaatgac atacttcaca
     1861 agtacactca ataccttgcc tgctgacagc tacccataat cctttttgag tcctgtttca
     1921 gcgaaatcca tgtgtttaag ttcaattttg tagcacacaa ataatattga gtaatttcta
     1981 gttagatgct gtaaacctgt gctatcatgg atttctattc tttccatttt tacagggctg
     2041 ctcgctccac tgtctgtgac ctttagcagg gattgtgttc ctctgatctt cagtgttgca
     2101 gttggtttgc ttagaagaac aattagggaa tcaggaagcc ttctaaacct attactacaa
     2161 atagtatata taaagattaa gattgttgtc tttggctcac attattgatc aaacacacat
     2221 atacgctctg tctagtagga gatgctgtgc tcccgatgta ggcattgcct gggtggaaca
     2281 agggtcaaac acaatccatg gaaagtatcc tctatgatag gtgtttggca ttccctctta
     2341 gtttctttat gtgtgtgtgt tttatacata tcacaagctt actggtaatg gtaacatttg
     2401 ccttgcccag cgagcaagac ccacttagtt tttgagaaag tgggtccaaa gaattctgta
     2461 ggccttgtag gcctgattaa ggttcatttt attttcatca attaatcctc attattggga
     2521 aaaaaataaa aacccaaatc attacaacct ataagaaata tgctacctaa atccatttcc
     2581 ggcccactcc ttcctgtttt taatgaagat aactcagtgt cacacctgat ttgggctgca
     2641 ttccagttat cctcatcctc agccaagcat gggcaaggtg gctgttgtgt tctttcctga
     2701 agcagcaatg cacacgttag tataaattag actttaacat ttttggtatt taatggcaag
     2761 ttttaaaact ggacatatta ggagttttgt ttgcgttttg gtttttgggt tttggggttt
     2821 tttttttttt gttttttgtt ttgttttggt ttggttttgg ttttggtttt agctcagcat
     2881 ggggcctagt atcctggata tcatcagtat acacctctaa ctcatcactg ttgggcccaa
     2941 caggttgggt tagagatgac ttgtcaaggt ttcagaatat ggtttgttga gtaccctaaa
     3001 taaaactaaa gacaacctaa catactccag ccttaggggt ttggaccatt tgatttattt
     3061 aattttcttt tattgcttta atttcatttt gaattgaatt ctgtagagct ccaagtttag
     3121 ggatacttag aaaggctgtg aaatgctgga gatacacctt gaagatttca tgcaaaatgt
     3181 ttaatatcag atacaaaaaa aagcttcaaa atgtttagta ctaaactgtt tggaaaaata
     3241 tttgttaact gtatgtaact taataaaatt ctatgttttc ttctcagaag agttcattga
     3301 gaccaaactg aacctctttt atagaaaaca atcgatgtgg gatcaatgta ctgtcctctt
     3361 gttattattt ccatgtggca ggatgaccca cttgccactg ttcccctttg cactgtactt
     3421 actgggaaat cattttctca ttgctttcat gaatctccat gaagtcagcc tttgcccagc
     3481 atagaaaaat tttggcctgc ttagctaatt aaagattcag tataaattta agtgtttatg
     3541 ctcatttcat ttcatactag attccatttc aataaataaa cattagcaaa atctttgagt
     3601 agatttattg ttaataatgc taaactgcaa atacaacaaa atgacccctt tgaccattcc
     3661 tcatttgctg ttatgcataa ttagataaaa ctcattatgg aagacataca ttcatagtat
     3721 gtggtaaaat gaatagcttg taattcctat tagttgggct tatagacata gcttataccc
     3781 ctctgtatgc atacacatcc caagccagcc tacctttctg tttttgataa tcaacactac
     3841 ttgagatttc tgttctcaag acctatttag tggttacaat tgaggcaaga tttatttttg
     3901 taaatgatta agatttatgt taatgtttct ttctgtttcc tttcccaaga gttgtctata
     3961 agagcattta ttagtgtaag taggtattcg agtggtttat tctaatatat gattagacac
     4021 attgcaatgg ggttcttgtt atctttgatt tagttagacc atttcctttg tgtctggtct
     4081 cacctgttgc atgggaagag gaaagcacca aatgatctgc atgtactagg actcatgtat
     4141 ccagaagtac tggtatgtat tattcaattt ataacagagg gattgtctgt attgtacaat
     4201 ttgtgtttct tatcatttgt tatgttcata gctatgacat atcaaatcaa atacttatat
     4261 gaaggcatat ggaaagcata aaataatttt gtgtaacaaa atagcattgt atcgccccat
     4321 atatagagaa ctctcatgta aataagttga taaactcaag ttcccccttt accatgccaa
     4381 agaaaatttt agctccttta tgatacctct cttgctaatt ttctggaaca aggtcaacaa
     4441 tccttccctc agaaattaag tttgctatca ttaaatgcaa tctgtcatca ctgatgttct
     4501 gaatagtaaa
//
