LOCUS       NM_130814               4978 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 12 (Fgf12), transcript
            variant 1, mRNA.
ACCESSION   NM_130814
VERSION     NM_130814.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4978)
  AUTHORS   Fan,Q., Wu,M., Li,C. and Li,J.
  TITLE     MiR-107 Aggravates Oxygen-Glucose Deprivation/Reoxygenation
            (OGD/R)-Induced Injury Through Inactivating PI3K-AKT Signalling
            Pathway by Targeting FGF9/FGF12 in PC12 Cells
  JOURNAL   J Stroke Cerebrovasc Dis 31 (4), 106295 (2022)
   PUBMED   35093630
  REMARK    GeneRIF: MiR-107 Aggravates Oxygen-Glucose
            Deprivation/Reoxygenation (OGD/R)-Induced Injury Through
            Inactivating PI3K-AKT Signalling Pathway by Targeting FGF9/FGF12 in
            PC12 Cells.
REFERENCE   2  (bases 1 to 4978)
  AUTHORS   Song,S.H., Kim,K., Jo,E.K., Kim,Y.W., Kwon,J.S., Bae,S.S.,
            Sung,J.H., Park,S.G., Kim,J.T. and Suh,W.
  TITLE     Fibroblast Growth Factor 12 Is a Novel Regulator of Vascular Smooth
            Muscle Cell Plasticity and Fate
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (9), 1928-1936 (2016)
   PUBMED   27470512
  REMARK    GeneRIF: FGF12 strongly induced the quiescent and contractile
            vascular smooth muscle cell phenotype and directly promoted VSMC
            lineage differentiation.
REFERENCE   3  (bases 1 to 4978)
  AUTHORS   Siekierska,A., Isrie,M., Liu,Y., Scheldeman,C., Vanthillo,N.,
            Lagae,L., de Witte,P.A., Van Esch,H., Goldfarb,M. and Buyse,G.M.
  TITLE     Gain-of-function FHF1 mutation causes early-onset epileptic
            encephalopathy with cerebellar atrophy
  JOURNAL   Neurology 86 (23), 2162-2170 (2016)
   PUBMED   27164707
REFERENCE   4  (bases 1 to 4978)
  AUTHORS   Wildburger,N.C., Ali,S.R., Hsu,W.C., Shavkunov,A.S., Nenov,M.N.,
            Lichti,C.F., LeDuc,R.D., Mostovenko,E., Panova-Elektronova,N.I.,
            Emmett,M.R., Nilsson,C.L. and Laezza,F.
  TITLE     Quantitative proteomics reveals protein-protein interactions with
            fibroblast growth factor 12 as a component of the voltage-gated
            sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian
            brain
  JOURNAL   Mol Cell Proteomics 14 (5), 1288-1300 (2015)
   PUBMED   25724910
  REMARK    GeneRIF: Fibroblast growth factor 12 is a component of the
            voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in
            the rat brain.
REFERENCE   5  (bases 1 to 4978)
  AUTHORS   Goldfarb,M., Schoorlemmer,J., Williams,A., Diwakar,S., Wang,Q.,
            Huang,X., Giza,J., Tchetchik,D., Kelley,K., Vega,A., Matthews,G.,
            Rossi,P., Ornitz,D.M. and D'Angelo,E.
  TITLE     Fibroblast growth factor homologous factors control neuronal
            excitability through modulation of voltage-gated sodium channels
  JOURNAL   Neuron 55 (3), 449-463 (2007)
   PUBMED   17678857
  REMARK    GeneRIF: Sodium channels in Fhf1-/-Fhf4-/- granule neurons
            inactivate at more negative membrane potential, inactivate more
            rapidly, and are slower to recover from the inactivated state.
REFERENCE   6  (bases 1 to 4978)
  AUTHORS   Olsen,S.K., Garbi,M., Zampieri,N., Eliseenkova,A.V., Ornitz,D.M.,
            Goldfarb,M. and Mohammadi,M.
  TITLE     Fibroblast growth factor (FGF) homologous factors share structural
            but not functional homology with FGFs
  JOURNAL   J Biol Chem 278 (36), 34226-34236 (2003)
   PUBMED   12815063
REFERENCE   7  (bases 1 to 4978)
  AUTHORS   Liu,C.J., Dib-Hajj,S.D., Renganathan,M., Cummins,T.R. and
            Waxman,S.G.
  TITLE     Modulation of the cardiac sodium channel Nav1.5 by fibroblast
            growth factor homologous factor 1B
  JOURNAL   J Biol Chem 278 (2), 1029-1036 (2003)
   PUBMED   12401812
REFERENCE   8  (bases 1 to 4978)
  AUTHORS   Liu,Cj., Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     Fibroblast growth factor homologous factor 1B binds to the C
            terminus of the tetrodotoxin-resistant sodium channel rNav1.9a
            (NaN)
  JOURNAL   J Biol Chem 276 (22), 18925-18933 (2001)
   PUBMED   11376006
REFERENCE   9  (bases 1 to 4978)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 3, 2021 this sequence version replaced NM_130814.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.252143.1, AB079374.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2156              JAXUCZ010000011.1  85801758-85803913
            2157-2267           JAXUCZ010000011.1  85853292-85853402
            2268-2371           JAXUCZ010000011.1  85878635-85878738
            2372-2570           JAXUCZ010000011.1  86049806-86050004
            2571-4978           JAXUCZ010000011.1  86067136-86069543
FEATURES             Location/Qualifiers
     source          1..4978
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..4978
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /note="fibroblast growth factor 12"
                     /db_xref="GeneID:170630"
                     /db_xref="RGD:620163"
     exon            1..2156
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             1958..2689
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /note="isoform 1 is encoded by transcript variant 1;
                     FHF-1; FGF-12; fibroblast growth factor homologous factor
                     1; fibroblast growth factor homologous factor 1b;
                     fibroblast growth factor 1a"
                     /codon_start=1
                     /product="fibroblast growth factor 12 isoform 1"
                     /protein_id="NP_570827.2"
                     /db_xref="GeneID:170630"
                     /db_xref="RGD:620163"
                     /translation="MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERH
                     VLGVFSKVRFCSGRKRPVRRRPEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSD
                     YTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYS
                     STLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGE
                     KQGRSRKSSGTPTMNGGKVVNQDST"
     exon            2157..2267
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2371
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2570
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..4978
                     /gene="Fgf12"
                     /gene_synonym="Fgf1a; Fhf1; Fhf1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgggagca gtgggcgcga gaaaagggag caagacccaa gcgccaggtt ttccagcgct
       61 ctgcaagccc agcccccaat tcagtcccac caggaaatct ttccagcttc ttaagagcca
      121 gagtaactcc agccgccgct cgctccccgt cccactcgcc ttctcagagg ctgctgtcgc
      181 ctctgcccag agtttcctgc ggagctagcg ctttggggga gacagcccgc ggcggcgccc
      241 aggagcttct gcccatgaat gggactccgc cctgagcgcc ccctcccggt ccaagggagg
      301 cggcgggggg cgccccgcga tcccgcggct cccagccgcc accggcgcag caagttgggc
      361 gagttggtgg ccgcctgcac ctgccgcctg tccccagccc cagagtcctc tcctggcccg
      421 gggagcctag gtggcacgcg cggccatctc ccgccgtcgc ctagggcggc ctaaggaccc
      481 tgcctgcgcc cgggcgccag accatggtgg gcagctgcga cccagagcca cagccaccgc
      541 gagccgacgt cgccctccac cagcccccgc cccacccgag cggacgcgcg ggggctcgca
      601 gcgctcggtc acttccttcc acggctggga tgggcggcgc gggaccgagc gagcggccca
      661 gcggcggccg ggtaacccct atctgagctg cggccgggag ctgccgaccg ccggggcgtg
      721 agagcctggg gtcccggagg cgcagcgatg acctgatccc aagcccgcca gggcgcccgt
      781 ccctcgcagc ccagctcgct tggagcctgt gcggagaccg gctcggtgcg gcggctcggg
      841 cgcacggtgg cggggagctc cggtgaaagg cgtgtgggcg ccgaggacac cttcggcagc
      901 tctgcctttg gaggggcttc tgtaaactac tgagtcattc cagatttagg atttcctaaa
      961 taatcaccaa ctgtgcccgt ctcgtgccgg aacgcaggca gtgagagcgg gagagcccgc
     1021 tttccggacc ccgccgatcc ccggggtgct tggccctcga ggatctccct ccctcccgtt
     1081 gtccctcccc ctccctcgtc tcccgctctc tttgcagtgc tgccggagga gaggcgcgct
     1141 caccgcagct ggaaacagct gccacccctc tccaaccccc cgccctgctc ccctaccccg
     1201 tgtctggtta atcgctccca cttttcgcct cttggaattc cagaagtggg gaggccggcc
     1261 cccggagaac cgcagccggg gcgatgcatt tcgtagacct cacccagccg ggacggacct
     1321 cctaatcttc agaaccgcgg gccacaggga gttaaattgc tgccttcctc ttctctgtcg
     1381 cggttggtgg ttcgttttct aaaggaacgt tttattcact ttttactata tatattttta
     1441 agccgggggc acgcttctag cctcggtcca gactctgcct tgtaaacggg tttctatgta
     1501 tatatgtgta ggtatacttt ggacacctta caacgcttgc gcctcgccaa ccggggcacg
     1561 gcttgttatt ttggacatct tttccccctt tccacttggt accccgaacg cagtgtgacc
     1621 aaactcccca ccgccctttg gacgtggatc gccttggggt gcaagtttgg ggtacaaacg
     1681 tctacttcgc aagaaggcct gggaccgccc cgcccccgcc gccagtggtt ggggaagttt
     1741 acatccggat tttcacacgt tttgttgcca cactgcccag actctgacta accttgtggg
     1801 ctccaggttt tcgatactgc aacctcctca aatattagca ctgcctcccc gcgcctgtcc
     1861 tattcctcca ggcccccgag gtcctgccct catcccggcg gagcaggaac ccgagggcgc
     1921 agtggagccc ggggcctccg gcccgcgctg agcagctatg gctgcggcga tagccagctc
     1981 cttgatccgg cagaagcggc aggcgaggga gtccaacagc gaccgggtgt cggcctccaa
     2041 gcgccgctcc agccccagca aagacgggcg ctccctgtgc gagaggcacg tcctcggggt
     2101 gttcagcaaa gtgcgcttct gcagcggccg caagaggcca gtgaggcgga gaccagaacc
     2161 ccagctgaaa gggattgtga caaggttatt cagccagcag ggatatttcc tgcagatgca
     2221 tccagatggt accattgatg ggaccaagga cgaaaacagc gactacaccc tcttcaatct
     2281 aattcctgtg ggactgcgtg tggtggccat ccaaggtgtg aaagccagcc tttatgtggc
     2341 catgaatgga gaaggctatc tctacagctc agatgttttt accccagaat gcaaatttaa
     2401 ggagtctgtg tttgaaaact actatgtgat ctattcctca accctgtatc gccagcagga
     2461 atcaggccgc gcatggtttc taggactcaa taaagaaggt caaatcatga aggggaacag
     2521 agtgaagaaa accaagccct catctcattt tgtaccaaaa cctattgaag tgtgtatgta
     2581 cagagaacca tctctacatg aaattggaga aaagcaagga cgctcgagga aaagttccgg
     2641 aacacccacc atgaatggag gcaaagtcgt gaatcaagat tctacatagc ctggctgaga
     2701 actcttctgt tcttccctct cctcccctcc cttcttcttc cctccctttc cccgttttct
     2761 ccagtaaatc cacccaatga gagagagaga aaaataaaac agcatcacag gacttagtag
     2821 ctgagatact gcactaaaaa tcttcctttg tgtaggacaa gaaatttgaa ccaaagcttg
     2881 cctgttgcaa tgtggtagaa aattcacatg cataacaatt attgcacata agagcaaagg
     2941 aaaaaataaa tcgggactcc acaaacatta aatttaactg tgttgttatt aatagagggt
     3001 taattgtaat aaagggaggc tataatgcag acaaaacaga gtcattgaat ggatgtaaaa
     3061 ggttttgaga aagtcactta aaatgtcatt gaactgtaaa cccttttaag ttttagagca
     3121 ttctgtaatg tgcagttttg tttcgttttt gtattttctt tacacttctg tccatgatac
     3181 acaattacat gctgtttcca ggatattcat tttcaatcat aaaattgaat atgacaaaat
     3241 tatattcttt taatatctga tagacacata gacagggacc aactcacatg aagaaaagtt
     3301 ttaaacttat tcttgatgtt agcaatattt ttttatttta gaaaaggaaa ctcttgtgtt
     3361 gcatttaatc atattagctg atttaattcc tttgtaagga gattcacatt cttcaagctg
     3421 aatattatat ttttatctag gtattgatct ggaattttat tattttttta gacattcagt
     3481 gaaaaggatt ttaatgtatt cctgaggaga cttaaagaac tcccgggcat ctgctgaaga
     3541 agcataggct tcttgaattt tccatccagt cttagtggga gtatctttga gtgtgtatgt
     3601 tgaacttata gctgtcatag aaagttgatt ttttttaacc ataccttgca gaaggagaga
     3661 agaaagatgg gttttacaga aggaaataag tctgatatat agactcaaag caaaatttca
     3721 ttgccttttt acatcgccag ggttttgcgt gtagattgtt ttctcaactc taggagaact
     3781 taggaagtat ggctgtgaaa ttcctacctt atcatctatg aagccagtgg catgtgtgtt
     3841 gggttttatc cacatttata agcctagttt gcaacaattc tacattgtag aaaacagaag
     3901 gtaattagtt aaacatagaa ttttcaaggg acagaggaaa aaatgtggaa ttaacagctt
     3961 tgaatctagt agccagggtt ttgtgggtgg gttcgtgcag tgaaaaagaa cttcacgtaa
     4021 gtgcgagcaa gtgcactatt agaacactga agtactagaa aacattaaca aagatgtgaa
     4081 gctataccac ggcattgaaa tcctagatct acttcgccct ggatatcagg aatggtgtag
     4141 agaaatccaa attcaaacaa accaaaccag aatgttaaaa aaaatgtttg cagctttatg
     4201 gatatcataa tgagaagact taagcatgta acttctccta tatctctact gtccagcatg
     4261 tgttattcca actaggactc cctaaaatac agactttgca gaagatctaa gccctcactt
     4321 caaacctttc cacgggttgc tgtattctat taaggtcaac ataatgtccc ccctctacac
     4381 aaacattatt cttcagtgta attcttgccc tataaattta tgttctctgg agggtggcag
     4441 aaaatgtact gggagaattt tttcataaac tttggaagaa tagaggttat gcacacagac
     4501 aagacttttc aacagatttt aaatagaata tatgtaaagc aacagaaata tatatatata
     4561 tatatatata tatatatata tatatatatg ttgctctctt aggaaaagta caactatgta
     4621 aagacacaca tccagaagtt gtatttgttg tcactgttga tccaacttga ttataagtac
     4681 acctgtcact tccaggacca aacaaatccc aagcacaagg ccttattttc tttaaaaaaa
     4741 taaataaata aagaggcttc aacaaaatgg gtcatgggct cttttaaagg gaagtgcctg
     4801 gagtttttta ggtgatatgt ttactaaacc ataatgcact gaggtacaca ggaagtgtca
     4861 ttggtggaaa tcacagttgc ccatctctct gaggatttca tgatagaaat ttaatctcat
     4921 tatttatgaa aatataatgc tgatattaat ctctaataaa atcccttctc tattttca
//
