LOCUS       NM_012951               4164 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 10 (Fgf10), mRNA.
ACCESSION   NM_012951
VERSION     NM_012951.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4164)
  AUTHORS   Bian,J., Zhang,B., Zhang,Y., Tian,Y., Yin,L. and Zou,W.
  TITLE     FGF 10 Inhibited Spinal Microglial Activation in Neuropathic Pain
            via PPAR-gamma/NF-kappaB Signaling
  JOURNAL   Neuroscience 500, 52-62 (2022)
   PUBMED   35934252
  REMARK    GeneRIF: FGF 10 Inhibited Spinal Microglial Activation in
            Neuropathic Pain via PPAR-gamma/NF-kappaB Signaling.
REFERENCE   2  (bases 1 to 4164)
  AUTHORS   Manso,L.A., Medeiros,B.C.M., Rodrigues,G.A., Ramos,J.G.,
            Marques,M.R., Taboga,S.R., Dos Santos,F.C.A. and Biancardi,M.F.
  TITLE     Testosterone exposure in prenatal life disrupts epithelial nuclear
            morphology, smooth muscle layer pattern, and FGF10 and Shh
            expression in prostate
  JOURNAL   Life Sci 271, 119198 (2021)
   PUBMED   33577857
  REMARK    GeneRIF: Testosterone exposure in prenatal life disrupts epithelial
            nuclear morphology, smooth muscle layer pattern, and FGF10 and Shh
            expression in prostate.
REFERENCE   3  (bases 1 to 4164)
  AUTHORS   Wu,J., Huang,Q., Li,P., Wang,Y., Zheng,C., Lei,X., Li,S., Gong,W.,
            Yin,B., Luo,C., Xiao,J., Zhou,W., Xu,Z., Chen,Y., Peng,F. and
            Long,H.
  TITLE     MicroRNA-145 promotes the epithelial-mesenchymal transition in
            peritoneal dialysis-associated fibrosis by suppressing fibroblast
            growth factor 10
  JOURNAL   J Biol Chem 294 (41), 15052-15067 (2019)
   PUBMED   31431501
REFERENCE   4  (bases 1 to 4164)
  AUTHORS   Shi,L., Tian,C., Sun,L., Cao,F. and Meng,Z.
  TITLE     The lncRNA TUG1/miR-145-5p/FGF10 regulates proliferation and
            migration in VSMCs of hypertension
  JOURNAL   Biochem Biophys Res Commun 501 (3), 688-695 (2018)
   PUBMED   29758198
  REMARK    GeneRIF: lncRNA TUG1/miR-145-5p/FGF10 promotes the proliferation
            and migration of Vascular smooth muscle cell in hypertensive state
            by activating the Wnt/beta-catenin pathway.
REFERENCE   5  (bases 1 to 4164)
  AUTHORS   Bless,E.P., Yang,J., Acharya,K.D., Nettles,S.A., Vassoler,F.M.,
            Byrnes,E.M. and Tetel,M.J.
  TITLE     Adult Neurogenesis in the Female Mouse Hypothalamus: Estradiol and
            High-Fat Diet Alter the Generation of Newborn Neurons Expressing
            Estrogen Receptor alpha
  JOURNAL   eNeuro 3 (4) (2016)
   PUBMED   27679811
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4164)
  AUTHORS   Park,W.Y., Miranda,B., Lebeche,D., Hashimoto,G. and Cardoso,W.V.
  TITLE     FGF-10 is a chemotactic factor for distal epithelial buds during
            lung development
  JOURNAL   Dev Biol 201 (2), 125-134 (1998)
   PUBMED   9740653
REFERENCE   7  (bases 1 to 4164)
  AUTHORS   Yamamoto,S., Mikami,T., Ohbayashi,N., Ohta,M. and Itoh,N.
  TITLE     Structure and expression of a novel isoform of mouse FGF homologous
            factor (FHF)-4
  JOURNAL   Biochim Biophys Acta 1398 (1), 38-41 (1998)
   PUBMED   9602045
REFERENCE   8  (bases 1 to 4164)
  AUTHORS   Bellusci,S., Grindley,J., Emoto,H., Itoh,N. and Hogan,B.L.
  TITLE     Fibroblast growth factor 10 (FGF10) and branching morphogenesis in
            the embryonic mouse lung
  JOURNAL   Development 124 (23), 4867-4878 (1997)
   PUBMED   9428423
REFERENCE   9  (bases 1 to 4164)
  AUTHORS   Beer,H.D., Florence,C., Dammeier,J., McGuire,L., Werner,S. and
            Duan,D.R.
  TITLE     Mouse fibroblast growth factor 10: cDNA cloning, protein
            characterization, and regulation of mRNA expression
  JOURNAL   Oncogene 15 (18), 2211-2218 (1997)
   PUBMED   9393979
REFERENCE   10 (bases 1 to 4164)
  AUTHORS   Yamasaki,M., Miyake,A., Tagashira,S. and Itoh,N.
  TITLE     Structure and expression of the rat mRNA encoding a novel member of
            the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (27), 15918-15921 (1996)
   PUBMED   8663172
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 3, 2022 this sequence version replaced NM_012951.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1982163.1,
                                           SRR26360194.774515.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1072              JAXUCZ010000002.1  52533939-52535010
            1073-1176           JAXUCZ010000002.1  52600816-52600919
            1177-4164           JAXUCZ010000002.1  52607993-52610980
FEATURES             Location/Qualifiers
     source          1..4164
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..4164
                     /gene="Fgf10"
                     /gene_synonym="FGF-10; Fgf5a"
                     /note="fibroblast growth factor 10"
                     /db_xref="GeneID:25443"
                     /db_xref="RGD:2606"
     exon            1..1072
                     /gene="Fgf10"
                     /gene_synonym="FGF-10; Fgf5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..1374
                     /gene="Fgf10"
                     /gene_synonym="FGF-10; Fgf5a"
                     /note="fibroblast growth factor 5a"
                     /codon_start=1
                     /product="fibroblast growth factor 10 precursor"
                     /protein_id="NP_037083.1"
                     /db_xref="GeneID:25443"
                     /db_xref="RGD:2606"
                     /translation="MWKWILTHCASAFPHLPGCCCCFLLLFLVSSVPVTCQALGQDMV
                     SPEATNSSSSSSSSSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKN
                     GKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLK
                     ERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS"
     exon            1073..1176
                     /gene="Fgf10"
                     /gene_synonym="FGF-10; Fgf5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..4164
                     /gene="Fgf10"
                     /gene_synonym="FGF-10; Fgf5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacatttaga ctccaggctt caacctgttt acaagcggct ttccaaggga cttggaggtg
       61 gagggaaggg ccaaacaaaa caccagccgc cagccgcccc ccaaactaga agtggctttc
      121 gggagacttc acatcaacag gcaccaccaa aaagagaaag gaaggagaag aaaacaacag
      181 cgcctgggta gctgcctcca gttctgacaa ctccaaagag acacactttt taagtggcca
      241 gcaggctggg actctgcaga gaaggaccag aaggtgccaa ccgcagaggg gcgcagatgt
      301 cttcctgcac ccccacccca cccactttgg gttttgttca ccgtcctgtc atctgttttt
      361 cagacctctt ttgcatctaa catggtgaag aaaggagtga agaagagaac aaagtaaccc
      421 ccggggggag cgaagagctc tggtgaccga caccaccagt tcctactgcc tcggccaccc
      481 acgtccactg ttcaccctga gactggagag acacaggcag cggatccgag gacggagcga
      541 ggacaggcag ccggcccttc cgaggagtta tggatgttgg tgcactcgct tctggccaga
      601 tccgtaccca gagggagcta accagtagcc atcacctcca gctgtctctt tgcctcgcac
      661 caggtcttac ccttccagta tgttccttct gatgagacaa tttccagtgc cgagagtttc
      721 agtacaatgt ggaaatggat actgacacat tgtgcctcag cctttcccca cctgccgggc
      781 tgctgttgct gcttcttgtt gctcttcttg gtgtcttccg tccctgtcac ctgccaagct
      841 cttggtcagg acatggtgtc accggaggct accaactcct cttcctcctc ctcttcctcc
      901 tcctcgtcct cttccttctc ctctccttcc agcgcgggga ggcatgtgcg gagctacaat
      961 cacctccagg gagatgtccg ctggagaaag ctgttctcct tcaccaagta ctttctcaag
     1021 attgaaaaga acggcaaggt cagcgggacc aagaaggaaa actgtccgta cagtatccta
     1081 gagataacat cagtggaaat cggagttgtt gccgtcaaag ccattaacag caactattac
     1141 ttagccatga acaagaaggg gaaactctat ggctcaaaag aatttaacaa tgactgtaaa
     1201 ctgaaagaga ggatagagga aaatggatac aacacgtatg catcttttaa ctggcagcac
     1261 aacggcaggc aaatgtatgt ggcattgaat ggaaaaggag ctcccaggag aggacaaaaa
     1321 acaagaagga aaaacacctc cgctcacttc ctccccatgg tggtccactc atagaagaag
     1381 gcaccgttgg tggatgcagt acaaccaatg actctttgcc aaaaagagat agtatcctca
     1441 ctgaagactg tagctcaaaa ggcaaagata gagcactgag ttcagcttgt ttaaaggaag
     1501 gaaggaaggc tttggatgtt tttgtactca ctgctgacat acgaagttct tttcactagc
     1561 tctgtgtcat tgcgtcatgc cttataccca agatagaggc aaatcaagtg tggatggaag
     1621 ttatcctcaa gtgaacaata ctgtggtggg ggttgggttt ttcgttttgt tttgttttga
     1681 ttttaagctt tttgttttga acttctgaga taggacgtaa aggacttaaa ggaacactct
     1741 gttgaatgat ctttgggaaa gttatttatg gaatatgaac acatatcaaa gactttcatt
     1801 gctcattcaa gcctgatgat tcaatgagca gtaagacacg caagcattta ctggaaagca
     1861 cttgggtcat atcatatgca caaccaaagg agctttgggt gtggcaccat ggaagaattg
     1921 gatcagattt acaaatataa acatagtagt gtgaaactgt cctaacaata caaatagtat
     1981 ggtatgcttg tgcattctgc ctccatcctt tctatttcct tctaagttat ttatttaata
     2041 ggatgttaaa tatcttttgg ggttttaaag aatatcctca gtgctgccct ctgatttacc
     2101 ttctctcttt ctctttcttt ttctctttct cttcctttct ctttctcttt ctctgtctct
     2161 ctttttggca ccatacacac gttcatgaca aagtgtttta aaacctttgc aaacacttca
     2221 gaagtaggag atgaggaaaa ggaagcagta tgaatgccct ttgtgctctc agttgactta
     2281 atttgcactt ctgcaacaca aagcatcagc gatgactatg tctgagttct gctatagctt
     2341 aagtgacaga gatctggcct catttgtcaa catatattgg ccctgaggga ctcttacctt
     2401 aaaatattga aggccaaatt ctctttcact gccttatttc atctcccaga atatactaaa
     2461 agaagaaaca tgaattgtta gattttagac taacctcggt tttttgttca tttgtttggt
     2521 tgttttgttt tgttttgttt tcctactgat gatggcttgc cacgggtcac aatgacaaat
     2581 gatgggaagg ctttctgcat atacatgagc cctttgtaag tcccacagaa tccctctccc
     2641 tcaaaggaac caaaaaggaa atttgatatg aagtgcatct ccccgtgggg cttagttgaa
     2701 gcaaatctat cctagtatgt gtgccaccat gtactgatac ctgttcaagc tgtatggtct
     2761 agtccttaca gaaccaaata aatcttgttt tctgtaaatt taaagtgttc tagaaggttc
     2821 cataatataa ccacattgaa attcatttta ttagagaagg catataaagc cgtacgtaag
     2881 cgtgccatgc accctcactg tgtagttcac taaataaaca cgtaagcctt atttgcagtg
     2941 tctgtagtga ttttaaaaac gtagaaaaca ttatttgtcc taaataattt taaactcaga
     3001 ctatattgac gctgcagtct tctttcttgt ttgggaatgt ctgtttattt ttattgtttg
     3061 gatacagtac tttgatacga actaaaagac tcagcaaatg tgtcttttaa ctaaaactta
     3121 acctccagaa cgactagtga tatgtgatcc tcttctaacc tatttgtgct gatgcttggc
     3181 cagtgcaaac cagttcttta aaatattatt attaaaggtt aatcagttat tttaaagaaa
     3241 tcggctttct tttttcagtc tgttcccaca gagcaaccca acacaggtca taatttatga
     3301 tgtctttgaa aagctggtat ttctagaaaa acacacaggg gcacagtgct ttggtttaca
     3361 ggtctaggat gcatttcgtg gtgttcttcc ttcaacttgt tttgggacaa ataggatttt
     3421 ttaaaacgtg gacttcttgt ggttggattc tgtatgtgag agtttaattg gtaactgagt
     3481 ctgtgtaatg cacttctagg agagctaggt atcttttctg cttttatttt aaaataataa
     3541 ttatacctga cacatgaaca tggaccaccc acaaacaaaa tgaaatgttt gggagacaaa
     3601 ctatagtatt cagtgaccaa agtgacagca aatatggcag acattggatt cttatttcac
     3661 attgccattt agattactaa agggactacg tgtaaacagt cgtcgctaca gtactcaaga
     3721 cattaaacag cttctagcaa aatgtatcaa agcctgcaga gttcaaaaat agaaaacatc
     3781 tttcctctct cccaccctac atctccccca tatacatccc aacagagata aatgcaaaaa
     3841 ggaaaatctt ctgcatttaa taaatgcata tttgtttgat attaataggg aattctggtc
     3901 ctttttacaa ctactgaaag aagtttagtc ctaaattttt gtgtgtttaa aaaaaaaaac
     3961 tcatcaagat gtcgggagtt ctgcctccgt gggaaacgtg ggcactggtc caccatactg
     4021 aagtgtgtta gcgatggata caggacatat atgagactct ttaaagatac agaatcactc
     4081 ccctcctcct atcccctaaa aggctgaaca gtgtatatta tgttacattt aaataaaggc
     4141 aataaaaatg ctgggaaaag aaaa
//
