LOCUS       NM_012846               1185 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus fibroblast growth factor 1 (Fgf1), mRNA.
ACCESSION   NM_012846
VERSION     NM_012846.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Denes,V., Kovacs,K., Lukats,A., Mester,A., Berta,G., Szabo,A. and
            Gabriel,R.
  TITLE     Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed by
            PAC1-immunopositive retinal ganglion cells in the postnatal rat
            retina
  JOURNAL   Eur J Histochem 66 (2), 3373 (2022)
   PUBMED   35477223
  REMARK    GeneRIF: Secreted key regulators (Fgf1, Bmp4, Gdf3) are expressed
            by PAC1-immunopositive retinal ganglion cells in the postnatal rat
            retina.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Kolodziejski,P.A., Sassek,M., Bien,J., Leciejewska,N.,
            Szczepankiewicz,D., Szczepaniak,B., Wojciechowska,M., Nogowski,L.,
            Nowak,K.W., Strowski,M.Z. and Pruszynska-Oszmalek,E.
  TITLE     FGF-1 modulates pancreatic beta-cell functions/metabolism: An in
            vitro study
  JOURNAL   Gen Comp Endocrinol 294, 113498 (2020)
   PUBMED   32360543
  REMARK    GeneRIF: FGF-1 modulates pancreatic beta-cell functions/metabolism:
            An in vitro study.
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Ghazavi,H., Hoseini,S.J., Ebrahimzadeh-Bideskan,A., Mashkani,B.,
            Mehri,S., Ghorbani,A., Sadri,K., Mahdipour,E., Ghasemi,F.,
            Forouzanfar,F., Hoseini,A., Pasdar,A.R., Sadeghnia,H.R. and
            Ghayour-Mobarhan,M.
  TITLE     Fibroblast Growth Factor Type 1 (FGF1)-Overexpressed
            Adipose-Derived Mesenchaymal Stem Cells (AD-MSCFGF1) Induce
            Neuroprotection and Functional Recovery in a Rat Stroke Model
  JOURNAL   Stem Cell Rev Rep 13 (5), 670-685 (2017)
   PUBMED   28795363
  REMARK    GeneRIF: FGF1-overexpressed adipose-derived mesenchymal stem induce
            neuroprotection and functional recovery in a rat stroke model.
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Huang,Z., Tan,Y., Gu,J., Liu,Y., Song,L., Niu,J., Zhao,L.,
            Srinivasan,L., Lin,Q., Deng,J., Li,Y., Conklin,D.J., Neubert,T.A.,
            Cai,L., Li,X. and Mohammadi,M.
  TITLE     Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning
            FGF1-FGF Receptor Dimer Stability
  JOURNAL   Cell Rep 20 (7), 1717-1728 (2017)
   PUBMED   28813681
  REMARK    GeneRIF: Suboptimal FGFR activation by a weak FGF1-FGFR dimer is
            sufficient to evoke a metabolic response, whereas full FGFR
            activation by stable and sustained dimerization is required to
            elicit a mitogenic response.
REFERENCE   5  (bases 1 to 1185)
  AUTHORS   Chapman,J.R., Katsara,O., Ruoff,R., Morgenstern,D., Nayak,S.,
            Basilico,C., Ueberheide,B. and Kolupaeva,V.
  TITLE     Phosphoproteomics of Fibroblast Growth Factor 1 (FGF1) Signaling in
            Chondrocytes: Identifying the Signature of Inhibitory Response
  JOURNAL   Mol Cell Proteomics 16 (6), 1126-1137 (2017)
   PUBMED   28298517
  REMARK    GeneRIF: This is the first time a comprehensive subset of proteins
            involved in FGF inhibitory response is defined. We were able to
            identify a number of targets and specifically discover glycogen
            synthase kinase3beta (GSK3beta) as a novel key mediator of FGF
            inhibitory response in chondrocytes.
REFERENCE   6  (bases 1 to 1185)
  AUTHORS   Cheng,H., Cao,Y. and Olson,L.
  TITLE     Spinal cord repair in adult paraplegic rats: partial restoration of
            hind limb function
  JOURNAL   Science 273 (5274), 510-513 (1996)
   PUBMED   8662542
REFERENCE   7  (bases 1 to 1185)
  AUTHORS   Ornitz,D.M., Xu,J., Colvin,J.S., McEwen,D.G., MacArthur,C.A.,
            Coulier,F., Gao,G. and Goldfarb,M.
  TITLE     Receptor specificity of the fibroblast growth factor family
  JOURNAL   J Biol Chem 271 (25), 15292-15297 (1996)
   PUBMED   8663044
REFERENCE   8  (bases 1 to 1185)
  AUTHORS   Chopin,D.K., Caruelle,J.P., Colombel,M., Palcy,S., Ravery,V.,
            Caruelle,D., Abbou,C.C. and Barritault,D.
  TITLE     Increased immunodetection of acidic fibroblast growth factor in
            bladder cancer, detectable in urine
  JOURNAL   J Urol 150 (4), 1126-1130 (1993)
   PUBMED   7690426
REFERENCE   9  (bases 1 to 1185)
  AUTHORS   Speir,E., Sasse,J., Shrivastav,S. and Casscells,W.
  TITLE     Culture-induced increase in acidic and basic fibroblast growth
            factor activities and their association with the nuclei of vascular
            endothelial and smooth muscle cells
  JOURNAL   J Cell Physiol 147 (2), 362-373 (1991)
   PUBMED   1710230
REFERENCE   10 (bases 1 to 1185)
  AUTHORS   Goodrich,S.P., Yan,G.C., Bahrenburg,K. and Mansson,P.E.
  TITLE     The nucleotide sequence of rat heparin binding growth factor 1
            (HBGF-1)
  JOURNAL   Nucleic Acids Res 17 (7), 2867 (1989)
   PUBMED   2470029
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Nov 26, 2020 this sequence version replaced NM_012846.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14232.1, SRR26643290.51353.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840115,
                                           SAMN12840117 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000018.1  30961161-30961393   c
            234-436             JAXUCZ010000018.1  30956654-30956856   c
            437-540             JAXUCZ010000018.1  30945778-30945881   c
            541-1185            JAXUCZ010000018.1  30940421-30941065   c
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p11"
     gene            1..1185
                     /gene="Fgf1"
                     /gene_synonym="FGF-1; Fgf2b; HBGF-1; HBGF1"
                     /note="fibroblast growth factor 1"
                     /db_xref="GeneID:25317"
                     /db_xref="RGD:2605"
     exon            1..233
                     /gene="Fgf1"
                     /gene_synonym="FGF-1; Fgf2b; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..436
                     /gene="Fgf1"
                     /gene_synonym="FGF-1; Fgf2b; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..735
                     /gene="Fgf1"
                     /gene_synonym="FGF-1; Fgf2b; HBGF-1; HBGF1"
                     /note="heparin-binding growth factor 1; aFGF; acidic
                     fibroblast growth factor; Fibroblast growth factor 1
                     (heparin binding); fibroblast growth factor 1 (acidic);
                     fibroblast growth factor 2b"
                     /codon_start=1
                     /product="fibroblast growth factor 1"
                     /protein_id="NP_036978.1"
                     /db_xref="GeneID:25317"
                     /db_xref="RGD:2605"
                     /translation="MAEGEITTFAALTERFNLPLGNYKKPKLLYCSNGGHFLRILPDG
                     TVDGTRDRSDQHIQLQLSAESAGEVYIKGTETGQYLAMDTEGLLYGSQTPNEECLFLE
                     RLEENHYNTYTSKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD"
     exon            437..540
                     /gene="Fgf1"
                     /gene_synonym="FGF-1; Fgf2b; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..1185
                     /gene="Fgf1"
                     /gene_synonym="FGF-1; Fgf2b; HBGF-1; HBGF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagggtg ggaggaaggg cggtaatctc taggaagcag aaggcaggtt tgcagaggac
       61 gctggatagg agatgaggtg ggggaaacca aggcctgggc ttcccgcagg ctgcagcaag
      121 gttttggtgc ttaccacagc agcaggaatg cattgaggga tgtgacagtg gaacgcaggt
      181 ggcagtgata ctcactgctg ctgaaggagc ccaaagaacc agcatctgac ctgtcttgaa
      241 cgcaccatcg acagttgctg ctgagtcatg gccgaagggg agatcacaac ctttgcagcc
      301 ctgaccgaga ggttcaatct gcctctaggg aactacaaaa aacccaaact gctctactgc
      361 agcaacgggg gccacttctt gaggattctt cccgatggca ccgtggatgg gaccagggac
      421 aggagcgacc agcacattca gctgcagctc agtgcggaaa gcgcgggcga agtgtatata
      481 aagggtacag agactggcca gtacttggcc atggacaccg aagggctttt atacggctcg
      541 cagacaccaa atgaagaatg cctattcctg gaaaggctag aagaaaacca ttataacact
      601 tacacatcca agaagcacgc ggagaagaac tggtttgtgg gcctcaagaa gaacgggagt
      661 tgtaagcgcg gtcctcggac tcactacggc cagaaagcca tcttgtttct ccccctcccg
      721 gtatcttctg actaaggagt ctgttctggg tgctccctat ttttggttga ccctaaaatg
      781 ttcccttgac cattggctgc gctaaccctc agcccacaga gcctgaattt gtaagcagtg
      841 cttctaaata gccagttcac ttttccgctg agcccttccc caccacccca gcacagtttg
      901 gaacacgggg accaaattac ttctagggga caactggctg gccagtctag gtctgggttt
      961 ggatatccag atgcttcagg gtacctgcta caagttggac ctcgtgatac aaagagggga
     1021 gccatgtgta gcatctggag gggtctaaga agtgggttct tttagtagct gcatgctctt
     1081 tccccttctg agtaatccct ggttttgagt acccccaggc acttagcatg actacccttc
     1141 cccctaccag cacctcataa atatcagtaa agaaactgat agtaa
//
